Clinical applications of focused ultrasound—The brain

References

• Lynn JG, Zwemer RL, Chick AJ, Miller AE. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol 1942; 26: 179–193
   PubMedGoogle Scholar
• Lynn JG, Putnam TJ. Histology of cerebral lesions produced by focused ultrasound. Am J Path 1944; 20: 637–652
   PubMedGoogle Scholar
• Wall PD, Fry WJ, Stephens R, Tucker D, Lettvin JY. Changes produced in the central nervous system by ultrasound. Science 1951; 114: 686–687
   PubMed Web of Science ®Google Scholar
• Fry WJ, Mosberg W, Barnard JW, Fry FJ. Production of focal destructive lesions in the central nervous system with ultrasound. J Neurosurg 1954; 11: 471–478
   PubMed Web of Science ®Google Scholar
• Fry WJ, Barnard JW, Fry FJ, Krumins RF, Brennan JF. Ultrasonic lesions in the mammalian central nervous system. Science 1955; 122: 517–518
   PubMed Web of Science ®Google Scholar
• Fry WJ, Barnard JW, Fry FJ. Ultrasonically produced localized selective lesions in the central nervous system. Am J Phys Med 1955; 34: 413–423
   PubMedGoogle Scholar
• Barnard JW, Fry WJ, Fry FJ, Brennan JF. Small localized ultrasonic lesions in the white and gray matter of the cat brain. AMA Arch Neurol 1956; 75: 15–35
   Google Scholar
• Barnard JW, Fry WJ, Fry FJ, Brennan JF. Small localized ultrasonic lesions in the white and gray matter of the cat brain. Arch Neurol Psychiatry 1956; 75: 15–35
   PubMedGoogle Scholar
• Bakay L, Hueter TF, Ballantine HT, Sosa D. Ultrasonically produced changes in the blood-brain barrier. Arch Neurol 1956; 76: 457–467
   Web of Science ®Google Scholar
• Lele PP. A simple method for production of trackless focal lesions with focused ultrasound: Physical factors. J Physiol 1962; 160: 494–512
   PubMed Web of Science ®Google Scholar
• Lele PP. Production of deep focal lesions by focused ultrasound—current status. Ultrasonics 1967; 5: 105–122
   PubMed Web of Science ®Google Scholar
• Lele PP, Pierce AD. The thermal hypothesis of the mechanism of ultrasonic focal destruction in organised tissues. Interaction of ultrasound and biological tissues. Bureau of Radiological Health, Washington, DC 1973; 121–128, FDA 73-8008 BRH/DBE
   Google Scholar
• Robinson TC, Lele PP. An analysis of lesion development in the brain and in plastic by high-intensity focused ultrasound at low-megaherz frequencies. J Acoust Soc Am 1972; 51: 1333–1351
   PubMed Web of Science ®Google Scholar
• Lele PP. Threshold and mechanisms of ultrasonic damage to organized animal tissues. Proceedings of a Symposium on Biological effects and characterization of ultrasound sources, Rockville, MDUSA, June 1–3, 1977, 224–239
   Google Scholar
• Lele PP. Effects of ultrasound on “solid” mammalian tissues and tumors in vivo. Ultrasound: Medical applications, biological effects and hazard potential, MH Repacholi, M Grondolfo, A Rindi. Plenum Pub. Corp., New York 1987; 273–306
   Google Scholar
• Vykhodtseva NI, Gavrilov LR, Mering TA, Iamshchikova NG. [Use of focused ultrasound for local destruction of different brain structures] Primenenie fokusirovannogo ul'trazvuka dlia lokal'nykh razrushenii razlichnykh struktur golovnogo mozga. Zh Nevropatol Psikhiatr 1976; 76: 1810–1816
   PubMedGoogle Scholar
• Fry WJ, Fry FJ. Fundamental neurological research and human neurosurgery using intense ultrasound. IRE Trans Med Electron 1960; ME-7: 166–181
   PubMedGoogle Scholar
• Fry FJ, Kossoff G, Eggleton RC, Dunn F. Threshold ultrasonic dosages for structural changes in the mammalian brain. J Acoust Soc Am 1970; 48: 1413–1417
   Google Scholar
