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International Journal of Hyperthermia Volume 40, 2023 - Issue 1
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Review Article

Clinical translation of abdominal histotripsy: a review of preclinical studies in large animal models

Katrina L. Falka Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA;b Department of Radiology, University of Wisconsin, Madison, Wisconsin, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7646-2541View further author information
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Paul F. Laesekea Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA;b Department of Radiology, University of Wisconsin, Madison, Wisconsin, USAORCID Iconhttps://orcid.org/0000-0002-8845-3930View further author information
ORCID Icon,
Meridith A. Kistingb Department of Radiology, University of Wisconsin, Madison, Wisconsin, USAORCID Iconhttps://orcid.org/0000-0003-3209-3822View further author information
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Annie M. Zlevorb Department of Radiology, University of Wisconsin, Madison, Wisconsin, USAORCID Iconhttps://orcid.org/0000-0003-4990-9461View further author information
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Emily A. Knottc Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USAORCID Iconhttps://orcid.org/0000-0002-0156-7696View further author information
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Amanda R. Smolockd Department of Radiology, Division of Interventional Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USAView further author information
,
Charles Bradleye School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USAORCID Iconhttps://orcid.org/0000-0002-8594-5307View further author information
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Eli Vlaisavljevichf Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USAORCID Iconhttps://orcid.org/0000-0002-4097-6257View further author information
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Fred T. Lee Jra Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA;b Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA;g Department of Urology, University of Wisconsin, Madison, Wisconsin, USAORCID Iconhttps://orcid.org/0000-0001-5984-9533View further author information
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Timothy J. Ziemlewiczb Department of Radiology, University of Wisconsin, Madison, Wisconsin, USAORCID Iconhttps://orcid.org/0000-0002-7033-1062View further author information
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Article: 2272065 | Received 14 Jun 2023, Accepted 12 Oct 2023, Published online: 24 Oct 2023

References

  • Xu Z, Ludomirsky A, Eun LY, et al. Controlled ultrasound tissue erosion. IEEE Trans Ultrason Ferroelectr Freq Control. 2004;51(6):726–736. doi: 10.1109/tuffc.2004.1308731.
  • Vlaisavljevich E, Maxwell A, Mancia L, et al. Visualizing the histotripsy process: bubble cloud–cancer cell interactions in a tissue-mimicking environment. Ultrasound Med Biol. 2016;42(10):2466–2477. doi: 10.1016/j.ultrasmedbio.2016.05.018.
  • Maxwell AD, Yuldashev PV, Kreider W, et al. A prototype therapy system for transcutaneous application of boiling histotripsy HHS public access. IEEE Trans Ultrason Ferroelectr Freq Control. 2017;64(10):1542–1557. doi: 10.1109/TUFFC.2017.2739649.
  • Vlaisavljevich E, Maxwell A, Warnez M, et al. Histotripsy-induced cavitation cloud initiation thresholds in tissues of different mechanical properties. IEEE Trans Ultrason Ferroelectr Freq Control. 2014;61(2):341–352. doi: 10.1109/TUFFC.2014.6722618.
  • Khokhlova TD, Canney MS, Khokhlova VA, et al. Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling. J Acoust Soc Am. 2011;130(5):3498–3510. doi: 10.1121/1.3626152.
  • Maxwell A, Sapozhnikov O, Bailey M, et al. Disintegration of tissue using high intensity focused ultrasound: two approaches that utilize shock waves. Acou. Today. 2012;8(4):24. doi: 10.1121/1.4788649.
  • Vlaisavljevich E, Kim Y, Allen S, et al. Image-guided non-invasive ultrasound liver ablation using histotripsy: feasibility study in an in-vivo procine model. Ultrasound Med Biol. 2013;39(8):1398–1409. doi: 10.1016/j.ultrasmedbio.2013.02.005.
  • Xu Z, Hall TL, Vlaisavljevich E, et al. Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound. Int J Hyperthermia. 2021;38(1):561–575. doi: 10.1080/02656736.2021.1905189.
  • Illing RO, Kennedy JE, Wu F, et al. The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population. Br J Cancer. 2005;93(8):890–895. doi: 10.1038/sj.bjc.6602803.
