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International Journal of Hyperthermia Volume 36, 2019 - Issue 1
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Original Articles

Reactivation of heat-inactivated Ku proteins by heat shock cognate protein HSC73

Makoto IharaDepartment of Radioisotope Medicine, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan; Correspondence[email protected]
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,
Kazuko ShichijoDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan; View further author information
,
Takashi KudoDepartment of Radioisotope Medicine, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan; View further author information
&
Kenzo OhtsukaLaboratory of Cell and Stress Biology, College of Bioscience and Biotechnology, Chubu University, Kasugai, JapanView further author information
Pages 437-442 | Received 25 Nov 2018, Accepted 20 Feb 2019, Published online: 28 Mar 2019

References

  • Chicheł A, Skowronek J, Kubaszewska M, et al. Hyperthermia-description of a method and a review of clinical applications. Rep Pract Oncol Radiother. 2007;12:267–275.
  • El-Awady RA, Dikomey E, Dahm-Daphi J. Heat effects on DNA repair after ionising radiation: hyperthermia commonly increases the number of non-repaired double-strand breaks and structural rearrangements. Nucleic Acids Res. 2001;29:1960–1966.
  • Ostapenko VV, Wang X, Ohnishi K, et al. Increased resistance of the radiosensitive M10 mutant cells of the L5178Y mouse lymphoma cell line to heat-induced apoptosis. Radiat Res. 1999;152:321–327.
  • Daugaard M, Rohde M, Jäättelä M. The heat shock protein 70 family: highly homologous proteins with overlapping and distinct functions. FEBS Lett. 2007;581:3702–3710.
  • Kim YE, Hipp MS, Bracher A, et al. Molecular chaperone functions in protein folding and proteostasis. Annu Rev Biochem. 2013;82:323–355.
  • Whitley D, Goldberg SP, Jordan WD. Heat shock proteins: a review of the molecular chaperones. J Vasc Surg. 1999;29:748–751.
  • Silver JT, Noble EG. Regulation of survival gene hsp70. Cell Stress Chaperones. 2012;17:1–9.
  • Ohtsuka K, Hata M. Molecular chaperone function of mammalian Hsp70 and Hsp40-a review. Int J Hyperthermia. 2000;16:231–245.
  • Liu T, Daniels CK, Cao S. Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential. Pharmacol Ther. 2012;136:354–374.
  • Burma S, Chen DJ. Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst). 2004;3:909–918.
  • Ihara M, Takeshita S, Okaichi K, et al. Heat exposure enhances radiosensitivity by depressing DNA-PK kinase activity during double strand break repair. Int J Hyperthermia. 2014;30:102–109.
  • Davis AJ, Chen BPC, Chen DJ. DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst). 2014;17:21–29.
  • Collis SJ, DeWeese TL, Jeggo PA, et al. The life and death of DNA-PK. Oncogene. 2005;24:949–961.
  • Okayasu R, Suetomi K, Yu Y, et al. A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse. Cancer Res. 2000;60:4342–4345.
  • Ihara M, Suwa A, Komatsu K, et al. Heat sensitivity of double-stranded DNA-dependent protein kinase (DNA-PK) activity. Int J Radiat Biol. 1999;75:253–258.
  • Burgman P, Ouyang H, Peterson S, et al. Heat inactivation of Ku autoantigen: possible role in hyperthermic radiosensitization. Cancer Res. 1997;57:2847–2850.
  • Komatsu K, Ohta T, Jinno Y, et al. Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8. Hum Mol Genet. 1993;2:1031–1034.
  • Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl Acids Res. 1983;11:1475–1489.
  • Suwa A, Hirakata M, Takeda Y, et al. DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. Proc Natl Acad Sci USA. 1994;91:6904–6908.
  • Yamane M, Hattori H, Sugito K, et al. Cotranslocation and colocalization of hsp40 (DnaJ) with hsp70 (DnaK) in mammalian cells. Cell Struct Funct. 1995;20:157–166.
  • Woudstra EC, Konings AWT, Jeggo PA, et al. Role of DNA-PK subunits in radiosensitization by hyperthermia. Radiat Res. 1999;152:214–218.
  • Dynlacht JR, Bittner ME, Bethel JA, et al. The non-homologous end-joining pathway is not involved in the radiosensitization of mammalian cells by heat shock. J Cell Physiol. 2003;196:557–564.
  • Umeda N, Matsumoto Y, Yin HL, et al. Difference in the heat sensitivity of DNA-dependent protein kinase activity among mouse, hamster and human cells. Int J Radiat Biol. 2003;79:671–680.
  • Kim D, Ouyang H, Yang SH, et al. A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen. J Biol Chem. 1995;270:15277–15284.
  • Bukau B, Weissman J, Horwich A. Molecular chaperones and protein quality control. Cell. 2006;125:443–451.
  • Rios PDL, Ben-Zvi A, Slutsky O, et al. Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling. Proc Natl Acad Sci. 2006;103:6166–6171.
  • Mattoo RUH, Goloubinoff P. Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins. Cell Mol Life Sci. 2014;71:3311–3325.

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