311
Views
6
CrossRef citations to date
0
Altmetric
Cornea

The Evaluation of TUNEL, PCNA and SOX2 Expressions in Lens Epithelial Cells of Cataract Patients with Pseudoexfoliation Syndrome

ORCID Icon & ORCID Icon
Pages 12-16 | Received 04 Feb 2019, Accepted 11 Aug 2019, Published online: 27 Aug 2019

References

  • Elhawy E, Kamthan G, Dong CQ, Danias J. Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations. Hum Genomics. 2012;6(1):22. doi:10.1186/1479-7364-6-22.
  • Schlötzer-Schrehardt U, Naumann GO. Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol. 2006;141(5):921–37. doi:10.1016/j.ajo.2006.01.047.
  • Ghosh M, Speakman JS. The origin of senile lens exfoliation. Can J Ophthalmol. 1983;18:340–43.
  • Kurowska AK, Kamińska A, Izdebska J, Szaflik JP, Szaflik J. Pseudoexfoliation syndrome (PEX)–a systemic disorder. Klin Oczna. 2009;111:160–64.
  • Mccarty CA, Taylor HR. Pseudoexfoliation syndrome in Australian adults. Am J Ophthalmol. 2000;129(5):629–33. doi:10.1016/S0002-9394(99)00466-3.
  • Ringvold A. Epidemiology of glaucoma in northern Europe. Eur J Ophthalmol. 1996;6(1):26–29. doi:10.1177/112067219600600107.
  • Jonasson F, Damji KF, Arnarsson A, Sverrisson T, Wang L, Sasaki H, Sasaki K. Prevalence of open-angle glaucoma in Iceland: Reykjavik eye study. Eye (Lond). 2003 Aug;17(6):747–53. doi:10.1038/sj.eye.6700374.
  • Tetsumoto K, Schlötzer-Schrehardt U, Küchle M, Dörfler S, Naumann GO. Precapsular layer of the anterior lens capsule in early pseudoexfoliation syndrome. Graefes Arch Clin Exp Ophthalmol. 1992;230:252–57.
  • Yan Q, Liu JP, Li DW. Apoptosis in lens development and pathology. Differentiation. 2006;74(5):195–211. doi:10.1111/j.1432-0436.2006.00068.x.
  • Martinez G, De Iongh RU. The lens epithelium in ocular health and disease. Int J Biochem Cell Biol. 2010;42(12):1945–63. doi:10.1016/j.biocel.2010.09.012.
  • Stadelmann C, Lassmann H. Detection of apoptosis in tissue sections. Cell Tissue Res. 2000;301(1):19–31. doi:10.1007/s004410000203.
  • Osnes-Ringen Ø, Berg KH, Moe MC, Zetterström C, Røger M, Nicolaissen B. Cell death pattern in lens epithelium of cataract patients. Acta Ophthalmol. 2016;94(5):514–20. doi:10.1111/aos.13009.
  • Spector A, Wang GM, Wang RR, Li WC, Kuszak JR. A brief photochemically induced oxidative insult causes irreversible lens damage and cataract. I: transparency and epithelial cell layer. Exp Eye Res. 1995;60(5):471–81. doi:10.1016/S0014-4835(05)80062-4.
  • Takamura Y, Kubo E, Tsuzuki S, Akagi Y. Apoptotic cell death in the lens epithelium of rat sugar cataract. Exp Eye Res. 2003;77(1):51–57. doi:10.1016/S0014-4835(03)00083-6.
  • Bhat SP. The ocular lens epithelium. Biosci Rep. 2001;21(4):537–63. doi:10.1023/A:1017952128502.
  • Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature. 2007;448(7151):313–17. doi:10.1038/nature05934.
  • Uchikawa M, Kamachi Y, Kondoh H. Two distinct subgroups of group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken. Mech Dev. 1999;84(1–2):103–20. doi:10.1016/S0925-4773(99)00083-0.
  • Vorkauf M, Duncker G, Nölle B, Sterry W. Adhesion molecules in normal human conjunctiva. An immunohistological study using monoclonal antibodies. Graefes Arch Clin Exp Ophthalmol. 1993;231:323–30.
  • Streeten BW, Li ZY, Wallace RN, Eagle RC Jr, Keshgegian AA. Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol. 1992;110(12):1757–62. doi:10.1001/archopht.1992.01080240097039.
  • Zhang Y, Jiang W, Xie Z, Wu W, Zhang D. Vitamin E and risk of age-related cataract: a meta-analysis. Public Health Nutr. 2015;18(15):2804–14. doi:10.1017/S1368980014003115.
