Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70, Gabriele Multhoff, International Journal of Hyperthermia, 2002;18:576–585

References

• Farkas B, Hantschel M, Magyarlaki M, Becker B, Scherer K, Landthaler M, Pfister K, Gehrmann M, Gross C, Mackensen A, Multhoff G. Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma. Melanoma Res 2003; 13: 147–152
   PubMed Web of Science ®Google Scholar
• Pfister K, Radons J, Busch R, Tidball JG, Pfeifer M, Freitag L, Feldmann HJ, Milani V, Issels R, Multhoff G. Patient survival by Hsp70 membrane phenotype: Association with different routes of metastasis. Cancer 2007; 110: 926–935
   PubMedGoogle Scholar
• Steiner K, Graf M, Hecht K, Reif S, Rossbacher L, Pfister K, Kolb HJ, Schmetzer HM, Multhoff G. High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis. Leukemia 2006; 20: 2076–2079
   PubMed Web of Science ®Google Scholar
• Gehrmann M, Schmetzer H, Eissner G, Haferlach T, Hiddemann W, Multhoff G. Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: A tumor specific recognition structure for the cytolytic activity of autologous NK cells. Haematologica 2003; 88: 474–476
   PubMed Web of Science ®Google Scholar
• Stangl S, Wortmann A, Guertler U, Multhoff G. Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells. J Immunol 2006; 176: 6270–6276
   PubMed Web of Science ®Google Scholar
• Multhoff G, Botzler C, Wiesnet M, Eissner G, Issels R. CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells. Blood 15-8-1995; 86: 1374–1382
   PubMed Web of Science ®Google Scholar
• Multhoff G, Botzler C, Jennen L, Schmidt J, Ellwart J, Issels R. Heat shock protein 72 on tumor cells: A recognition structure for natural killer cells. J Immunol 1997; 158: 4341–4350
   PubMed Web of Science ®Google Scholar
• Radons J, Multhoff G. Immunostimulatory functions of membrane-bound and exported heat shock protein 70. Exerc Immunol Rev 2005; 11: 17–33
   PubMed Web of Science ®Google Scholar
• Multhoff G, Mizzen L, Winchester CC, Milner CM, Wenk S, Eissner G, Kampinga HH, Laumbacher B, Johnson J. Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Exp Hematol 1999; 27: 1627–1636
   PubMed Web of Science ®Google Scholar
• Botzler C, Kolb HJ, Issels RD, Multhoff G. Noncytotoxic alkyl-lysophospholipid treatment increases sensitivity of leukemic K562 cells to lysis by natural killer (NK) cells. Int J Cancer 1996; 65: 633–638
   PubMed Web of Science ®Google Scholar
• Multhoff G, Hightower LE. Cell surface expression of heat shock proteins and the immune response. Cell Stress Chaperones 1996; 1: 167–176
   PubMed Web of Science ®Google Scholar
• Gehrmann M, Liebisch G, Schmitz G, Anderson R, Steinem C, De MA, Pockley G, Multhoff G. Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. PLoS ONE 2008; 3: e1925
   PubMed Web of Science ®Google Scholar
• Gastpar R, Gross C, Rossbacher L, Ellwart J, Riegger J, Multhoff G. The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells. J Immunol 2004; 172: 972–980
   PubMed Web of Science ®Google Scholar
• Gross C, Koelch W, DeMaio A, Arispe N, Multhoff G. Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. J Biol Chem 2003; 278: 41173–41181
   PubMed Web of Science ®Google Scholar
• Hightower LE, Guidon PT, Jr. Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins. J Cell Physiol 1989; 138: 257–266
   PubMed Web of Science ®Google Scholar
• Arispe N, Doh M, Simakova O, Kurganov B, De Maio A. Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability. FASEB J 2004; 18: 1636–1645
   PubMed Web of Science ®Google Scholar
