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Review

Neurobiological Mechanisms Of Depression Following Traumatic Brain Injury

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Pages 24-33 | Received 03 Mar 2022, Accepted 23 Aug 2022, Published online: 14 Nov 2022

References

  • Centers for disease control and prevention, national center for health statistics: mortality data on CDC WONDER. 2019. [accessed 2022 Feb 1]. https://wonder.cdc.gov/mcd.html
  • Jourdan C, Azouvi P, Genêt F, Selly N, Josseran L, Schnitzler A. Disability and health consequences of traumatic brain injury national prevalence. Am J Phys Med Rehabil. 2018;97(5):323–31. doi:10.1097/PHM.0000000000000848. Cited in: PMID: 29016402.
  • Kreutzer JS, Seel RT, Gourley E. The prevalence and symptom rates of depression after traumatic brain injury: a comprehensive examination. Brain Inj. 2001;15(7):563–76. doi:10.1080/02699050010009108. Cited in: PMID: 11429086.
  • Seel RT, Kreutzer JS, Rosenthal M, Hammond FM, Corrigan JD, Black K. Depression after traumatic brain injury: a National institute on disability and rehabilitation research model systems multicenter investigation. Arch Phys Med Rehabil. 2003;84(2):177–84. doi:10.1053/apmr.2003.50106. Cited in: PMID: 12601647.
  • Malec JF, Brown AW, Moessner AM, Stump TE, Monahan P. A preliminary model for posttraumatic brain injury depression. Arch Phys Med Rehabil. 2010;91(7):1087–97. doi:10.1016/j.apmr.2010.04.002. Cited in: PMID: 20599048.
  • Kumar RG, Gao S, Juengst SB, Wagner AK, Fabio A. The effects of post-traumatic depression on cognition, pain, fatigue, and headache after moderate-to-severe traumatic brain injury: a thematic review. Brain Inj. 2018;32(4):383–94. doi:10.1080/02699052.2018.1427888. Cited in: PMID: 29355429.
  • Jorge RE, Starkstein SE. Pathophysiologic aspects of major depression following traumatic brain injury. J Head Trauma Rehabil. 2005;20(6):475–87. doi:10.1097/00001199-200511000-00001. Cited in: PMID:16304485.
  • Miles SR, Hammond FM, Neumann D, Silva MA, Tang X, Kajankova M, Dillahunt-Aspillaga C, Nakase-Richardson R. Evolution of irritability, anger, and aggression after traumatic brain injury: identifying and predicting subgroups. J Neurotrauma. 2021;38(13):1827–33. doi:10.1089/neu.2020.7451. Cited in: PMID: 33470179.
  • Howlett JR, Nelson LD, Stein MB. Mental health consequences of traumatic brain injury. Biol Psych. 2022;91(5):413–20. doi:10.1016/j.biopsych.2021.09.024. Cited in: PMID: 34893317.
  • Harnod D, Harnod T, Lin CL, Shen WC, Kao CH. Increased risks of suicide attempt and suicidal drug overdose following admission for head injury in patients with depression. Int J Environ Res Public Health. 2019;16(19):3524. doi:10.3390/ijerph16193524. Cited in: PMID: 3154720.
  • Kivunja S, River J, Gullick J. Experiences of giving and receiving care in traumatic brain injury: an integrative review. J Clin Nurs. 2018;27(7–8):1304–28. doi:10.1111/jocn.14283. Cited in: PMID: 29396883.
  • Narapareddy BR, Narapareddy L, Lin A, Wigh S, Nanavati J, Dougherty J 3rd, Nowrangi M, Roy D. Treatment of depression after traumatic brain injury: a systematic review focused on pharmacological and neuromodulatory interventions. Psychosomatics. 2020 Sep-Oct;61(5):481–97. doi:10.1016/j.psym.2020.04.012. 2020. Cited in: PMID: 32660873.
  • Roy D, Koliatsos V, Vaishnavi S, Han D, Rao V. Risk factors for new-onset depression after first-time traumatic brain injury. Psychosomatics. 2018;59(1):47–57. doi:10.1016/j.psym.2017.07.008. Cited in: PMID: 28844451.
  • Wang Y, Neumann M, Hansen K, Hong SM, Kim S, Noble-Haeusslein LJ, Liu J. Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. J Neurotrauma. 2011 Feb;28(2):259–68. doi:10.1089/neu.2010.1648. Cited in: PMID: 21175261.
