The Effect of Therapeutic Human Serum Drops on Corneal Stromal Wound-Healing Activity

REFERENCES

• Daniels J T, Khaw P T. Temporal stimulation of corneal fibroblast wound-healing activity by differentiating epithelium in vitro. Invest Ophthalmol Vis Sci 2000; 41(12)3754–3762
   PubMed Web of Science ®Google Scholar
• Wilson S E, Liu J J, Mohan R R. Stromal-epithelial interactions in the cornea. Prog Retin Eye Res. 1999; 18(3)293–309
   PubMed Web of Science ®Google Scholar
• Nakamura K. Interaction between injured corneal epithelial cells and stromal cells. Cornea. 2003; 22(7)S35–S47
   PubMed Web of Science ®Google Scholar
• Wilson S E, Kim W J. Keratocyte apoptosis: Implications on corneal wound healing, tissue organization, and disease. Invest Ophthalmol Vis Sci 1998; 39(2)220–226
   PubMed Web of Science ®Google Scholar
• Daniels J T, Schultz G S, Blalock T D, Garrett Q, Grotendorst G R, Dean N M, et al. Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: A role for connective tissue growth factor in contractile scarring. Am J Pathol. 2003; 163(5)2043–2052
   PubMed Web of Science ®Google Scholar
• Poon A C, Geerling G, Dart J KG, Fraenkel G E, Daniels J T. Autologous serum eyedrops for dry eyes and epithelial defects: Clinical and in vitro toxicity studies. Br J Ophthalmol. 2001; 85: 1188–1197
   PubMed Web of Science ®Google Scholar
• Esquenazi S, He J, Bazan H, Bazan N. Use of autologous serum in corneal epithelial defects post-lamellar surgery. Cornea 2005; 24(8)992–997
   PubMed Web of Science ®Google Scholar
• Schulze S D, Sekundo W, Kroll P. Autologous serum for the treatment of corneal epithelial abrasions in diabetic patients undergoing vitrectomy. Am J Ophthalmol. 2006; 142(2)207–211
   PubMed Web of Science ®Google Scholar
• Mukerji N, Sinha R, Vajpayee R B. Role of autologous serum in persistent epithelial defects. Br J Ophthalmol. 2002; 86(7)832
   PubMed Web of Science ®Google Scholar
• Bonini S, Lambiase A, Rama P, Caprioglio G. Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology. 2000; 107: 1347–1352
   PubMed Web of Science ®Google Scholar
• Tsubota K, Goto E, Shimmura S, Shimazaki J. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology. 1999; 106: 1984–1989
   PubMed Web of Science ®Google Scholar
• Matsumoto Y, Dogru M, Goto E, Ohashi Y, Kojima T, Ishida R, et al. Autologous serum application in the treatment of neurotrophic keratopathy. Ophthalmology. 2004; 111(6)1115–1120
   PubMed Web of Science ®Google Scholar
• Ferreira D S, Kruse F E, Seitz B. Autologous serum for otherwise therapy-resistant corneal epithelial defects—Prospective report on the first 70 eyes. Klin Monatsbl Augenheilkd. 2001; 218(11)720–726
   PubMed Web of Science ®Google Scholar
• Nakamura T, Ang L P, Rigby H, Sekiyama E, Inatomi T, Sotozono C, et al. The use of autologous serum in the development of corneal and oral epithelial equivalents in patients with Stevens-Johnson syndrome. Invest Ophthalmol Vis Sci. 2006; 47(3)909–916
   PubMed Web of Science ®Google Scholar
• Ang L P, Nakamura T, Inatomi T, Sotozono C, Koizumi N, Yokoi N, et al. Autologous serum-derived cultivated oral epithelial transplants for severe ocular surface disease. Arch Ophthalmol. 2006; 124(11)1543–1551
   PubMedGoogle Scholar
• Tsubota K, Higuchi A. Serum application for the treatment of ocular surface disorders. Int Ophthalmol Clin. 2000; 40(4)113–122
   PubMedGoogle Scholar
