Subchoroidal Release of VEGF and bFGF Produces Choroidal Neovascularization in Rabbit

References

• National Eye Institute. Available at http://www.nei.nih.gov/.
   Google Scholar
• Abselsalam, A, Del Priore L, Zarbin MA. Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression. Surv Ophthalmol 1999;44:1–29.
   PubMed Web of Science ®Google Scholar
• Rattner A, Nathans J. Macular degeneration: recent advances and therapeutic opportunities. Nat Rev Neurosci 2006;7:860–872.
   PubMed Web of Science ®Google Scholar
• Crabb JW, Miyagi M, Gu X, Shadrach K, West KA, Sakaguchi H, et al. Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci USA 2002;99:14682–14687.
   PubMed Web of Science ®Google Scholar
• Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthal 2003;48:257–293.
   PubMed Web of Science ®Google Scholar
• Ryan SJ. Subretinal neovascularization: natural history of an experimental model. Arch Ophthal 1982;100:1804–1809.
   PubMedGoogle Scholar
• Miller H, Miller B, Ryan SJ. The role of retinal pigment epithelium in the involution of subretinal neovascularization. Invest Ophthalmol Vis Sci 1986;27:1644–1652.
   PubMed Web of Science ®Google Scholar
• Frank RN, Das A, Weber ML. A model of subretinal neovascularization in the pigmented rat. Curr Eye Res 1989;8:239–247.
   PubMed Web of Science ®Google Scholar
• Kiilgaard JF, Andersen MVN, Wiencke AK, Scherfig E, La Cour M, Tezel TH, et al. A new animal model of choroidal neovascularization. Acta Ophthalmol Scandinavica 2005;83:697–704.
   PubMedGoogle Scholar
• Hsu HT, Goodnight R, Ryan SJ. Subretinal choroidal neovascularization as a response to penetrating retinal injury in the pigmented rabbit. Jpn J Ophthalmol 1989;33:358–366.
   PubMed Web of Science ®Google Scholar
• El Dirini AA, Ogden TE, Ryan SJ. Subretinal endophotocoagulation: a new model of subretinal neovascularization in the rabbit. Retina 1991;11:244–249.
   PubMed Web of Science ®Google Scholar
• Wong CG, Rich KA, Liaw LHL, Hsu HT, Berns MW. Intravitreal VEGF and bFGF produce florid retinal neovascularization and hemorrhage in the rabbit. Curr Eye Res 2001;22:140–147.
   PubMed Web of Science ®Google Scholar
• Erb MH, Sioulis CE, Kuppermann BD, Osann K, Wong CG. Differential retinal angiogenic response to sustained intravitreal release of VEGF and bFGF in different pigmented rabbit breeds. Curr Eye Res 2002;24:245–252.
   PubMed Web of Science ®Google Scholar
• Adamis AP, Miller JW, Bernal MT, D’Amico DJ, Folkman J, Yeo TK, et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994;118:445–450.
   PubMed Web of Science ®Google Scholar
• Aiello LP, Avert RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994;331:1480–1487.
   PubMed Web of Science ®Google Scholar
• Sivalingam A, Kinney J, Brown GC, Benson WE, Donoso L. Basic fibroblast growth factor levels in the vitreous of patients with proliferative diabetic retiopathy. Arch Ophthalmol 1990;108:869–872.
   PubMed Web of Science ®Google Scholar
• Frank RN, Amin RH, Eliott D, Puklin JE, Abrams GW. Basic fibroblast growth factor and vascular endothelilial growth factor are present in epiretinal and choroidal neovascular membranes. Am J Ophthalmol 1996;122:393–403.
   PubMed Web of Science ®Google Scholar
• Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature 2000;407:242–248.
   PubMed Web of Science ®Google Scholar
• Wong CG, Gum GG, Hagemann L, Marques L, Kuppermann BD, de Carvalho RP. Induction of choroidal neovascularization by sustained release of VEGF/bFGF in rabbits: angiographic characterization and histologic correlation on different patterns of the choroidal vascular response. Invest Ophthalmol Vis Sci 2005; 46e-abstract 1417.