  • Meythaler JM, Depalma L, Devivo MJ, Guin-Renfroe S, Novack TA. Sertraline to improve arousal and alertness in severe traumatic brain injury secondary to motor vehicle crashes. Brain Inj. 2001 Apr;15(4):321–31. doi:10.1080/026990501750111274. Cited in: PMID: 11299133.
  • Rapoport MJ, Chan F, Lanctot K, Herrmann N, McCullagh S, Feinstein A. An open-label study of citalopram for major depression following traumatic brain injury. J Psychopharmacol. 2008 Nov;22(8):860–64. doi:10.1177/0269881107083845. Epub 2008 Jan 21. Cited in: PMID: 18208921.
  • Fann JR, Bombardier CH, Vannoy S, Dyer J, Ludman E, Dikmen S, Marshall K, Barber J, Temkin N. Telephone and in-person cognitive behavioral therapy for major depression after traumatic brain injury: a randomized controlled trial. J Neurotrauma. 2015 Jan 1;32(1):45–57. doi:10.1089/neu.2014.3423. Cited in: PMID: 25072405; PMCID: PMC4273196.
  • Khan-Bourne N, Brown RG. Cognitive behaviour therapy for the treatment of depression in individuals with brain injury. NeuropsycholRehabil. 2003 Jan-Mar;13(1–2):89–107. doi:10.1080/09602010244000318. Cited in: PMID: 21854329.
  • Kreitzer N, Ancona R, McCullumsmith C, Kurowski BG, Foreman B, Ngwenya LB, Adeoye O. The effect of antidepressants on depression after traumatic brain injury: a meta-analysis. J Head Trauma Rehabil. 2019 May;34(3):E47–E54. doi:10.1097/HTR.0000000000000439. Cited in: PMID: 30169440.
  • Cheng YS, Tseng PT, Wu YC, Tu YK, Wu CK, Hsu CW, Lei WT, Li DJ, Chen TY, Stubbs B, et al. Therapeutic benefits of pharmacologic and nonpharmacologic treatments for depressive symptoms after traumatic brain injury: a systematic review and network meta-analysis. J Psychiatry Neurosci. 2021 Jan 21;46(1):E196–E207. doi:10.1503/jpn.190122. Cited in: PMID: 33497170.
  • Köhler O, Benros ME, Nordentoft M, Farkouh ME, Iyengar RL, Mors O, Krogh J. Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry. 2014 1;71(12):1381–91. doi:10.1001/jamapsychiatry.2014.1611. Cited in: PMID: 25322082.
  • Fenn AM, Skendelas JP, Moussa DN, Muccigrosso MM, Popovich PG, Lifshitz J, Eiferman DS, Godbout JP. Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice. J Neurotrauma. 2015 Jan 15;32(2):127–38. doi:10.1089/neu.2014.3514. 2014. Cited in: PMID: 25070744; PMCID: PMC4291210.
  • Lim SW, Sung KC, Shiue YL, Wang CC, Chio CC, Kuo JR. Hyperbaric oxygen effects on depression-like behavior and neuroinflammation in traumatic brain injury rats. World Neurosurg. 2017;100:128–37. doi:10.1016/j.wneu.2016.12.118. Cited in: PMID: 28065873.
  • Lim J, Kim HI, Bang Y, Choi HJ. Peroxisome proliferator-activated receptor gamma: a novel therapeutic target for cognitive impairment and mood disorders that functions via the regulation of adult neurogenesis. Arch Pharm Res. 2021 Jun;44(6):553–63. doi:10.1007/s12272-021-01333-7. 2021. Cited in: PMID: 34138417.
  • Lim SW, Shiue YL, Liao JC, Wee HY, Wang CC, Chio CC, Chang CH, Hu CY, Kuo JR. Simvastatin therapy in the acute stage of traumatic brain injury attenuates brain trauma-induced depression-like behavior in rats by reducing neuroinflammation in the hippocampus. Neurocrit Care. 2017;26(1):122–32. doi:10.1007/s12028-016-0290-6. Cited in: PMID: 27406816.
  • Ghajar J. Traumatic brain injury. Lancet. 2000;356(9233):923–29. doi:10.1016/S0140-6736(00)02689-1. Cited in: PMID: 11036909.
