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Research Article

Control over pathogen exposure and basal immunological activity influence disgust and pathogen-avoidance motivation

, , , &
Pages 568-580 | Received 21 Apr 2020, Accepted 15 Jan 2022, Published online: 09 Feb 2022

References

  • Abramson, S., Korchak, H., Ludewig, R., Edelson, H., Haines, K., Levin, R. I., … Weissmann, G. (1985). Modes of action of aspirin-like drugs. Proceedings of the National Academy of Sciences, 82(21), 7227–7231. https://doi.org/10.1073/pnas.82.21.7227
  • Ackerman, J. M., Becker, D. V., Mortensen, C. R., Sasaki, T., Neuberg, S. L., & Kenrick, D. T. (2009). A pox on the mind: Disjunction of attention and memory in the processing of physical disfigurement. Journal of Experimental Social Psychology, 45(3), 478–485. https://doi.org/10.1016/j.jesp.2008.12.008
  • Ackerman, J. M., Hill, S. E., & Murray, D. R. (2018). The behavioral immune system: Current concerns and future directions. Social and Personality Psychology Compass, 12(2), e12371. https://doi.org/10.1111/spc3.12371
  • Ajzen, I. (1991). The theory of planned behavior. Organizational Behavior and Human Decision Processes, 50(2), 179–211. https://doi.org/10.1016/0749-5978(91)90020-T
  • Batres, C., & Perrett, D. I. (2020). Pathogen disgust sensitivity changes according to the perceived harshness of the environment. Cognition and Emotion, 34(2), 377–383. https://doi.org/10.1080/02699931.2019.1612735
  • Benedek, I. H., Joshi, A. S., Pieniaszek, H. J., King, S. Y. P., & Kornhauser, D. M. (1995). Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers. The Journal of Clinical Pharmacology, 35(12), 1181–1186. https://doi.org/10.1002/j.1552-4604.1995.tb04044.x
  • Borg, C., & De Jong, P. J. (2012). Feelings of disgust and disgust-induced avoidance weaken following induced sexual arousal in women. PloS one, 7(9), e44111. https://doi.org/10.1371/journal.pone.0044111
  • Breckler, S. J., & Wiggins, E. C. (1989). Affect versus evaluation in the structure of attitudes. Journal of Experimental Social Psychology, 25(3), 253–271. https://doi.org/10.1016/0022-1031(89)90022-X
  • Brown, D. W., Giles, W. H., & Croft, J. B. (2001). White blood cell count. Journal of Clinical Epidemiology, 54(3), 316–322. https://doi.org/10.1016/S0895-4356(00)00296-1
  • Case, T. I., Repacholi, B. M., & Stevenson, R. J. (2006). My baby doesn't smell as bad as yours: The plasticity of disgust. Evolution and Human Behavior, 27(5), 357–365.
  • Cepon-Robins, T. J., Blackwell, A. D., Gildner, T. E., Liebert, M. A., Urlacher, S. S., Madimenos, F. C., … Sugiyama, L. S. (2021). Pathogen disgust sensitivity protects against infection in a high pathogen environment. Proceedings of the National Academy of Sciences, 118(8), e2018552118. https://doi.org/10.1073/pnas.2018552118
  • Cizauskas, C. A., Turner, W. C., Pitts, N., & Getz, W. M. (2015). Seasonal patterns of hormones, macroparasites, and microparasites in wild african ungulates: The interplay among stress, reproduction, and disease. PloS One, 10(4), e0120800. https://doi.org/10.1371/journal.pone.0120800
  • wCurtis, V., Aunger, R., & Rabie, T. (2004). Evidence that disgust evolved to protect from risk of disease. Proceedings of the Royal Society of London. Series B: Biological Sciences, 271(suppl_4), S131–S133. https://doi.org/10.1098/rsbl.2003.0144
  • Curtis, V., & Biran, A. (2001). Dirt, disgust, and disease: Is hygiene in our genes? Perspectives in Biology and Medicine, 44(1), 17–31. https://doi.org/10.1353/pbm.2001.0001
  • Curtis, V., de Barra, M., & Aunger, R. (2011). Disgust as an adaptive system for disease avoidance behaviour. Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1563), 389–401. https://doi.org/10.1098/rstb.2010.0117
