Forskolin Induces Myosin Light Chain Dephosphorylation in Bovine Trabecular Meshwork Cells

REFERENCES

• Gong H, Tripathi R C, Tripathi B J. Morphology of the aqueous outflow pathway. Microsc Res Tech. 1996; 33: 336–367
   PubMed Web of Science ®Google Scholar
• Thieme H, Stumpff F, Ottlecz A, Percicot C L, Lambrou G N, Wiederholt M. Mechanisms of action of unoprostone on trabecular meshwork contractility. Invest Ophthalmol Vis Sci. 2001; 42: 3193–3201
   PubMed Web of Science ®Google Scholar
• Wiederholt M, Thieme H, Stumpff F. The regulation of trabecular meshwork and ciliary muscle contractility. Prog Retin Eye Res. 2000; 19: 271–295
   PubMed Web of Science ®Google Scholar
• Tian B, Geiger B, Epstein D L, Kaufman P L. Cytoskeletal involvement in the regulation of aqueous humor outflow. Invest Ophthalmol Vis Sci. 2000; 41: 619–623
   PubMed Web of Science ®Google Scholar
• Rosenthal R, Choritz L, Schlott S, et al. Effects of ML-7 and Y-27632 on carbachol-and endothelin-1-induced contraction of bovine trabecular meshwork. Exp Eye Res. 2005; 80: 837–845
   PubMed Web of Science ®Google Scholar
• Alvarado J A, Franse-Carman L, McHolm G, Murphy C. Epinephrine effects on major cell types of the aqueous outflow pathway: In vitro studies/clinical implications. Trans Am Ophthalmol Soc 1990; 267–282, discussion 283–268
   Google Scholar
• Bartels S P, Lee S R, Neufeld A H. Forskolin stimulates cyclic AMP synthesis, lowers intraocular pressure and increases outflow facility in rabbits. Curr Eye Res. 1982; 2: 673–681
   PubMed Web of Science ®Google Scholar
• Kaufman P L. Adenosine 3',5'-cyclic-monophosphate and outflow facility in monkey eyes with intact and retrodisplaced ciliary muscle. Exp Eye Res. 1987; 44: 415–423
   PubMed Web of Science ®Google Scholar
• Neufeld A H. Influences of cyclic nucleotides on outflow facility in the vervet monkey. Experimental eye research 1978; 27: 387–397
   PubMed Web of Science ®Google Scholar
• Polansky J R. Beta-adrenergic therapy for glaucoma. International ophthalmology clinics 1990; 30: 219–229
   Google Scholar
• Kamm K E, Stull J T. Dedicated myosin light chain kinases with diverse cellular functions. The Journal of biological chemistry 2001; 276: 4527–4530
   PubMed Web of Science ®Google Scholar
• Somlyo A P, Somlyo A V. Ca2 + sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev. 2003; 83: 1325–1358
   PubMed Web of Science ®Google Scholar
• Ito M, Nakano T, Erdodi F, Hartshorne D J. Myosin phosphatase: Structure, regulation and function. Mol Cell Biochem. 2004; 259: 197–209
   PubMed Web of Science ®Google Scholar
• Bill A, Phillips C I. Uveoscleral drainage of aqueous humour in human eyes. Exp Eye Res 1971; 12: 275–281
   PubMed Web of Science ®Google Scholar
• Rao P V, Deng P, Sasaki Y, Epstein D L. Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. Exp Eye Res. 2005; 80: 197–206
   PubMed Web of Science ®Google Scholar
• Khurana R N, Deng P F, Epstein D L, Vasantha R P. The role of protein kinase C in modulation of aqueous humor outflow facility. Exp Eye Res 2003; 76: 39–47
   PubMed Web of Science ®Google Scholar
• Mettu P S, Deng P F, Misra U K, Gawdi G, Epstein D L, Rao P V. Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. Invest Ophthalmol Vis Sci. 2004; 45: 2263–2271
   PubMed Web of Science ®Google Scholar
• Rao P V, Deng P F, Kumar J, Epstein D L. Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest Ophthalmol Vis Sci. 2001; 42: 1029–1037
   PubMed Web of Science ®Google Scholar
• Gilabert R, Gasull X, Pales J, Belmonte C, Bergamini M V, Gual A. Facility changes mediated by cAMP in the bovine anterior segment in vitro. Vision Res. 1997; 37: 9–15
   PubMed Web of Science ®Google Scholar
• Stamer W D, Roberts B C, Epstein D L. Hydraulic pressure stimulates adenosine 3′,5′-cyclic monophosphate accumulation in endothelial cells from Schlemm's canal. Invest Ophthalmol Vis Sci. 1999; 40: 1983–1988
   Google Scholar
• Srinivas S P, Maertens C, Goon L H, et al. Cell volume response to hyposmotic shock and elevated cAMP in bovine trabecular meshwork cells. Exp Eye Res. 2004; 78: 15–26
   Google Scholar
• Qiao J, Huang F, Lum H. PKA inhibits RhoA activation: A protection mechanism against endothelial barrier dysfunction. Am J Physiol 2003; 284: L972–980
   PubMed Web of Science ®Google Scholar
