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Cornea

Influence of Biochemical Cues in Human Corneal Stromal Cell Phenotype

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Pages 135-146 | Received 14 Dec 2017, Accepted 10 Oct 2018, Published online: 29 Oct 2018

References

  • Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: a global perspective. Bull World Health Organ. 2001;79(3):214–21. doi:10.1111/ceo.12330.
  • Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96(5):614–18. doi:10.1136/bjophthalmol-2011-300539.
  • Rasouli M, Caraiscos VB, Slomovic AR. Efficacy of routine notification and request on reducing corneal transplantation wait times in Canada. Can J Ophthalmol. 2009;44(1):31–35. doi:10.3129/i08-187.
  • Reinhard T, Böhringer D, Bogen A, Sundmacher R. The transplantation law: a chance to overcome the shortage of corneal grafts in Germany? Transplant Proc. 2002;34(4):1322–24. doi:10.1016/s0041-1345(02)02783-5.
  • de By TM. Shortage in the face of plenty: improving the allocation of corneas for transplantation. Dev Ophthalmol. 2003;36:56–61. doi:10.1159/000067656.
  • Griffith M, Alarcon EI, Brunette I. Regenerative approaches for the cornea. J Intern Med. 2016;280(3):276–86. doi:10.1111/joim.12502.
  • Ghezzi CE, Rnjak-Kovacina J, Kaplan DL. Corneal tissue engineering: recent advances and future perspectives. Tissue Eng Part B Rev. 2015;21(3):278–87. doi:10.1089/ten.teb.2014.0397.
  • Jester JV, Huang J, Møller-Pedersen T, Sax CM, Kays WT, Cavanagh HD, Petroll WM, Piatigorsky J. The cellular basis of corneal transparency: evidence for “corneal crystallins.”. J Cell Sci. 1999;112:613–22.
  • Berryhill BL, Kader R, Kane BP, Birk DE, Feng J, Hassell JR. Partial restoration of the keratocyte phenotype to bovine keratocytes made fibroblastic by serum. Invest Ophthalmol Vis Sci. 2002;43:3416–21.
  • Lynch AP, O’Sullivan F, Ahearne M. The effect of growth factor supplementation on corneal stromal cell phenotype in vitro using a serum-free media. Exp Eye Res. 2016;151:26–37. doi:10.1016/j.exer.2016.07.015.
  • Wilson SL, Wimpenny I, Ahearne M, Rauz S, El Haj AJ, Yang Y. Chemical and topographical effects on cell differentiation and matrix elasticity in a corneal stromal layer model. Adv Funct Mater. 2012;22(17):3641–49. doi:10.1002/adfm.201200655.
  • Sidney LE, Hopkinson A. Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ß3 and retinoic acid. J Tissue Eng Regen Med. 2016;12(1):e203–15. doi:10.1002/term.2316.
  • Fini ME. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res. 1999;18(4):529–51. doi:10.1016/S1350-9462(98)00033-0.
  • Xu -Z-Z, Li Z-J, Du L-X, Li J, Wang L-Y. Using bovine pituitary extract to increase proliferation of keratocytes and maintain their phenotype in vitro. Int J Ophthalmol. 2013;6:758–65.
  • Beales MP, Funderburgh JL, Jester JV, Hassell JR. Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: maintenance of the keratocyte phenotype in culture. Invest Ophthalmol Vis Sci. 1999;40:1658–63.
  • Espana EM, He H, Kawakita T, Di Pascuale MA, Raju VK, Liu CY, Tseng SC. Human keratocytes cultured on amniotic membrane stroma preserve morphology and express keratocan. Invest Ophthalmol Vis Sci. 2003;44(12):5136–41. doi:10.1167/iovs.03-0484.
  • Masur SK, Dewal HS, Dinh TT, Erenburg I, Petridou S. Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci USA. 1996;93(9):4219–23. doi:10.1073/pnas.93.9.4219.
  • Pot SA, Liliensiek SJ, Myrna KE, Bentley E, Jester JV, Nealey PF, Murphy CJ. Nanoscale topography-induced modulation of fundamental cell behaviors of rabbit corneal keratocytes, fibroblasts, and myofibroblasts. Invest Ophthalmol Vis Sci. 2010;51(3):1373–81. doi:10.1167/iovs.09-4074.
  • Guerriero E, Chen J, Sado Y, Mohan RR, Wilson SE, Funderburgh JL, SundarRaj N. Loss of alpha3(IV) collagen expression associated with corneal keratocyte activation. Invest Ophthalmol Vis Sci. 2007;48(2):627–35. doi:10.1167/iovs.06-0635.
