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Original Articles

Effects of Intravitreal Aflibercept on Galectin-1 and Vascular Endothelial Growth Factor-A Plasma Levels in Patients with Diabetic Retinopathy

, , , , , & show all
Pages 368-375 | Received 28 Jul 2017, Accepted 06 Nov 2017, Published online: 27 Nov 2017

References

  • Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–36. doi:10.1016/S0140-6736(09)62124-3.
  • Moss SE, Klein R, Klein BE. The 14-year incidence of visual loss in a diabetic population. Ophthalmology. 1998;105(6):998–1003. doi:10.1016/S0161-6420(98)96025-0.
  • Ding J, Wong TY. Current epidemiology of diabetic retinopathy and diabetic macular edema. Curr Diab Rep. 2012;12(4):346–54. doi:10.1007/s11892-012-0283-6.
  • Das A, McGuire PG, Monickaraj F. Novel pharmacotherapies in diabetic retinopathy: current status and what’s in the horizon? Indian J Ophthalmol. 2016;64(1):4–13. doi:10.4103/0301-4738.178154.
  • Cohen SR, Gardner TW. Diabetic retinopathy and diabetic macular edema. Dev Ophthalmol. 2016;55:137–46.
  • Roy S, Kern TS, Song B, Stuebe C. Mechanistic insights into pathological changes in the diabetic retina: implications for targeting diabetic retinopathy. Am J Pathol. 2017;187(1):9–19. doi:10.1016/j.ajpath.2016.08.022.
  • Das A, McGuire PG. Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition. Prog Retin Eye Res. 2003;22(6):721–48. doi:10.1016/j.preteyeres.2003.08.001.
  • Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994;331(22):1480–87. doi:10.1056/NEJM199412013312203.
  • Funatsu H, Noma H, Mimura T, Eguchi S, Hori S. Association of vitreous inflammatory factors with diabetic macular edema. Ophthalmology. 2009;116(1):73–79. doi:10.1016/j.ophtha.2008.09.037.
  • Funk M, Schmidinger G, Maar N, Bolz M, Benesch T, Zlabinger GJ, Schmidt-Erfurth UM. Angiogenic and inflammatory markers in the intraocular fluid of eyes with diabetic macular edema and influence of therapy with bevacizumab. Retina. 2010;30(9):1412–19. doi:10.1097/IAE.0b013e3181e095c0.
  • Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A. 2002;99(17):11393–98. doi:10.1073/pnas.172398299.
  • Kanda A, Noda K, Saito W, Ishida S. Aflibercept Traps Galectin-1, an Angiogenic Factor Associated with Diabetic Retinopathy. Sci Rep. 2015;5:17946. doi:10.1038/srep17946.
  • Thijssen VL, Heusschen R, Caers J, Griffioen AW. Galectin expression in cancer diagnosis and prognosis: A systematic review. Biochim Biophys Acta. 2015;1855(2):235–47.
  • Chong Y, Tang D, Gao J, Jiang X, Xu C, Xiong Q, et al. Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway. Oncotarget. 2016;7(50):83611–26.
  • Croci DO, Cerliani JP, Dalotto-Moreno T, Méndez-Huergo SP, Mascanfroni ID, Dergan-Dylon S, Toscano M, Caramelo J, García-Vallejo J, Ouyang J, et al. Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell. 2014;156(4):744–58. doi:10.1016/j.cell.2014.01.043.
  • Wang X, Sawada T, Sawada O, Saishin Y, Liu P, Ohji M. Serum and plasma vascular endothelial growth factor concentrations before and after intravitreal injection of aflibercept or ranibizumab for age-related macular degeneration. Am J Ophthalmol. 2014;158(4):738–44e1. doi:10.1016/j.ajo.2014.06.009.
  • Yoshida I, Shiba T, Taniguchi H, Takahashi M, Murano T, Hiruta N, Hori Y, Bujo H, Maeno T. Evaluation of plasma vascular endothelial growth factor levels after intravitreal injection of ranibizumab and aflibercept for exudative age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2014;252(9):1483–89. doi:10.1007/s00417-014-2717-0.
  • Zehetner C, Kralinger MT, Modi YS, Waltl I, Ulmer H, Kirchmair R, Bechrakis NE, Kieselbach GF. Systemic levels of vascular endothelial growth factor before and after intravitreal injection of aflibercept or ranibizumab in patients with age-related macular degeneration: a randomised, prospective trial. Acta Ophthalmol. 2015;93(2):e154–9. doi:10.1111/aos.2015.93.issue-2.
  • Avery RL, Castellarin AA, Steinle NC, Dhoot DS, Pieramici DJ, See R, Couvillion S, Nasir MA, Rabena MD, Maia M, et al. Systemic pharmacokinetics and pharmacodynamics of intravitreal aflibercept, bevacizumab, and ranibizumab. Retina. 2017;37:1847–58. doi:10.1097/IAE.0000000000001493.
