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International Journal of Hyperthermia Volume 15, 1999 - Issue 6
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Research Article

Effectiveness of 2',2'difluorodeoxycytidine (Gemcitabine) combined with hyperthermia in rat R-1 rhabdomyosarcoma in vitro and in vivo

C. Van Bree, C. Beumer, H. M. Rodermond, J. Haveman, P. J. M. Bakker Department of Medical Oncology, Division of Internal Medicine &Department of Radiotherapy, Academic Medical Centre, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands
Pages 549-556 | Published online: 09 Jul 2009

References

  • AUER, H., OEHLER, R., LINDNER, R., KOWALSKI, H., SLIUTZ, G., OREL, L., KUCERA, E., SIMON, M. M., and GLossL, J., 1997, Cha acterisation of genotoxic properties of 2',2' -difluorodeoxycytidine. Mutation Research, 393, 165–173.
  • CARMICHAEL, J., 1998, The role of gemcitabine in the treatment of other tumours. British Journal of Cancer, 78, 21–25.
  • DAHL, O., 1994, Mechanisms of thermal enhancement of chemotherapeutic cytotoxicity. Hyperthermia and Oncology, edited by M. Urano and E. Douple (Utrecht, The Netherlands: VSP), pp. 9–28.
  • HAVEMAN, J., RIETBROEK, R. C., GEERDINK, A., VAN RUN, J., and BAKKER, P. J., 1995, Effect of hyperthermia on the cytotoxicity of 2',2' -difluorodeoxycytidine (gemcitabine) in cultured SW1573 cells. International Journal of Cancer, 62, 627–630.
  • HEINEMANN, V., XU, Y. Z., CHUBB, S., SEN, A., HERTEL, L. W., GRINDEY, G. B., and PLUNKETT, W., 1992, Cellular elimination of 2,2' -difluorodeoxycytidine 5' -triphos-phate: a mechanism of self-potentiation. Cancer Research, 52, 533–539.
  • HERTEL, L W., BODER, G. B., KRoiN, J. S., RINZEL, S. M., POORE, G. A., TODD, G. C., and
  • GRINDEY, G. B., 1990, Evaluation of the antitumor activity of gemcitabine-difluoro-2' -deoxycytidine). Cancer Research, 50, 4417–4422.
  • MIZUNO, S., AMAGAI, M., and ISHIDA, A., 1980, Synergistic cell killing by antitumor agents and hyperthermia in cultured cells. Gann, 71, 471–478.
  • PLUNKETT, W., HUANG, P., and GANDHI, V., 1995, Preclinical cha acteristics of gemcitabine. Anti-Cancer Drugs, 6 (Suppl 6), 7–13.
  • ROCKWELL, S., and GRINDEY, G. B., 1992, Effect of 2%2' -difluorodeoxycytidine on the via-bility and radiosensitivity of EMT6 cells in vitro. Oncology Research, 4, 151–155.
  • ROSE, W. C., VERAS, G. H., LASTER, W. R. J., and SCHABEL, F. M., JR., 1979, Evaluation of whole-body hyperthermia as an adjunct to chemotherapy in murine tumors. Cancer Treatment Reports, 63, 1311–1325.
  • SCHOPMAN, E. M., VAN BREE, C., BAKKER, P. J., Kipp, J. B., and BARENDSEN, G. W., 1996, Hyperthermia-enhanced effectiveness of mitoxantrone in an experimental rat tumour. International Journal of Hyperthermia, 12, 241–254.
  • STEWARD, W. P., 1998, Combination studies with gemcitabine in the treatment of non-small lung cancer. British Journal of Cancer, 78, 15–19.
  • VAN BREE, C., KROOSHOOP, J. J., RIETBROEK, R. C., Kipp, J. B., and BAKKER, P. J., 1996a, Hyperthermia enhances tumor uptake and antitumor efficacy of thermostable liposomal daunorubicin in a rat solid tumor. Cancer Research, 56, 563–568.
  • VAN BREE, C., RIETBROEK, R. C., SCHOPMAN, E. M., KIPP, J. B., and BAKKER, P. J., 1996b, Local hyperthermia enhances the effect of cis-diamminedichloro-platinum(II) on non-irradiated and preirradiated rat solid tumors. International Journal of Radiation Oncology, Biology, Physics, 36, 135–140.
  • VONHOFF, D. D., GOODWIN, A. L., and GARCIA, L, 1998, Advances in the treatment of patients with pancreatic cancer-improvement in symptoms and survival time. British Journal of Cancer, 78, 9–13.

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