• Cher I. Blink-related microtrauma: When the ocular surface harms itself. Clin Exp Ophthalmol. 2003; 31(3)183–190
   PubMed Web of Science ®Google Scholar
• Schultz G S, Davis J B, Eiferman R A. Growth factors and corneal epithelium. Cornea. 1988; 7(2)96–101
   PubMed Web of Science ®Google Scholar
• Schultz G S, Chegini N, Grant M, Khaw P T, MacKay S. Effects of growth factors on corneal wound healing. Acta Ophthalmol Suppl 1992; 70(202)60–66
   Google Scholar
• Skuta G L, Parrish R K. Wound healing in glaucoma filtering surgery. Surv Ophthalmol. 1987; 32(3)149–170
   PubMed Web of Science ®Google Scholar
• Friedenwald J. Some problems in the diagnosis and treatment of glaucoma. Am J Ophthalmol. 1950; 33(10)1523–1538
   PubMed Web of Science ®Google Scholar
• Smith M F, Magauran R GI, Betchkal J, Doyle J W. Treatment of postfiltration bleb leaks with autologous blood. Ophthalmology. 1995; 102(6)868–871
   PubMed Web of Science ®Google Scholar
• Wise J B. Treatment of chronic postfiltration hypotony by intrableb injection of autologous blood. Arch Ophthalmol. 1993; 111(6)827–830
   PubMedGoogle Scholar
• Fini M E. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res. 1999; 18(4)529–551
   PubMed Web of Science ®Google Scholar
• Jester J V, Huang J, Petroll W M, Cavanagh H D. TGF-beta induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGF-beta, PDGF, and integrin signaling. Exp Eye Res. 2002; 75(6)645–657
   PubMed Web of Science ®Google Scholar
• Netto M V, Mohan R R, Ambrosio R J, Hutcheon A EK, Zieske J D, Wilson S E. Wound healing in the cornea: A review of refractive surgery complications and new prospects for therapy. Cornea. 2005; 24(5)509–522
   PubMed Web of Science ®Google Scholar
• Jester J V, Ho-Chang J. Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control in vitro contractility and extracellular matrix contraction. Exp Eye Res. 2003; 77(5)581–593
   PubMed Web of Science ®Google Scholar
• Tarpila E, Ghassemifar R M, Franzen L E. Fibroblast movements during contraction of collagen lattices—A quantitative study using a new three-dimensional time-lapse technique with phase-contrast laser scanning microscopy. In Vitro Cell Dev Biol Anim. 1998; 34(8)640–645
   PubMed Web of Science ®Google Scholar
• Tomasek J J, Gabbiani G, Hinz B, Chaponnier C, Brown R A. Myofibroblasts and mechano-regulation of connective tissue remodeling. Nat Rev Mol Cell Biol. 2002; 3(5)349–363
   PubMed Web of Science ®Google Scholar
• Daniels J T, Cambrey A D, Occleston N L, Garrett Q, Tarnuzzer R W, Schultz G S, et al. Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro. Invest Ophthalmol Vis Sci 2003; 44(3)1104–1110
   PubMed Web of Science ®Google Scholar
• Wong T T, Sethi C, Daniels J T, Limb G A, Murphy G, Khaw P T. Matrix metalloproteinases in disease and repair processes in the anterior segment. Surv Ophthalmol. 2002; 47(3)239–256
   PubMed Web of Science ®Google Scholar
• Daniels J T, Geerling G, Alexander R A, Murphy G, Khaw P T, Saarialho-Kere U. Temporal and spatial expression of matrix metalloproteinases during wound healing of human corneal tissue. Exp Eye Res. 2003; 77(6)653–664
   PubMed Web of Science ®Google Scholar
• Espana E M, Romano A C, Kawakita T, Di P M, Smiddy R, Tseng S C. Novel enzymatic isolation of an entire viable human limbal epithelial sheet. Invest Ophthalmol Vis Sci. 2003; 44(10)4275–4281
   PubMed Web of Science ®Google Scholar
