TRPV4 modulation participates in paraoxon-induced brain injury via NMDA and NLRP3 regulation

References

• McDonough JH, Jr., Shih TM. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci Biobehav Rev. 1997;21(5):559–79. doi: 10.1016/s0149-7634(96)00050-4.
   PubMed Web of Science ®Google Scholar
• McDonough JH, Jr., Shih TM. A study of the N-methyl-D-aspartate antagonistic properties of anticholinergic drugs. Pharmacol Biochem Behav. 1995;51(2–3):249–53. doi: 10.1016/0091-3057(94)00372-p.
   PubMed Web of Science ®Google Scholar
• Shih T, McDonough JH, Jr., Koplovitz I. Anticonvulsants for soman-induced seizure activity. J Biomed Sci. 1999;6(2):86–96. doi: 10.1007/bf02256439.
   PubMed Web of Science ®Google Scholar
• Skovira JW, JH M, Shih TM. Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801. J Mol Neurosci. 2010;40(1–2):56–62. doi: 10.1007/s12031-009-9253-0.
   PubMed Web of Science ®Google Scholar
• Braitman DJ, Sparenborg S. MK-801 protects against seizures induced by the cholinesterase inhibitor soman. Brain Res Bull. 1989;23(1–2):145–48. doi: 10.1016/0361-9230(89)90173-1.
   PubMed Web of Science ®Google Scholar
• Shih TM, Koenig JA, Acon Chen C. Comparative effects of scopolamine and phencynonate on organophosphorus nerve agent-induced seizure activity, neuropathology and lethality. Toxicol Mech Methods. 2019;29(5):322–33. doi: 10.1080/15376516.2018.1558322.
   PubMed Web of Science ®Google Scholar
• Ferrara-Bowens TM, Chandler JK, Guignet MA, Irwin JF, Laitipaya K, Palmer DD, Shumway LJ, Tucker LB, McCabe JT, Wegner MD, et al. Neuropathological and behavioral sequelae in IL-1R1 and IL-1Ra gene knockout mice after soman (GD) exposure. Neurotoxicology. 2017;63:43–56.
   PubMed Web of Science ®Google Scholar
• Johnson EA, Guignet MA, Dao TL, Hamilton TA, Kan RK. Interleukin-18 expression increases in response to neurovascular damage following soman-induced status epilepticus in rats. J Inflamm (Lond). 2015;12:43. doi: 10.1186/s12950-015-0089-9.
   PubMed Web of Science ®Google Scholar
• Svensson I, Waara L, Johansson L, Bucht A, Cassel G. Soman-induced interleukin-1 beta mRNA and protein in rat brain. Neurotoxicology. 2001;22(3):355–62. doi: 10.1016/s0161-813x(01)00022-5.
   PubMed Web of Science ®Google Scholar
• Williams AJ, Berti R, Yao C, Price RA, Velarde LC, Koplovitz I, Schultz SM, Tortella FC, Dave JR. Central neuro-inflammatory gene response following soman exposure in the rat. Neurosci Lett. 2003;349(3):147–50. doi: 10.1016/s0304-3940(03)00818-8.
   PubMed Web of Science ®Google Scholar
• Bai JZ, Lipski J. Involvement of TRPV4 channels in Abeta(40)-induced hippocampal cell death and astrocytic Ca(2+) signalling. Neurotoxicology. 2014;41:64–72. doi: 10.1016/j.neuro.2014.01.001.
   PubMed Web of Science ®Google Scholar
• Jie P, Hong Z, Tian Y, Li Y, Lin L, Zhou L, Du Y, Chen L, Chen L. Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways. Cell Death Disease. 2015;6(6):e1775. doi: 10.1038/cddis.2015.146.
   PubMedGoogle Scholar
• Lu KT, Huang TC, Tsai YH, Yang YL. Transient receptor potential vanilloid type 4 channels mediate Na-K-Cl-co-transporter-induced brain edema after traumatic brain injury. J Neurochem. 2017;140(5):718–27. doi: 10.1111/jnc.13920.
   PubMed Web of Science ®Google Scholar
• Li L, Qu W, Zhou L, Lu Z, Jie P, Chen L, Chen L. Activation of transient receptor potential vanilloid 4 increases NMDA-Activated Current in hippocampal pyramidal neurons. Front Cell Neurosci. 2013;7:17. doi: 10.3389/fncel.2013.00017.
   PubMed Web of Science ®Google Scholar
• Jokanović M, Kosanović M. Neurotoxic effects in patients poisoned with organophosphorus pesticides. Environ Toxicol Pharmacol. 2010 May;29(3):195–201. doi: 10.1016/j.etap.2010.01.006.
   PubMed Web of Science ®Google Scholar
• Wang S, He H, Long J, Sui X, Yang J, Lin G, Wang Q, Wang Y, Luo Y. TRPV4 regulates soman-induced status epilepticus and secondary brain injury via NMDA receptor and NLRP3 inflammasome. Neurosci Bull. 2021;37(7):905–20. doi: 10.1007/s12264-021-00662-3.
   PubMed Web of Science ®Google Scholar
• Jie P, Lu Z, Hong Z, Li L, Zhou L, Li Y, Zhou R, Zhou Y, Du Y, Chen L. Activation of transient receptor potential vanilloid 4 is involved in neuronal injury in middle cerebral artery occlusion in mice. Mol Neurobiol. 2016;53(1):8–17. doi: 10.1007/s12035-014-8992-2.
