Minimally invasive isolated limb perfusion – technical details and initial outcome of a new treatment method for limb malignancies

References

• Grunhagen DJ, de Wilt JH, van Geel AN, et al. Isolated limb perfusion with TNF-alpha and melphalan in locally advanced soft tissue sarcomas of the extremities. Recent Results Cancer Res. 2009;179:257–270.
   PubMedGoogle Scholar
• Olofsson R, Bergh P, Berlin O, et al. Long-term outcome of isolated limb perfusion in advanced soft tissue sarcoma of the extremity. Ann Surg Oncol. 2012;19:1800–1807.
   PubMed Web of Science ®Google Scholar
• Olieman AF, Lienard D, Eggermont AM, et al. Hyperthermic isolated limb perfusion with tumor necrosis factor alpha, interferon gamma, and melphalan for locally advanced nonmelanoma skin tumors of the extremities: a multicenter study. Arch Surg. 1999;134:303–307.
   PubMedGoogle Scholar
• Paramo JC, Benavides C, Tang LW, et al. Complete remission of previously intractable peripheral cutaneous T-cell lymphoma of the lower extremity using isolated hyperthermic limb perfusion with melphalan (1-phenylalanine mustard). Cancer Invest. 2004;22:545–549.
   PubMed Web of Science ®Google Scholar
• Kobold S, Killic N, Lutkens T, et al. Isolated limb perfusion with melphalan for the treatment of intractable primary cutaneous diffuse large B-cell lymphoma leg type. Acta Haematol. 2010;123:179–181.
   PubMed Web of Science ®Google Scholar
• Jansen RF, van Geel BN, van der Zee J, et al. Intractible cutaneous non-Hodgkin lymphoma of the lower limb. Complete remission after sequential regional isolated hyperthermic perfusion and perfusion with 1-phenylalanine-mustard (melphalan, L-Pam). Cancer. 1989;64:392–395.
   PubMed Web of Science ®Google Scholar
• Grunhagen DJ, de Wilt JH, Verhoef C, et al. TNF-based isolated limb perfusion in unresectable extremity desmoid tumours. Eur J Surg Oncol. 2005;31:912–916.
   PubMed Web of Science ®Google Scholar
• Zeitouni NC, Giordano CN, Kane JM, 3rd, et al. In-transit Merkel cell carcinoma treated with isolated limb perfusion or isolated limb infusion: a case series of 12 patients. Dermatol Surg. 2011;37:357–364.
   PubMed Web of Science ®Google Scholar
• Belgrano V, Ben-Shabat I, Bergh P, et al. Isolated limb perfusion as a treatment option for rare types of tumours. Int J Hyperthermia. 2016;32:595–599.
   PubMed Web of Science ®Google Scholar
• Creech O, Jr., Krementz ET, Ryan RF, et al. Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg. 1958;148:616–632.
   PubMed Web of Science ®Google Scholar
• Minor DR, Allen RE, Alberts D, et al. A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma. Cancer. 1985;55:2638–2644.
   PubMed Web of Science ®Google Scholar
• Beasley GM, Caudle A, Petersen RP, et al. A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US. J Am Coll Surg. 2009;208:706–715.
   PubMed Web of Science ®Google Scholar
• Kroon HM, Huismans AM, Kam PC, et al. Isolated limb infusion with melphalan and actinomycin D for melanoma: a systematic review. J Surg Oncol. 2014;109:348–351.
   PubMed Web of Science ®Google Scholar
• Dossett LA, Ben-Shabat I, Olofsson Bagge R, et al. Clinical response and regional toxicity following isolated limb infusion compared with isolated limb perfusion for in-transit melanoma. Ann Surg Oncol. 2016;23:2330–2335.
   PubMed Web of Science ®Google Scholar
• Moreno-Ramirez D, de la Cruz-Merino L, Ferrandiz L, et al. Isolated limb perfusion for malignant melanoma: systematic review on effectiveness and safety. Oncologist. 2010;15:416–427.
   PubMed Web of Science ®Google Scholar
• Olofsson R, Mattsson J, Lindner P. Long-term follow-up of 163 consecutive patients treated with isolated limb perfusion for in-transit metastases of malignant melanoma. Int J Hyperthermia. 2013;29:551–557.