  • Kennedy JE. High-intensity focused ultrasound in the treatment of solid tumors. Nat Rev Cancer. 2005;5(4):321–327. doi: 10.1038/nrc1591.
  • Wu F, Wang ZB, Cao YD, et al. A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer. Br J Cancer. 2003;89(12):2227–2233. doi: 10.1038/sj.bjc.6601411.
  • Wu F, Chen WZ, Bai J, et al. Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound. Ultrasound Med Biol. 2001;27(8):1099–1106. doi: 10.1016/s0301-5629(01)00389-1.
  • Brace CL. Microwave tissue ablation: biophysics, technology, and applications. Crit Rev Biomed Eng. 2010;38(1):65–78. doi: 10.1615/critrevbiomedeng.v38.i1.60.
  • Brace CL. Thermal tumor ablation in clinical use. IEEE Pulse. 2011;2(5):28–38. doi: 10.1109/MPUL.2011.942603.
  • Ahmed M, Solbiati L, Brace CL, Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe., et al. Image-guided tumor ablation: standardization of terminology and reporting criteria – a 10-year update. Radiology. 2014;273(1):241–260. doi: 10.1148/radiol.14132958.
  • Nikfarjam M, Muralidharan V, Christophi C. Mechanisms of focal heat destruction of liver tumors. J Surg Res. 2005;127(2):208–223. doi: 10.1016/j.jss.2005.02.009.
  • Decadt B, Siriwardena AK. Radiofrequency ablation of liver tumours: systematic review. Lancet Oncol. 2004;5(9):550–560. doi: 10.1016/S1470-2045(04)01567-0.
  • Huang SKS. Advances in applications of radiofrequency current to catheter ablation therapy. Pacing Clin Electrophysiol. 1991;14(1):28–42. doi: 10.1111/j.1540-8159.1991.tb04044.x.
  • Lubner MG, Brace CL, Hinshaw JL, et al. Microwave tumor ablation: mechanism of action, clinical results and devices. J Vasc Interv Radiol. 2010;21(8 Suppl):S192–S203. doi: 10.1016/j.jvir.2010.04.007.
  • Weber SM, Lee FT, Chinn DO, et al. Perivascular and intralesional tissue necrosis after hepatic cryoablation: results in a porcine model. Surgery. 1997;122(4):742–747. doi: 10.1016/s0039-6060(97)90082-9.
  • Livraghi T, Meloni F, Solbiati L, et al. Complications of microwave ablation for liver tumors: results of a multicenter study. Cardiovasc Intervent Radiol. 2012;35(4):868–874. doi: 10.1007/s00270-011-0241-8.
  • Schmitz JJ, Schmit GD, Viers BR, et al. Renal microwave ablation resulting in ureteropelvic junction stricture remote from the ablation site. J Vasc Interv Radiol. 2017;28(9):1278–1280.e1. doi: 10.1016/j.jvir.2017.03.010.
  • Ziemlewicz TJ, Hinshaw JL, Lubner MG, et al. Percutaneous microwave ablation of hepatocellular carcinoma with a gas-cooled system: initial clinical results with 107 tumors. J Vasc Interv Radiol. 2015;26(1):62–68. doi: 10.1016/j.jvir.2014.09.012.
  • Marchal F, Elias D, Leroux A, et al. Biliary lesions during radiofrequency ablation in liver. Eur Surg Res. 2004;36(2):88–94. doi: 10.1159/000076648.
  • Teratani T, Yoshida H, Shiina S, et al. Radiofrequency ablation for hepatocellular carcinoma in so-called high-risk locations. Hepatology. 2006;43(5):1101–1108. doi: 10.1002/hep.21164.
  • Pinkhasov GI, Raman JD. Management and prevention of renal ablative therapy complications. World J Urol. 2010;28(5):559–564. doi: 10.1007/s00345-010-0550-6.
  • Orsi F, Zhang L, Arnone P, et al. High-intensity focused ultrasound ablation: effective and safe therapy for solid tumors in difficult locations. Am J Roentgenol. 2010;195:245–252.
  • Nabi G, Goodman C, Melzer A. High intensity focused ultrasound treatment of small renal masses: clinical effectiveness and technological advances. Indian J Urol. 2010;26(3):331–337. doi: 10.4103/0970-1591.70561.