• Dunn F, Lohnes JE, Fry FJ. Frequency dependence of threshold ultrasonic dosages for irreversible structural changes in mammalian brain. J Acoust Soc Am 1975; 58: 512–514
   PubMed Web of Science ®Google Scholar
• Heimburger RF. Ultrasound augmentation of central nervous system tumor therapy. Indiana Med 1985; 78: 469–476
   PubMedGoogle Scholar
• Fry FJ, Sanghvi NT, Morris RF, Smithson S, Atkinson L, Dines K, Franklin T, Hastings J, et al. A focused ultrasound system for tissue volume ablation in deep seated brain sites. IEEE 1986 Ultrasonics Symp Proc (Cat.No.86CH2375-4), 1001. 1986
   Google Scholar
• Guthkelch AN, Carter LP, Cassady JR, Hynynen K, Iacono RP, Johnson PC, Obbens EAMT, Roemer RB, Seeger JF, Shimm DS, Stea B, et al. Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: Results of a phase I trial. J Neurooncol 1991; 10: 271–284
   PubMed Web of Science ®Google Scholar
• Anhalt DP, Hynynen K, Roemer RB. Patterns of changes of tumour temperatures during clinical hyperthermia: Implications for treatment planning, evaluation and control. Effect of phase errors on field patterns generated by an ultrasound phased-array hyperthermia applicator. Int J Hyperthermia 1995; 11: 425–436
   PubMed Web of Science ®Google Scholar
• McDannold N, Moss M, Killiany R, Rosene DL, King RL, Jolesz FA, Hynynen K, et al. MRI-guided focused ultrasound surgery in the brain: Tests in a primate model. Magn Reson Med 2003; 49: 1188–1191
   PubMed Web of Science ®Google Scholar
• Ram Z, Cohen ZR, Harnof S, Tal S, Faibel M, Nass D, Maier SE, Hadoni M, Mardor Y, et al. Magnetic resonance imaging-guided, high-intensity focused ultrasound for brain tumor therapy. Neurosurgery 2006; 59: 949–955
   PubMed Web of Science ®Google Scholar
• Park JW, Jung S, Junt TY, Lee MC. Focused ultrasound surgery for the treatment of recurrent anaplastic astrocytoma: A preliminary report. Therapeutic ultrasound. 5th International Symposium on Therapeutic Ultrasound. 2006, GT Clement, NJ McDannold, K Hynynen. American Institute of Physics, New York, 238–240
   Google Scholar
• Fry FJ. Transkull transmission of an intense focused ultrasonic beam. Ultrasound Med Biol 1977; 3: 179–184
   PubMedGoogle Scholar
• Fry FJ, Goss SA. Further studies of the transkull transmission of an intense focused ultrasonic beam: Lesion production at 500 kHz. Ultrasound Med Biol 1980; 6: 33–38
   PubMed Web of Science ®Google Scholar
• Fry FJ, Goss SA, Patrick JT. Transkull focal lesions in cat brain produced by ultrasound. J Neurosurg 1981; 54: 659–663
   PubMed Web of Science ®Google Scholar
• Do-Huu JP, Hartemann P. Annular array transducer for deep acoustic hyperthermia. IEEE Ultrasonics Symp 1981; 81CH1689-9: 705–710
   Google Scholar
• Ocheltree KB, Benkeser PJ, Frizzell LA, Cain CA. An ultrasonic phased array applicator for hyperthermia. IEEE Trans Sonics Ultras 1984; SU-31: 526–531
   Web of Science ®Google Scholar
• Benkeser PJ, Frizzell LA, Ocheltree KB, Cain CA. A tapered phased array ultrasound transducer for hyperthermia treatment. IEEE Trans Ultrason Ferroelectr Freq Control 1987; UFFC-34: 446–453
   Web of Science ®Google Scholar
• Frizzell LA, Benkeser PJ, Ocheltree KB, Cain CA. Ultrasound phased arrays for hyperthermia treatment. IEEE Ultrasonics Symp 1985; 2: 931–935
   Google Scholar
• Cain CA, Umemura SA. Concentric-ring and sector vortex phased array applicators for ultrasound hyperthermia therapy. Effect of phase errors on field patterns generated by an ultrasound phased-array hyperthermia applicator. IEEE Trans Microwave Theory Tech 1986; MTT-34: 542–551
   Web of Science ®Google Scholar
