Alterations in retinal nerve fiber layer thickness in early stages of diabetic retinopathy and potential risk factors

References

• Stitt AW, Curtis TM, Chen M, Medina RJ, McKay GJ, Jenkins A, Gardiner TA, Lyons TJ, Hammes H-P, Simó R, et al. The progress in understanding and treatment of diabetic retinopathy. Prog Retin Eye Res. 2016;51:156–86. doi:10.1016/j.preteyeres.2015.08.001.
   PubMed Web of Science ®Google Scholar
• Simo R, Hernandez C. Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence. Prog Retin Eye Res. 2015;48:160–80. doi:10.1016/j.preteyeres.2015.04.003.
   PubMed Web of Science ®Google Scholar
• Hernandez C, Simo-Servat A, Bogdanov P, Simo R. Diabetic retinopathy: new therapeutic perspectives based on pathogenic mechanisms. J Endocrinol Invest. 2017;40:925–35. doi:10.1007/s40618-017-0648-4.
   PubMed Web of Science ®Google Scholar
• Kadlubowska J, Malaguarnera L, Waz P, Zorena K. Neurodegeneration and neuroinflammation in diabetic retinopathy: potential approaches to delay neuronal loss. Curr Neuropharmacol. 2016;14:831–39. doi:10.2174/1570159X14666160614095559.
   PubMed Web of Science ®Google Scholar
• Picconi F, Parravano M, Ylli D, Pasqualetti P, Coluzzi S, Giordani I, Malandrucco I, Lauro D, Scarinci F, Giorno P, et al. Retinal neurodegeneration in patients with type 1 diabetes mellitus: the role of glycemic variability. Acta Diabetol. 2017;54:489–97. doi:10.1007/s00592-017-0971-4.
   PubMed Web of Science ®Google Scholar
• Feng Y, Wang Y, Li L, Wu L, Hoffmann S, Gretz N, Hammes H-P, Câmara N. Gene expression profiling of vasoregression in the retina–involvement of microglial cells. Plos One. 2011;6:e16865. doi:10.1371/journal.pone.0016865.
   PubMed Web of Science ®Google Scholar
• Kusari J, Zhou S, Padillo E, Clarke KG, Gil DW. Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci. 2007;48:5152–59. doi:10.1167/iovs.07-0427.
   PubMed Web of Science ®Google Scholar
• Sohn EH, Van Dijk HW, Jiao C, Kok PH, Jeong W, Demirkaya N, Garmager A, Wit F, Kucukevcilioglu M, Van Velthoven MEJ, et al. Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc Natl Acad Sci USA. 2016;113:E2655–E2664. doi:10.1073/pnas.1522014113.
   PubMed Web of Science ®Google Scholar
• Cheung AK, Fung MK, Lo AC, Lam TT, So KF, Chung SS, Chung SK. Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice. Diabetes. 2005;54:3119–25. doi:10.2337/diabetes.54.11.3119.
   PubMed Web of Science ®Google Scholar
• Van Dijk HW, Verbraak FD, Kok PH, Stehouwer M, Garvin MK, Sonka M, DeVries JH, Schlingemann RO, Abràmoff MD. Early neurodegeneration in the retina of type 2 diabetic patients. Invest Ophthalmol Vis Sci. 2012;53:2715–19. doi:10.1167/iovs.11-8997.
   PubMed Web of Science ®Google Scholar
• Chihara E, Matsuoka T, Ogura Y, Matsumura M. Retinal nerve fiber layer defect as an early manifestation of diabetic retinopathy. Ophthalmology. 1993;100:1147–51. doi:10.1016/S0161-6420(93)31513-7.
   PubMed Web of Science ®Google Scholar
• Dhasmana R, Sah S, Gupta N. Study of retinal nerve fibre layer thickness in patients with diabetes mellitus using fourier domain optical coherence tomography. J Clin Diagn Res. 2016;10:C5–C9.
   Web of Science ®Google Scholar
• Wang B, Wang F, Zhang Y, Zhao SH, Zhao WJ, Yan SL, Wang Y-G. Effects of RAS inhibitors on diabetic retinopathy: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2015;3:263–74. doi:10.1016/S2213-8587(14)70256-6.