  • Ladak AA, Enam SA, Ibrahim MT. A review of the molecular mechanisms of traumatic brain injury. World Neurosurg. 2019;131:126–32. doi:10.1016/j.wneu.2019.07.039. Cited in: PMID: 31301445.
  • Ng SY, Lee AYW. Traumatic brain injuries: pathophysiology and potential therapeutic targets. Front Cell Neurosci. 2019;13:528. doi:10.3389/fncel.2019.00528. Cited in: PMID: 31827423.
  • Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J. Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron. 2017;95(6):1246–65. doi:10.1016/j.neuron.2017.07.010. Cited in: PMID: 28910616.
  • Ziebell JM, Morganti-Kossmann MC. Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury. Neurotherapeutics. 2010;7(1):22–30. doi:10.1016/j.nurt.2009.10.016. Cited in: PMID: 20129494.
  • Needham EJ, Helmy A, Zanier ER, Jones JL, Coles AJ, Menon DK. The immunological response to traumatic brain injury. J Neuroimmunol. 2019;332:112–25. doi:10.1016/j.jneuroim.2019.04.005. Cited in: PMID: 31005712.
  • Simon DW, McGeachy MJ, Bayır H, Clark RS, Loane DJ, Kochanek PM. The far-reaching scope of neuroinflammation after traumatic brain injury. Nat Rev Neurol. 2017;13(3):171–91. doi:10.1038/nrneurol.2017.13. Cited in: PMID: 28186177.
  • Henze K, Martin W. Evolutionary biology: essence of mitochondria. Nature. 2003;426(6963):127–28. doi:10.1038/426127a. Cited in: PMID: 14614484.
  • Hinzman JM, Wilson JA, Mazzeo AT, Bullock MR, Hartings JA. Excitotoxicity and metabolic crisis are associated with spreading depolarizations in severe traumatic brain injury patients. J Neurotrauma. 2016;33(19):1775–83. doi:10.1089/neu.2015.4226. Cited in: PMID: 26586606.
  • Veech RL, Valeri CR, VanItallie TB. The mitochondrial permeability transition pore provides a key to the diagnosis and treatment of traumatic brain injury. IUBMB Life. 2012;64(2):203–07. doi:10.1002/iub.590. Cited in: PMID: 22241645.
  • Khatri N, Thakur M, Pareek V, Kumar S, Sharma S, Datusalia AK. Oxidative stress: major threat in traumatic brain injury. CNS Neurol Disord Drug Targets. 2018;17(9):689–95. doi:10.2174/1871527317666180627120501. Cited in: PMID: 29952272.
  • Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 2014;94(3):909–50. doi:10.1152/physrev.00026.2013. Cited in: PMID: 24987008.
  • Pun PB, Lu J, Moochhala S. Involvement of ROS in BBB dysfunction. Free Radic Res. 2009;43(4):348–64. doi:10.1080/10715760902751902. Cited in: PMID: 19241241.
  • Kozlov AV, Bahrami S, Redl H, Szabo C. Alterations in nitric oxide homeostasis during traumatic brain injury. BiochimBiophys Acta Mol Basis Dis. 2017;1863(10 Pt B):2627–32. doi:10.1016/j.bbadis.2016.12.020. Cited in: PMID: 28064018.
  • Czarny P, Wigner P, Galecki P, Sliwinski T. The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2018;80(Pt C):309–21. doi:10.1016/j.pnpbp.2017.06.036. Cited in: PMID: 28669580.
  • Hahn WS, Kuzmicic J, Burrill JS, Donoghue MA, Foncea R, Jensen MD, Lavandero S, Arriaga EA, Bernlohr DA. Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics. Am J Physiol Endocrinol Metab. 2014;306(9):1033–45. doi:10.1152/ajpendo.00422.2013. Cited in: PMID: 24595304.
  • McGuire JL, Ngwenya LB, McCullumsmith RE. Neurotransmitter changes after traumatic brain injury: an update for new treatment strategies. Mol Psychiatry. 2019;24(7):995–1012. doi:10.1038/s41380-018-0239-6. Cited in: PMID: 30214042.
  • Guerriero RM, Giza CC, Rotenberg A. Glutamate and GABA imbalance following traumatic brain injury. Curr Neurol Neurosci Rep. 2015;15(5):27. doi:10.1007/s11910-015-0545-1. Cited in: PMID: 25796572.
