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Original Articles

BRCA2 protects mammalian cells from heat shock

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Pages 795-801 | Received 18 Jun 2017, Accepted 17 Aug 2017, Published online: 10 Sep 2017

References

  • Takahashi A, Matsumoto H, Nagayama K, et al. (2004). Evidence for the involvement of double-strand breaks in heat-induced cell killing. Cancer Res 64:8839–45.
  • Takahashi A, Mori E, Somakos GI, et al. (2008). Heat induces γH2AX foci formation in mammalian cells. Mutat Res 656:88–92.
  • Ohnishi T, Mori E, Takahashi A. (2009). DNA double-strand breaks: their production, recognition, and repair in eukaryotes. Mutat Res 669:8–12.
  • Davis AJ, Chen DJ. (2013). DNA double strand break repair via non-homologous end-joining. Transl Cancer Res 2:130–43.
  • Chapman JR, Taylor MR, Boulton SJ. (2012). Playing the end game: DNA double-strand break repair pathway choice. Mol Cell 47:497–510.
  • Prakash R, Zhang Y, Feng W, Jasin M. (2015). Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb Perspect Biol 7:a016600.
  • Davies AA, Masson JY, McIlwraith MJ, et al. (2001). Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol Cell 7:273–82.
  • Takahashi A, Mori E, Nakagawa Y, et al. (2017). Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells. Int J Hyperthermia 33:336–42.
  • Oei AL, Vriend LE, Crezee J, et al. (2015). Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all. Radiat Oncol 10:165.
  • Ihara M, Suwa A, Komatsu K, et al. (1999). Heat sensitivity of double-stranded DNA-dependent protein kinase (DNA-PK) activity. Int J Radiat Biol 75:253–8.
  • Woudstra EC, Konings AW, Jeggo PA, Kampinga HH. (1999). Role of DNA-PK subunits in radiosensitization by hyperthermia. Radiat Res 152:214–18.
  • Ihara M, Takeshita S, Okaichi K, et al. (2014). Heat exposure enhances radiosensitivity by depressing DNA-PK kinase activity during double strand break repair. Int J Hyperthermia 30:102–9.
  • Burgman P, Ouyang H, Peterson S, et al. (1997). Heat inactivation of Ku autoantigen: possible role in hyperthermic radiosensitization. Cancer Res 57:2847–50.
  • Beck BD, Dynlacht JR. (2001). Heat-induced aggregation of XRCC5 (Ku80) in nontolerant and thermotolerant cells. Radiat Res 156:767–74.
  • Krawczyk PM, Eppink B, Essers J, et al. (2011). Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proc Natl Acad Sci USA 108:9851–6.
  • Bergs JW, Oei AL, Ten Cate R, et al. (2016). Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia. Int J Mol Med 38:243–50.
  • Harnicek D, Kampmann E, Lauber K, et al. (2016). Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair. Int J Cancer 139:467–79.
  • van den Tempel N, Laffeber C, Odijk H, et al. (2017). The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination. Oncotarget 8:44593–604.
  • Oei AL, Ahire VR, van Leeuwen CM, et al. (2017). Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i. Int J Hyperthermia. [Epub ahead of print]. DOI: 10.1080/02656736.2017.1324642.
  • van den Tempel N, Odijk H, van Holthe N, et al. (2017). Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies. Int J Hyperthermia. [Epub ahead of print]. DOI: 10.1080/02656736.2017.1355487.
  • Wiegant WW, Overmeer RM, Godthelp BC, et al. (2006). Chinese hamster cell mutant, V-C8, a model for analysis of Brca2 function. Mutat Res 600:79–88.
  • Nakagawa Y, Kajihara A, Takahashi A, et al. (2014). The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells. Oncol Rep 31:2001–6.
  • Bruun D, Folias A, Akkari Y, et al. (2003). siRNA depletion of BRCA1, but not BRCA2, causes increased genome instability in Fanconi anemia cells. DNA Repair (Amst) 2:1007–13.
  • Kondo N, Takahashi A, Mori E, et al. (2011). FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS One 6:e19659.
  • Schlacher K, Christ N, Siaud N, et al. (2011). Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell 145:529–42.
  • Noda T, Takahashi A, Kondo N, et al. (2011). Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage. Biochem Biophys Res Commun 404:206–10.
  • Seno JD, Dynlacht JR. (2004). Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock. J Cell Physiol 199:157–70.
  • Zhu WG, Seno JD, Beck BD, Dynlacht JR. (2001). Translocation of MRE11 from the nucleus to the cytoplasm as a mechanism of radiosensitization by heat. Radiat Res 156:95–102.
  • Takahashi A, Mori E, Ohnishi T. (2010). The foci of DNA double strand break-recognition proteins localize with γH2AX after heat treatment. J Radiat Res 51:91–5.
  • Xian Ma Y, Fan S, Xiong J, et al. (2003). Role of BRCA1 in heat shock response. Oncogene 22:10–27.
  • Genet SC, Fujii Y, Maeda J, et al. (2013). Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner. J Cell Physiol 228:1473–81.
  • Iliakis G, Seaner R. (1990). A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth. Int J Hyperthermia 6:801–12.
  • Dynlacht JR, Bittner ME, Bethel JA, Beck BD. (2003). The non-homologous end-joining pathway is not involved in the radiosensitization of mammalian cells by heat shock. J Cell Physiol 196:557–64.
  • van Oorschot B, Granata G, Di Franco S, et al. (2016). Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment. Oncotarget 7:65504–13.
  • Pennisi R, Ascenzi P, di Masi A. (2015). Hsp90: a new player in DNA repair? Biomolecules 5:2589–618.