• Occleston N L, Alexander R A, Mazure A, Larkin G, Khaw P T. Effects of single exposures to antiproliferative agents on ocular fibroblast-mediated collagen contraction. Invest Ophthalmol Vis Sci. 1994; 35(10)3681–3690
   PubMed Web of Science ®Google Scholar
• Bell E, Ivarsson B, Merrill C. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc Natl Acad Sci USA. 1979; 76(3)1274–1278
   PubMed Web of Science ®Google Scholar
• Ehrlich H P, Rajaratnam J B. Cell locomotion forces versus cell contraction forces for collagen lattice contraction: An in vitro model of wound contraction. Tissue Cell. 1990; 22(4)407–417
   PubMed Web of Science ®Google Scholar
• Arora P D, Narani N, McCulloch C A. The compliance of collagen gels regulates transforming growth factor-beta induction of alpha-smooth muscle actin in fibroblasts. Am J Pathol. 1999; 154(3)871–882
   PubMed Web of Science ®Google Scholar
• Varani J, Hattori Y, Chi Y, Schmidt T, Perone P, Zeigler M E, et al. Collagenolytic and gelatinolytic matrix metalloproteinases and their inhibitors in basal cell carcinoma of skin: Comparison with normal skin. Br J Cancer. 2000; 82(3)657–665
   PubMed Web of Science ®Google Scholar
• Elder M J, Hiscott P, Dart J K. Intermediate filament expression by normal and diseased human corneal epithelium. Hum Pathol. 1997; 28(12)1348–1354
   PubMed Web of Science ®Google Scholar
• Daniels J T, Harris I R, Kearney J N, Ingham E. Calcium: A crucial consideration in serum-free keratinocyte culture. Exp Dermatol. 1995; 4(1)183–191
   PubMedGoogle Scholar
• Geerling G, Daniels J T, Dart J K, Cree I A, Khaw P T. Toxicity of natural tear substitutes in a fully defined culture model of human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2001; 42(5)948–956
   PubMed Web of Science ®Google Scholar
• Toda I, Shinozaki N, Tsubota K. Hydroxypropyl methylcellulose for the treatment of severe dry eye associated with Sjögren's syndrome. Cornea. 1996; 15(2)120–128
   PubMed Web of Science ®Google Scholar
• Versura P, Maltarello M C, Stecher F, Caramazza R, Laschi R. Dry eye before and after therapy with hydroxypropyl methylcellulose. Ultrastructural and cytochemical study in 20 patients. Ophthalmologica. 1989; 198(3)152–162
   PubMed Web of Science ®Google Scholar
• Adams J, Wilcox M J, Trousdale M D, Chien D S, Shimizu R W. Morphologic and physiologic effects of artificial tear formulations on corneal epithelial derived cells. Cornea. 1992; 11(3)234–241
   PubMedGoogle Scholar
• Grene R B, Lankston P, Mordaunt J, Harrold M, Gwon A, Jones R. Unpreserved carboxymethylcellulose artificial tears evaluated in patients with keratoconjunctivitis sicca. Cornea. 1992; 11(4)294–301
   PubMed Web of Science ®Google Scholar
• Nelson J D, Drake M M, Brewer J T, Jr, Tuley M. Evaluation of a physiological tear substitute in patients with keratoconjunctivitis sicca. Adv Exp Med Biol. 1994; 350: 453–457
   PubMedGoogle Scholar
• Daniels J T, Limb G A, Saarialho-Kere U, Murphy G, Khaw P T. Human corneal epithelial cells require MMP-1 for HGF-mediated migration on collagen I. Invest Ophthalmol Vis Sci. 2003; 44(3)1048–1055
   PubMed Web of Science ®Google Scholar
• Medina A, Scott P, Ghahary A, Tredget E. Pathophysiology of chronic nonhealing wounds. J Burn Care Rehabil. 2005; 26(4)306–319
   PubMedGoogle Scholar
• Ma D H, Zhang F, Shi W, Yao J Y, Hsiao C H, Wu H C, et al. Expression of tissue inhibitor of metalloproteinase-4 in normal human corneal cells and experimental corneal neovascularization. Ophthalmic Res. 2003; 35(4)199–207
   PubMed Web of Science ®Google Scholar