  • Eierud C, Craddock RC, Fletcher S, Aulakh M, King-Casas B, Kuehl D, LaConte SM. Neuroimaging after mild traumatic brain injury: review and meta-analysis. Neuroimage Clin. 2014 Jan 4;4:283–94. doi:10.1016/j.nicl.2013.12.009. Cited in: PMID: 25061565.
  • Le TH, Gean AD. Neuroimaging of traumatic brain injury. Mt Sinai J Med. 2009 Apr;76(2):145–62. doi:10.1002/msj.20102. Cited in: PMID: 19306377.
  • Smith LGF, Milliron E, Ho ML, Hu HH, Rusin J, Leonard J, Sribnick EA. Advanced neuroimaging in traumatic brain injury: an overview. Neurosurg Focus. 2019 Dec;47(6):E17. doi:10.3171/2019.9.FOCUS19652. Erratum in: Neurosurg Focus. 2021 Jan;50(1):E22. Cited in: PMID: 32364704.
  • Irimia A, Van Horn JD. Functional neuroimaging of traumatic brain injury: advances and clinical utility. Neuropsychiatr Dis Treat. 2015 Sep 15;11:2355–65. doi:10.2147/NDT.S79174. Cited in: PMID: 26396520.
  • Belanger HG, Vanderploeg RD, Curtiss G, Warden DL. Recent neuroimaging techniques in mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2007;19(1):5–20. doi:10.1176/jnp.2007.19.1.5. Winter, Cited in: PMID: 17308222.
  • Lin AP, Liao HJ, Merugumala SK, Prabhu SP, Meehan WP 3rd, Ross BD. Metabolic imaging of mild traumatic brain injury. Brain Imaging Behav. 2012 Jun;6(2):208–23. doi:10.1007/s11682-012-9181-4. Cited in: PMID: 22684770.
  • Kato T, Nakayama N, Yasokawa Y, Okumura A, Shinoda J, Iwama T. Statistical image analysis of cerebral glucose metabolism in patients with cognitive impairment following diffuse traumatic brain injury. J Neurotrauma. 2007 Jun;24(6):919–26. doi:10.1089/neu.2006.0203. Cited in: PMID: 17600509.
  • Garnett MR, Corkill RG, Blamire AM, Rajagopalan B, Manners DN, Young JD, Styles P, Cadoux-Hudson TA. Altered cellular metabolism following traumatic brain injury: a magnetic resonance spectroscopy study. J Neurotrauma. 2001 Mar;18(3):231–40. doi:10.1089/08977150151070838. PMID: 11284544.
  • Shin SS, Bales JW, Edward Dixon C, Hwang M. Structural imaging of mild traumatic brain injury may not be enough: overview of functional and metabolic imaging of mild traumatic brain injury. Brain Imaging Behav. 2017 Apr;11(2):591–610. doi:10.1007/s11682-017-9684-0. PMID: 28194558.
  • Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF. Major depressive disorder. Nat Rev Dis Primers. 2016;2(1):16065. doi:10.1038/nrdp.2016.65. Cited in: PMID: 27629598.
  • Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002 Mar 28;34(1):13–25. doi:10.1016/s0896-6273(02)00653-0. Cited in: PMID: 11931738.
  • Young JJ, Bruno D, Pomara N. A review of the relationship between proinflammatory cytokines and major depressive disorder. J Affect Disord. 2014 Dec;169:15–20. Epub 2014 Jul 30. Cited in: PMID: 25128861. doi:10.1016/j.jad.2014.07.032
  • O’Brien SM, Scott LV, Dinan TG. Cytokines: abnormalities in major depression and implications for pharmacological treatment. Hum Psychopharmacol. 2004 Aug;19(6):397–403. doi:10.1002/hup.609. Cited in: PMID: 15303243.
  • Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 2006 Jan;27(1):24–31. doi:10.1016/j.it.2005.11.006. Epub 2005 Nov 28. Cited in: PMID: 16316783.
  • Pariante CM. Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation. Eur Neuropsychopharmacol. 2017;27(6):554–59. doi:10.1016/j.euroneuro.2017.04.001. Cited in: PMID: 28479211.
  • Iob E, Kirschbaum C, Steptoe A. Persistent depressive symptoms, HPA-axis hyperactivity, and inflammation: the role of cognitive-affective and somatic symptoms. Mol Psychiatry. 2020;25(5):1130–40. doi:10.1038/s41380-019-0501-6. Cited in: PMID: 31435001.
