Salivary microRNA as a prospective tool for concussion diagnosis and management: A scoping review

References

• Gardner RC, Yaffe K. 2015. Epidemiology of mild traumatic brain injury and neurodegenerative disease. Mol Cell Neurosci. 66:75–80. doi:10.1016/j.mcn.2015.03.001.
   PubMed Web of Science ®Google Scholar
• Surveillance Report of Traumatic Brain Injury-related Emergency. Department visits, hospitalizations, and deaths. 24.
   Google Scholar
• Clark R, Stanfill AG. 2019. A systematic review of barriers and facilitators for concussion reporting behavior among student athletes. J Trauma Nurs. 26(6):297–311. doi:10.1097/JTN.0000000000000468.
   PubMed Web of Science ®Google Scholar
• Scorza KA; Hospital FBC, Belvoir F. Current concepts in concussion. Evaluation and Management. 2012;85(2):10.
   Google Scholar
• De Stefano F, Fiani B, Mayo T. A foundational “survival guide” overview of sports-related head injuries. Cureus. 2020;12(11): doi:10.7759/cureus.11636.
   PubMed Web of Science ®Google Scholar
• Broglio SP, Cantu RC, Gioia GA, Guskiewicz KM, Kutcher J, Palm M, McLeod TCV. National athletic trainers’ association position statement: management of sport concussion. J Athl Train. 2014;49(2):245–65. doi:10.4085/1062-6050-49.1.07.
   PubMed Web of Science ®Google Scholar
• Choe MC. 2016. The pathophysiology of concussion. Curr Pain Headache Rep. 20(6):42. doi:10.1007/s11916-016-0573-9.
   PubMed Web of Science ®Google Scholar
• McCrory P, Meeuwisse W, Dvorak J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ, Castellani RJ, et al. Consensus statement on concussion in sport—the 5 th international conference on concussion in sport held in Berlin, October 2016. Br J Sports Med. Published online April 26 2017. doi:10.1136/bjsports-2017-097699.
   Web of Science ®Google Scholar
• Gardner AJ, Quarrie KL, Iverson GL. 2019. The epidemiology of sport-related concussion: what the rehabilitation clinician needs to know. J Orthop Sports Phys Ther. 49(11):768–78. doi:10.2519/jospt.2019.9105.
   PubMed Web of Science ®Google Scholar
• Harmon KG, Clugston JR, Dec K, Hainline B, Herring S, Kane SF, Kontos AP, Leddy JJ, McCrea M, Poddar SK. American medical society for sports medicine position statement on concussion in sport. Br J Sports Med. 2019;53(4):213–25. doi:10.1136/bjsports-2018-100338.
   PubMed Web of Science ®Google Scholar
• Pearson WS, Sugerman DE, McGuire LC, Coronado VG. 2012. Emergency department visits for traumatic brain injury in older adults in the United States: 2006–08. West J Emerg Med. 13(3):289–93. doi:10.5811/westjem.2012.3.11559.
   PubMedGoogle Scholar
• Bryan MA, Rowhani-Rahbar A, Comstock RD, Rivara F. 2016. On behalf of the seattle sports concussion research collaborative. sports- and recreation-related concussions in US youth. PEDIATRICS. 138(1):e20154635–e20154635. doi:10.1542/peds.2015-4635.
   PubMed Web of Science ®Google Scholar
• Norman RS, Shah MN, Turkstra LS. 2019. Reaction time and cognitive-linguistic performance in adults with mild traumatic brain injury. Brain Inj. 33(9):1173–83. doi:10.1080/02699052.2019.1632487.
   PubMed Web of Science ®Google Scholar
• Cunningham J, Broglio SP, O’Grady M, Wilson F. 2020. History of sport-related concussion and long-term clinical cognitive health outcomes in retired athletes: a systematic review. J Athl Train. 55(2):132–58. doi:10.4085/1062-6050-297-18.
   PubMed Web of Science ®Google Scholar
• Register-Mihalik JK, Williams RM, Marshall SW, Linnan LA, Mihalik JP, Guskiewicz KM, McLeod TCV. Demographic, Parental, And Personal Factors And Youth Athletes‘ Concussion-Related Knowledge And Beliefs. J Athl Train. 2018;53(8):768–75. doi:10.4085/1062-6050-223-17.
   PubMed Web of Science ®Google Scholar
• Gardner A, Iverson GL, Levi CR, Schofield PW, Kay-Lambkin F, Kohler RMN, Stanwell P. A systematic review of concussion in rugby league. Br J Sports Med. 2015;49(8):495–98. doi:10.1136/bjsports-2013-093102.
   PubMed Web of Science ®Google Scholar
• Di Pietro V, Porto E, Ragusa M, Barbagallo C, Davies D, Forcione M, Logan A, Di Pietro C, Purrello M, Grey M, et al. Salivary microRNAs: diagnostic markers of mild traumatic brain injury in contact-sport. Front Mol Neurosci. 2018;11:290.