  • Musselmann K, Kane BP, Alexandrou B, Hassell JR. Stimulation of collagen synthesis by insulin and proteoglycan accumulation by ascorbate in bovine keratocytes in vitro. Invest Ophthalmol Vis Sci. 2006;47(12):5260–66. doi:10.1167/iovs.06-0612.
  • Saika S, Kanagawa R, Uenoyama K, Hiroi K, Hiraoka J. L-ascorbic acid 2-phosphate, a phosphate derivative of L-ascorbic acid, enhances the growth of cultured rabbit keratocytes. Graefe’s Arch Clin Exp Ophthalmol. 1991;229(1):79–83. doi:10.1007/bf00172267.
  • Stone N, Meister A. Function of ascorbic acid in the conversion of proline to collagen hydroxyproline. Nature. 1962;194(4828):555–57. doi:10.1038/194555a0.
  • Tajima S, Pinnell SR. Regulation of collagen synthesis by ascorbic acid increases type I procollagen mRNA. Biochem Biophys Res Commun. 1982;106(2):632–37. doi:10.1016/0006-291X(82)91157-3.
  • Lyons BL, Schwarz RI. Ascorbate stimulation of PAT cells causes an increase in transcription rates and a decrease in degradation rates of procollagen mRNA. Nucleic Acids Res. 1984;12(5):2569–79. doi:10.1093/nar/12.5.2569.
  • Gouveia RM, Connon CJ. The effects of retinoic acid on human corneal stromal keratocytes cultured in vitro under serum-free conditions. Invest Opthalmol Vis Sci. 2013;54(12):7483. doi:10.1167/iovs.13-13092.
  • Kenney MC, Shih LM, Labermeir U, Satterfield D. Modulation of rabbit keratocyte production of collagen, sulfated glycosaminoglycans and fibronectin by retinol and retinoic acid. Biochim Biophys Acta. 1986;889:156–62. doi:10.1016/0167-4889(86)90099-6.
  • Abidin FZ, Gouveia RM, Connon CJ. Application of retinoic acid improves form and function of tissue engineered corneal construct. Organogenesis. 2015;11(3):122–36. doi:10.1080/15476278.2015.1093267.
  • Lynch AP, Ahearne M. Retinoic acid enhances the differentiation of adipose-derived stem cells to keratocytes in vitro. Trans Vis Sci Technol. 2017;6(1):6. doi:10.1167/tvst.6.1.6.
  • Long CJ, Roth MR, Tasheva ES, Funderburgh ML, Smit R, Conrad GW, Funderburgh JL. Fibroblast growth factor-2 promotes keratan sulfate proteoglycan expression by keratocytes in vitro. J Biol Chem. 2000;275(18):13918–23. doi:10.1074/jbc.275.18.13918.
  • Jester JV, Barry-Lane P, Cavanagh HD, Petroll WM. Induction of smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes. Cornea. 1996;505–16. doi:10.1097/00003226-199609000-00011.
  • Etheredge L, Kane BP, Hassell JR. The effect of growth factor signaling on keratocytes in vitro and its relationship to the phases of stromal wound repair. Invest Ophthalmol Vis Sci. 2009;50(7):3128–36. doi:10.1167/iovs.08-3077.
  • Jester JV, Ho-Chang J. Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control in vitro contractility and extracellular matrix contraction. Exp Eye Res. 2003;77(5):581–92. doi:10.1016/s0014-4835(03)00188-x.
  • Chen J, Guerriero E, Sado Y, Sundarraj N. Rho-mediated regulation of TGF-beta1-and FGF-2-induced activation of corneal stromal keratocytes. Invest Ophthalmol Vis Sci. 2009;50(8):3662–70. doi:10.1167/iovs.08-3276.
  • Chen J, Wong-Chong J, SundarRaj N. FGF-2- and TGF-β1-induced downregulation of lumican and keratocan in activated corneal keratocytes by JNK signaling pathway. Invest Ophthalmol Vis Sci. 2011;52(12):8957–64. doi:10.1167/iovs.11-8078.
  • Toti P, Tosi GM, Traversi C, Schürfeld K, Cardone C, Caporossi A. CD-34 stromal expression pattern in normal and altered human corneas. Ophthalmology. 2002;109(6):1167–71. doi:10.1016/s0161-6420(02)01042-4.
  • Kim W-J, Mohan RR, Mohan RR, Wilson SE. Effect of PDGF, IL-la, and BMP2/4 on corneal fibroblast chemotaxis: expression of the platelet derived growth factor system in the cornea. Invest Ophthalmol Vis Sci. 1999;40:1364–72.
