References
- Giacino JT, Katz DI, Schiff ND, Whyte J, Ashman EJ, Ashwal S, Barbano R, Hammond FM, Laureys S, Ling G, et al. Practice guideline update recommendations summary: disorders of consciousness: report of the guideline development, dissemination, and implementation subcommittee of the American academy of neurology; the American congress of rehabilitation medicine; and the national institute on disability, independent living, and rehabilitation research. Neurology 2018 04;91(10):450–60. doi:https://doi.org/10.1212/WNL.0000000000005926
- Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, et al. European academy of neurology guideline on the diagnosis of coma and other disorders of consciousness. Eur J Neurol. 2020 May;27(5):741–56. doi:https://doi.org/10.1111/ene.14151.
- Laureys S, Celesia GG, Cohadon F, Lavrijsen J, León-Carrión J, Sannita WG, Sazbon L, Schmutzhard E, von Wild KR, Zeman A, et al. Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Med. 2010 Nov;1(8):68. doi:https://doi.org/10.1186/1741-7015-8-68
- Giacino JT, Ashwal S, Childs N, Cranford R, Jennett B, Katz DI, Kelly JP, Rosenberg JH, Whyte J, Zafonte RD, et al. The minimally conscious state: definition and diagnostic criteria. Neurology. 2002 Feb 12;58(3):349–53. doi:https://doi.org/10.1212/WNL.58.3.349.
- Royal College of Physicians. Prolonged Disorders of consciousness following sudden onset brain injury: national clinical guidelines. London: RCP; 2020.
- Whyte J, Nordenbo AM, Kalmar K, Merges B, Bagiella E, Chang H, Yablon S, Cho S, Hammond F, Khademi A, et al. Medical complications during inpatient rehabilitation among patients with traumatic disorders of consciousness. Arch Phys Med Rehabil. 2013 Oct;94(10):1877–83. doi:https://doi.org/10.1016/j.apmr.2012.12.027.
- Pistoia F, Sacco S, Franceschini M, Sarà M, Pistarini C, Cazzulani B, Simonelli I, Pasqualetti P, Carolei A. Comorbidities: a key issue in patients with disorders of consciousness. J Neurotrauma. 2015 May 15;32(10):682–88. doi:https://doi.org/10.1089/neu.2014.3659.
- Estraneo A, Loreto V, Masotta O, Pascarella A, Trojano L. Do medical complications impact long-term outcomes in prolonged disorders of consciousness? Arch Phys Med Rehabil. 2018;99(12):2523–2531.e3. doi:https://doi.org/10.1016/j.apmr.2018.04.024.
- Estraneo A, Masotta O, Bartolo M, Pistoia F, Perin C, Marino S, Lucca, L., Pingue, V, Casanova E, Romoli A. Multi-center study on overall clinical complexity of patients with prolonged disorders of consciousness of different etiologies. Brain Injury. 2021Dec 17;35(1):1–7. doi:https://doi.org/10.1080/02699052.2020.1861652
- Pisa FE, Cosano G, Giangreco M, Giorgini T, Biasutti E, Barbone F, Group for the Study of Medication Use in Centers for Post-acute Brain Injury Rehabilitation. Prescribing practice and off-label use of psychotropic medications in post-acute brain injury rehabilitation centres: a cross-sectional survey. Brain Injury. 2015;29(4):508–16. doi:https://doi.org/10.3109/02699052.2014.992474.
- Hantus S. Monitoring for seizures in the intensive care unit. Handb Clin Neurol. 2019;161:103–07.
- Baguley IJ, Perkes IE, Fernandez-Ortega J-F, Rabinstein AA, Dolce G, Hendricks HT, Consensus Working Group. Paroxysmal sympathetic hyperactivity after acquired brain injury: consensus on conceptual definition, nomenclature, and diagnostic criteria. J Neurotrauma. 2014;31(17):1515–20. doi:https://doi.org/10.1089/neu.2013.3301.
- Kirschen M, Dupont-Thibodeau G, Kubis S, Hewlett J, Berg R, Topjian A. Paroxysmal sympathetic hyperactivity after acquired brain injury in critically ill children. Crit Care Med. 2015;43(12):130–31. doi:https://doi.org/10.1097/01.ccm.0000474344.83332.30.
