Liraglutide Up-regulation Thioredoxin Attenuated Müller Cells Apoptosis in High Glucose by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

References

• Karadeniz S. Diabetic retinopathy: from evidence and promise to real life observations. Diabetes Res Clin Pract. 2017;124:102–04. doi:10.1016/j.diabres.2017.01.018.
   PubMed Web of Science ®Google Scholar
• Tang L, Zhang Y, Jiang Y, Willard L, Ortiz E, Wark L, Medeiros D, Lin D. Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes. Adv Exp Med Biol. 2011;236(9):1051–63. doi:10.1258/ebm.2011.010400.
   Web of Science ®Google Scholar
• Sugimoto M, Sasoh M, Ido M, Wakitani Y, Takahashi C, Uji Y. Detection of early diabetic change with optical coherence tomography in type 2 diabetes mellitus patients without retinopathy. Ophthalmologica. 2005;219(6):379–85. doi:10.1159/000088382.
   PubMed Web of Science ®Google Scholar
• Kim J, Kim J, Park J, Lee S, Kim W, Yu Y, Kim K. Blood-neural barrier intercellular communication atglio-vascular interface. J Biochem Mol Biol. 2006;39(4):339–45. doi:10.5483/bmbrep.2006.39.4.339.
   PubMedGoogle Scholar
• Kuhrt H, Wurm A, Karl A, Iandiev I, Wiedemann P, Reichenbach A, Bringmann A, Pannicke T. Müller cell gliosis in retinal organ culture mimics gliotic alterations after ischemia in vivo. Int J Dev Neurosci. 2008;26(7):745–51. doi:10.1016/j.ijdevneu.2008.07.003.
   PubMed Web of Science ®Google Scholar
• Verma A, Rani P, Raman R, Pal S, Laxmi G, Gupta M, Sahu C, Vaitheeswaran K, Sharma T. Is neuronal dysfunction an early sign of diabetic retinopathy Microperimetry and spectral domain optical coherence tomography (SD-OCT) study in individuals with diabetes, but no diabetic retinopathy. Eye Vis (London). 2009;23(9):1824–30. doi:10.1038/eye.2009.184.
   PubMed Web of Science ®Google Scholar
• Boynton G, Stem M, Kwark L, Jackson G, Farsiu S, Gardner T. Multimodal characterization of proliferative diabetic retinopathy reveals alterations in outer retinal function and structure. Ophthalmology. 2015;122(5):957–67. doi:10.1016/j.ophtha.2014.12.001.
   PubMed Web of Science ®Google Scholar
• Barber A, Antonetti D, Gardner T. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State retina research group. Invest Ophthalmol Visual Sci. 2000;41:3561–68.
   PubMed Web of Science ®Google Scholar
• Pannicke T, Iandiev I, Wurm A, Uckermann O, Vom Hagen F, Reichenbach A, Wiedemann P, Hammes HP, Bringmann A. Diabetes alters osmotic swelling characteristics and membrane conductance of glial cells in rat retina. Diabetes. 2006;55(3):633–39. doi:10.2337/diabetes.55.03.06.db05-1349.
   PubMed Web of Science ®Google Scholar
• Lieth E, Barber A, Xu B, Dice C, Ratz M, Tanase D, Strother J. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State retina research group. Diabetes. 1998;47:815–20. doi:10.2337/diabetes.47.5.815.
   PubMed Web of Science ®Google Scholar
• Xu G, Kaneto H, Laybutt D, Duvivier-Kali V, Trivedi N, Suzuma K, King G, Weir G, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007;56(6):1551–58. doi:10.2337/db06-1033.
   PubMed Web of Science ®Google Scholar
• Malendowicz L, Macchi C, Nussdorfer G, Nowak K, Zyterska A, Ziolkowska A. Effects of prolonged exendin-4 administration on entero-insular axis of normal and streptozotocin-induced diabetic rats. Int J Mol Med. 2003;11:763–66.
   PubMed Web of Science ®Google Scholar
• Baggio L, Drucker D. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132(6):2131–57. doi:10.1053/j.gastro.2007.03.054.
   PubMed Web of Science ®Google Scholar
• Willard F, Sloop K. Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor. Diabetes Res Clin Pract. 2012;2012:470851.
   Google Scholar
• Iepsen E, Torekov S, Holst J. Liraglutide for type 2 diabetes and obesity: a 2015 update. Expert Rev Cardiovasc Ther. 2015;13(7):753–67. doi:10.1586/14779072.2015.1054810.
   PubMed Web of Science ®Google Scholar
• Wang J, Wang C, Li S, Li W, Yuan G, Pan Y, Chen H. Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway. Biomed Pharmacother. 2017;95:1669–77. doi:10.1016/j.biopha.2017.09.104.
   PubMed Web of Science ®Google Scholar
• Hernández C, Bogdanov P, Corraliza L, García-Ramírez M, Solà-Adell C, Arranz J, Arroba A, Valverde A, Simó R. Topical administration of GLP-1 receptor agonists prevents retinal neurodegeneration in experimental diabetes. Diabetes. 2016;65:172–87. doi:10.2337/db15-0443.