  • Diabetic Retinopathy Clinical Research N, Wells JA, Glassman AR, Ayala AR, Jampol LM, Aiello LP, et al. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. N Engl J Med. 2015;372(13):1193–203. doi:10.1056/NEJMoa1414264.
  • Heier JS, Bressler NM, Avery RL, Bakri SJ, Boyer DS, Brown DM, Dugel PU, Freund KB, Glassman AR, Kim JE, et al. Comparison of aflibercept, bevacizumab, and ranibizumab for treatment of diabetic macular edema: extrapolation of data to clinical practice. JAMA Ophthalmol. 2016;134(1):95–99. doi:10.1001/jamaophthalmol.2015.4110.
  • Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110(9):1677–82. doi:10.1016/S0161-6420(03)00475-5.
  • Ferrara N, Gerber H-P, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9(6):669–76. doi:10.1038/nm0603-669.
  • Takahashi H, Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond). 2005;109(3):227–41. doi:10.1042/CS20040370.
  • Uehara F, Ohba N, Ozawa M. Isolation and characterization of galectins in the mammalian retina. Invest Ophthalmol Vis Sci. 2001;42(10):2164–72.
  • Ridano ME, Subirada PV, Paz MC, Lorenc VE, Stupirski JC, Gramajo AL, Luna JD, Croci DO, Rabinovich GA, Sánchez MC. Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF. Oncotarget. 2017. doi:10.18632/oncotarget.17129.
  • Papadopoulos N, Martin J, Ruan Q, Rafique A, Rosconi MP, Shi E, Pyles EA, Yancopoulos GD, Stahl N, Wiegand SJ. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012;15(2):171–85. doi:10.1007/s10456-011-9249-6.
  • Powner MB, McKenzie JA, Christianson GJ, Roopenian DC, Fruttiger M. Expression of neonatal Fc receptor in the eye. Invest Ophthalmol Vis Sci. 2014;55(3):1607–15. doi:10.1167/iovs.13-12574.
  • Zehetner C, Bechrakis NE, Stattin M, Kirchmair R, Ulmer H, Kralinger MT, Kieselbach GF. Systemic counterregulatory response of placental growth factor levels to intravitreal aflibercept therapy. Invest Ophthalmol Vis Sci. 2015;56(5):3279–86. doi:10.1167/iovs.15-16686.
  • Bolinger MT, Antonetti DA. Moving Past Anti-VEGF: novel therapies for treating diabetic retinopathy. Int J Mol Sci. 2016;17(9). doi:10.3390/ijms17091498.
  • Montassar F, Darche M, Blaizot A, Augustin S, Conart J-B, Millet A, Elayeb M, Sahel J-A, Réaux-Le Goazigo A, Sennlaub F, et al. Lebecetin, a C-type lectin, inhibits choroidal and retinal neovascularization. Faseb J. 2017;31(3):1107–19. doi:10.1096/fj.201600351R.
  • Croci DO, Mendez-Huergo SP, Cerliani JP, Rabinovich GA. Immune-mediated and hypoxia-regulated programs: accomplices in resistance to anti-angiogenic therapies. In Handbook of experimental pharmacology. Berlin, Heidelberg: Springer; 2017.
  • Gunsilius E, Petzer A, Stockhammer G, Nussbaumer W, Schumacher P, Clausen J, Gastl G. Thrombocytes are the major source for soluble vascular endothelial growth factor in peripheral blood. Oncology. 2000;58(2):169–74. doi:10.1159/000012095.
  • Walz JM, Boehringer D, Deissler HL, Faerber L, Goepfert JC, Heiduschka P, Kleeberger SM, Klettner A, Krohne TU, Schneiderhan-Marra N, et al. Pre-analytical parameters affecting vascular endothelial growth factor measurement in plasma: identifying confounders. PLoS One. 2016;11(1):e0145375. doi:10.1371/journal.pone.0145375.
  • Aguilar-Mahecha A, Kuzyk MA, Domanski D, Borchers CH, Basik M, Krauss-Etschmann S. The effect of pre-analytical variability on the measurement of MRM-MS-based mid- to high-abundance plasma protein biomarkers and a panel of cytokines. PLoS One. 2012;7(6):e38290. doi:10.1371/journal.pone.0038290.
  • Schlingemann RO, Van Noorden CJ, Diekman MJ, Tiller A, Meijers JC, Koolwijk P, Wiersinga WM. VEGF levels in plasma in relation to platelet activation, glycemic control, and microvascular complications in type 1 diabetes. Diabetes Care. 2013;36(6):1629–34. doi:10.2337/dc12-1951.
  • Niers TMH, Richel DJ, Meijers JCM, Schlingemann RO, Lee T. Vascular endothelial growth factor in the circulation in cancer patients may not be a relevant biomarker. PLoS One. 2011;6(5):e19873. doi:10.1371/journal.pone.0019873.

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