- Perkes I, Baguley IJ, Nott MT, Menon DK. A review of paroxysmal sympathetic hyperactivity after acquired brain injury. Ann Neurol. 2010;68(2):126–35. doi:https://doi.org/10.1002/ana.22066.
- Pignolo L, Rogano S, Quintieri M, Leto E, Dolce G. Decreasing incidence of paroxysmal sympathetic hyperactivity syndrome in the vegetative state. Journal of Rehabilitation Medicine. 2012;44(6):502–04. doi:https://doi.org/10.2340/16501977-0981.
- Fogang Y, Legros B, Depondt C, Mavroudakis N, Gaspard N. Yield of repeated intermittent EEG for seizure detection in critically ill adults. Neurophysiol Clin. 2017 Feb;47(1):5–12. doi:https://doi.org/10.1016/j.neucli.2016.09.001.
- Limotai C, Ingsathit A, Thadanipon K, McEvoy M, Attia J, Thakkinstian A. How and whom to monitor for seizures in an ICU: a systematic review and meta-analysis. Crit Care Med. 2019 Apr;47(4):e366–73. doi:https://doi.org/10.1097/CCM.0000000000003641.
- Claassen J, Jetté N, Chum F, Green R, Schmidt M, Choi H, Jirsch J, Frontera JA, Connolly ES, Emerson RG, et al. Electrographic seizures and periodic discharges after intracerebral hemorrhage. Neurology. 2007 Sep 25;69(13):1356–65. doi:https://doi.org/10.1212/01.wnl.0000281664.02615.6c.
- Holtkamp M, Meierkord H. Nonconvulsive status epilepticus: a diagnostic and therapeutic challenge in the intensive care setting. Ther Adv Neurol Disord. 2011 May;4(3):169–81. doi:https://doi.org/10.1177/1756285611403826.
- Kubota Y, Nakamoto H, Kawamata T. Nonconvulsive status epilepticus in the neurosurgical setting. Neurol Med Chir (Tokyo). 2016 Oct 15;56(10):626–31. doi: https://doi.org/10.2176/nmc.ra.2016-0118.
- Rossetti AO, Schindler K, Alvarez V, Sutter R, Novy J, Oddo M, Warpelin-Decrausaz L. Does continuous video-EEG in patients with altered consciousness improve patient outcome? Current evidence and randomized controlled trial design. J Clin Neurophysiol. 2018 Sep;35(5):359–64. doi:https://doi.org/10.1097/WNP.0000000000000467.
- Towne AR, Waterhouse EJ, Boggs JG, Garnett LK, Brown AJ, Smith Jr JR, DeLorenzo RJ. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology. 2000 Jan 25;54(2):340–45. doi:https://doi.org/10.1212/WNL.54.2.340.
- Vespa PM, Miller C, McArthur D, Eliseo M, Etchepare M, Hirt D, Glenn TC, Martin N, Hovda D. Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Crit Care Med. 2007 Dec;35(12):2830–36. doi:https://doi.org/10.1097/00003246-200712000-00023.
- Dikmen SS, Temkin NR, Miller B, Machamer J, Winn HR. Neurobehavioral effects of phenytoin prophylaxis of posttraumatic seizures. JAMA. 1991 Mar 13;265(10):1271–77. doi: https://doi.org/10.1001/jama.1991.03460100073027.
- Dikmen SS, Machamer JE, Winn HR, Anderson GD, Temkin NR. Neuropsychological effects of valproate in traumatic brain injury: a randomized trial. Neurology. 2000 Feb 22;54(4):895–902. doi: https://doi.org/10.1212/WNL.54.4.895.
- Goldstein LB. Prescribing of potentially harmful drugs to patients admitted to hospital after head injury. J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):753–55. doi:https://doi.org/10.1136/jnnp.58.6.753.
- Massagli TL. Neurobehavioral effects of phenytoin, carbamazepine, and valproic acid: implications for use in traumatic brain injury. Arch Phys Med Rehabil. 1991 Mar;72(3):219–26.
- Meador KJ, Loring DW, Abney OL, Allen ME, Moore EE, Zamrini EY, King DW. Effects of carbamazepine and phenytoin on EEG and memory in healthy adults. Epilepsia. 1993 Feb;34(1):153–57. doi:https://doi.org/10.1111/j.1528-1157.1993.tb02389.x.