  • Cheung TT, Ma KW, She WH. A review on radiofrequency, microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis. Hepatobiliary Surg Nutr. 2021;10(2):193–209. doi: 10.21037/hbsn.2020.03.11.
  • Hinshaw JL, Lee FT. Cryoablation for liver cancer. Tech Vasc Interv Radiol. 2007;10(1):47–57. doi: 10.1053/j.tvir.2007.08.005.
  • Llovet JM, De Baere T, Kulik L, et al. Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2021;18(5):293–313. doi: 10.1038/s41575-020-00395-0.
  • Hsiao CY, Huang KW. Irreversible electroporation: a novel ultrasound-guided modality for non-thermal tumor ablation. J Med Ultrasound. 2017;25(4):195–200. doi: 10.1016/j.jmu.2017.08.003.
  • Wagstaff PGK, Buijs M, van den Bos W, et al. Irreversible electroporation: state of the art. Onco Targets Ther. 2016;9:2437–2446. doi: 10.2147/OTT.S88086.
  • Davalos RV, Mir LM, Rubinsky B. Tissue ablation with irreversible electroporation. Ann Biomed Eng. 2005;33(2):223–231. doi: 10.1007/s10439-005-8981-8.
  • Rubinsky B, Onik G, Mikus P. Irreversible electroporation: a new ablation modality – clinical implications. Technol Cancer Res Treat. 2007;6(1):37–48. doi: 10.1177/153303460700600106.
  • Cornelis FH, Durack JC, Kimm SY, et al. A comparative study of ablation boundary sharpness after percutaneous radiofrequency, cryo-, microwave, and irreversible electroporation ablation in normal swine liver and kidneys. Cardiovasc Intervent Radiol. 2017;40(10):1600–1608. doi: 10.1007/s00270-017-1692-3.
  • Niessen C, Igl J, Pregler B, et al. Factors associated with short-term local recurrence of liver cancer after percutaneous ablation using irreversible electroporation: a prospective single-center study. J Vasc Interv Radiol. 2015;26(5):694–702. doi: 10.1016/j.jvir.2015.02.001.
  • Knott EA, Zlevor AM, Hinshaw JL, et al. A comparison study of microwave ablation vs. histotripsy for focal liver treatments in a swine model. Eur Radiol. 2023;33(2):1050–1062. doi: 10.1007/s00330-022-09112-8.
  • Scudamore CH, Lee SI, Patterson EJ, et al. Radiofrequency ablation followed by resection of malignant liver tumors. Am J Surg. 1999;177(5):411–417. doi: 10.1016/s0002-9610(99)00068-9.
  • Kasper HU, Bangard C, Gossmann A, et al. Pathomorphological changes after radiofrequency ablation in the liver. Pathol Int. 2010;60(3):149–155. doi: 10.1111/j.1440-1827.2009.02498.x.
  • Kopelman D, Inbar Y, Hanannel A, et al. Magnetic resonance-guided focused ultrasound surgery (MRgFUS): ablation of liver tissue in a porcine model. Eur J Radiol. 2006;59(2):157–162. doi: 10.1016/j.ejrad.2006.04.008.
  • Hensen B, Drenkmann U, Frericks B, et al. Detection of ablation boundaries using different MR sequences in a swine liver model. Cardiovasc Intervent Radiol. 2022;45(7):1010–1018. doi: 10.1007/s00270-022-03143-w.
  • Lee FT, Chosy SG, Littrup PJ, et al. CT-monitored percutaneous cryoablation in a pig liver model: pilot study. Radiology. 1999;211(3):687–692. doi: 10.1148/radiology.211.3.r99jn29687.
  • Lee EW, Loh CT, Kee ST. Imaging guided percutaneous irreversible electroporation: ultrasound and immunohistological correlation. Technol Cancer Res Treat. 2007;6(4):287–294. doi: 10.1177/153303460700600404.
  • Edd JF, Horowitz L, Davalos RV, et al. In vivo results of a new focal tissue ablation technique: irreversible electroporation. IEEE Trans Biomed Eng. 2006;53(7):1409–1415. doi: 10.1109/TBME.2006.873745.