   Web of Science ®Google Scholar
• Wong CG, Bruice TC, You TT. Experimental CNV after trans-scleral implantation of VEGF/bFGF-implant within the suprachoroidal space for defining potential long-term synergistic actions of ranibizumab (Lucentis) with small low cost molecules in ameliorating wet AMD. Invest Ophthalmol Vis Sci 2008; 49e-abstract 1372.
   Google Scholar
• Rabin D, Bruice TC, You TT, Wong CG. Both edema and leakage are expressed and are separable in long-term experimental CNV via sustained simultaneous release of VEGF and bFGF within the suprachoroidal space through trans-scleral implantation of a delivery device. Invest Ophthalmol Vis Sci 2008; 49e-abstract 1374.
   Google Scholar
• Chen L, Miyamura N, Ninomiya Y, Handa JT. Distribution of the collagen IV isoforms in human Bruch’s membrane. Br J Ophthalmol 2003;87:212–215.; 83:141–152.
   PubMed Web of Science ®Google Scholar
• Seghezzi G, Patel S, Ren CJ, Gualandris A, Pintucci G, Robbins ES, et al. Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol 1998;141:1659–1673.
   PubMed Web of Science ®Google Scholar
• Sylvie J, Kreppel F, Beck S, Heiduschka P, Brito V, Schnichels S, et al. A reproducible and quantifiable model of choroidal neovascularization induced by VEGF A165 after subretinal adenoviral gene transfer in the rabbit. Molecular Vis 2008;14:1358–1372.
   PubMed Web of Science ®Google Scholar
• Ni M, Holland M, Jarstadmarken H, DeVries G. Time-course of experimental choroidal neovascularization in Dutch-Belted rabbit: clinical and histological evaluation. Exp Eye Res 2005;8:286–297.
   Web of Science ®Google Scholar
• Qiu G, Stewart JM, Sadda S, Freda R, Lee S, Guven D, et al. A new model of experimental subretinal neovascularization in the rabbit. Exp Eye Res 2006;83:141–152.
   PubMed Web of Science ®Google Scholar
• Zahn G, Vossmeyer D, Stragies R, Wills M, Wong CG, Löffler KU, et al. Pre-clinical evaluation of the novel small-molecule integrin α5β1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization. Arch Ophthalmol 2009;127:1329–1335.
   PubMedGoogle Scholar
• Geroski DH, Edelhauser HF. Transscleral drug delivery for posterior segment disease. Adv Drug Deliv Rev 2001;52:37–48.
   PubMed Web of Science ®Google Scholar
• Kim SH, Lutz RJ, Wang NS, Robinson MR. Transport barriers in transscleral drug delivery for retinal diseases. Ophthalmic Res 2007;39:244–254.
   PubMed Web of Science ®Google Scholar
• Barocas VH, Balachandran RK. Sustained transscleral drug delivery. Expert Opin Drug Deliv 2008;5:1–10.
   PubMed Web of Science ®Google Scholar
• Pearce W, Hsu J, Yeh S. Advances in drug delivery to the posterior segment. Curr Opin Ophthalmol 2015;26:233–239.
   PubMed Web of Science ®Google Scholar
• Patel RS, Lin ASP, Edelhauser HF, Rausnitz MR. Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm Res 2011;28:166–176.
   PubMed Web of Science ®Google Scholar
• Lambrou FH, Chilbert M, Mieler WF, Williams GA, Olsen KA. New technique for subchoroidal implantation of experimental malignant melanoma. Invest Ophthal Vis Sci 1988;29:995–998.
   PubMed Web of Science ®Google Scholar
• Rabin DL, Rabin RL, Blenkinsop TA, Temple S, Stern JH. Chronic oxidative stress upregulates drusen‐related protein expression in adult human RPE stem cell‐derived RPE cells: A novel culture model for dry AMD. Aging 2013;5:51–66.
   PubMedGoogle Scholar
• Ambati J, Atkinson JP, Gelfand BD. Immunology of age-related macular degeneration. Nat Rev Immunol 2013;13:438–451.
   PubMed Web of Science ®Google Scholar
• Bhutto I, Lutty G. Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex. Mol Aspects Med 2012;33:295–317.
   PubMed Web of Science ®Google Scholar