  • Dröge, W. (2002). Free radicals in the physiological control of cell function. Physiological Reviews, 82(1), 47–95. https://doi.org/10.1152/physrev.00018.2001
  • Fessler, D. M., Eng, S. J., & Navarrete, C. D. (2005). Elevated disgust sensitivity in the first trimester of pregnancy. Evolution and Human Behavior, 26(4), 344–351. https://doi.org/10.1016/j.evolhumbehav.2004.12.001
  • Franceschi, C., & Campisi, J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(Suppl_1), S4–S9. https://doi.org/10.1093/gerona/glu057
  • Fumagalli, M., Sironi, M., Pozzoli, U., Ferrer-Admettla, A., Pattini, L., & Nielsen, R. (2011). Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution. PLoS Genetics, 7(11), e1002355. https://doi.org/10.1371/journal.pgen.1002355
  • Gassen, J., Makhanova, A., Maner, J. K., Plant, E. A., Eckel, L. A., Nikonova, L., … Hill, S. E. (2019a). Experimentally-induced inflammation predicts present focus. Adaptive Human Behavior and Physiology, 5, 148–163. https://doi.org/10.1007/s40750-019-00110-7
  • Gassen, J., Prokosch, M. L., Eimerbrink, M. J., Proffitt, R. L., White, J. D., Peterman, J. L., … Hill, S. E. (2019b). Inflammation predicts decision-making characterized by impulsivity, present focus, and an inability to delay gratification. Scientific Reports, 9(1), 4928–4928. https://doi.org/10.1038/s41598-019-41437-1
  • Gassen, J., Prokosch, M. L., Makhanova, A., Eimerbrink, M. J., White, J. D., Leyva, R. P. P., … McNulty, J. K. (2018). Behavioral immune system activity predicts downregulation of chronic basal inflammation. PloS one, 13(9), e0203961. https://doi.org/10.1371/journal.pone.0203961
  • Haktanir, A., Can, N., Seki, T., Kurnaz, M. F., & Dilmaç, B. (2021). Do we experience pandemic fatigue? Current state, predictors, and prevention. Current Psychology, 1–12. https://doi.org/10.1007/s12144-021-02397-w
  • Hawkins, D. (2020). Differential occupational risk for COVID-19 and other infection exposure according to race and ethnicity. American Journal of Industrial Medicine, 63(9), 817–820. https://doi.org/10.1002/ajim.23145
  • Hayasaka, M., Takahashi, Y., Nishida, Y., Yoshida, Y., Hidaka, S., & Asai, S. (2013). Comparative effect of clopidogrel plus aspirin and aspirin monotherapy on hematological parameters using propensity score matching. Vascular Health and Risk Management, 9, 65–70. https://doi.org/10.2147/VHRM.S39351.
  • Jones, B. C., Hahn, A. C., Fisher, C. I., Wang, H., Kandrik, M., Lee, A. J., … DeBruine, L. M. (2018). Hormonal correlates of pathogen disgust: Testing the compensatory prophylaxis hypothesis. Evolution and Human Behavior, 39(2), 166–169. https://doi.org/10.1016/j.evolhumbehav.2017.12.004
  • Kakoschke, N., Kemps, E., & Tiggemann, M. (2017). Impulsivity moderates the effect of approach bias modification on healthy food consumption. Appetite, 117, 117–125. https://doi.org/10.1016/j.appet.2017.06.019
  • Kesteloot, H. (2004). Alcohol intake and markers of inflammation. European Heart Journal, 25(23), 2075–2076. https://doi.org/10.1016/j.ehj.2004.09.029
  • Krieglmeyer, R., & Deutsch, R. (2010). Comparing measures of approach–avoidance behaviour: The manikin task vs. Two versions of the joystick task. Cognition & Emotion, 24(5), 810–828. https://doi.org/10.1080/02699930903047298
  • Krings, F., Green, E. T., Bangerter, A., Staerklé, C., Clémence, A., Wagner-Egger, P. A. S. C. A. L., & Bornand, T. (2012). Preventing contagion With avian influenza: Disease salience, attitudes toward foreigners, and avoidance Beliefs1. Journal of Applied Social Psychology, 42(6), 1451–1466. https://doi.org/10.1111/j.1559-1816.2012.00907.x