  • Leistner C, Menke A. Hypothalamic-pituitary-adrenal axis and stress. Handb Clin Neurol. 2020;175:55–64. doi:10.1016/B978-0-444-64123-6.00004-7. Cited in: PMID: 33008543.
  • Ménard C, Pfau ML, Hodes GE, Russo SJ. Immune and neuroendocrine mechanisms of stress vulnerability and resilience. Neuropsychopharmacology. 2017 Jan;42(1):62–80. doi:10.1038/npp.2016.90. Cited in: PMID: 27291462.
  • Sapolsky RM. Glucocorticoids, the evolution of the stress-response, and the primate predicament. neurobiology of Stress. 2021;14:100320. doi:10.1016/j.ynstr.2021.100320. Cited in: PMID: 33869683.
  • Gjerstad JK, Lightman SL, Spiga F. Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility. Stress. 2018;21(5):403–16. doi:10.1080/10253890.2018.1470238. Cited in: PMID: 29764284.
  • Zunszain PA, Anacker C, Cattaneo A, Carvalho LA, Pariante CM. Glucocorticoids, cytokines and brain abnormalities in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(3):722–29. doi:10.1016/j.pnpbp.2010.04.011. Cited in: PMID: 20406665.
  • Vogelzangs N, Beekman AT, van Reedtdortland AK, Schoevers RA, Giltay EJ, de Jonge P, Penninx BW. Inflammatory and metabolic dysregulation and the 2-year course of depressive disorders in antidepressant users. Neuropsychopharmacology. 2014 Jun;39(7):1624–34. doi:10.1038/npp.2014.9. Cited in: PMID: 24442097.
  • Choi GE, Han HJ. Glucocorticoid impairs mitochondrial quality control in neurons. Neurobiol Dis. 2021;152:105301. doi:10.1016/j.nbd.2021.105301. Cited in: PMID: 33609641.
  • Hunter RG, Seligsohn M, Rubin TG, Griffiths BB, Ozdemir Y, Pfaff DW, Datson NA, McEwen BS. Stress and corticosteroids regulate rat hippocampal mitochondrial DNA gene expression via the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2016;113(32):9099–104. doi:10.1073/pnas.1602185113. Cited in: PMID: 27457949.
  • Belleau EL, Treadway MT, Pizzagalli DA. The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology. Biol Psychiatry. 2019;85(6):443–53. doi:10.1016/j.biopsych.2018.09.031. Cited in: PMID: 30470559.
  • Liu CH, Zhang GZ, Li B, Li M, Woelfer M, Walter M, Wang L. Role of inflammation in depression relapse. J Neuroinflammation. 2019;16(1):90. doi:10.1186/s12974-019-1475-7. Cited in: PMID: 30995920.
  • Wohleb ES, Franklin T, Iwata M, Duman RS. Integrating neuroimmune systems in the neurobiology of depression. Nat Rev Neurosci. 2016;17(8):497–511. doi:10.1038/nrn.2016.69. Cited in: PMID: 27277867.
  • Leighton SP, Nerurkar L, Krishnadas R, Johnman C, Graham GJ, Cavanagh J. Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis. Mol Psychiatry. 2018;23(1):48–58. doi:10.1038/mp.2017.205. Cited in: PMID: 29133955.
  • Ghasemi M. Nitric oxide: antidepressant mechanisms and inflammation. Adv Pharmacol. 2019;86:121–52. doi:10.1016/bs.apha.2019.04.004. Cited in: PMID: 31378250.
  • McLeod TM, López-Figueroa AL, López-Figueroa MO. Nitric oxide, stress, and depression. Psychopharmacol Bull. 2001;35(1):24–41. Cited in: PMID: 12397868 Winter.
  • Bodnar CN, Morganti JM, Bachstetter AD. Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism. Neural Regen Res. 2018;13(10):1693–704. doi:10.4103/1673-5374.238604. Cited in: PMID: 30136679.
  • Caruso G, Benatti C, Blom JMC, Caraci F, Tascedda F. The many faces of mitochondrial dysfunction in depression: from pathology to treatment. Front Pharmacol. 2019;10:995. doi:10.3389/fphar.2019.00995. Cited in: PMID: 31551791.
