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An overview of the role of sympathetic regulation of immune responses in infectious disease and autoimmunity

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Pages 135-143 | Received 18 Sep 2017, Accepted 27 Nov 2017, Published online: 02 Mar 2018

References

  • Costanzo ES, Sood AK, Lutgendorf SK. (2011). Biobehavioral influences on cancer progression. Immunol Allergy Clin North Am 31:109–32.
  • Schneiderman N, Ironson G, Siegel SD. (2005). Stress and health: psychological, behavioral, and biological determinants. Annu Rev Clin Psychol 1:607–28.
  • Brown EJ, Vosloo A. (2017). The involvement of the hypothalamopituitary-adrenocortical axis in stress physiology and its significance in the assessment of animal welfare in cattle. Onderstepoort J Vet Res 84:e1–9.
  • Miller DB, O’Callaghan JP. (2002). Neuroendocrine aspects of the response to stress. Metabolism 51:5–10.
  • Bucsek MJ, Qiao G, MacDonald CR, et al. (2017). Beta-adrenergic signaling in mice housed at standard temperatures suppresses an effector phenotype in CD8+ T cells and undermines checkpoint inhibitor therapy. Cancer Res 77:5639–51.
  • Eng JW, Reed CB, Kokolus KM, et al. (2015). Housing temperature-induced stress drives therapeutic resistance in murine tumour models through beta-adrenergic receptor activation. Nat Commun 6:6426.
  • Emeny RT, Gao D, Lawrence DA. (2007). β1-adrenergic receptors on immune cells impair innate defenses against Listeria. J Immunol 178:4876–84.
  • Cao L, Filipov NM, Lawrence DA. (2002). Sympathetic nervous system plays a major role in acute cold/restraint stress inhibition of host resistance to Listeria monocytogenes. J Neuroimmunol 125:94–102.
  • Cao L, Hudson CA, Lawrence DA. (2003). Acute cold/restraint stress inhibits host resistance to Listeria monocytogenes via β1-adrenergic receptors. Brain Behav Immun 17:121–33.
  • Miura T, Kudo T, Matsuki A, et al. (2001). Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection. Infect Immun 69:7234–41.
  • Rice PA, Boehm GW, Moynihan JA, et al. (2002). Chemical sympathectomy increases numbers of inflammatory cells in the peritoneum early in murine listeriosis. Brain Behav Immun 16:654–62.
  • Dimopoulos G, Theodorakopoulou M, Armaganidis A, et al. (2015). Esmolol: immunomodulator in pyelonephritis by Pseudomonas aeruginosa. J Surg Res 198:175–84.
  • Straub RH, Linde HJ, Männel DN, et al. (2000). A bacteria-induced switch of sympathetic effector mechanisms augments local inhibition of TNF-α and IL-6 secretion in the spleen. FASEB J 14:1380–8.
  • Gabanyi I, Muller Paul A, Feighery L, et al. (2016). Neuro-immune interactions drive tissue programming in intestinal macrophages. Cell 164:378–91.
  • Mazloomi E, Jazani NH, Shahabi S. (2012). A novel adjuvant, mixture of alum and the beta-adrenergic receptor antagonist propranolol, elicits both humoral and cellular immune responses for heat-killed Salmonella typhimurium vaccine. Vaccine 30:2640–6.
  • Seeley EJ, Barry SS, Narala S, et al. (2013). Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice. J Immunol 190:4717–24.
  • Johnson JD, Cortez V, Kennedy SL, et al. (2008). Role of central β-adrenergic receptors in regulating proinflammatory cytokine responses to a peripheral bacterial challenge. Brain Behav Immun 22:1078–86.
  • Merli M, Lucidi C, Di Gregorio V, et al. (2015). The chronic use of beta-blockers and proton pump inhibitors may affect the rate of bacterial infections in cirrhosis. Liver Int 35:362–9.
  • Breivik T, Gundersen Y, Opstad PK, Fonnum F. (2005). Chemical sympathectomy inhibits periodontal disease in Fischer 344 rats. J Periodontal Res 40:325–30.
  • Pachnio A, Ciaurriz M, Begum J, et al. (2016). Cytomegalovirus infection leads to development of high frequencies of cytotoxic virus-specific CD4+ T cells targeted to vascular endothelium. PLoS Pathog 12:e1005832.
  • Sanders VM. (1998). The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2, and B lymphocyte function. Adv Exp Med Biol 437:269–78.
  • Kim SB, Han YW, Rahman MM, et al. (2009). Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with [beta]2-adrenergic agonist. Exp Mol Med 41:812–23.
  • Kohut ML, Martin AE, Senchina DS, Lee W. (2005). Glucocorticoids produced during exercise may be necessary for optimal virus-induced IL-2 and cell proliferation whereas both catecholamines and glucocorticoids may be required for adequate immune defense to viral infection. Brain Behav Immun 19:423–35.
  • Logan HL, Lutgendorf S, Hartwig A, et al. (1998). Immune, stress, and mood markers related to recurrent oral herpes outbreaks. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86:48–54.
  • Freeman ML, Sheridan BS, Bonneau RH, Hendricks RL. (2007). Psychological stress compromises CD8(+) T cell control of latent herpes simplex virus type 1 infections. J Immunol 179:322–8.