  • Lin, L., Dahl, D. W., & Argo, J. J. (2013). Do the crime, always Do the time? Insights into consumer-to-consumer punishment decisions. Journal of Consumer Research, 40(1), 64–77. https://doi.org/10.1086/668641
  • Liu, Y., Fang, S., Li, X., Feng, J., Du, J., Guo, L., … Wang, S. (2017). Aspirin inhibits LPS-induced macrophage activation via the NF-κB pathway. Scientific Reports, 7(1), 11549. https://doi.org/10.1038/s41598-017-10720-4
  • Lochmiller, R. L., & Deerenberg, C. (2000). Trade-offs in evolutionary immunology: Just what is the cost of immunity? Oikos, 88(1), 87–98. https://doi.org/10.1034/j.1600-0706.2000.880110.x
  • Mannini, L., Marcucci, R., Paniccia, R., Antonucci, E., Giglioli, C., Valente, S., … Abbate, R. (2006). Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients. Clinical Hemorheology and Microcirculation, 35(1-2), 175–181.
  • Medzhitov, R. (2008). Origin and physiological roles of inflammation. Nature, 454(7203), 428–435. https://doi.org/10.1038/nature07201.
  • Morris, T., Stables, M., Hobbs, A., de Souza, P., Colville-Nash, P., Warner, T., … Gilroy, D. W. (2009). Effects of low-dose aspirin on acute inflammatory responses in humans. The Journal of Immunology, 183(3), 2089–2096. https://doi.org/10.4049/jimmunol.0900477
  • Mortensen, C. R., Becker, D. V., Ackerman, J. M., Neuberg, S. L., & Kenrick, D. T. (2010). Infection breeds reticence. Psychological Science, 21(3), 440–447. https://doi.org/10.1177/0956797610361706
  • Muthén, L. K., & Muthén, B. O. (2012). Mplus user’s guide: Seventh edition. Muthén & Muthén.
  • Nguyen, L. H., Drew, D. A., Graham, M. S., Joshi, A. D., Guo, C. G., Ma, W., … Zhang, F. (2020). Risk of COVID-19 among front-line health-care workers and the general community: A prospective cohort study. The Lancet Public Health, 5(9), e475–e483. https://doi.org/10.1016/S2468-2667(20)30164-X
  • Oaten, M., Stevenson, R. J., & Case, T. I. (2009). Disgust as a disease-avoidance mechanism. Psychological Bulletin, 135(2), 303–321. https://doi.org/10.1037/a0014823.
  • Oaten, M. J., Stevenson, R. J., & Case, T. I. (2017). Compensatory up-regulation of behavioral disease avoidance in immuno-compromised people with rheumatoid arthritis. Evolution and Human Behavior, 38(3), 350–356. https://doi.org/10.1016/j.evolhumbehav.2016.11.006
  • O’Connor, M. F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., … Thomas, K. S. (2009). To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers. Brain, Behavior, and Immunity, 23(7), 887–897. https://doi.org/10.1016/j.bbi.2009.04.005
  • Ortiz-Muñoz, G., Mallavia, B., Bins, A., Headley, M., Krummel, M. F., & Looney, M. R. (2014). Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood, 124(17), 2625–2634. https://doi.org/10.1182/blood-2014-03-562876
  • Ortmann, A., & Hertwig, R. (2002). The costs of deception: Evidence from psychology. Experimental Economics, 5(2), 111–131. https://doi.org/10.1023/A:1020365204768
  • Park, J. H., Van Leeuwen, F., & Chochorelou, Y. (2013). Disease-avoidance processes and stigmatization: Cues of substandard health arouse heightened discomfort with physical contact. The Journal of Social Psychology, 153(2), 212–228. https://doi.org/10.1080/00224545.2012.721812
  • Porzig-Drummond, R., Stevenson, R., Case, T., & Oaten, M. (2009). Can the emotion of disgust be harnessed to promote hand hygiene? Experimental and field-based tests. Social Science & Medicine, 68(6), 1006–1012. https://doi.org/10.1016/j.socscimed.2009.01.013
  • Reynolds, L. M., McCambridge, S. A., Bissett, I. P., & Consedine, N. S. (2014). Trait and state disgust: An experimental investigation of disgust and avoidance in colorectal cancer decision scenarios. Health Psychology, 33(12), 1495–1506. https://doi.org/10.1037/hea0000023.