  • Tamási V, Petschner P, Adori C, Kirilly E, Ando RD, Tothfalusi L, Juhasz G, Bagdy G. Transcriptional evidence for the role of chronic venlafaxine treatment in neurotrophic signaling and neuroplasticity including also Glutamatergic [corrected] - and insulin-mediated neuronal processes. PLoS One. 2014;9(11):e113662. doi:10.1371/journal.pone.0113662. Cited in: PMID: 25423262.
  • Eren I, Naziroğlu M, Demirdaş A. Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain. Neurochem Res. 2007;32(7):1188–95. doi:10.1007/s11064-007-9289-x. Cited in: PMID: 17401662.
  • Gong Y, Chai Y, Ding JH, Sun XL, Hu G. Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain. Neurosci Lett. 2011;488(1):76–80. doi:10.1016/j.neulet.2010.11.006. Cited in: PMID:21070835.
  • Gamaro GD, Streck EL, Matté C, Prediger ME, Wyse AT, Dalmaz C. Reduction of hippocampal Na+, K+-ATPase activity in rats subjected to an experimental model of depression. Neurochem Res. 2003;28(9):1339–44. doi:10.1023/a:1024988113978. Cited in: PMID: 12938855.
  • Xia JJ, Deng FL, Liang WW, Wu J, Yin BM, Dong MX, Chen JJ, Ye F, Wang HY, Zheng P, et al. Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study. Transl Psychiatry. 2018;8(1):130. doi:10.1038/s41398-018-0183-x. Cited in: PMID: 29991685.
  • Maes M, Ringel K, Kubera M, Berk M, Rybakowski J. Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression. J Affect Disord. 2012;136(3):386–92. doi:10.1016/j.jad.2011.11.016. Cited in: PMID: 22166399.
  • Arango V, Underwood MD, Mann JJ. Serotonin brain circuits involved in major depression and suicide. Prog Brain Res. 2002;136:443–53. doi:10.1016/s0079-6123(02)36037-0. Cited in: PMID: 12143401.
  • Joensuu M, Tolmunen T, Saarinen PI, Tiihonen J, Kuikka J, Ahola P, Vanninen R, Lehtonen J. Reduced midbrain serotonin transporter availability in drug-naïve patients with depression measured by SERT-specific [(123)I] nor-beta-CIT SPECT imaging. Psychiatry Res. 2007 Feb 28;154(2):125–31. doi:10.1016/j.pscychresns.2006.08.001. Epub 2007 Feb 7. Cited in: PMID: 17289353.
  • Underwood MD, Kassir SA, Bakalian MJ, Galfalvy H, Dwork AJ, Mann JJ, Arango V. Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity. Transl Psychiatry. 2018 Dec 14;8(1):279. doi:10.1038/s41398-018-0309-1. Cited in: PMID: 30552318.
  • Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry. 2010 May;167(5):509–27. doi:10.1176/appi.ajp.2010.09101452. Epub 2010 Mar 15. Cited in: PMID: 20231323.
  • Duman RS, Sanacora G, Krystal JH. Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments. Neuron. 2019;102(1):75–90. doi:10.1016/j.neuron.2019.03.013. Cited in: PMID: 30946828.
  • Rajkowska G, Stockmeier CA. Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. Curr Drug Targets. 2013;14(11):1225–36. doi:10.2174/13894501113149990156. Cited in: PMID: 234699229810.
  • Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014;140(3):774–815. doi:10.1037/a0035302. Cited in: PMID: 24417575.
  • Haroon E, Chen X, Li Z, Patel T, Woolwine BJ, Hu XP, Felger JC, Miller AH. Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia. Transl Psychiatry. 2018;8(1):189. doi:10.1038/s41398-018-0241-4. Cited in: PMID: 30202011.
  • Vezzani A, Viviani B. Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability. Neuropharmacology. 2015;96:70–82. doi:10.1016/j.neuropharm.2014.10.027. Cited in: PMID: 25445483.
  • van Velzen LS, Kelly S, Isaev D, Aleman A, Aftanas LI, Bauer J, Baune BT, Brak IV, Carballedo A, Connolly CG, et al. White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group. Mol Psychiatry. 2020 Jul;25(7):1511–25. DOI:10.1038/s41380-019-0477-2. Epub 2019 Aug 30. Cited in: PMID: 31471575.
  • Tham MW, Woon PS, Sum MY, Lee TS, Sim K. White matter abnormalities in major depression: evidence from post-mortem, neuroimaging and genetic studies. J Affect Disord. 2011 Jul;132(1–2):26–36. doi:10.1016/j.jad.2010.09.013. Epub 2010 Oct 2. Cited in: PMID: 20889213.