• Arispe N, Doh M, De Maio A. Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70. Cell Stress Chaperones 2002; 7: 330–338
   PubMed Web of Science ®Google Scholar
• Vega VL, Rodriguez-Silva M, Frey T, Gehrmann M, Diaz JC, Steinem C, Multhoff G, Arispe N, De Maio A. Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J Immunol 2008; 180: 4299–4307
   PubMed Web of Science ®Google Scholar
• Falguieres T, Maak M, von WC, Sarr M, Sastre X, Poupon MF, Robine S, Johannes L, Janssen KP. Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool. Mol Cancer Ther 2008; 7: 2498–2508
   PubMed Web of Science ®Google Scholar
• Yeh C-H, Tseng R, Zhang Z, Cortes J, O`Brien S, Giles F, Hannah G, Estrov Z, Keating M, Kantarjian H, Albitar M. Circulating Hsp70 and progression in patients with chronic myeloid leukemia. Leukemia Res 2009; 33: 212–217
   PubMed Web of Science ®Google Scholar
• Njemini R, Demanet C, Mets T. Comparison of two ELISAs for the determination of Hsp70 in serum. J Immunol Methods 2005; 306: 176–182
   PubMed Web of Science ®Google Scholar
• Hartl FU, Hayer-Hartl M. Molecular chaperones in the cytosol: From nascent chain to folded protein. Science 2002; 295: 1852–1858
   PubMed Web of Science ®Google Scholar
• Pockley AG, Shepherd J, Corton JM. Detection of heat shock protein 70 (Hsp70) and anti-Hsp70 antibodies in the serum of normal individuals. Immunol Invest 1998; 27: 367–377
   PubMed Web of Science ®Google Scholar
• Pockley AG, Georgiades A, Thulin T, deFaire U, Frostegard J. Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension. Hypertension 2003; 42: 235–238
   PubMed Web of Science ®Google Scholar
• De Gassart A, Geminard C, Fevrier B, Raposo G, Vidal M. Lipid raft-associated protein sorting in exosomes. Blood 2003; 102: 4336–4344
   PubMed Web of Science ®Google Scholar
• Gross C, Hansch D, Gastpar R, Multhoff G. Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94. Biol Chem 2003; 384: 267–279
   PubMed Web of Science ®Google Scholar
• Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc Natl Acad Sci USA 2004; 101: 16606–16611
   PubMed Web of Science ®Google Scholar
• Elsner L, Muppala V, Gehrmann M, Lozano J, Malzahn D, Bickeboller H, Brunner E, Zientkowska M, Herrmann T, Walter L, Alves F, Multhoff G, Dressel R. The heat shock protein (Hsp70) promotes mouse NK cell activity against tumors that express inducible NKG2D ligands. J Immunol 2007; 179: 5523–5533
   PubMed Web of Science ®Google Scholar
• Gehrmann M, Radons J, Molls M, Multhoff G. The therapeutic implications of clinically applied modifiers of the Hsp70 expression by tumors. Cell Stress Chaperones 2008; 13: 1–10
   PubMed Web of Science ®Google Scholar
• Gasser S, Orsulic S, Brown EJ, Raulet DH. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 2005; 436: 1186–1190
   PubMed Web of Science ®Google Scholar
• Dayanc BE, Beachy SH, Ostberg JR, Repasky EA. Dissecting the role of hyperthermia in natural killer cell mediated anti-tumor responses. Int J Hyperthermia 2008; 24: 41–56
   PubMed Web of Science ®Google Scholar
• Krause SW, Gastpar R, Andreesen R, Gross C, Ullrich H, Thonigs G, Pfister K, Multhoff G. Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: A clinical phase I trial. Clin Cancer Res 2004; 10: 3699–3707
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Casares N, Pequignot MO, Chaput N, Albert ML, Kroemer G. Immune response against dying tumor cells. Adv Immunol 2004; 84: 131–179
   PubMedGoogle Scholar
• Camphausen K, Tofilon PJ. Inhibition of Hsp90: A multi-target approach to radiosensitization. Clin Cancer Res 2007; 13: 4326–4330
   PubMed Web of Science ®Google Scholar