   PubMed Web of Science ®Google Scholar
• Wieberdink J, Benckhuysen C, Braat RP, et al. Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions. Eur J Cancer Clin Oncol. 1982;18:905–910.
   PubMedGoogle Scholar
• World Health Organization. WHO handbook for reporting results of cancer treatment. Geneva: World Health Organization; 1979.
   Google Scholar
• Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–213.
   PubMed Web of Science ®Google Scholar
• Lequier L, Horton SB, McMullan DM, et al. Extracorporeal membrane oxygenation circuitry. Pediatr Crit Care Med. 2013;14:S7–S12.
   PubMed Web of Science ®Google Scholar
• Vierhout BP, Pol RA, El Moumni M, et al. Editor’s choice - arteriotomy closure devices in EVAR, TEVAR, and TAVR: a systematic review and meta-analysis of randomised clinical trials and cohort studies. Eur J Vasc Endovasc Surg. 2017;54:104–115.
   PubMed Web of Science ®Google Scholar
• Beasley GM, Petersen RP, Yoo J, et al. Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion. Ann Surg Oncol. 2008;15:2195–2205.
   PubMed Web of Science ®Google Scholar
• Raymond AK, Beasley GM, Broadwater G, et al. Current trends in regional therapy for melanoma: lessons learned from 225 regional chemotherapy treatments between 1995 and 2010 at a single institution. J Am Coll Surg Aug. 2011;213:306–316.
   PubMed Web of Science ®Google Scholar
• Muilenburg DJ, Beasley GM, Thompson ZJ, et al. Burden of disease predicts response to isolated limb infusion with melphalan and actinomycin D in melanoma. Ann Surg Oncol. 2015;22:482–488.
   PubMed Web of Science ®Google Scholar
• Testori A, Verhoef C, Kroon HM, et al. Treatment of melanoma metastases in a limb by isolated limb perfusion and isolated limb infusion. J Surg Oncol. 2011;104:397–404.
   PubMed Web of Science ®Google Scholar
• Siemann DW, Chapman M, Beikirch A. Effects of oxygenation and pH on tumor cell response to alkylating chemotherapy. Int J Radiat Oncol Biol Phys. 1991;20:287–289.
   PubMed Web of Science ®Google Scholar
• Kroon HM, Coventry BJ, Giles MH, et al. Australian multicenter study of isolated limb infusion for melanoma. Ann Surg Oncol. 2016;23:1096–1103.
   PubMed Web of Science ®Google Scholar
• Lindner P, Doubrovsky A, Kam PC, et al. Prognostic factors after isolated limb infusion with cytotoxic agents for melanoma. Ann Surg Oncol. 2002;9:127–136.
   PubMed Web of Science ®Google Scholar
• Long GV, Stroyakovskiy D, Gogas H, et al. Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N Engl J Med. 2014;371:1877–1888.
   PubMed Web of Science ®Google Scholar
• Larkin J, Ascierto PA, Dreno B, et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N Engl J Med. 2014;371:1867–1876.
   PubMed Web of Science ®Google Scholar
• Robert C, Karaszewska B, Schachter J, et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med. 2015;372:30–39.
   PubMed Web of Science ®Google Scholar
• Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:1290–1723.
   Web of Science ®Google Scholar
• Schachter J, Ribas A, Long GV, et al. Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006). Lancet. 2017;390:1853–1862.
   PubMed Web of Science ®Google Scholar
• Topalian SL, Sznol M, McDermott DF, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. JCO. 2014;32:1020–1030.
   PubMed Web of Science ®Google Scholar
• Luu C, Khushalani NI, Zager JS. Intralesional and systemic immunotherapy for metastatic melanoma. Expert Opin Biol Ther. 2016;16:1491–1499.
   PubMed Web of Science ®Google Scholar
• Thompson JF, Agarwala SS, Smithers BM, et al. Phase 2 study of intralesional PV-10 in refractory metastatic melanoma. Ann Surg Oncol. 2015;22:2135–2142.
   PubMed Web of Science ®Google Scholar