• Srinivas S P, Satpathy M, Gallagher P, Lariviere E, Van Driessche W. Adenosine induces dephosphorylation of myosin II regulatory light chain in cultured bovine corneal endothelial cells. Exp Eye Res. 2004; 79: 543–551
   PubMed Web of Science ®Google Scholar
• Lang P, Gesbert F, Delespine-Carmagnat M, Stancou R, Pouchelet M, Bertoglio J. Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. EMBO J. 1996; 15: 510–519
   PubMed Web of Science ®Google Scholar
• Essler M, Staddon J M, Weber P C, Aepfelbacher M. Cyclic A MP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling. J Immunol. 2000; 164: 6543–6549
   PubMedGoogle Scholar
• Murthy K S. Signaling for contraction and relaxation in smooth muscle of the gut. Annu Rev Physiol. 2006; 68: 345–374
   PubMed Web of Science ®Google Scholar
• Grierson I, Millar L, De Yong J, et al. Investigations of cytoskeletal elements in cultured bovine meshwork cells. Invest Ophthalmol Vis Sci. 1986; 27: 1318–1330
   PubMed Web of Science ®Google Scholar
• Satpathy M, Gallagher P, Lizotte-Waniewski M, Srinivas S P. Thrombin-induced phosphorylation of the regulatory light chain of myosin II in cultured bovine corneal endothelial cells. Exp Eye Res. 2004; 79: 477–486
   PubMed Web of Science ®Google Scholar
• Satpathy M, Gallagher P, Jin Y, Srinivas S P. Extracellular A TP opposes thrombin-induced myosin light chain phosphorylation and loss of barrier integrity in corneal endothelial cells. Exp Eye Res. 2005; 81: 183–192
   PubMed Web of Science ®Google Scholar
• Moolenaar W H, van Meeteren L A, Giepmans B N. The ins and outs of lysophosphatidic acid signaling. Bioessays 2004; 26: 870–881
   PubMed Web of Science ®Google Scholar
• Hersch E, Huang J, Grider J R, Murthy K S. Gq/G13 signaling by ET-1 in smooth muscle: MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB. Am J Physiol Cell Physiol 2004; 287: C1209–1218
   Web of Science ®Google Scholar
• van Horck F P, Ahmadian M R, Haeusler L C, Moolenaar W H, Kranenburg O. Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. J Biol Chem 2001; 276: 4948–4956
   PubMed Web of Science ®Google Scholar
• Birukova A A, Liu F, Garcia J G, Verin A D. Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly. Am J Physiol 2004; 287: L86–93
   Google Scholar
• Palazzo A F, Gundersen G G. Microtubule-actin cross-talk at focal adhesions. Sci STKE 2002, 2002:PE31
   Google Scholar
• Moolenaar W H, Kranenburg O, Postma F R, Zondag G C. Lysophosphatidic acid: G-protein signalling and cellular responses. Curr Opin Cell Biol. 1997; 9: 168–173
   PubMed Web of Science ®Google Scholar
• van Corven E J, Groenink A, Jalink K, Eichholtz T, Moolenaar W H. Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins. Cell. 1989; 59: 45–54
   PubMed Web of Science ®Google Scholar
• Clark R B, Salmon D M, Honeyman T W. Phosphatidic acid inhibition of PGE1-stimulated cAMP accumulation in WI-38 fibroblasts: Similarities with carbachol inhibition. J Cyclic Nucleotide Res. 1980; 6: 37–49
   Google Scholar
• Schimmel R J, Honeyman T W, McMahon K K, Serio R, Clark R B. Inhibition of cyclic AMP accumulation in hamster adipocytes with phosphatidic acid: Differences and similarities with alpha adrenergic effects. J Cyclic Nucleotide Res. 1980; 6: 437–449
   Google Scholar
• Rebsamen M C, Church D J, Morabito D, Vallotton M B, Lang U. Role of cAMP and calcium influx in endothelin-1-induced ANP release in rat cardiomyocytes. Am J Physiol 1997; 273: E922–931
   Google Scholar
• Takagi Y, Ninomiya H, Sakamoto A, Miwa S, Masaki T. Structural basis of G protein specificity of human endothelin receptors. A study with endothelinA/B chimeras. J Biol Chem. 1995; 270: 10072–10078
   Google Scholar
• Tomic M, Zivadinovic D, Van Goor F, Yuan D, Koshimizu T, Stojilkovic S S. Expression of Ca(2+)-mobilizing endothelin(A) receptors and their role in the control of Ca(2+) influx and growth hormone secretion in pituitary somatotrophs. J Neurosci. 1999; 19: 7721–7731
   Google Scholar
• Choritz L, Rosenthal R, Fromm M, Foerster M H, Thieme H. Pharmacological and functional characterization of endothelin receptors in bovine trabecular meshwork and ciliary muscle. Ophthalmic Res. 2005; 37: 179–187
   PubMed Web of Science ®Google Scholar
• Clark A F, Brotchie D, Read A T, et al. Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue. Cell Motil Cytoskel. 2005; 60: 83–95
   PubMedGoogle Scholar
• Underwood J L, Murphy C G, Chen J, et al. Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions. Am J Physiol 1999; 277: C330–342