- Steiner TJ, Dellaportas CI, Findley LJ, Gross M, Gibberd FB, Perkin GD, Park DM, Abbott R. Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin. Epilepsia. 1999;40(5):601–07. doi:https://doi.org/10.1111/j.1528-1157.1999.tb05562.x.
- Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med. 2012 Mar 1;366(9):819–26. doi:https://doi.org/10.1056/NEJMoa1102609.
- Moher D, Liberati A, Tetzlaff J, Altman DG, the PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 2009 Jul 21;6(7):e1000097. doi:https://doi.org/10.1371/journal.pmed.1000097.
- Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016 Dec 5;5(1):210. doi: https://doi.org/10.1186/s13643-016-0384-4.
- National Heart, Lung, and Blood Institute. Quality assessment tool for observational cohort and cross-sectional studies. Bethesda: National Institutes of Health, Department of Health and Human Services; 2014.
- Tate RL, Perdices M, Rosenkoetter U, McDonald S, Togher L, Shadish W, Horner R, Kratochwill T, Barlow DH, Kazdin A, et al. The single-case reporting guideline in behavioural interventions (SCRIBE) 2016: Explanation and elaboration. Archives of Scientific Psychology. 2016 04 14;4(1):10. doi:https://doi.org/10.1037/arc0000027.
- Torbic H, Forni AA, Anger KE, Degrado JR, Greenwood BC. Use of antiepileptics for seizure prophylaxis after traumatic brain injury. Am J Health Syst Pharm. 2013 May 1;70(9):759–66. doi: https://doi.org/10.2146/ajhp120203.
- Hirsch LJ, LaRoche SM, Gaspard N, Gerard E, Svoronos A, Herman ST, Mani R, Arif H, Jette N, Minazad Y, et al. American clinical neurophysiology society’s standardized critical care EEG terminology: 2012 version. Journal of Clinical Neurophysiology. 2013;30(1):1–27. doi:https://doi.org/10.1097/WNP.0b013e3182784729.
- Pascarella A, Trojano L, Loreto V, Bilo L, Moretta P, Estraneo A. Long-term outcome of patients with disorders of consciousness with and without epileptiform activity and seizures: a prospective single centre cohort study. J Neurol. 2016 Oct;263(10):2048–56. doi:https://doi.org/10.1007/s00415-016-8232-y.
- Bagnato S, Boccagni C, Sant’Angelo A, Prestandrea C, Virgilio V, Galardi G. EEG epileptiform abnormalities at admission to a rehabilitation department predict the risk of seizures in disorders of consciousness following a coma. Epilepsy Behav. 2016 Mar;56:83–87. doi:https://doi.org/10.1016/j.yebeh.2015.12.012.
- Kim LG, Johnson TL, Marson AG, Chadwick DW. Prediction of risk of seizure recurrence after a single seizure and early epilepsy: further results from the MESS trial. The Lancet Neurology. 2006 Apr 1;5(4):317–22. doi: https://doi.org/10.1016/S1474-4422(06)70383-0.
- Ganesh S, Guernon A, Chalcraft L, Harton B, Smith B, Pape TL-B. Medical comorbidities in disorders of consciousness patients and their association with functional outcomes. Arch Phys Med Rehabil. 2013 Oct;94(10):1899–907. doi:https://doi.org/10.1016/j.apmr.2012.12.026.
- Bagnato S, Boccagni C, Galardi G. Structural epilepsy occurrence in vegetative and minimally conscious states. Epilepsy Res. 2013 Jan;103(1):106–09. doi:https://doi.org/10.1016/j.eplepsyres.2012.09.008.
- American Congress of Rehabilitation Medicine, Brain Injury-Interdisciplinary Special Interest Group, Disorders of Consciousness Task Force, Seel RT, Sherer M, Whyte J, Katz DI, Giacino JT, Rosenbaum AM, Hammond FM, Kalmar K, et al. Assessment scales for disorders of consciousness: evidence-based recommendations for clinical practice and research. Arch Phys Med Rehabil. 2010 Dec 1;91(12):1795–813. doi:https://doi.org/10.1016/j.apmr.2010.07.218.
- Rappaport M, Hall KM, Hopkins K, Belleza T, Cope DN. Disability rating scale for severe head trauma: coma to community. Arch Phys Med Rehabil. 1982 Mar;63(3):118–23.