   PubMed Web of Science ®Google Scholar
• Lempke LB, Schmidt JD, Lynall RC. Athletic trainers’ concussion-assessment and -management practices: an update. J Athl Train. 2019 Published online December 19;55(1):17–26. doi:10.4085/1062-6050-322-18.
   PubMed Web of Science ®Google Scholar
• Covassin T, E RJ Iii, Stiller-Ostrowski JL, Kontos AP. Immediate post-concussion assessment and cognitive testing (impact) practices of sports medicine professionals. 6
   Google Scholar
• Sandel N, Sandel N, Schatz P. 2013. Sensitivity and specificity of the online version of impact in high school and collegiate athletes. Am J Sports Med. 41(2):321–26. doi:10.1177/0363546512466038.
   PubMed Web of Science ®Google Scholar
• Schatz P, Pardini J, Lovell M, Collins M, Podell K. 2006. Sensitivity and specificity of the ImPACT test battery for concussion in athletes. Arch Clin Neuropsychol. 21(1):91–99. doi:10.1016/j.acn.2005.08.001.
   PubMed Web of Science ®Google Scholar
• Alsalaheen B, Stockdale K, Pechumer D, Broglio SP. 2016. Validity of the Immediate Post Concussion Assessment and Cognitive Testing (ImPACT). Sports Med. 46(10):1487–501. doi:10.1007/s40279-016-0532-y.
   PubMed Web of Science ®Google Scholar
• Walton SR, Broshek DK, Freeman JR, Cullum CM, Resch JE. 2018. Valid but invalid: suboptimal ImPACT baseline performance in university athletes. Med Sci Sports Exerc. 50(7):1377–84. doi:10.1249/MSS.0000000000001592.
   PubMed Web of Science ®Google Scholar
• Resch JE, Schneider MW, Munro Cullum C. The test-retest reliability of three computerized neurocognitive tests used in the assessment of sport concussion. Int J Psychophysiol. 2018;132:31–38. doi:10.1016/j.ijpsycho.2017.09.011.
   PubMed Web of Science ®Google Scholar
• Resch J, Driscoll A, McCaffrey N, Brown C, Ferrara MS, Macciocchi S, Baumgartner T, Walpert K. ImPact test-retest reliability: reliably unreliable? J Athl Train. 2013;48(4):506–11. doi:10.4085/1062-6050-48.3.09.
   PubMed Web of Science ®Google Scholar
• Cantu RC. Test-retest reliability of computerized concussion assessment programs. Yearb Sports Med. 2009;2009:24–26. doi:10.1016/S0162-0908(09)79464-4.
   Google Scholar
• Atif H, Hicks SD. A review of microrna biomarkers in traumatic brain injury. Journal of Experimental Neuroscience. 2019;13:1179069519832286. doi:10.1177/1179069519832286.
   Web of Science ®Google Scholar
• Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH. 2005. Chronic traumatic encephalopathy in a national football league player. Neurosurgery. 57(1):128–34. doi:10.1227/01.NEU.0000163407.92769.ED.
   PubMed Web of Science ®Google Scholar
• Hicks SD, Ignacio C, Gentile K, Middleton FA. 2016. Salivary miRNA profiles identify children with autism spectrum disorder, correlate with adaptive behavior, and implicate ASD candidate genes involved in neurodevelopment. BMC Pediatr. 16(1):52. doi:10.1186/s12887-016-0586-x.
   PubMed Web of Science ®Google Scholar
• Hicks SD, Johnson J, Carney MC, Bramley H, Olympia RP, Loeffert AC, Thomas NJ. Overlapping microRNA expression in saliva and cerebrospinal fluid accurately identifies pediatric traumatic brain injury. J Neurotrauma. 2018;35(1):64–72. doi:10.1089/neu.2017.5111.
   PubMed Web of Science ®Google Scholar
• Hicks SD, Onks C, Kim RY, Zhen KJ, Loeffert J, Loeffert AC, Olympia RP, Fedorchak G, DeVita S, Rangnekar A, et al. Diagnosing mild traumatic brain injury using saliva RNA compared to cognitive and balance testing. Clin Transl Med. 2020;10(6). doi:10.1002/ctm2.197.
   PubMed Web of Science ®Google Scholar
• Di Pietro V, Ragusa M, Davies D, Su Z, Hazeldine J, Lazzarino G, Hill LJ, Crombie N, Foster M, Purrello M, et al. MicroRNAs as novel biomarkers for the diagnosis and prognosis of mild and severe traumatic brain injury. J Neurotrauma. 2017;34(11):1948–56. doi:10.1089/neu.2016.4857.
   PubMed Web of Science ®Google Scholar
• Hammond SM. An overview of microRNAs. Adv Drug Deliv Rev. 2015;87:3–14. doi: 10.1016/j.addr.2015.05.001.