  • de Diego-Adeliño J, Pires P, Gómez-Ansón B, Serra-Blasco M, Vives-Gilabert Y, Puigdemont D, Martín-Blanco A, Alvarez E, Pérez V, Portella MJ. Microstructural white-matter abnormalities associated with treatment resistance, severity and duration of illness in major depression. Psychol Med. 2014 Apr;44(6):1171–82. doi:10.1017/S003329171300158X. Epub 2013 Aug 21. Cited in: PMID: 23962469.
  • Cole J, Chaddock CA, Farmer AE, Aitchison KJ, Simmons A, McGuffin P, Fu CH. White matter abnormalities and illness severity in major depressive disorder. Br J Psychiatry. 2012 Jul;201(1):33–39. doi:10.1192/bjp.bp.111.100594. Epub 2012 May 10. Cited in: PMID: 22576724.
  • Liu J, Xu X, Luo Q, Luo Y, Chen Y, Lui S, Wu M, Zhu H, Kemp GJ, Gong Q. Brain grey matter volume alterations associated with antidepressant response in major depressive disorder. Sci Rep. 2017 Sep 5;7(1):10464. doi:10.1038/s41598-017-10676-5. Cited in: PMID: 28874763.
  • Chen CH, Ridler K, Suckling J, Williams S, Fu CH, Merlo-Pich E, Bullmore E. Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment. Biol Psychiatry. 2007 Sep 1;62(5):407–14. doi:10.1016/j.biopsych.2006.09.018. Epub 2007 Jan 9. Cited in: PMID: 17217921.
  • Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, Mathews VP, Kalnin A, Lowe MJ. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry. 2005 May 15;57(10):1079–88. doi:10.1016/j.biopsych.2005.02.021. Cited in: PMID: 15866546.
  • Kaiser RH, Andrews-Hanna JR, Wager TD, Pizzagalli DA. Large-Scale Network Dysfunction in Major Depressive Disorder: a Meta-analysis of Resting-State Functional Connectivity. JAMA Psychiatry. 2015 Jun;72(6):603–11. doi:10.1001/jamapsychiatry.2015.0071. Cited in: PMID: 25785575.
  • Chan KL, Cathomas F, Russo SJ. Central and peripheral inflammation link metabolic syndrome and major depressive disorder. Physiology (Bethesda). 2019;34(2):123–33. doi:10.1152/physiol.00047.2018. Cited in: PMID: 30724127.
  • Sharma S, Akundi RS. Mitochondria: a connecting link in the major depressive disorder jigsaw. CurrNeuropharmacol. 2019;17(6):550–62. doi:10.2174/1570159X16666180302120322. Cited in: PMID: 29512466.
  • Dantzer R. Neuroimmune interactions: from the brain to the immune system and vice versa. Physiol Rev. 2018;98(1):477–504. doi:10.1152/physrev.00039.2016. Cited in: PMID: 29351513.
  • Popovic V, Pekic S, Pavlovic D, Maric N, Jasovic-Gasic M, Djurovic B, Medic-Stojanoska M, Zivkovic V, Stojanovic M, Doknic M, et al. Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive disabilities and mental distress. J Endocrinol Invest. 2004 Dec;27(11):1048–54. DOI:10.1007/BF03345308. Cited in: PMID: 15754737.
  • Bay E, Covassin T. Chronic stress, somatic and depressive symptoms following mild to moderate traumatic brain injury. Arch PsychiatrNurs. 2012 Dec;26(6):477–86. doi:10.1016/j.apnu.2012.06.002. Cited in: PMID: 23164404.
  • Bay E, Sikorskii A, Gao F. Functional status, chronic stress, and cortisol response after mild-to-moderate traumatic brain injury. Biol Res Nurs. 2009 Jan;10(3):213–25. doi:10.1177/1099800408326453. Epub 2008 Nov 17. Cited in: PMID: 19015162.
  • Bay E, Hagerty B, Williams RA, Kirsch N. Chronic stress, salivary cortisol response, interpersonal relatedness, and depression among community-dwelling survivors of traumatic brain injury. J NeurosciNurs. 2005 Feb;37(1):4–14. doi:10.1097/01376517-200502000-00002. PMID: 15794439.