- Formisano R, Barba C, Buzzi MG, Newcomb-Fernandez J, Menniti-Ippolito F, Zafonte R, Vinicola V, Spanedda F. The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic brain injury. Brain Inj. 2007 May;21(5):499–504. doi:https://doi.org/10.1080/02699050701310994.
- Thompson K, Pohlmann‐Eden B, Campbell LA, Abel H. Pharmacological treatments for preventing epilepsy following traumatic head injury. Cochrane Database of Systematic Reviews. 2015;(8):CD009900. doi:https://doi.org/10.1002/14651858.CD009900.pub2
- Bagnato S, Boccagni C, Sant’angelo A, Galardi G. A range of antiepileptic drugs do not affect the recovery of consciousness in vegetative and minimally conscious states. Epilepsy Behav. 2013 May;27(2):365–70. doi:https://doi.org/10.1016/j.yebeh.2013.02.005.
- Al-Adawi S, Burke DT, Mastronardi SE. Seizure heralding functional recovery in a patient with apallic syndrome: a case report with retrospective-prospective observation. Epilepsy Behav. 2006 Jun;8(4):776–80. doi:https://doi.org/10.1016/j.yebeh.2006.03.001.
- Pape TL-B, Senno RG, Guernon A, Kelly JP. A measure of neurobehavioral functioning after coma. Part II: clinical and scientific implementation. JRRD. 2005;42(1):19. doi:https://doi.org/10.1682/JRRD.2004.03.0033.
- Kletzel SL, Aaronson AL, Guernon A, Carbone C, Chaudhry N, Walsh E, Conneely M, Patil V, Roth E, Steiner M, et al. Safety considerations for the use of transcranial magnetic stimulation as treatment for coma recovery in people with severe traumatic brain injury. Journal of Head Trauma Rehabilitation. 2020 Nov;35(6):430–38. doi:https://doi.org/10.1097/HTR.0000000000000636.
- Estraneo A, Pascarella A, Moretta P, Loreto V, Trojano L. Clinical and electroencephalographic on-off effect of amantadine in chronic non-traumatic minimally conscious state. J Neurol. 2015 Jun;262(6):1584–86. doi:https://doi.org/10.1007/s00415-015-7771-y.
- Turner AL, Perry MS. Outside the box: Medications worth considering when traditional antiepileptic drugs have failed. Seizure - European Journal of Epilepsy. 2017 Aug;1(50):173–85. doi:https://doi.org/10.1016/j.seizure.2017.06.022.
- Drake ME, Pakalnis A, Denio LS, Phillips B. Amantadine hydrochloride for refractory generalized epilepsy in adults. Acta Neurol Belg. 1991;91(3):159–64.
- Carney N, Totten AM, O’Reilly C, Ullman JS, Hawryluk GWJ, Bell MJ, Bratton SL, Chesnut R, Harris OA, Kissoon N, et al. Guidelines for the management of severe traumatic brain injury. Neurosurgery. 2017;80(1):6–15. doi:https://doi.org/10.1227/NEU.0000000000001432
- Martens G, Lejeune N, O’Brien AT, Fregni F, Martial C, Wannez S, Laureys S, Thibaut A. Randomized controlled trial of home-based 4-week tDCS in chronic minimally conscious state. Brain Stimul. 2018;11(5):982–90. doi:https://doi.org/10.1016/j.brs.2018.04.021.
- Martens G, Kroupi E, Bodien Y, Frasso G, Annen J, Cassol H, Barra A, Martial C, Gosseries O, Lejeune N, et al. Behavioral and electrophysiological effects of network-based frontoparietal tDCS in patients with severe brain injury: a randomized controlled trial. NeuroImage: Clinical. 2020;28:102426. doi:https://doi.org/10.1016/j.nicl.2020.102426
- Angelakis E, Liouta E, Andreadis N, Korfias S, Ktonas P, Stranjalis G, Sakas DE. Transcranial direct current stimulation effects in disorders of consciousness. Arch Phys Med Rehabil. 2014 Feb;95(2):283–89. doi:https://doi.org/10.1016/j.apmr.2013.09.002.