• Ohji M, SundarRaj N, Thoft R A. Transforming growth factor-beta stimulates collagen and fibronectin synthesis by human corneal stromal fibroblasts in vitro. Curr Eye Res. 1993; 12(8)703–709
   PubMed Web of Science ®Google Scholar
• Beales M P, Funderburgh J L, Jester J V, Hassell J R. Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: Maintenance of the keratocyte phenotype in culture. Invest Ophthalmol Vis Sci. 1999; 40(8)1658–1663
   PubMed Web of Science ®Google Scholar
• Hibino T, Wada Y, Mishima H, Otori T. The effect of corneal epithelial cells on the collagen gel contraction by keratocytes. Jpn J Ophthalmol. 1998; 42(3)174–179
   PubMed Web of Science ®Google Scholar
• Wilson S E, Netto M, Ambrosio R, Jr. Corneal cells: Chatty in development, homeostasis, wound healing, and disease. Am J Ophthalmol. 2003; 136(3)530–536
   PubMed Web of Science ®Google Scholar
• Wilson S E, He Y G, Weng J, Li Q, McDowall A W, Vital M, et al. Epithelial injury induces keratocyte apoptosis: Hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing. Exp Eye Res. 1996; 62(4)325–327
   PubMed Web of Science ®Google Scholar
• Wilson S E, Mohan R R, Mohan R R, Ambrosio R, Jr, Hong J, Lee J. The corneal wound-healing response: Cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res. 2001; 20(5)625–637
   PubMed Web of Science ®Google Scholar
• Lim M, Goldstein M H, Tuli S, Schultz G S. Growth factor, cytokine, and protease interactions during corneal wound healing. Ocul Surf. 2003; 1(2)53–65
   PubMedGoogle Scholar
• Wu K Y, Wang H Z, Hong S J. Effects of antibiotics and corticosteroid eyedrops on cellular proliferation in cultured human corneal keratocytes. Kaohsiung J Med Sci. 2006; 22(8)385–389
   PubMedGoogle Scholar
• Foreman D M, Pancholi S, Jarvis-Evans J, McLeod D, Boulton M E. A simple organ culture model for assessing the effects of growth factors on corneal re-epithelialization. Exp Eye Res. 1996; 62: 555–564
   PubMed Web of Science ®Google Scholar
• Ogawa Y, Okamoto S, Mori T, Yamada M, Mashima Y, Watanabe R, et al. Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transpl. 2003; 31(7)579–583
   PubMed Web of Science ®Google Scholar
• Geerling G, MacLennan S, Hartwig D. Autologous serum eye drops for ocular surface disorders. Br J Ophthalmol. 2004; 88(11)1467–1474
   PubMed Web of Science ®Google Scholar
• Noble B A, Loh R S, MacLennan S, Pesudovs K, Reynolds A, Bridges L R, et al. Comparison of autologous serum eye drops with conventional therapy in a randomized controlled crossover trial for ocular surface disease. Br J Ophthalmol. 2004; 88(5)647–652
   PubMed Web of Science ®Google Scholar
• Tananuvat N, Daniell M, Sullivan L J, Yi Q, McKelvie P, McCarty D J, et al. Controlled study of the use of autologous serum in dry eye patients. Cornea. 2001; 20(8)802–806
   PubMed Web of Science ®Google Scholar
• Tsubota K, Satake Y, Ohyama M, Toda I, Takano Y, Ono M, et al. Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. Am J Ophthalmol. 1996; 122: 38–52
   PubMed Web of Science ®Google Scholar
• Tsubota K, Goto E, Fujita H, Ono M, Inoue H, Saito I, et al. Treatment of dry eye by autologous serum application in Sjögren's syndrome. Br J Ophthalmol. 1999; 83: 390–395
   PubMed Web of Science ®Google Scholar
• Fox R I, Chan R, Michelson J, Belmont J, Michelson P. Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. Arthritis Rheum. 1984; 27: 459–461
   PubMed Web of Science ®Google Scholar