REFERENCES
- Coux O, et al. Structure and functions of the 20s and 26s proteasomes. Ann Rev Biochem. 1996; 65: 801–847
- Girao H, et al. Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation. IOVS. 2005; 46(4)1386–1392
- Guo W, et al. Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation. IOVS. 2006; 47(6)2569–2575
- Taylor A, Davies K JA. Protein oxidation and loss of protease activity may lead to cataract formation in the aged lens. Free Radic Biol Med. 1987; 3: 371–377
- Srivastava P. Age-related increase in concentration and aggregation of degraded polypeptides in human lenses. Exp Eye Res. 1988; 47: 525–543
- Kisselev A F, et al. Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown. Mol Cell. 1999; 4(3)395–402
- Kisselev A F, et al. The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem. 2003; 278(38)35869–35877
- Rivett A J. Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases. J Biol Chem. 1985; 260(1)300–305
- Murakami K, et al. Lens proteasome shows enhanced rates of degradation of hydroxyl radical modified alpha-crystallin. Free Radic Biol Med. 1990; 8(3)217–222
- Harrington V, et al. Crystallins in water soluble-high molecular weight protein fractions and water insoluble protein fractions in aging and cataractous human lenses. Mol Vis. 2004; 10: 476–489
- Lou M F. Redox regulation in the lens. Prog Retin Eye Res. 2003; 22(5)657–682
- Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med 1999; 27(9-10)916–921
- Griffith O W. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med 1999; 27(9–10)922–935
- Wu G, et al. Glutathione metabolism and its implications for health. J Nutr. 2004; 134(3)489–492
- Forman H J, Dickinson D A. Oxidative signaling and glutathione synthesis. Biofactors 2003; 17(1–4)1–12
- Dickinson D A, et al. Cytoprotection against oxidative stress and the regulation of glutathione synthesis. Biol Chem. 2003; 384(4)527–537
- Demasi M, Davies K J. Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism. FEBS Lett 2003; 542(1–3)89–94
- Demasi M, et al. Glutathiolation of the proteasome is enhanced by proteolytic inhibitors. Arch Biochem Biophys. 2001; 389(2)254–263
- Zetterberg M, et al. Glutathiolation enhances the degradation of gammac-crystallin in lens and reticulocyte lysates, partially via the ubiquitin-proteasome pathway. IOVS. 2006; 47(8)3467–3473
- Petersen A, et al. Potential protective effects of NSAIDs/ASA in oxidatively stressed human lens epithelial cells and intact mouse lenses in culture. Ophthalmic Res. 2005; 37(6)318–327
- Andersson M, et al. Proteolytic cleavage of n-succ-leu-leu-val-tyr-amc by the proteasome in lens epithelium from clear and cataractous human lenses. Exp Eye Res. 1998; 67(2)231–236
- Waheed A A, Gupta P D. Estimation of submicrogram quantities of protein using the dye eosin Y. J Biochem Biophys Methods. 2000; 42(3)125–132
- Petersen A, et al. A new model for assessing proteolysis in the intact mouse lens in organ culture. Ophthalmic Res. 2004; 36(1)25–30
- Keelan J, et al. Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane. J Neurosci Res. 2001; 66(5)873–884
- Kirkwood T B. Human senescence. Bioessays. 1996; 18(12)1009–1016
- Sohal R S, Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 1996; 273(5271)59–63
- Ying W. Deleterious network hypothesis of aging. Med Hypotheses. 1997; 48(2)143–148
- Spector A. The lens and oxidative stress. Oxidative Stress: Oxidants and Antioxidants, H Siesed. Academic Press, Düsseldorf 1991; 529–558
- Bhuyan K C, et al. Lipid peroxidation in cataract of the human. Life Sci. 1986; 38: 1463–1471
- Spector A, Garner W H. Hydrogen peroxide and human cataract. Exp Eye Res. 1981; 33(6)673–681
- Jacques P F, et al. Long-term vitamin c supplement use and prevalence of early age-related lens opacities. Am J Clin Nutr. 1997; 66(4)911–916
- Leske M C, et al. Antioxidant vitamins and nuclear opacities: The longitudinal study of cataract. Ophthalmology. 1998; 105(5)831–836
- Truscott R J. Age-related nuclear cataract-oxidation is the key. Exp Eye Res. 2005; 80(5)709–725
- Giblin F J. Glutathione: a vital lens antioxidant. J Ocul Pharmacol Ther. 2000; 16(2)121–135
- Calvin H I, et al. Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice. Science. 1986; 233(4763)553–555
- David L L, Shearer T R. State of sulfhydryl in selenite cataract. Toxicol Appl Pharmacol. 1984; 74(1)109–115
- Padgaonkar V, et al. Disulfide cross-linking of urea-insoluble proteins in rabbit lenses treated with hyperbaric oxygen. Exp Eye Res. 1989; 49(5)887–899
- Lou M F, Dickerson J E, Jr. Protein-thiol mixed disulfides in humanlens. Exp Eye Res 1992; 55(6)889–896
- Lou M F, et al. Effect of opacification and pigmentation on human lens protein thiol/disulfide and solubility. Curr Eye Res. 1989; 8(9)883–890
- Jahngen-Hodge J, et al. Regulation of ubiquitin-conjugating enzymes by glutathione following oxidative stress. J Biol Chem. 1997; 272(45)28218–28226
- Obin M, et al. Redox regulation of ubiquitin-conjugating enzymes: Mechanistic insights using the thiol-specific oxidant diamide. FASEB J. 1998; 12(7)561–569
- Petersen A, et al. Intracellular effects of NSAIDs/ASA in oxidatively stressed human lens epithelial cells in culture. Ophthalmic Res, Accepted 12 July 2007
- Meriin A B, et al. Proteasome inhibitors activate stress kinases and induce hsp72. Diverse effects on apoptosis. J Biol Chem. 1998; 273(11)6373–6379
- Andersson M, et al. Caspase and proteasome activity during staurosporin-induced apoptosis in lens epithelial cells. IOVS. 2000; 41(9)2623–2632
- Awasthi N, Wagner B J. Interferon-gamma induces apoptosis of lens alphatn4-1 cells and proteasome inhibition has an antiapoptotic effect. IOVS. 2004; 45(1)222–229