   PubMed Web of Science ®Google Scholar
• Tian B, Kaufman P L, Volberg T, Gabelt B T, Geiger B. H-7 disrupts the actin cytoskeleton and increases outflow facility. Arch Ophthalmol 1998; 116: 633–643
   PubMed Web of Science ®Google Scholar
• Thieme H, Nass J U, Nuskovski M, Wiederholt M. The effects of the carbonic anhydrase inhibitors methazolamide, diclofenamide and dorzolamide on trabecular meshwork and ciliary muscle contractility. Exp Eye Res. 1999; 69: 455–458
   Google Scholar
• Honjo M, Inatani M, Kido N, et al. Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes. Arch Ophthalmol 2001; 119: 1171–1178
   PubMed Web of Science ®Google Scholar
• Nakamura Y, Sagara T, Seki K, Hirano S, Nishida T. Permissive effect of fibronectin on collagen gel contraction mediated by bovine trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2003; 44: 4331–4336
   Google Scholar
• Nakamura Y, Hirano S, Suzuki K, Seki K, Sagara T, Nishida T. Signaling mechanism of TGF-beta1-induced collagen contraction mediated by bovine trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2002; 43: 3465–3472
   Google Scholar
• Vittitow J L, Garg R, Rowlette L L, Epstein D L, O'Brien E T, Borras T. Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures. Mol Vis. 2002; 8: 32–44
   PubMed Web of Science ®Google Scholar
• Song J, Deng P F, Stinnett S S, Epstein D L, Rao P V. Effects of cholesterol-lowering statins on the aqueous humor outflow pathway. Invest Ophthalmol Vis Sci. 2005; 46: 2424–2432
   PubMed Web of Science ®Google Scholar
• Kjoller L, Hall A. Signaling to Rho GTPases. Exp Cell Res. 1999; 253: 166–179
   PubMed Web of Science ®Google Scholar
• Ridley A J. Rho-related proteins: Actin cytoskeleton and cell cycle. Curr Opin Genet Dev. 1995; 5: 24–30
   PubMed Web of Science ®Google Scholar
• Hollinger S, Ramineni S, Hepler J R. Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i. Biochem. 2003; 42: 811–819
   PubMed Web of Science ®Google Scholar
• Tamma G, Klussmann E, Procino G, Svelto M, Rosenthal W, Valenti G. cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI. J Cell Sci. 2003; 116: 1519–1525
   PubMed Web of Science ®Google Scholar
• Chen Y, Wang Y, Yu H, Wang F, Xu W. The cross talk between protein kinase A-and RhoA-mediated signaling in cancer cells. Exp Biol Med. 2005; 230: 731–741
   Google Scholar
• Fleming Y M, Frame M C, Houslay M D. PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration. J Cell Sci. 2004; 117: 2377–2388
   PubMed Web of Science ®Google Scholar
• Hocke A C, Temmesfeld-Wollbrueck B, Schmeck B, et al. Perturbation of endothelial junction proteins by Staphylococcus aureus alpha-toxin: Inhibition of endothelial gap formation by adrenomedullin. Histochem Cell Biol. 2006; 126: 305–316
   Google Scholar
• Srinivas S P, Satpathy M, Guo Y, Anandan V. Histamine-induced phosphorylation of the regulatory light chain of myosin II disrupts the barrier integrity of corneal endothelial cells. Invest Ophthalmol Vis Sci. 2006; 47: 4011–4018
   PubMed Web of Science ®Google Scholar
• Gohla A, Schultz G, Offermanns S. Role for G(12)/G(13) in agonist-induced vascular smooth muscle cell contraction. Circ Res. 2000; 87: 221–227
   PubMed Web of Science ®Google Scholar
• Sah V P, Seasholtz T M, Sagi S A, Brown J H. The role of Rho in G protein-coupled receptor signal transduction. Annu Rev Pharmacol Toxicol. 2000; 40: 459–489
   PubMed Web of Science ®Google Scholar
• Bindewald K, Gunduz D, Hartel F, et al. Opposite effect of cAMP signaling in endothelial barriers of different origin. Am J Physiol Cell Physiol 2004; 287: C1246–1255
   Web of Science ®Google Scholar
• Wooldridge A A, MacDonald J A, Erdodi F, et al. Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. J Biol Chem. 2004; 279: 34496–34504
   PubMed Web of Science ®Google Scholar
• Peterson J A, Tian B, McLaren J W, Hubbard W C, Geiger B, Kaufman P L. Latrunculins' effects on intraocular pressure, aqueous humor flow, and corneal endothelium. Invest Ophthalmol Vis Sci. 2000; 41: 1749–1758
   PubMed Web of Science ®Google Scholar
• Goeckeler Z M, Wysolmerski R B. Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation. J Biol Chem. 2005; 280: 33083–33095
   Google Scholar
• Lawler S. Regulation of actin dynamics: The L IM kinase connection. Curr Biol 1999; 9: R800–802
   PubMedGoogle Scholar