   PubMed Web of Science ®Google Scholar
• Zhao H, Zhang K, Tang R, Meng H, Zou Y, Wu P, Hu R, Liu X, Feng H, Chen Y. TRPV4 blockade preserves the blood-brain barrier by inhibiting stress fiber formation in a rat model of intracerebral hemorrhage. Front Mol Neurosci. 2018;11:97. doi: 10.3389/fnmol.2018.00097.
   PubMed Web of Science ®Google Scholar
• Hunt RF, Hortopan GA, Gillespie A, Baraban SC. A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors. Exp Neurol. 2012;237(1):199–206. doi: 10.1016/j.expneurol.2012.06.013.
   PubMed Web of Science ®Google Scholar
• Chen X, Yang M, Sun F, Liang C, Wei Y, Wang L, Yue J, Chen B, Li S, Liu S, et al. Expression and cellular distribution of transient receptor potential vanilloid 4 in cortical tubers of the tuberous sclerosis complex. Brain Res. 2016;1636:183–92. doi: 10.1016/j.brainres.2016.02.012.
   PubMed Web of Science ®Google Scholar
• Li Y, Sun W, Han S, Li J, Ding S, Wang W, Yin Y. IGF-1-Involved negative feedback of NR2B NMDA subunits protects cultured hippocampal neurons against NMDA-Induced excitotoxicity. Mol Neurobiol. 2017;54(1):684–96. doi: 10.1007/s12035-015-9647-7.
   PubMed Web of Science ®Google Scholar
• Ormandy GC, Jope RS, Snead OC, 3rd. Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats. Exp Neurol. 1989;106(2):172–80. doi: 10.1016/0014-4886(89)90091-5.
   PubMed Web of Science ®Google Scholar
• Chen J, Li Z, Hatcher JT, Chen QH, Chen L, Wurster RD, Chan SL, Cheng Z. Deletion of TRPC6 attenuates NMDA receptor-mediated Ca(2+) entry and Ca(2+)-induced neurotoxicity following cerebral ischemia and oxygen-glucose deprivation. Front Neurosci. 2017;11:138. doi: 10.3389/fnins.2017.00138.
   PubMed Web of Science ®Google Scholar
• Menigoz A, Ahmed T, Sabanov V, Philippaert K, Pinto S, Kerselaers S, Segal A, Freichel M, Voets T, Nilius B, et al. TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons. Pflugers Arch Eur J Physiol. 2016;468(4):593–607. doi: 10.1007/s00424-015-1764-7.
   PubMed Web of Science ®Google Scholar
• Liu M, Liu X, Wang L, Wang Y, Dong F, Wu J, Qu X, Liu Y, Liu Z, Fan H, et al. TRPV4 inhibition improved myelination and reduced glia reactivity and inflammation in a cuprizone-induced mouse Model of demyelination. Front Cell Neurosci. 2018;12:392.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhou L, An D, Xu W, Wu C, Sha S, Li Y, Zhu Y, Chen A, Du Y, et al. TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice. Cell Death Disease. 2019;10(6):386. doi: 10.1038/s41419-019-1612-3.
   PubMedGoogle Scholar
• Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ, Mattson MP. Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal. 2010 Dec 1;13(11):1763–811. doi: 10.1089/ars.2009.3074.
   PubMed Web of Science ®Google Scholar
• Calabrese V, Giordano J, Signorile A, Laura Ontario M, Castorina S, De Pasquale C, Eckert G, Calabrese EJ. Major pathogenic mechanisms in vascular dementia: roles of cellular stress response and hormesis in neuroprotection. J Neurosci Res. 2016 Dec;94(12):1588–603. doi: 10.1002/jnr.23925.
   PubMed Web of Science ®Google Scholar
• Freyre EO, Valencia AT, Guzmán DD, Maldonado IC, Ledezma LEB, Carrillo MFZ, Escorza MAQ. Oxidative stress as a molecular mechanism of exposure to organophosphorus pesticides: a review. Curr Protein Pept Sci. 2021 Dec 27;22(12):890–97. doi: 10.2174/1389203722666211122092309.
   PubMed Web of Science ®Google Scholar
• Liu X, Cai H, Peng L, Ma H, Yan Y, Li W, Zhao J. Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization. Free Radic Biol Med. 2024 Mar;214:87–100. doi: 10.1016/j.freeradbiomed.2024.01.047.
   PubMed Web of Science ®Google Scholar
• Li Q, Cheng Y, Zhang S, Sun X, Wu J. TRPV4-induced müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway. J Neuroinflammation. 2021 Nov 17;18(1):271. doi:10.1186/s12974-021-02315-8.
   PubMed Web of Science ®Google Scholar
• Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM. Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity. Nat Rev Neurosci. 2007 Oct;8(10):766–75. doi: 10.1038/nrn2214.
   PubMed Web of Science ®Google Scholar
• Hong Z, Tian Y, Yuan Y, Qi M, Li Y, Du Y, Chen L, Chen L. Enhanced oxidative stress is responsible for TRPV4-induced neurotoxicity. Front Cell Neurosci. 2016 Oct 17;10:232. doi: 10.3389/fncel.2016.00232.
   PubMed Web of Science ®Google Scholar