Advanced search
Publication Cover
International Journal of Hyperthermia Volume 19, 2003 - Issue 5
Submit an article Journal homepage
240
Views
18
CrossRef citations to date
0
Altmetric
Research Article

Quercetin sensitizes cells in a tumour-like low pH environment to hyperthermia

P. R. Wachsberger Department of Radiation Oncology Kimmel Cancer Center and Thomas Jefferson University Philadelphia PA 19107 USA
,
R. Burd Department of Biochemistry and Molecular Pharmacology Kimmel Cancer Center and Thomas Jefferson University Philadelphia PA 19107 USA
,
A. Bhala Department of Radiation Oncology Kimmel Cancer Center and Thomas Jefferson University Philadelphia PA 19107 USA
,
S. B. Bobyock Department of Biochemistry and Molecular Pharmacology Kimmel Cancer Center and Thomas Jefferson University Philadelphia PA 19107 USA
,
M. L. Wahl Department of Radiation Oncology Kimmel Cancer Center and Thomas Jefferson University Philadelphia PA 19107 USA
,
C. S. Owen Department of Biochemistry and Molecular Pharmacology Kimmel Cancer Center and Thomas Jefferson University Philadelphia PA 19107 USA
,
S. B. Rifat Department of Radiation Oncology Kimmel Cancer Center and Thomas Jefferson University Philadelphia PA 19107 USA
&
D. B. Leeper Department of Biochemistry and Molecular Pharmacology Kimmel Cancer Center and Thomas Jefferson University Philadelphia PA 19107 USA
 show all
Pages 507-519 | Published online: 09 Jul 2009

  • Engin K, Leeper DB, Thistlethwaite AJ, Tupchong L, McFarlane JD. Extracellular pH distribution in human tumours. Int J Hyperthermia 1995; 11: 211-6.
  • Vaupel P, Habil M, Kelleher DK, Thews O. Modulation of tumor oxygenation. Int J Radiat Oncol Biol Phys 1998; 42: 843-8.
  • Rockwell S, Hughes CS. Microenvironmental changes in irradiated tumors. Prog Clin Biol Res 1990; 354B: 67-80.
  • Wahl ML, Coss RA, Bobyock SB, Leeper DB, Owen CS. Thermotolerance and intracellular pH in two Chinese hamster cell lines adapted to growth at low pH. / Cell Physiol 1996; 166: 438-45.
  • Wahl ML, Bobyock SB, Leeper DB, Owen CS. Effects of 420C hyperthermia on intracellular pH in ovarian carcinoma cells during acute or chronic exposure to low extracellular pH. Int J Radiat Oncol Biol Phys 1997; 38: 205-12.
  • Subjeck JR, Sciandra, JJ, Johnson RJ. Heat shock proteins and thermotolerance; a comparison of induction kinetics. Br J Radial 1982; 55: 579-84.
  • Li GC, Laszlo A. Thermotolerance in mammalian cells: a possible role for heat shock proteins. In: Atkinson BG and Waiden DB, eds. Changes in Eukaryotic Gene Expression in Response to Environmental Stress. New York: Academic Press, 1985; 227-54.
  • Mizzen L, Welch WJ. Characterization of the thermotolerant cell. 1. Effects on protein synthesis activity and the regulation of heat-shock protein 70 expression. / Cell Biol 1988; 106: 1105-16.
  • Lee YJ, Erdos G, Hou Z, Kim SH, Kim JH, Cho JM, Corry PM. Mechanism of quercetin-induced suppression and delay of heat shock gene expression and thermotolerance development in HT-29 cells. MoI Cell Biochem 1994; 137: 141-54.
  • Lindquist S, Craig EA. The heat shock proteins. Annu Rev Genet 1988; 22: 631-77.
  • Welch WJ. Mammalian stress response: cell physiology, structure/function of stress proteins and implication for medicine and diseases. Physiol Rev 1992; 72: 1063-81.