   PubMed Web of Science ®Google Scholar
• LaRocca D, Barns S, Hicks SD, Brindle A, Williams J, Uhlig R, Johnson P, Neville C, Middleton FA. Comparison of serum and saliva miRNAs for identification and characterization of mTBI in adult mixed martial arts fighters. Zheng Y, editors. PLoS ONE. 2019;14(1):e0207785. doi: 10.1371/journal.pone.0207785.
   Google Scholar
• Johnson JJ, Loeffert AC, Stokes J, Olympia RP, Bramley H, Hicks SD. 2018. Association of salivary microRNA changes with prolonged concussion symptoms. JAMA Pediatr. 172(1):65. doi:10.1001/jamapediatrics.2017.3884.
   PubMed Web of Science ®Google Scholar
• Martini DN, Broglio SP. Long-term effects of sport concussion on cognitive and motor performance: a review. Int J Psychophysiol. 2018;132:25–30. doi:10.1016/j.ijpsycho.2017.09.019.
   PubMed Web of Science ®Google Scholar
• White RG, Hakim AJ, Salganik MJ, Spiller MW, Johnston LG, Kerr L, Kendall C, Drake A, Wilson D, Orroth K, et al. Strengthening the reporting of observational studies in epidemiology for respondent-driven sampling studies: “STROBE-RDS” statement. J Clin Epidemiol. 2015;68(12):1463–71. doi:10.1016/j.jclinepi.2015.04.002.
   PubMed Web of Science ®Google Scholar
• Di Pietro V, O’Halloran P, Watson CN, Begum G, Acharjee A, Yakoub KM, Bentley C, Davies DJ, Iliceto P, Candilera G, et al. Unique diagnostic signatures of concussion in the saliva of male athletes: the study of concussion in rugby union through microRNAs (SCRUM). Br J Sports Med. 2021;55(24):1395–404. Published online March 23. doi:10.1136/bjsports-2020-103274.
   PubMed Web of Science ®Google Scholar
• Fedorchak G, Rangnekar A, Onks C, Loeffert AC, Loeffert J, Olympia RP, DeVita S, Leddy J, Haider MN, Roberts A, et al. Saliva RNA biomarkers predict concussion duration and detect symptom recovery: a comparison with balance and cognitive testing. J Neurol. 2021;268(11):4349–61. Published online May 24. doi:10.1007/s00415-021-10566-x.
   PubMed Web of Science ®Google Scholar
• Hicks SD, Olympia RP, Onks C, Kim RY, Zhen KJ, Fedorchak G, DeVita S, Rangnekar A, Heller M, Zwibel H, et al. Saliva microrna biomarkers of cumulative concussion. Int J Mol Sci. 2020;21(20):7758. doi:10.3390/ijms21207758.
   PubMed Web of Science ®Google Scholar
• Hicks SD, Onks C, Kim RY, Zhen KJ, Loeffert J, Loeffert AC, Olympia RP, Fedorchak G, DeVita S, Gagnon Z, et al. Refinement of saliva microRNA biomarkers for sports-related concussion. J Sport Health Sci. Published online August 2021; S209525462100096X. doi:10.1016/j.jshs.2021.08.003.
   Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG; for the PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339(jul211):b2535–b2535. doi:10.1136/bmj.b2535.
   PubMed Web of Science ®Google Scholar
• Zemek R, Barrowman N, Freedman SB, Gravel J, Gagnon I, McGahern C, Aglipay M, Sangha G, Boutis K, Beer D, et al. Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED. JAMA. 2016;315(10):1014. doi:10.1001/jama.2016.1203.
   PubMed Web of Science ®Google Scholar
• Svingos AM, Asken BM, Bauer RM, DeKosky ST, Hromas GA, Jaffee MS, Hayes RL, Clugston JR. Exploratory study of sport-related concussion effects on peripheral micro-RNA expression. Brain Inj. 2019;33(4):1–7. doi:10.1080/02699052.2019.1573379.
   PubMed Web of Science ®Google Scholar
• Kelly KM, Kiderman A, Akhavan S, Quigley MR, Snell ED, Happ E, Synowiec AS, Miller ER, Bauer MA, Oakes LP, et al. Oculomotor, vestibular, and reaction time effects of sports-related concussion: video-oculography in assessing sports-related concussion. J Head Trauma Rehabil. 2019;34(3):176–88. doi:10.1097/HTR.0000000000000437.
   PubMed Web of Science ®Google Scholar
• Breedlove KM, Ortega JD, Kaminski TW, Harmon KG, Schmidt JD, Kontos AP, Clugston JR, Chrisman SPD, McCrea MA, McAllister TW, et al. King-devick test reliability in national collegiate athletic association athletes: a national collegiate athletic association–department of defense concussion assessment, research and education report. J Athl Train. 2019;54(12):1241–46. Published online October 16. doi:10.4085/1062-6050-219-18.
   PubMed Web of Science ®Google Scholar