  • Ben-David E, Ahmed M, Faroja M, et al. Irreversible electroporation : treatment effect is susceptible to local environment and tissue properties. Radiology. 2013;269(3):738–747. doi: 10.1148/radiol.13122590.
  • Lee EW, Chen C, Prieto VE, et al. Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. Radiology. 2010;255(2):426–433. doi: 10.1148/radiol.10090337.
  • Kingham TP, Karkar AM, D'Angelica MI, et al. Ablation of perivascular hepatic malignant tumors with irreversible electroporation. J Am Coll Surg. 2012;215(3):379–387. doi: 10.1016/j.jamcollsurg.2012.04.029.
  • Silk MT, Wimmer T, Lee KS, et al. Percutaneous ablation of peribiliary tumors with irreversible electroporation. J Vasc Interv Radiol. 2014;25(1):112–118. doi: 10.1016/j.jvir.2013.10.012.
  • Vlaisavljevich E, Kim Y, Owens G, et al. Effects of tissue mechanical properties on susceptibility to histotripsy-induced tissue damage. Phys Med Biol. 2014;59(2):253–270. doi: 10.1088/0031-9155/59/2/253.
  • Vlaisavljevich E, Xu Z, Arvidson A, et al. The effects of thermal preconditioning on tissue susceptibility to histotripsy. Ultrasound Med Biol. 2015;41(11):2938–2954. doi: 10.1016/j.ultrasmedbio.2015.07.016.
  • Hendricks-Wenger A, Schwenker H, Meduri C, et al. Determining dose effects of critical structures for intra-abdominal histotripsy ablation. Histotripsy Symp. 2022.
  • Hendricks-Wenger A, Hutchison R, Vlaisavljevich E, et al. Immunological effects of histotripsy for cancer therapy. Front Oncol. 2021;11:681629. doi: 10.3389/fonc.2021.681629.
  • Qu S, Worlikar T, Felsted AE, et al. Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy. J Immunother Cancer. 2020;8(1):e000200. doi: 10.1136/jitc-2019-000200.
  • Pepple AL, Guy JL, Mcginnis R, et al. Spatiotemporal local and abscopal cell death and immune responses to histotripsy focused ultrasound tumor ablation. Front Immunol. 2023;14:1012799. doi: 10.3389/fimmu.2023.1012799.
  • Worlikar T, Vlaisavljevich E, Gerhardson T, et al. Histotripsy for non-invasive ablation of hepatocellular carcinoma (HCC) tumor in a subcutaneous xenograft murine model. IEEE Eng Med Biol Soc Annu Int Conf. 2018;2018:6064–6067.
  • Smolock AR, Cristescu MM, Vlaisavljevich E, et al. Robotically assisted sonic therapy as a noninvasive nonthermal ablation modality: proof of concept in a porcine liver model. Radiology. 2018;287(2):485–493. doi: 10.1148/radiol.2018171544.
  • Longo KC, Knott EA, Watson RF, et al. Robotically assisted sonic therapy (RAST) for noninvasive hepatic ablation in a porcine model: mitigation of body wall damage with a modified pulse sequence. Cardiovasc Intervent Radiol. 2019;42(7):1016–1023. doi: 10.1007/s00270-019-02215-8.
  • Longo KC, Zlevor AM, Laeseke PF, et al. Histotripsy ablations in a porcine liver model: feasibility of respiratory motion compensation by alteration of the ablation zone prescription shape. Cardiovasc Intervent Radiol. 2020;43(11):1695–1701. doi: 10.1007/s00270-020-02582-7.
  • Knott EA, Longo KC, Vlaisavljevich E, et al. Transcostal histotripsy ablation in an in vivo acute hepatic porcine model. Cardiovasc Intervent Radiol. 2021;44(10):1643–1650. doi: 10.1007/s00270-021-02914-1.
  • Khokhlova TD, Wang YN, Simon JC, et al. Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model. Proc Natl Acad Sci U S A. 2014;111(22):8161–8166. doi: 10.1073/pnas.1318355111.