• Ebbini ES, Umemura SI, Ibbini M, Cain C. A cylindrical- section ultrasound phased array applicator for hyperthermia cancer therapy. Effect of phase errors on field patterns generated by an ultrasound phased-array hyperthermia applicator. IEEE Trans Ultrason Ferroelectr Freq Cont 1988; 35: 561–572
   PubMed Web of Science ®Google Scholar
• Diederich C, Hynynen K. The feasibility of using electrically focussed ultrasound arrays to induce deep hyperthermia via body cavities. IEEE Trans Ultrason Ferroelectr Freq Cont 1991; 38: 207–219
   PubMed Web of Science ®Google Scholar
• Fan X, Hynynen K. Control of the necrosed tissue volume during noninvasive ultrasound surgery using a 16 element phased array. Med Phys 1995; 22: 297–308
   PubMed Web of Science ®Google Scholar
• Daum DR, Hynynen K. A 256 element ultrasonic phased array system for treatment of large volumes of deep seated tissue. IEEE Trans Ultrason Ferroelectr Freq Cont 1999; 46: 1254–1268
   PubMed Web of Science ®Google Scholar
• Daum DR, Buchanan MT, Fjield T, Hynynen K. Design and evaluation of a feedback based phased array system for ultrasound surgery. IEEE Trans Ultrason Ferroelectr Freq Cont 1998; 45: 431–438
   PubMed Web of Science ®Google Scholar
• Thomas J-L, Fink MA. UItrasonic beam focusing through tissue inhomogeneities with a time reversal mirror: Application to transskull therapy. IEEE Trans Ultrason Ferroelectr Freq Cont 1996; 43: 1122–1129
   Web of Science ®Google Scholar
• Hynynen K, Jolesz FA. Demonstration of potential noninvasive ultrasound brain therapy through an intact skull. Ultrasound Med Biol 1998; 24: 275–283
   PubMed Web of Science ®Google Scholar
• Smith SW, Trahey G.E, von Ramm OT. Phased array ultrasound imaging through planar tissue layers. Ultrasound Med Biol (UK) 1986; 12: 229–243
   PubMed Web of Science ®Google Scholar
• Sun J, Hynynen K. Focusing of therapeutic ultrasound through a human skull: A numerical study. J Acoust Soc Am 1998; 104: 1705–1715
   PubMed Web of Science ®Google Scholar
• Sun J, Hynynen K. The potential of transskull ultrasound therapy and surgery using the maximum available skull surface area. J Acoust Soc Am 1999; 105: 2519–2527
   PubMed Web of Science ®Google Scholar
• Clement GT, White J, Hynynen K. Investigation of a large-area phased array for focused ultrasound surgery through the skull. Phys Med Biol 2000; 45: 1071–1083
   PubMed Web of Science ®Google Scholar
• Clement GT, Sun J, Giesecke T, Hynynen K. A hemisphere array for non-invasive ultrasound brain therapy and surgery. Phys Med Biol 2000; 45: 3707–3719
   PubMed Web of Science ®Google Scholar
• Tanter M, Thomas J-L, Fink MA. Focusing and steering through absorbing and aberrating layers: Application to ultrasonic propagation through the skull. J Acoust Soc Am 1998; 103: 2403–2410
   PubMed Web of Science ®Google Scholar
• Clement GT, Hynynen K. Micro-receiver guided transcranial beam steering. IEEE Trans Ultrason Ferroelectr Freq Cont 2002; 49: 447–453
   PubMed Web of Science ®Google Scholar
• Clement GT, Hynynen K. A noninvasive method for focusing ultrasound through the human skull. Phys Med Biol 2002; 47: 1219–1236
   PubMed Web of Science ®Google Scholar
• Aubry JF, Tanter M, Pernot M, Thomas J-L, Fink MA. Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans. J Acoust Soc Am 2003; 113: 84–93
   PubMed Web of Science ®Google Scholar
• Clement GT, Hynynen K. Correlation of ultrasound phase with physical skull properties. Ultrasound Med Biol 2002; 28: 617–624
   PubMed Web of Science ®Google Scholar
• Connor CW, Clement GT, Hynynen K. A unified model for the speed of sound in cranial bone based on genetic algorithm optimization. Phys Med Biol 2002; 47: 3925–3944