  • Ryan, S., Oaten, M., Stevenson, R. J., & Case, T. I. (2012). Facial disfigurement is treated like an infectious disease. Evolution and Human Behavior, 33(6), 639–646. https://doi.org/10.1016/j.evolhumbehav.2012.04.001
  • Schaller, M., Miller, G. E., Gervais, W. M., Yager, S., & Chen, E. (2010). Mere visual perception of other people’s disease symptoms facilitates a more aggressive immune response. Psychological Science, 21(5), 649–652. https://doi.org/10.1177/0956797610368064
  • Schaller, M., & Park, J. H. (2011). The behavioral immune system (and why it matters). Current Directions in Psychological Science, 20(2), 99–103. https://doi.org/10.1177/0963721411402596
  • Shankar, A., Wang, J. J., Rochtchina, E., Mimi, C. Y., Kefford, R., & Mitchell, P. (2006). Association between circulating white blood cell count and cancer mortality. Archives of Internal Medicine, 166(2), 188–194. https://doi.org/10.1001/archinte.166.2.188
  • Shook, N. J., Sevi, B., Lee, J., Oosterhoff, B., & Fitzgerald, H. N. (2020). Disease avoidance in the time of COVID-19: The behavioral immune system is associated with concern and preventative health behaviors. PloS one, 15(8), e0238015. https://doi.org/10.1371/journal.pone.0238015
  • Siddle, K. J., & Quintana-Murci, L. (2014). The Red queen's long race: Human adaptation to pathogen pressure. Current Opinion in Genetics & Development, 29, 31–38. https://doi.org/10.1016/j.gde.2014.07.004
  • Stevenson, R. J., Hodgson, D., Oaten, M. J., Moussavi, M., Langberg, R., Case, T. I., & Barouei, J. (2012). Disgust elevates core body temperature and up-regulates certain oral immune markers. Brain, Behavior, and Immunity, 26(7), 1160–1168. https://doi.org/10.1016/j.bbi.2012.07.010
  • Travis, J. (2009). On the origin of the immune system. Science, 324(5927), 580–582. https://doi.org/10.1126/science.324_580
  • Tybur, J. M., Bryan, A. D., Magnan, R. E., & Hooper, A. E. C. (2011). Smells like safe Sex. Psychological Science, 22(4), 478–480. https://doi.org/10.1177/0956797611400096
  • Tybur, J. M., Çınar, Ç, Karinen, A. K., & Perone, P. (2018). Why do people vary in disgust? Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1751), 20170204. https://doi.org/10.1098/rstb.2017.0204
  • Tybur, J. M., Lieberman, D., Kurzban, R., & DeScioli, P. (2013). Disgust: Evolved function and structure. Psychological Review, 120(1), 65–84. https://doi.org/10.1037/a0030778.
  • Van Leeuwen, F., Dukes, A., Tybur, J. M., & Park, J. H. (2017). Disgust sensitivity relates to moral foundations independent of political ideology. Evolutionary Behavioral Sciences, 11(1), 92–98. https://doi.org/10.1037/ebs0000075.
  • Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology, 54(6), 1063–1070. https://doi.org/10.1037/0022-3514.54.6.1063.
  • Wiers, R. W., Rinck, M., Dictus, M., & Van den Wildenberg, E. (2009). Relatively strong automatic appetitive action-tendencies in male carriers of the OPRM1 G-allele. Genes, Brain and Behavior, 8(1), 101–106. https://doi.org/10.1111/j.1601-183X.2008.00454.x
  • Yin, M. J., Yamamoto, Y., & Gaynor, R. B. (1998). The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature, 396(6706), 77-80. doi:10.1038/23948

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