- Thibaut A, Wannez S, Donneau A-F, Chatelle C, Gosseries O, Bruno M-A, Laureys S. Controlled clinical trial of repeated prefrontal tDCS in patients with chronic minimally conscious state. Brain Inj. 2017;31(4):466–74. doi:https://doi.org/10.1080/02699052.2016.1274776.
- Estraneo A, Pascarella A, Moretta P, Masotta O, Fiorenza S, Chirico G, Crispino E, Loreto V, Trojano L. Repeated transcranial direct current stimulation in prolonged disorders of consciousness: a double-blind cross-over study. J Neurol Sci. 2017 Apr;375:464–70. doi:https://doi.org/10.1016/j.jns.2017.02.036.
- Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, et al. ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology. Epilepsia. 2017 Apr;58(4):512–21. doi:https://doi.org/10.1111/epi.13709.
- Beghi E, Carpio A, Forsgren L, Hesdorffer DC, Malmgren K, Sander JW, Tomson T, Hauser W. Recommendation for a definition of acute symptomatic seizure. Epilepsia. 2010 Apr;51(4):671–75.
- Qian C, Löppönen P, Tetri S, Huhtakangas J, Juvela S, Turtiainen H-ME, Bode MK, Hillbom M. Immediate, early and late seizures after primary intracerebral hemorrhage. Epilepsy Res. 2014 May 1;108(4):732–39. doi:https://doi.org/10.1016/j.seizure.2015.10.002.
- Thapa A, Chandra SP, Sinha S, Sreenivas V, Sharma BS, Tripathi M. Post-traumatic seizures: a prospective study from a tertiary level trauma center in a developing country. Seizure. 2010 May;19(4):211–16. doi:https://doi.org/10.1016/j.seizure.2010.02.004.
- Gunawardane N, Fields M. Acute symptomatic seizures and provoked seizures: to treat or not to treat? Curr Treat Options Neurol. 2018 Aug 23;20(10):41. doi: https://doi.org/10.1007/s11940-018-0525-2.
- Lucke-Wold BP, Nguyen L, Turner RC, Logsdon AF, Chen Y-W, Smith KE, Huber JD, Matsumoto R, Rosen CL, Tucker ES, et al. Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure. Seizure. 2015 Dec;33:13–23. doi:https://doi.org/10.1016/j.seizure.2015.10.002
- Quirins M, Dussaule C, Denier C, Masnou P. Epilepsy after stroke: Definitions, problems and a practical approach for clinicians. Rev Neurol (Paris). 2019 Mar;175(3):126–32. doi:https://doi.org/10.1016/j.neurol.2018.02.088.
- Camilo O, Goldstein LB. Seizures and epilepsy after ischemic stroke. Stroke. 2004 Jul;35(7):1769–75. doi:https://doi.org/10.1161/01.STR.0000130989.17100.96.
- Englander J, Bushnik T, Duong TT, Cifu DX, Zafonte R, Wright J, Hughes R, Bergman W. Analyzing risk factors for late posttraumatic seizures: a prospective, multicenter investigation. Arch Phys Med Rehabil. 2003 Mar;84(3):365–73. doi:https://doi.org/10.1053/apmr.2003.50022.
- Ferguson PL, Smith GM, Wannamaker BB, Thurman DJ, Pickelsimer EE, Selassie AW. A population-based study of risk of epilepsy after hospitalization for traumatic brain injury. Epilepsia. 2010 May;51(5):891–98. doi:https://doi.org/10.1111/j.1528-1167.2009.02384.x.
- Hesdorffer DC, Benn EKT, Cascino GD, Hauser WA. Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure. Epilepsia. 2009 May;50(5):1102–08. doi:https://doi.org/10.1111/j.1528-1167.2008.01945.x.
- Majidi S, Makke Y, Ewida A, Sianati B, Qureshi AI, Koubeissi MZ. Prevalence and risk factors for early seizure in patients with traumatic brain injury: analysis from national trauma data bank. Neurocrit Care. 2017 Aug;27(1):90–95. doi:https://doi.org/10.1007/s12028-016-0363-6.
- Mazzini L, Cossa FM, Angelino E, Campini R, Pastore I, Monaco F. Posttraumatic epilepsy: neuroradiologic and neuropsychological assessment of long-term outcome. Epilepsia. 2003 Apr;44(4):569–74. doi:https://doi.org/10.1046/j.1528-1157.2003.34902.x.