  • Luo L, Chai Y, Jiang R, Chen X, Yan T. Cortisol supplement combined with psychotherapy and citalopram improves depression outcomes in patients with hypocortisolism after traumatic brain injury. Aging Dis. 2015 Nov 17;6(6):418–25. doi:10.14336/AD.2015.0507. Cited in: PMID: 26618043.
  • Moreno-López L, Sahakian BJ, Manktelow A, Menon DK, Stamatakis EA. Depression following traumatic brain injury: a functional connectivity perspective. Brain Inj. 2016;30(11):1319–28. doi:10.1080/02699052.2016.1186839. Epub 2016 Jul 28. Cited in: PMID: 2746789.
  • Bergold PJ. Treatment of traumatic brain injury with anti-inflammatory drugs. Experimental Neurology. 2016;275:367–80. doi:10.1016/j.expneurol.2015.05.024. Cited in: PMID: 26112314.
  • Kappelmann N, Lewis G, Dantzer R, Jones PB, Khandaker GM. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol Psychiatry. 2018;23(2):335–43. doi:10.1038/mp.2016.167. Cited in: PMID: 2775207.
  • Lehrer S, Rheinstein PH. Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce suicidal ideation and depression. Discov Med. 2019 Oct;28(154):205–12. Cited in: PMID: 31928628.
  • Kohler O, Krogh J, Mors O, Benros ME. Inflammation in Depression and the Potential for Anti-Inflammatory Treatment. CurrNeuropharmacol. 2016;14(7):732–42. doi:10.2174/1570159x14666151208113700. Cited in: PMID: 27640518.
  • Gallagher PJ, Castro V, Fava M, Weilburg JB, Murphy SN, Gainer VS, Churchill SE, Kohane IS, Iosifescu DV, Smoller JW, et al. Antidepressant response in patients with major depression exposed to NSAIDs: a pharmacovigilance study. Am J Psychiatry. 2012 Oct;169(10):1065–72. doi:10.1176/appi.ajp.2012.11091325. Cited in: PMID: 23032386.
  • Uzzan S, Azab AN. Anti-TNF-α compounds as a treatment for depression. Molecules. 2021 Apr 19;26(8):2368. doi:10.3390/molecules26082368. Cited in: PMID: 33921721.
  • Brymer KJ, Romay-Tallon R, Allen J, Caruncho HJ, Kalynchuk LE. Exploring the potential antidepressant mechanisms of TNFα antagonists. Front Neurosci. 2019 Feb 11;13:98. doi:10.3389/fnins.2019.00098. Cited in: PMID: 30804748.
  • De Giorgi R, Rizzo Pesci N, Quinton A, De Crescenzo F, Cowen PJ, Harmer CJ. Statins in depression: an evidence-based overview of mechanisms and clinical studies. Front Psychiatry. 2021 Jul 27;12:702617. doi:10.3389/fpsyt.2021.702617. Cited in: PMID: 34385939.
  • Colle R, de Larminat D, Rotenberg S, Hozer F, Hardy P, Verstuyft C, Fève B, Corruble E. PPAR-γ agonists for the treatment of major depression: a review. Pharmacopsychiatry. 2017 Mar;50(2):49–55. doi:10.1055/s-0042-120120. Epub 2016 Dec 15. Cited in: PMID: 27978584.
  • Tsai PY, Chen YC, Wang JY, Chung KH, Lai CH. Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis. Sci Rep. 2021 Aug 20;11(1):16940. doi:10.1038/s41598-021-95838-2. Cited in: PMID: 34417481.
  • Siddiqi SH, Trapp NT, Hacker CD, Laumann TO, Kandala S, Hong X, Trillo L, Shahim P, Leuthardt EC, Carter AR, et al. Repetitive transcranial magnetic stimulation with resting-state network targeting for treatment-resistant depression in traumatic brain injury: a randomized, controlled, double-blinded pilot study. J Neurotrauma. 2019 Apr 15;36(8):1361–74. doi:10.1089/neu.2018.5889. Epub 2019 Jan 7. Cited in: PMID: 30381997.
  • Reti IM, Schwarz N, Bower A, Tibbs M, Rao V. Transcranial magnetic stimulation: a potential new treatment for depression associated with traumatic brain injury. Brain Inj. 2015;29(7–8):789–97. doi:10.3109/02699052.2015.1009168. Epub 2015 May 7. Cited in: PMID: 25950260.
  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. 2013. doi:10.1176/appi.books.9780890425596.

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