   PubMed Web of Science ®Google Scholar
• Persistent effects of intensive glycemic control on retinopathy in type 2 diabetes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) follow-on study. Diabetes Care. 2016;39:1089–100. doi:10.2337/dc16-0024.
   PubMed Web of Science ®Google Scholar
• Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra S, Greven CM, Hubbard L, Esser BA, Lovato JF, Perdue LH, Goff DC Jr, Cushman WC, Ginsberg HN, Elam MB, Genuth S, Gerstein HC, Schubart U, Fine LJ. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med. 2010;363:233–44. doi:10.1056/NEJMoa1001288.
   PubMed Web of Science ®Google Scholar
• Firth J. Fenofibrate and diabetic retinopathy. Lancet. 2008;371:722, 722. doi:10.1016/S0140-6736(08)60334-7.
   PubMed Web of Science ®Google Scholar
• Gungor A, Ates O, Bilen H, Kocer I. Retinal nerve fiber layer thickness in early-stage diabetic retinopathy with Vitamin D deficiency. Invest Ophthalmol Vis Sci. 2015;56:6433–37. doi:10.1167/iovs.15-16872.
   PubMed Web of Science ®Google Scholar
• Peng PH, Hsu SY, Wang WS, Ko ML. Age and axial length on peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography in nonglaucomatous Taiwanese participants. Plos One. 2017;12:e179320. doi:10.1371/journal.pone.0179320.
   Web of Science ®Google Scholar
• Wilkinson CP, Ferris FR, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110:1677–82. doi:10.1016/S0161-6420(03)00475-5.
   PubMed Web of Science ®Google Scholar
• Basevi V, Di Mario S, Morciano C, Nonino F, Magrini N. Comment on: American Diabetes Association. Standards of medical care in diabetes–2011. Diabetes Care. 2011;34(Suppl. 1):S11–S61. DIABETES CARE 2011;34:e53, e54. doi:10.2337/dc11-S011.
   PubMed Web of Science ®Google Scholar
• Vujosevic S, Midena E. Retinal layers changes in human preclinical and early clinical diabetic retinopathy support early retinal neuronal and Muller cells alterations. J Diabetes Res. 2013;2013:905058. doi:10.1155/2013/905058.
   PubMed Web of Science ®Google Scholar
• Chhablani J, Sharma A, Goud A, Peguda HK, Rao HL, Begum VU, Barteselli G. Neurodegeneration in type 2 diabetes: evidence from spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2015;56:6333–38. doi:10.1167/iovs.15-17334.
   PubMed Web of Science ®Google Scholar
• Cabrera DD, Somfai GM. Early detection of retinal thickness changes in diabetes using optical coherence tomography. Med Sci Monit. 2010;16:T15–T21.
   Web of Science ®Google Scholar
• Takahashi H, Goto T, Shoji T, Tanito M, Park M, Chihara E. Diabetes-associated retinal nerve fiber damage evaluated with scanning laser polarimetry. Am J Ophthalmol. 2006;142:88–94. doi:10.1016/j.ajo.2006.02.016.
   PubMed Web of Science ®Google Scholar
• Choi JA, Ko SH, Park YR, Jee DH, Ko SH, Park CK. Retinal nerve fiber layer loss is associated with urinary albumin excretion in patients with type 2 diabetes. Ophthalmology. 2015;122:976–81. doi:10.1016/j.ophtha.2015.01.001.
   PubMed Web of Science ®Google Scholar
• Lopes DFJ, Russ H, Costa VP. Retinal nerve fibre layer loss in patients with type 1 diabetes mellitus without retinopathy. Br J Ophthalmol. 2002;86:725–28. doi:10.1136/bjo.86.7.725.
   PubMed Web of Science ®Google Scholar
• Leung CK, Lam S, Weinreb RN, Liu S, Ye C, Liu L, He J, Lai GWK, Li T, Lam DSC. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: analysis of the retinal nerve fiber layer map for glaucoma detection. Ophthalmology. 2010;117:1684–91. doi:10.1016/j.ophtha.2010.01.026.
   PubMed Web of Science ®Google Scholar
• Jonas JB, Mardin CY, Schlotzer-Schrehardt U, Naumann GO. Morphometry of the human lamina cribrosa surface. Invest Ophthalmol Vis Sci. 1991;32:401–05.