  • Machan CM, Hrynchak PK, Irving EL. Age-related cataract is associated with type 2 diabetes and statin use. Optom Vis Sci. 2012;89(8):1165–71. doi:10.1097/OPX.0b013e3182644cd1.
  • Brennan LA, Kantorow M. Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations. Exp Eye Res. 2009;88(2):195–203. doi:10.1016/j.exer.2008.05.018.
  • Palsamy P, Bidasee KR, Ayaki M, Augusteyn RC, Chan JY, Shinohara T. Methylglyoxal induces endoplasmic reticulum stres and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts. Free Radic Biol Med. 2014;72:134–48. doi:10.1016/j.freeradbiomed.2014.04.010.
  • Harocopos GJ, Alvares KM, Kolker AE, Beebe DC. Human age-related cataract and lens epithelial cell death. Invest Ophthalmol Vis Sci. 1998;39:2696–706.
  • Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science. 1993;262(5137):1274–77. doi:10.1126/science.8235659.
  • Majima K, Itonaga K, Yamamoto N, Marunochi T. Localization of cell apoptosis in the opaque portion of anterior polar cataract and anterior capsulotomy margin. Ophthalmologica. 2003;217(3):215–18. doi:10.1159/000068971.
  • Mihara E, Miyata H, Nagata M, Ohama E. Lens epithelial cell damage and apoptosis in atopic cataract. Histopathological and immunohistochemical studies. Jpn J Ophthalmol. 2000;44(6):695–96. doi:10.1016/S0021-5155(00)00264-1.
  • Andersson M, Honarvar A, Sjöstrand J, Peterson A, Karlsson JO. Decreased caspase-3 activity in human lens epithelium from posterior subcapsular cataracts. Exp Eye Res. 2003;76(2):175–82. doi:10.1016/S0014-4835(02)00283-X.
  • Takamura Y, Sugimoto Y, Kubo E, Takahashi Y, Akagi Y. Immunohistochemical study of apoptosis of lens epithelial cells in human and diabetic rat cataracts. Jpn J Ophthalmol. 2001;45(6):559–63. doi:10.1016/S0021-5155(01)00418-X.
  • Oltulu P, Oltulu R. The Association of Cataract and Lens Epithelial Cell Apoptosis in Patients with Pseudoexfoliation Syndrome. Curr Eye Res. 2018 Mar;43(3):300–303.
  • Fan H, Suzuki T, Ogata M, Nakagawa Y, Onouchi H, Kawai K. Expression of PCNA,ICAM-1, and vimentin in lens epithelial cells of cataract patients with and without type 2 diabetes. Tokai J Exp Clin Med. 2012;37:51–56.
  • Seomun Y, Kim JT, Kim HS, Park JY, Joo CK. Induction of p21Cip1-mediated G2/M arrest in H2O2-treated lens epithelial cells. Mol Vis. 2005;11:764–74.
  • Tanito M, Kaidzu S, Takai Y, Ohira A. Status of systemic oxidative stresses in patients with primary open-angle glaucoma and pseudoexfoliation syndrome. PLoS One. 2012;7(11):e49680. doi:10.1371/journal.pone.0049680.
  • Spector A. Oxidative stress-induced cataract: mechanism of action. Faseb J. 1995;9(12):1173–82. doi:10.1096/fasebj.9.12.7672510.
  • Spector A, Garner WH. Hydrogen peroxide and human cataract. Exp Eye Res. 1981;33(6):673–81. doi:10.1016/S0014-4835(81)80107-8.
  • Zhou M, Leiberman J, Xu J, Lavker RM. A hierarchy of proliferative cells exists in mouse lens epithelium: implications for lens maintenance. Invest Ophthalmol Vis Sci. 2006;47(7):2997–3003. doi:10.1167/iovs.06-0130.
  • Fu Q, Qin Z, Yu J, Yu Y, Tang Q, Lyu D, Zhang L, Chen Z, Yao K. Effects of senescent lens epithelial cells on the severity of age-related cortical cataract in humans: a case-control study. Medicine (Balt). 2016;95(25):e3869. doi:10.1097/MD.0000000000003869.
  • López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194–217. doi:10.1016/j.cell.2013.05.039.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.