REFERENCES
- Schirra F, Richards S M, Liu M, et al. Androgen regulation of lipogenic pathways in the mouse meibomian gland. Exp Eye Res 2006; 83: 291–296
- Voet D, Voet J G. Biochemistry. 2nd ed. John Wiley & Sons, New York 1995
- Sakakura Y, Shimano H, Sone H, et al. Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis. Biochem Biophys Res Commun 2001; 286: 176–183
- Swinnen J V, Heemers H, van de Sande T, et al. Androgens, lipogenesis and prostate cancer. J Steroid Biochem Mol Biol 2004; 92: 273–279
- Leon C, Hill J S, Wasan K M. Potential role of acyl-coenzyme A: cholesterol transferase (ACAT) inhibitors as hypolipidemic and antiatherosclerosis drugs. Pharm Res 2005; 22: 1578–1588
- Azhar S, Khan I, Gibori G. The influence of estradiol on cholesterol processing by the corpus luteum. Biol Reprod. 1989; 40: 961–971
- Ariga H, Edwards J, Sullivan D A. Androgen control of autoimmune expression in lacrimal glands of MRL/Mp-lpr/lpr mice. Clin Immunol Immunopathol 1989; 53: 499–508
- Schirra F, Suzuki T, Richards S M, et al. Androgen control of gene expression in the mouse meibomian gland. Invest Ophthalmol Vis Sci 2005; 46: 3666–3675
- Thiboutot D, Jabara S, McAllister J M, et al. Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). J Invest Dermatol 2003; 120: 905–914
- Rocha E M, Wickham L A, Silveira L A, et al. Identification of androgen receptor protein and 5α-reductase mRNA in human ocular tissues. Br J Ophthalmol 2000; 84: 76–84
- Schirra F, Suzuki T, Dickinson D P, et al. Identification of steroidogenic enzyme mRNAs in the human lacrimal gland, meibomian gland, cornea and conjunctiva. Cornea. 2006; 25: 438–442
- Lawn R M, Wade D P, Garvin M R, et al. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest. 1999; 104: R25–31
- Santamarina-Fojo S, Remaley A T, Neufeld E B, Brewer H B, Jr. Regulation and intracellular trafficking of the ABCA1 transporter. J Lipid Res. 2001; 42: 1339–1345
- Wang N, Silver D L, Thiele C, Tall A R. ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein. J Biol Chem 2001; 276: 23742–23747
- Rosignoli C, Nicolas J C, Jomard A, Michel S. Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo. Exp Dermatol 2003; 480–489
- Yagyu H, Kitamine T, Osuga J, et al. Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J Biol Chem 2000; 275: 21324–21330
- Sullivan D A, Sullivan B D, Ullman M D, et al. Androgen influence on the meibomian gland. Invest Ophthalmol Vis Sci. 2000; 41: 3732–3742
- Krenzer K L, Dana M R, Ullman M D, et al. Effect of androgen deficiency on the human meibomian gland and ocular surface. J Clin Endocr Metab 2000; 85: 4874–4882
- Sullivan B D, Evans J E, Krenzer K L, et al. Impact of antiandrogen treatment on the fatty acid profile of neutral lipids in human meibomian gland secretions. J Clin Endocr Metab 2000; 85: 4866–4873
- Sullivan D A, Sullivan B D, Evans J E, et al. Androgen deficiency, meibomian gland dysfunction and evaporative dry eye. Ann NY Acad Sci 2002; 966: 211–222
- Sullivan B D, Evans J E, Dana M R, Sullivan D A. Impact of androgen deficiency on the lipid profiles in human meibomian gland secretions. Adv Exp Med Biol 2002; 506: 449–458
- Zeligs M A. Dehydroepiandrosterone therapy for the treatment of dry eye disorders. Int Patent Application, WO 94/04155, 1994
- Worda C, Nepp J, Huber J C, Sator M O. Treatment of keratoconjunctivitis sicca with topical androgen. Maturitas 2001; 37: 209–212
- Sullivan B D, Evans J E, Cermak J M, et al. Complete androgen insensitivity syndrome: Effect on human meibomian gland secretions. Arch Ophthalmol 2002; 120: 1689–1699
- Cermak J M, Krenzer K L, Sullivan R M, et al. Is complete androgen insensitivity syndrome associated with alterations in the meibomian gland and ocular surface?. Cornea 2003; 22: 516–521