Advanced search
Publication Cover
International Journal of Hyperthermia Volume 20, 2004 - Issue 2: Radiosensitization by hyperthermia: Mechanisms and clinical Implications
Submit an article Journal homepage
230
Views
26
CrossRef citations to date
0
Altmetric
Original Article

Transfection of human tumour cells with Mre11 siRNA and the increase in radiation sensitivity and the reduction in heat-induced radiosensitization

M. Xu Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USACorrespondence[email protected]
,
R. J. Myerson Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
,
C. Hunt Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
,
S. Kumar Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
,
E. G. Moros Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
,
W. L. Straube Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
&
J. L. Roti Roti Radiation Oncology Department, Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
 show all
Pages 157-162 | Received 13 Jun 2003, Accepted 04 Sep 2003, Published online: 09 Jul 2009

References

  • Kampinga HH, Dikomey E. Hyperthermic radiosensitization: mode of action and clinical relevance. Int J Radiat Biol 2001; 77: 399–408.
  • Overgaard J, Gonzalez DG, Hulshof MGG, Arcangelli G, Dahl O, Mella O, Bentzen SM. Randomized trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. Lancet 1995; 345: 540–3.
  • Overgaard J, Gonzalez DG, Hulshof MGG, Arcangelli G, Dahl O, Mella O, Bentzen SM. Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermia Oncology. Int J Hyperthermia 1996; 12: 3–20.
  • Vernon CC, Hand JW, Field SB, Machin D, Whaley JB, Vanderzee J, Van Putten WU, Van Rhoon GC, Van Dijk JDP, Gonzalez Gonzalez D, Liu FF, Goodman P, Sherar M. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. Int J Radiat Oncol Biol Phys 1996, 35: 731–44.
  • Sneed PK, Stauffer PR, McDermott MW, Diederich CJ, Lamborn KR, Prados MD, Chang S, Weaver KA, Spry L, Malec MK, Lamb SA, Voss B, Davis RL, Wara WM, Larson DA, Phillips TL, Gutin PH. A benefit of hyperthermia in a prospective rando- mized trial of brachytherapy boosthyperthermia for glioblastoma multiforme. Int JRadiat Oncol Biol Phys 1998; 40: 287–95.
  • Dewey WC, Hopwood LE, Sapareto SA, Gerweck LD. Cellular responses to combina-tions of hyperthermia and radiation. Radiology 1982; 123: 463–74.
  • Perez CA, Emami B. A review of current clinical experience with irradiation and hyperthermia. Endocuriether Hyperthermia Oncol 1985; 1: 265–77.
  • Lee HK, Antell AG, Perez CA, Straube WL, Ramachandran G, Myerson RJ, Emami B, Molmenti EP, Buckner A, Lockett MA. Superficial hyperthermia and irradiation for recurrent breast carcinoma of the chest wall: prognostic factors in 196 tumors. Int J Radiat Oncol Biol Phys 1998; 40: 365–75.
  • Riess H, Loffel J, Wust P, Rau B, Gremmler M, Speidel A, Schlag P. A pilot study of a new therapeutic approach in the treatment of locally advanced stages of rectal cancer: neoadjuvant radiation, chemotherapy and regional hyperthermia. Eur J Cancer 1995; 31: 1356–60.
  • Vanderzee J, Gonzalez Gonzalez D, Van Rhoon GC, Van Dijk JD, Van Puten WL, Hart AAM. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective randomized, multicentre trial. Dutch Deep Hyperthermia Group. Lancet 2000; 355: 1119–25.
  • Cummings WJ, Zolan ME. Functions of DNA repair genes during meiosis. Curr Topics Develop Biol 1998; 37: 117–40.
  • Game JC. DNA double strand breaks and the RAD5O-RAD57 genes in Saccharornyces. Sem Cancer Biol 1993; 4: 73–83.
  • Kironmai KM, Muniyappa K. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharornyces cerevisiae. Genes Cells 1997; 2: 443–55.
  • Boulton Si, Jackson SP. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J 1998; 17: 1819–28.
  • Nugent CL, Bosco G, Ross LO, Evans SK, Salinger AP, Moore JK, Haber JE, Lundblad V. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr Biol 1998; 8: 657–60.
  • Xu M, Myerson RJ, Straube WL, Moros EG, Lagroye I, Wang LL, Lee JT, Roti Roti JL. Radiosensitization of heat resistant human tumor cells by 1 hour at 41.1°C and its effect on DNA repair. Int J Hypertherrnia 2002; 18: 385–403.
  • Zhu WG, Seno JD, Beck BD, Dynlacht JR. Translocation of MREll from the nucleus to the cytoplasm as a mechanism of radiosensitization by heat. Radiat Res 2001; 95–102.
  • Hammond SM, Caudy AA, Hannon GJ. Post-transcriptional gene silencing by double-stranded RNA. Nature 2001; 2: 110–19.
  • Xu M, Wright WD, Higashikubo R, Roti Roti JL. Chronic thermotolerance with continued cell proliferation. Int J Hypertherrnia 1996; 12: 645–60.
  • Stracker TH, Carson CT, Weitzman MD. Adenovirus oncoproteins inactivate the Mrell-Rad5O-NBS1 DNA repair complex. Nature 2002; 418: 348–52.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.