  • Morimoto RI, Sarge KD, Abravaya K. Transcriptional regulation of heat shock genes. JBiol Chem 1992; 267: 21987-90.
  • Hoj A, Jakobsen BK. A short element required for turning offbeat shock transcription factor. EBBO J 1994; 13: 2617-24.
  • Kirn D, Ouyang H, Li GC. Heat shock protein HSP70 accelerates the recovery of heatshocked mammalian cells through its modulation of heat shock transcription factor HSFl. Proc Natl Acad Sd USA 1995; 92: 2126-30.
  • Cotto JJ, Kline M, Morimoto RI. Activation of heat shock factor! DNA binding precedes stress-induced serine phosphorylation. J Biol Chem 1996; 271: 3355-8.
  • Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK. Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor 1. J Biol Chem 1996; 271: 30847-57.
  • McMillan RD, Xiao X, Shao L, Graves K, Benjamin IJ. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heatinducible apoptosis. J Biol Chem 1998; 273: 7523-8.
  • Dunnick JK, Hailey JR. Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundamental Appl Toxicol 1992; 19: 423-31.
  • Kim JH, Kim SH, Alfieri AA, Young CW. Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells. Cancer Res 1984; 44: 102-6.
  • Kantengwa S, Polla BS. Flavonoids, but not protein kinase C inhibitors, prevent stress protein synthesis during erythrophagocytosis. Biochem Biophys Res Commun 1991; 180: 308-14.
  • Hosokawa N, Hirayoshi K, Kudo H, Takechi H, Aoike A, Kawai K, Nagata K. Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. MoI Cell Biol 1992; 12: 3490-8.
  • Lee YJ, Curetty L, Hou Z, Kim SH, Kim JH, Corry PM. Effect of pH on quercetininduced suppression of heat shock gene expression and thermotolerance development in HT-29 cells. Biochem Biophys Res Commun 1992; 186: 1121-8.
  • Elia G, Amici C, Rossi A, Santoro G. Modulation of prostaglandin A !-induced thermotolerance by quercetin in human leukemic cells: role of heat shock prtoein 70. Cancer Res 1996; 56: 210-7.
  • Wei Y, Zhao X, Kariya Y, Fukagta H, Teshigawara K, Uchida A. Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res 1994; 54: 4952-7.
  • Nagai N, Nakai A, Nagata K. Quercetin suppresses heat-shock response by down-regulation of HSFl. Biochem Biophys Res Comm 1995; 208: 1099-105.
  • Cochet C, Feige JJ, Pirollet F, Keramides M, Chambaz EM. Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols. Biochem Pharmacol 1982; 31: 1357-61.
  • Geschwendt M, Horn F, Kittstein W, Marks F. Inhibition of the calcium and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin. Biochem Biophys Res Commun 1983; 117: 444-7.
  • Levy J, Teuerstein I, Marbach M, Radian S, Sharon Y. Tyrosine protein kinase activity in the DMBA-induced ramt mammary tumor: inhibition by quercetin. Biochem Biophys Res Commun 1984; 123: 1227-33.
  • Srivastasa AK. Inhibitiion of phosphorylase kinase and tyrosine protein kinase activities by quercetin. Biochem Biophys Res Commun 1985; 131: 1-5.
  • Matter WF, Brown RF, Vlahos CJ. The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs. Biochem Biophys Res Commun 1992; 86: 624-31.
  • Sinclair WK, Morton RA. X-ray and ultraviolet sensitivity of synchronized Chinese hamster cells at various stages of the cell cycle. Biophys J 1965; 5: 1-25.
  • Owen CS, Pooler PM, Wahl ML, Coss RA, Leeper DB. Altered proton extrusion in cells adapted to growth at low extracellular pH. / Cell Physiol 1997; 173: 397-405.
  • Stevens MF, McCaIl CJ, Lelieveld P, Alexander P, Richter A, Davies DE. Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin. J Medicinal Chem 1994; 37: 1689-95.