  • Hoppenreijs VPT, Pels E, Vrensen GFJM, Felten PC, Treffers WF. Platelet-derived growth factor: receptor expression in corneas and effects on corneal cells. Invest Ophthalmol Vis Sci. 1993;34:637–49.
  • Kim A, Lakshman N, Karamichos D, Petroll WM. Growth factor regulation of corneal keratocyte differentiation and migration in compressed collagen matrices. Invest Ophthalmol Vis Sci. 2010;51(2):864. doi:10.1167/iovs.09-4200.
  • Kamiyama K, Iguchi I, Wang X, Imanishi J. Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells. Cornea. 1998;17(3):315–25. doi:10.1097/00003226-199805000-00013.
  • Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. J Cell Sci. 2004;117:4619–28. doi:10.1242/jcs.01481.
  • Jiménez C, Portela RA, Mellado M, Rodríguez-Frade JM, Collard J, Serrano A, Martínez AC, Avila J, Carrera AC. Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J Cell Biol. 2000;151(2):249–62. doi:10.1083/jcb.151.2.249.
  • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;414(6865):799–806. doi:10.1038/414799a.
  • LeRoith D, Roberts CT. The insulin-like growth factor system and cancer. Cancer Lett. 2003;195(2):127–37. doi:10.1016/s0304-3835(03)00159-9.
  • Haeusler RA, McGraw TE, Accili D. Biochemical and cellular properties of insulin receptor signalling. Nat Rev Mol Cell Biol. 2017;19(1):31–44. doi:10.1038/nrm.2017.89.
  • Yanai R, Yamada N, Kugimiya N, Inui M, Nishida T. Mitogenic and antiapoptotic effects of various growth factors on human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2002;43:2122–26.
  • Sarenac T, Trapecar M, Gradisnik L, Rupnik MS, Pahor D. Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in human keratocytes in vitro. Sci Rep. 2016;6(1):34373. doi:10.1038/srep34373.
  • Parsons WJ, Ramkumar V, Stiles GL. Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi. Mol Pharmacol. 1988;34:37–41.
  • Foster JW, Gouveia RM, Connon CJ. Low-glucose enhances keratocyte-characteristic phenotype from corneal stromal cells in serum-free conditions. Sci Rep. 2015;5:10839. doi:10.1038/srep10839.
  • Andresen JL, Ledet T, Ehlers N. Keratocyte migration and peptide growth factors: the effect of PDGF, bFGF, EGF, IGF-I, aFGF and TGF-beta on human keratocyte migration in a collagen gel. Curr Eye Res. 1997;16(6):605–13. doi:10.1076/ceyr.16.6.605.5081.
  • West-Mays JA, Cook JR, Sadow PM, Mullady DK, Bargagna-Mohan P, Strissel KJ, Fini ME. Differential inhibition of collagenase and interleukin-l a gene expression in cultured corneal fibroblasts by TGF-b, dexamethasone, and retinoic acid. Invest Ophthalmol Vis Sci. 1999;40:887–96.
  • Massagué J, Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. The EMBO Journal. 2000;19(8):1745–1754. doi:10.1093/emboj/19.8.1745.
  • Rønnov-Jessen L, Petersen OW. A function for filamentous α-smooth muscle actin: retardation of motility in fibroblasts. J Cell Biol. 1996;134(1):67–80. doi:10.1083/jcb.134.1.67.
  • Karamichos D, Hutcheon AEK, Zieske JD. Reversal of fibrosis by TGF-β3 in a 3D in vitro model. Exp Eye Res. 2014;124:31–36. doi:10.1016/j.exer.2014.04.020.
  • Karamichos D, Hutcheon AEK, Zieske JD. Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model. J Tissue Eng Regen Med. 2011;5:228–38. doi:10.1016/j.exer.2014.04.020.
  • Sriram S, Tran JA, Guo X, Hutcheon AEK, Lei H, Zieske JD. PDGFR a is a key regulator of T1 and T3’s differential effect on SMA expression in human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2017;58:1179–86. doi:10.1167/iovs.16-20016.
  • Lakshman N, Petroll WM. Growth factor regulation of corneal keratocyte mechanical phenotypes in 3-D collagen matrices. Invest Ophthalmol Vis Sci. 2012;53(3):1077–86. doi:10.1167/iovs.11-8609.
  • Wilson SE, Mohan RR, Mohan RR, Ambrósio R, Hong J, Lee J. The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res. 2001;20(5):625–37. doi:10.1016/S1350-9462(01)00008-8.