  • Khokhlova TD, Schade GR, Wang YN, et al. Pilot in vivo studies on transcutaneous boiling histotripsy in porcine liver and kidney. Sci Rep. 2019;9(1):20176. doi: 10.1038/s41598-019-56658-7.
  • Vlaisavljevich E, Owens G, Lundt J, et al. Non-invasive liver ablation using histotripsy: preclinical safety study in an in-vivo porcine model. Ultrasound Med Biol. 2017;43(6):1237–1251. doi: 10.1016/j.ultrasmedbio.2017.01.016.
  • Mauch SC, Zlevor AM, Knott EA, et al. Hepatic and renal histotripsy in an anticoagulated porcine model. J Vasc Interv Radiol. 2023;34(3):386–394.e2. doi: 10.1016/j.jvir.2022.11.034.
  • Kim Y, Vlaisavljevich E, Owens GE, et al. In vivo transcostal histotripsy therapy without aberration correction. Phys Med Biol. 2014;59(11):2553–2568. doi: 10.1088/0031-9155/59/11/2553.
  • Thomas GPL, Khokhlova TD, Khokhlova VA. Partial respiratory motion compensation for abdominal extracorporeal boiling histotripsy treatments with a robotic arm. IEEE Trans Ultrason Ferroelectr Freq Control. 2021;68(9):2861–2870. doi: 10.1109/TUFFC.2021.3075938.
  • Winterholler J, Kisting M, Falk K, et al. Reduction of respiratory motion effect on histotripsy ablation in porcine liver models by use of jet ventilation. Soc Interv Radiol Conf. 2023.
  • Vlaisavljevich E, Greve J, Cheng X, et al. Non-invasive ultrasound liver ablation using histotripsy: chronic study in an in vivo rodent model. Ultrasound Med Biol. 2016;42(8):1890–1902. doi: 10.1016/j.ultrasmedbio.2016.03.018.
  • Heo J, Joung C, Pahk K, et al. Investigation of the long-term healing response of the liver to boiling histotripsy treatment in vivo. Sci Rep. 2022;12(1):14462. doi: 10.1038/s41598-022-18544-7.
  • Worlikar T, Mendiratta-Lala M, Vlaisavljevich E, et al. Effects of histotripsy on local tumor progression in an in vivo orthotopic rodent liver tumor model. BME Front. 2020;2020:1–26. doi: 10.34133/2020/9830304.
  • Worlikar T, Zhang M, Ganguly A, et al. Impact of histotripsy on development of intrahepatic metastases in a rodent liver tumor model. Cancers (Basel). 2022;14(7):1612. doi: 10.3390/cancers14071612.
  • Hendricks-Wenger A, Nagai-Singer MA, Uh K, et al. Employing novel porcine models of subcutaneous pancreatic cancer to evaluate oncological therapies. Biomed Eng Technol. 2022:883–895.
  • Thomas GPL, Khokhlova TD, Sapozhnikov OA, et al. In vivo aberration correction for transcutaneous HIFU therapy using a multielement array. IEEE Trans Ultrason Ferroelectr Freq Control. 2022;69(10):2955–2964. doi: 10.1109/TUFFC.2022.3200309.
  • Matula TJ, Wang YN, Khokhlova T, et al. Treating porcine abscesses with histotripsy: a pilot study. Ultrasound Med Biol. 2021;47(3):603–619. doi: 10.1016/j.ultrasmedbio.2020.10.011.
  • Froghi S, de Andrade MO, Hadi LM, et al. Liver ultrasound histotripsy: novel analysis of the histotripsy site cell constituents with implications for histotripsy application in cell transplantation and cancer therapy. Bioengineering. 2023;10(2):276. doi: 10.3390/bioengineering10020276.
  • Pahk KJ, Mohammad GH, Malago M, et al. A novel approach to ultrasound-mediated tissue decellularization and intra-hepatic cell delivery in rats. Ultrasound Med Biol. 2016;42(8):1958–1967. doi: 10.1016/j.ultrasmedbio.2016.03.020.
  • Roberts WW, Hall TL, Ives K, et al. Pulsed cavitational ultrasound : a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney. J Urol. 2006;175(2):734–738. doi: 10.1016/S0022-5347(05)00141-2.