  • Shen F, Herenyiova M, Weber G. Synergestic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin in human ovarian carcinoma cells. Life Sei 1999; 65: 1869-76.
  • Anderson RL, Fong KJ, Gabrielle T, Lavagnini P, Hahn GM, Evans JW, Waldren CA, Stmato TD, Giaccia AJ. Loss of the intrinsic heat resistance of human cells and changes in Mr 70000 heat shock protein expression in human _ hamster hybrids. Cancer Res 1991 ; 51 : 2636-41.
  • Leeper DB, Rifat SB, Wahl ML, Owen CS. Heat shock protein synthesis in mammalian cells adapted to growth at low pHe. In: Hagen U, Harder D, Jung H, Streifer C, eds. Radiât Res lffh Int Cong Proc 2. 1995; 973-76, Wurzburg: Universitad tdruckerei H. Sturt.
  • Gerwick LE, Jennings M, Richards B. Influence of pH on the response of cells to single and split doses of hyperthermia. Cancer Res 1980; 40: 4019-24.
  • Koishi M, Hosokawa N, Sato M, Nakai A, Hirayoshi K, Hiraoka M, Abe M, Nagata K. Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line. Jpn J Cancer Res 1992; 83: 1216-22.
  • Landry J, Chretien P, Lambert H, Hickey E, Weber LA. Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells. J Cell Biol 1989; 109: 7-15.
  • Lavoie JN, Lambert H, Hickey E, Weber LA, Landry J. Modulation of cellular thermorésistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. MoI Cell Biol 1995; 15: 506-16.
  • Wachsberger PR, Landry J, Storck C, Davis K, O'Hara MD, Owen CS, Leeper DB. Mammalian cells adapted to growth at pH 6.7 have elevated HSP27 levels and are resistant to cisplatin. Int J Hyperthermia 1997; 13: 251-5.
  • Graziani Y, Chayoth R, Karny N, Feldman B, Levy J. Regulation of protein kinase activity by quercetin in Ehrlich ascites tumor cells. Biochem Biophys Acta 1981; 714: 415-21.
  • End DW, Look RA, Shafler NL, Balles EA, Persico FJ. Non-selective inhibition of mammalian protein kinases by flavonoids in vitro. Res Comm Chem Pathol Pharmacol 1987; 56: 75-86.
  • Nagasaka Y, Nakamura K. Modulation of the heat-induced activation of mitogenactivated protein (MAP) kinase by quercetin. Biochem Pharmacol 1998; 56: 1151-5.
  • Legagneux V, Dubois MF, Morange M, Bensaude O. Phosphorylation of the 90 kDa heat shock protein in heat-shocked HeLa cell lysates. FEBS Lett 1988; 231: 417-20.
  • Lavoie JN, Gingras-Breton G, Tanguay RM, Landry J. Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization. J Biol Chem 1993; 268: 3420-9.
  • Keyse SM. An emerging family of dual specificity MAP kinase phophatases. Biochem Biophys Acta 1995; 1265: 152-60.
  • Makita H, Tanaka T, Fujitsuka H, Tatematsu N, Satoh K, Kara A, Mori H. Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin. Cancer Res 1996; 56: 4904-9.
  • Kang ZC, Tsai SJ, Lee H. Quercetin inhibits benzo[a] pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 [A] gene expxression. Nutrit Cancer 1999; 35: 175-9.
  • Asea A, Ara G, Teicher BA, Stevenson MA, Calderwood SK. Treatment of prostate tumor with hyperthermia and tyrosine kinase inhibitors. Int J Hyperthermia 2001; 17: 347-56.
  • Shoskes DA, Zeitlin SI, Shahed A, Rajfer J. Quercetin in men with category HI chronic prostatitis: a preliminary prospective, double blind, placebo-controlled trial. Urology 1999; 54: 960-3.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.