  • Leo NA, Bonneau RH. (2000). Mechanisms underlying chemical sympathectomy-induced suppression of herpes simplex virus-specific cytotoxic T lymphocyte activation and function. J Neuroimmunol 110:45–56.
  • Grebe KM, Hickman HD, Irvine KR, et al. (2009). Sympathetic nervous system control of anti-influenza CD8+ T cell responses. Proc Natl Acad Sci USA 106:5300–5.
  • Estrada LD, Ağaç D, Farrar JD. (2016). Sympathetic neural signaling via the β2-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8+ T-cell effector function. Eur J Immunol 46:1948–58.
  • Liao YT, Wang SM, Wang JR, et al. (2015). Norepinephrine and epinephrine enhanced the infectivity of enterovirus 71. PLoS One 10:e0135154.
  • Shahabi S, Mohammadzadeh Hajipirloo H, Keramati A, et al. (2014). Evaluation of the adjuvant activity of propranolol, a Beta-adrenergic receptor antagonist, on efficacy of a malaria vaccine model in BALB/c mice. Iran J Allergy Asthma Immunol 13:307–16.
  • Garcia-Miss Mdel R, Mut-Martin MC, Gongora-Alfaro JL. (2015). Beta-Adrenergic blockade protects BALB/c mice against infection with a small inoculum of Leishmania mexicana mexicana (LV4). Int Immunopharmacol 24:59–67.
  • Machado MPR, Rocha AM, Oliveira LFd, et al. (2012). Autonomic nervous system modulation affects the inflammatory immune response in mice with acute Chagas disease. Exp Physiol 97:1186–202.
  • de Waal EJ, de Jong WH, van der Stappen AJ, et al. (1999). Effects of salmeterol on host resistance to Trichinella spiralis in rats. Int J Immunopharmacol 21:523–9.
  • Langhorst J, Cobelens PM, Kavelaars A, et al. (2007). Stress-related peripheral neuroendocrine–immune interactions in women with ulcerative colitis. Psychoneuroendocrinology 32:1086–96.
  • Deng Q, Chen H, Liu Y, et al. (2016). Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model. Brain Behav Immun 57:243–54.
  • Muller DM, Pender MP, Greer JM. (2000). A neuropathological analysis of experimental autoimmune encephalomyelitis with predominant brain stem and cerebellar involvement and differences between active and passive induction. Acta Neuropathol 100:174–82.
  • Simonini MV, Polak PE, Sharp A, et al. (2010). Increasing CNS noradrenaline reduces EAE severity. J Neuroimmune Pharmacol 5:252–9.
  • Haerter K, Vroon A, Kavelaars A, et al. (2004). In vitro adrenergic modulation of cellular immune functions in experimental autoimmune encephalomyelitis. J Neuroimmunol 146:126–32.
  • Del Rey A, Kabiersch A, Petzoldt S, Besedovsky HO. (2003). Sympathetic abnormalities during autoimmune processes: potential relevance of noradrenaline-induced apoptosis. Ann NY Acad Sci 992:158–67.
  • del Rey A, Wolff C, Wildmann J, et al. (2008). Disrupted brain–immune system–joint communication during experimental arthritis. Arthritis Rheum 58:3090–9.
  • Pawlak CR, Jacobs R, Mikeska E, et al. (1999). Patients with systemic lupus erythematosus differ from healthy controls in their immunological response to acute psychological stress. Brain Behav Immun 13:287–302.
  • Lubahn CL, Lorton D, Schaller JA, et al. (2014). Targeting alpha- and beta-Adrenergic receptors differentially shifts Th1, Th2, and inflammatory cytokine profiles in immune organs to attenuate adjuvant arthritis. Front Immunol 5:346.
  • Ahmed YM, Messiha BAS, Abo-Saif AA. (2017). Granisetron and carvedilol can protect experimental rats against adjuvant-induced arthritis. Immunopharmacol Immunotoxicol 39:97–104.
  • Straub RH, Rauch L, Rauh L, Pongratz G. (2011). Sympathetic inhibition of IL-6, IFN-γ, and KC/CXCL1 and sympathetic stimulation of TGF-β in spleen of early arthritic mice. Brain Behav Immun 25:1708–15.
  • Mao YF, Zhang YL, Yu QH, et al. (2012). Chronic restraint stress aggravated arthritic joint swell of rats through regulating nitric oxide production. Nitric Oxide 27:137–42.
  • Baerwald CG, Laufenberg M, Specht T, et al. (1997). Impaired sympathetic influence on the immune response in patients with rheumatoid arthritis due to lymphocyte subset-specific modulation of beta 2-adrenergic receptors. Br J Rheumatol 36:1262–9.
  • Kuis W, de Jong-de Vos van Steenwijk CCE, Sinnema G, et al. (1996). The autonomic nervous system and the immune system in juvenile rheumatoid arthritis. Brain Behav Immun 10:387–98.
  • Roupe van der Voort C, Heijnen CJ, Wulffraat N, et al. (2000). Stress induces increases in IL-6 production by leucocytes of patients with the chronic inflammatory disease juvenile rheumatoid arthritis: a putative role for α1-adrenergic receptors. J Neuroimmunol 110:223–9.
  • Kokolus KM, Capitano ML, Lee CT, et al. (2013). Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature. Proc Natl Acad Sci USA 110:20176–81.
  • Leigh ND, Kokolus KM, O’Neill RE, et al. (2015). Housing temperature-induced stress is suppressing murine graft-versus-host disease through beta2-Adrenergic receptor signaling. J Immunol 195:5045–54.

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