  • Hall TL, Kieran K, Ives K, et al. Histotripsy of rabbit renal tissue in vivo : temporal histologic trends. J Endourol. 2007;21(10):1159–1166. doi: 10.1089/end.2007.9915.
  • Styn NR, Hall TL, Fowlkes JB, et al. Technology and engineering histotripsy of renal implanted VX-2 tumor in a rabbit model : investigation of metastases. Urology. 2012;80(3):724–729. doi: 10.1016/j.urology.2012.06.020.
  • Knott EA, Swietlik JF, Longo KC, et al. Robotically-assisted sonic therapy for renal ablation in a live porcine model: initial preclinical results. J Vasc Interv Radiol. 2019;30(8):1293–1302. doi: 10.1016/j.jvir.2019.01.023.
  • Couillard AB, Kisting MA, Rossebo AE, et al. A comparison study of histotripsy and cryoablation for renal ablation in a porcine model. Soc Interv Radiol Conf. 2022.
  • Lake AM, Xu Z, Wilkinson JE, et al. Renal ablation by histotripsy—does it spare the collecting system? J Urol. 2008;179(3):1150–1154. doi: 10.1016/j.juro.2007.10.033.
  • Schade GR, Wang Y-N, D'Andrea S, et al. Boiling histotripsy ablation of renal cell carcinoma in the Eker rat promotes a systemic inflammatory response. Ultrasound Med Biol. 2019;45(1):137–147. doi: 10.1016/j.ultrasmedbio.2018.09.006.
  • R El D, Touma NJ, Kapoor A. Cryoablation vs radiofrequency ablation for the treatment of renal cell carcinoma : a meta- analysis of case series studies. BJU Int. 2012;110(4):510–516. doi: 10.1111/j.1464-410X.2011.10885.x.
  • Hendricks-Wenger A, Arnold L, Gannon J, et al. Histotripsy ablation in preclinical animal models of cancer and spontaneous tumors in veterinary patients: a review. IEEE Trans Ultrason Ferroelectr Freq Control. 2022;69(1):5–26. doi: 10.1109/TUFFC.2021.3110083.
  • Hendricks-Wenger A, Zeher A, Sereno J, et al. Histotripsy is an effective pancreatic tumor ablation strategy that releases immunostimulatory molecules and promoted anti-tumor immunity. Focus Ultrasound Found Symp Virtual Conf. 2020.
  • Hendricks A, Brock RM, Gannon J, et al. Determining the mechanism of the immune response to histotripsy ablation of pancreatic cancer. Am Assoc Immunol Virtual Conf. 2020.
  • Gannon J, Khan I, Edwards M, et al. Histotripsy for the treatment of pancreatic tumors: feasibility study in an in vivo porcine model. 21st Annu Int Symp Ther Ultrasound. 2021.
  • Khokhlova TD, Hwang JH. HIFU for palliative treatment of pancreatic cancer. J Gastroinestional Oncol. 2011;2(3):175–184.
  • Vidal-Jove J, Perich E, Alvarez de Castillo M. Ultrasonics sonochemistry ultrasound guided high intensity focused ultrasound for malignant tumors : the Spanish experience of survival advantage in stage III and IV pancreatic cancer. Ultrason Sonochem. 2015;27:703–706. doi: 10.1016/j.ultsonch.2015.05.026.
  • Wu F. High intensity focused ultrasound : a noninvasive therapy for locally advanced pancreatic cancer. World J Gastroenterol. 2014;20(44):16480–16488. doi: 10.3748/wjg.v20.i44.16480.
  • Ning Z, Xie J, Chen Q, et al. HIFU is safe, effective, and feasible in pancreatic cancer patients: a monocentric retrospective study among 523 patients. Onco Targets Ther. 2019;12:1021–1029. doi: 10.2147/OTT.S185424.
  • Mancia L, Vlaisavljevich E, Yousefi N, et al. Modeling tissue-selective cavitation damage. Phys Med Biol. 2019;64(22):225001. doi: 10.1088/1361-6560/ab5010.
  • Hendricks-Wenger A, Aycock KN, Nagai-Singer MA, et al. Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible electroporation. Sci Rep. 2021;11(1):7584. doi: 10.1038/s41598-021-87228-5.

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