   PubMed Web of Science ®Google Scholar
• Shen L, Walter S, Melles RB, Glymour MM, Jorgenson E. Diabetes pathology and risk of primary open-angle glaucoma: evaluating causal mechanisms by using genetic information. Am J Epidemiol. 2016;183:147–55.
   PubMed Web of Science ®Google Scholar
• Zhao D, Cho J, Kim MH, Friedman DS, Guallar E. Diabetes, fasting glucose, and the risk of glaucoma: a meta-analysis. Ophthalmology. 2015;122:72–78. doi:10.1016/j.ophtha.2014.07.051.
   PubMed Web of Science ®Google Scholar
• Jeon SJ, Kwon JW, La TY, Park CK, Choi JA. Characteristics of retinal nerve fiber layer defect in nonglaucomatous eyes with type II diabetes. Invest Ophthalmol Vis Sci. 2016;57:4008–15. doi:10.1167/iovs.16-19525.
   PubMed Web of Science ®Google Scholar
• Chen X, Nie C, Gong Y, Zhang Y, Jin X, Wei S, Zhang M. Peripapillary retinal nerve fiber layer changes in preclinical diabetic retinopathy: a meta-analysis. Plos One. 2015;10:e125919.
   PubMed Web of Science ®Google Scholar
• Gray EJ, Gardner TW. Retinal failure in diabetes: a feature of retinal sensory neuropathy. Curr Diab Rep. 2015;15:107. doi:10.1007/s11892-015-0683-5.
   PubMed Web of Science ®Google Scholar
• Singh RP, Habbu K, Ehlers JP, Lansang MC, Hill L, Stoilov I. The impact of systemic factors on clinical response to ranibizumab for diabetic macular Edema. Ophthalmology. 2016;123:1581–87. doi:10.1016/j.ophtha.2016.03.038.
   PubMed Web of Science ®Google Scholar
• Keech AC, Mitchell P, Summanen PA, O’Day J, Davis TM, Moffitt MS, Taskinen MR, Simes RJ, Tse D, Williamson E, Merrifield A, Laatikainen LT, d’Emden MC, Crimet DC, O’Connell RL, Colman PG, FIELD study investigators. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet, 2007;370:1687–97. doi:10.1016/S0140-6736(07)61607-9.
   PubMed Web of Science ®Google Scholar
• Mazereeuw G, Herrmann N, Bennett SA, Swardfager W, Xu H, Valenzuela N, Fai S, Lanctôt KL. Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. Neurosci Biobehav Rev. 2013;37:1611–21. doi:10.1016/j.neubiorev.2013.06.010.
   PubMed Web of Science ®Google Scholar
• Yoda K, Inaba M, Hamamoto K, Yoda M, Tsuda A, Mori K, Yamada S, Emoto M, Koyama H, Imanishi Y. Association between glycemic control and morning blood pressure surge with vascular endothelial dysfunction in type 2 diabetic patients. Diabetes Care. 2014;37:644–50. doi:10.2337/dc13-1102.
   PubMed Web of Science ®Google Scholar
• Cho NH, Kim TH, Woo SJ, Park KH, Lim S, Cho YM, Park KS, Jang HC, Choi SH. Optimal HbA1c cutoff for detecting diabetic retinopathy. Acta Diabetol. 2013;50:837–42. doi:10.1007/s00592-013-0452-3.
   PubMed Web of Science ®Google Scholar
• Papaioannou GI, Seip RL, Grey NJ, Katten D, Taylor A, Inzucchi SE, Young LH, Chyun DA, Davey JA, Wackers FJT, et al. Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in asymptomatic diabetics-brachial artery reactivity study). Am J Cardiol. 2004;94:294–99. doi:10.1016/j.amjcard.2004.04.022.
   PubMed Web of Science ®Google Scholar
• Oshitari T, Hanawa K, Adachi-Usami E. Changes of macular and RNFL thicknesses measured by Stratus OCT in patients with early stage diabetes. Eye (Lond). 2009;23:884–89. doi:10.1038/eye.2008.119.
   PubMed Web of Science ®Google Scholar
• Pekel E, Altincik SA, Pekel G. Evaluation of optic disc, retinal nerve fiber and macular ganglion cell layers in pediatric diabetes. Int Ophthalmol. 2017. doi:10.1007/s10792-017-0683-3.
   PubMed Web of Science ®Google Scholar