   PubMed Web of Science ®Google Scholar
• Clement GT, Hynynen KH. Criteria for the design and calibration of large area arrays for transskull ultrasound surgery and therapy. IEEE 2000 Ultrasonics Symp 2000; 2: 1243–1246
   Google Scholar
• Clement GT, White PJ, King RL, McDannold N, Hynynen K. A magnetic resonance imaging-compatible, large-scale array for trans-skull ultrasound surgery and therapy. J Ultrasound Med 2005; 24: 1117–1125
   PubMed Web of Science ®Google Scholar
• Hynynen K, Darkazanli A, Unger E, Schenck JF. MRI-guided noninvasive ultrasound surgery. Med Phys 1993; 20: 107–115
   PubMed Web of Science ®Google Scholar
• Darkazanli A, Hynynen K, Unger E, Schenck JF. On-line monitoring of ultrasound surgery with MRI. J Mag Res Imag 1993; 3: 509–514
   PubMed Web of Science ®Google Scholar
• Cline HE, Hynynen K, Hardy CJ, Watkins RD, Schenck JF, Jolesz FA. MR temperature mapping of focused ultrasound surgery. Magn Reson Med 1994; 30: 98–106
   Web of Science ®Google Scholar
• Hynynen K, Freund WR, Cline HE, Chung AH, Watkins RD, Vetro JP, Jolesz FA, et al. A clinical noninvasive MRI monitored ultrasound surgery method. Radiographics 1996; 16: 185–195
   PubMed Web of Science ®Google Scholar
• Hynynen K, Chung A, Fjield T, Buchanan MT, Daum D, Colucci V, Lopath, Jolesz F, et al. Feasibility of using ultrasound phased arrays for MRI monitored noninvasive surgery. IEEE Trans Ultrason Ferroelectr Freq Cont 1996; 43: 1043–1053
   Web of Science ®Google Scholar
• Hynynen K, Clement GT, McDannold N, Vykhodtseva N, King R, White PJ, Vitek S, Jolesz FA, et al. 500-element ultrasound phased array system for noninvasive focal surgery of the brain: A preliminary rabbit study with ex vivo human skulls. Magn Reson Med 2004; 52: 100–107
   PubMed Web of Science ®Google Scholar
• Connor CW, Hynynen K. Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery. IEEE Trans Biomed Eng 2004; 51: 1693–1706
   PubMed Web of Science ®Google Scholar
• White J, Clement GT, Hynynen K. Transcranial ultrasound focus reconstruction with phase and amplitude correction. IEEE Trans Ultrason Ferroelectr Freq Cont 2005; 52: 1518–1522
   PubMed Web of Science ®Google Scholar
• Hynynen K, Vykhodtseva NI, Chung A, Sorrentino V, Colucci V, Jolesz FA. Thermal effects of focused ultrasound on the brain: Determination with MR Imaging. Radiology 1997; 204: 247–253
   PubMed Web of Science ®Google Scholar
• Pernot M, Aubry JF, Tanter M, Thomas JL, Fink M. High power transcranial beam steering for ultrasonic brain therapy. Phys Med Biol 2003; 48: 2577–2589
   PubMed Web of Science ®Google Scholar
• Pernot M, Aubry JF, Tanter M, Boch AL, Kujas M, Fink M. Adaptive focusing for ultrasonic transcranial brain therapy: First in vivo investigation on 22 sheep. AIP Conf Proc 2005; 754: 174–177
   Google Scholar
• Marquet F, Aubry JF, Tanter M, Fink M. Non invasive transcranial brain therapy guided by CT scans: An in vivo monkey study. Presented in the 6th ISTU meeting. OxfordUK, 2006
   Google Scholar
• Hynynen K, McDannold N, Clement G, Jolesz FA, Zadicario E, Killiany R, Moore T, Rosen D, et al. Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain—A primate study. Eur J Radiol 2006; 59: 149–156
   PubMed Web of Science ®Google Scholar
• Hynynen K. The threshold for thermally significant cavitation in dog's thigh muscle in vivo. Ultrasound Med Biol 1991; 17: 157–169
   PubMed Web of Science ®Google Scholar
• Holt RG, Roy RA. Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material. Ultrasound Med Biol 2003; 27: 1399–1412
   Web of Science ®Google Scholar
