114
Views
22
CrossRef citations to date
0
Altmetric
Original

Effects of medroxyprogesterone acetate on cerebral oedema and spatial learning performance after traumatic brain injury in rats

, , & , PhD
Pages 107-113 | Received 05 Nov 2007, Accepted 14 Dec 2007, Published online: 03 Jul 2009

References

  • Roof RL, Hall ED. Gender differences in acute cns trauma and stroke: neuroprotective effects of estrogen and progesterone. Journal of Neurotrauma 2000; 17: 367–388
  • Schumacher M, Guennoun R, Ghoumari A, Massaad C, Robert F, El-Etr M, Akwa Y, Rajkowski K, Baulieu EE. Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system. Endocrinology Review 2007; 28: 387–439
  • Schumacher M, Guennoun R, Stein DG, et al. Progesterone: therapeutic opportunities for neuroprotection and myelin repair. Pharmacology and Therapeutics 2007; 116: 77–107
  • Stein DG. Progesterone exerts neuroprotective effects after brain injury. Brain Research 2007, in press
  • Stein DG. Progesterone in the experimental treatment of peripheral and central nervous system injuries. Future Neurology 2006; 1: 429–438
  • Thomas T, Rhodin J, Clark L, Garces A. Progestins initiate adverse events of menopausal estrogen therapy. Climacteric 2003; 6: 293–301
  • Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. A clinical trial of estrogen-replacement therapy after ischemic stroke. New England Journal of Medicine 2001; 345: 1243–1249
  • Rossouw JE, Anderson GL, Prentice RL, Lacroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA 2002; 288: 321–333
  • Singh M. Progestins and neuroprotection: are all progestins created equal?. Minerva Endocrinology 2007; 32: 95–102
  • Hapgood JP, Koubovec D, Louw A, Africander D. Not all progestins are the same: implications for usage. Trends in Pharmacology Science 2004; 25: 554–557
  • Kuhl H, Stevenson J. The effect of medroxyprogesterone acetate on estrogen-dependent risks and benefits—an attempt to interpret the women's health initiative results. Gynecology & Endocrinology 2006; 22: 303–317
  • Singh M. Progesterone-induced neuroprotection. Endocrine 2006; 29: 271–274
  • Cagnacci A, Arangino S, Baldassari F, Alessandrini C, Landi S, Volpe A. A comparison of the central effects of different progestins used in hormone replacement therapy. Maturitas 2004; 48: 456–462
  • Roof RL, Duvdevani R, Stein DG. Gender influences outcome of brain injury: progesterone plays a protective role. Brain Research 1993; 607: 333–336
  • Djebaili M, Guo Q, Pettus EH, Hoffman SW, Stein DG. The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. Journal of Neurotrauma 2005; 22: 106–118
  • Shear DA, Galani R, Hoffman SW, Stein DG. Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury. Experimental Neurology 2002; 178: 59–67
  • Abdi H. Z-scores. Encyclopedia of measurement and statistics., NJ Salkind. Sage, Thousand Oaks, CA 2007; 1057–1058
  • Koubovec D, Ronacher K, Stubsrud E, Louw A, Hapgood JP. Synthetic progestins used in hrt have different glucocorticoid agonist properties. Molecular Cell Endocrinology 2005; 242: 23–32
  • Shadoan MK, Kavanagh K, Zhang L, Anthony MS, Wagner JD. Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue. Metabolism 2007; 56: 830–837
  • Bernardi F, Pluchino N, Pieri M, Begliuomini S, Lenzi E, Puccetti S, Casarosa E, Luisi M, Genazzani AR. Progesterone and medroxyprogesterone acetate effects on central and peripheral allopregnanolone and beta-endorphin levels. Neuroendocrinology 2006; 83: 348–359
  • Nilsen J, Morales A, Brinton RD. Medroxyprogesterone acetate exacerbates glutamate excitotoxicity. Gynecology & Endocrinology 2006; 22: 355–361
  • Garcia-Becerra R, Cooney AJ, Borja-Cacho E, Lemus AE, Perez-Palacios G, Larrea F. Comparative evaluation of androgen and progesterone receptor transcription selectivity indices of 19-nortestosterone-derived progestins. Journal of Steroid Biochemistry & Molecular Biology 2004; 91: 21–27
  • Bamberger CM, Else T, Bamberger AM, Beil FU, Schulte HM. Dissociative glucocorticoid activity of medroxyprogesterone acetate in normal human lymphocytes. Journal of Clinical Endocrinology Metabolism 1999; 84: 4055–4061
  • Cutler SM, Cekic M, Miller D, Wali B, Vanlandingham JW, Stein DG. Progesterone improves acute recovery after traumatic brain injury in the aged rat. Journal of Neurotrauma 2007; 24(9)1475–1486
  • Vanlandingham JW, Cekic M, Cutler SM, Hoffman SW, Stein DG. Neurosteroids reduce inflammation after tbi through cd55 induction. Neuroscience Letters 2007, in press
  • Stein DG, Wright DW, Kellermann AL. Does progesterone have neuroprotective properties?. Annals of Emergency Medicine 2007, in press DOI http://dx.doi.org/10.1016/j.annemergmed.2007.05.001
  • Schumacher M, Guennoun R, Robert F, Carelli C, Gago N, Ghoumari A, Gonzalez Deniselle MC, Gonzalez SL, Ibanez C, Labombarda F, et al. Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Hormone IGF Research 2004; 14(Suppl A)S18–S33
  • Schumacher M, Weill-Engerer S, Liere P, Robert F, Franklin RJ, Garcia-Segura LM, Lambert JJ, Mayo W, Melcangi RC, Parducz A, et al. Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Progress in Neurobiology 2003; 71: 3–29
  • Meffre D, Delespierre B, Gouezou M, Schumacher M, Stein DG, Guennoun R. 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mrna expression in rat brain: effect of pseudopregnancy and traumatic brain injury. Journal of Steroid Biochemistry & Molecular Biology 2007; 104: 293–300
  • Meffre D, Pianos A, Liere P, Eychenne B, Cambourg A, Schumacher M, Stein DG, Guennoun R. Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry. Endocrinology 2007; 148: 2505–2517
  • Guennoun R, Meffre D, Labombarda F, Gonzalez SL, Deniselle MC, Stein DG, De Nicola AF, Schumacher M. The membrane-associated progesterone-binding protein 25-dx: expression, cellular localization and up-regulation after brain and spinal cord injuries. Brain Research Review 2007, in press DOI http://dx.doi.org/10.1016/j.brainresrev.2007.05.009
  • Meffre D, Delespierre B, Gouezou M, Leclerc P. The membrane-associated progesterone-binding protein 25-dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury. Journal of Neurochemistry 2005; 93: 1314–1326

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.