• Sokka SD, King R, Hynynen K. MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh. Phys Med Biol 2003; 48: 223–241
   PubMed Web of Science ®Google Scholar
• Sokka SD, Gauthier TP, Hynynen K. Theoretical and experimental validation of a dual-frequency excitation method for spatial control of cavitation. Phys Med Biol 2005; 50: 2167–2179
   PubMed Web of Science ®Google Scholar
• Tran BC, Seo J, Hall TL, Fowlkes JB, Cain CA. Microbubble-enhanced cavitation for noninvasive ultrasound surgery. IEEE Trans Ultrason Ferroelectr Freq Cont 2003; 50: 1296–1304
   PubMed Web of Science ®Google Scholar
• McDannold NJ, Vykhodtseva NI, Hynynen K. Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. Radiology 2006; 241: 95–106
   PubMed Web of Science ®Google Scholar
• Vykhodtseva NI, Koroleva VI. [Changes in the steady potential in various structures of the rat brain induced by focused ultrasound] Sdvigi postoiannogo potentsiala v razlichnykh strukturakh golovnogo mozga krysy pri deistvii fokusirovannogo ul′trazvuka. Dokl Akad Nauk SSSR 1986; 287: 248–251
   PubMedGoogle Scholar
• Akiyama M, Ishibashi T, Yamada T, Furuhata H. Low-frequency ultrasound penetrates the cranium and enhances thrombolysis in vitro. Neurosurgery 1998; 43: 828–832
   PubMed Web of Science ®Google Scholar
• Alexandrov AV, Demchuk AM, Felberg RA, Christou I, Barber PA, Burgin WS, Malkoff M, Wojner AW, Grotta JC, et al. High rate of complete recanalization and dramatic clinical recovery during tPA infusion when continuously monitored with 2-MHz transcranial Doppler monitoring. Stroke 2000; 31: 610–614
   PubMed Web of Science ®Google Scholar
• Frenkel V, Oberoi J, Stone MJ, Park M, Deng C, Wood BJ, Neeman Z, Horne M, III, Li KC, et al. Pulsed high-intensity focused ultrasound enhances thrombolysis in an in vitro model. Radiology 2006; 239: 86–93
   PubMed Web of Science ®Google Scholar
• Moonen C, Madio D, de Zwart J, Olson A, DesPres D, van Gelderen PE, Mandel M, Voisin P, Canioni P, Vekris A, et al. MRI-guided focused ultrasound as a potential tool for control of gene therapy. Eur Radiol 1997; 7: 1165
   Google Scholar
• Silcox CE, Smith RC, King R, McDannold N, Bromley P, Walsh K, et al. MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate. Ultrasound Med Biol 2005; 31: 965–970
   PubMed Web of Science ®Google Scholar
• Hynynen K, McDannold N, Vykhodtseva NI, Jolesz FA. Noninvasive MR image guided focal opening of the blood–brain barrier. Radiology 2001; 220: 640–646
   PubMed Web of Science ®Google Scholar
• McDannold N, Vykhodtseva N, Hynynen K. Targeted disruption of the blood-brain barrier with focused ultrasound: Association with cavitation activity. Phys Med Biol 2006; 51: 793–807
   PubMed Web of Science ®Google Scholar
• Hynynen K, McDannold N, Sheikov NA, Jolesz FA, Vykhodtseva N. Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage 2005; 24: 12–20
   PubMed Web of Science ®Google Scholar
• Sheikov N, McDannold N, Jolesz F, Zhang YZ, Tam K, Hynynen K. Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood–brain barrier. Ultrasound Med Biol 2006; 32: 1399–1409
   PubMed Web of Science ®Google Scholar
• Kinoshita M, McDannold N, Jolesz FA, Hynynen K. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption. Proc Natl Acad Sci USA 2006; 103: 11719–11723
   PubMed Web of Science ®Google Scholar
• Treat LH, McDannold NJ, Vykhodtseva NI, Zhang Y, Tam K, Hynynen K (2006) Targeted drun delivery to the brain by MRI-guided focused ultrasound. Therapeutic ultrasound: 5th International Symposium on Therapeutic Ultrasound. 2005, GT Clement, NJ McDannold, K Hynynen. American Institute of Physics, 266–270
   Google Scholar