   PubMed Web of Science ®Google Scholar
• Wu Y, Tang L, Chen B. Oxidative stress: implications for the development of diabetic retinopathy and antioxidant therapeutic perspectives. Oxid Med Cell Longev. 2014;2014:752387. doi:10.1155/2014/752387.
   PubMed Web of Science ®Google Scholar
• Abhary S, Burdon KP, Laurie K, Thorpe S, Landers J, Goold L, Lake S, Petrovsky N, Craig J. Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility. Diabetes Care. 2010;33(8):1834–36. doi:10.2337/dc09-1893.
   PubMed Web of Science ®Google Scholar
• Huang J, Li X, Li M, Li J, Xiao W, Ma W, Chen X, Liang X, Tang S, Luo Y. Mitochondria targeted antioxidant peptide SS31 protects the retinas of diabetic rats. Curr Mol Med. 2013;13:936–45. doi:10.2174/15665240113139990049.
   Web of Science ®Google Scholar
• Ma J, Wang J, Zhang S. The unfolded protein response and diabetic retinopathy. J Diabetes Res. 2014;2014:160140. doi:10.1155/2014/160140.
   PubMed Web of Science ®Google Scholar
• Chevet E, Cameron P, Pelletier M. The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation. Curr Opin Struct Biol. 2001;11:120–24. doi:10.1016/S0959-440X(00)00168-8.
   PubMed Web of Science ®Google Scholar
• Oshitari T, Hata N, Yamamoto S. Endoplasmic reticulum stress and diabetic retinopathy. Vasc Health Risk Manag. 2008;4(1):115–22. doi:10.2147/VHRM.S2293.
   PubMedGoogle Scholar
• Hu W, Liu R, Pei H, Li B. Endoplasmic reticulum stress-related factors protect against diabetic retinopathy. Diabetes Res Clin Pract. 2012;2012:507986.
   Google Scholar
• Chen G, Li X, Huang M, Li M, Zhou X, Li Y, Bai J. Thioredoxin-1 increases survival in sepsis by inflammatory response through suppressing endoplasmic reticulum stress. Shock. 2016;46(1):67–74. doi:10.1097/SHK.0000000000000570.
   PubMed Web of Science ®Google Scholar
• Zhao X, Zhao J, Li X, Zhang Y, Jiao X. The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury. Acta Physiol Sinica. 2010;62:261–68.
   PubMedGoogle Scholar
• Masutani H, Ueda S, Yodoi J. The thioredoxin system in retroviral infection and apoptosis. Cell Death Differ. 2005;12(Suppl 1):991–98. doi:10.1038/sj.cdd.4401625.
   PubMed Web of Science ®Google Scholar
• Barber A. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Retin Eye Res. 2003;27:283–90.
   Google Scholar
• Zhou T, Che D, Lan Y, Fang Z, Xie J, Gong H, Li C, Feng J, Hong H, Qi W, et al. Mesenchymal marker expression is elevated in Müller Cells exposed to high glucose and in animal models of diabetic retinopathy. Oncotarget. 2017;8(3):4582–94. doi:10.18632/oncotarget.13945.
   PubMedGoogle Scholar
• Villarroel M, Ciudin A, Hernández C, Simó R. Neurodegeneration: an early event of diabetic retinopathy. World J Diabetes. 2010;1(2):57–64. doi:10.4239/wjd.v1.i2.57.
   PubMedGoogle Scholar
• Rungger-Brändle E, Dosso A, Leuenberger PM. Glial reactivity an early feature of diabetic retinopathy. Invest Ophthalmol Visual Sci. 2000;41:1971–80.
   PubMed Web of Science ®Google Scholar
• Vázquez-Carrera M. Unraveling the effects of ppar-β/δ on insulin resistance and cardiovascular disease. Trends Endocrinol Metab. 2016;27(5):319–34. doi:10.1016/j.tem.2016.02.008.
   PubMed Web of Science ®Google Scholar
• Lewis G, Fisher S. Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression. Int Rev Cytol. 2003;230:263–90.
   PubMed Web of Science ®Google Scholar
• Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov S, Osborne N, Reichenbach A. Müller cells in the healthy and diseased retina. Prog Retin Eye Res. 2006;25(4):397–424. doi:10.1016/j.preteyeres.2006.05.003.
   PubMed Web of Science ®Google Scholar
• Cai X, McGinnis J. Diabetic retinopathy: animal models,therapies,and perspectives. J Diabetes Res. 2016;2016:3789217. doi:10.1155/2016/3789217.
   PubMed Web of Science ®Google Scholar
• Yichao F, Kun L, Qingping W, Yuanyuan R, Wen Y. Exendin-4 protects retinal cells from early diabetes in Goto-Kakizaki rats by Increasing the Bcl-2/Bax and Bcl-Xl/Bax ratios and reducing reactive gliosis. Mol Vis. 2014;20:1557–68.
   PubMed Web of Science ®Google Scholar
• Bringmann A, Iandiev I, Pannicke T, Wurm A, Hollborn M, Wiedemann P, Osborne N, Reichenbach A. Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects. Prog Retin Eye Res. 2009;28(6):423–51. doi:10.1016/j.preteyeres.2009.07.001.
   PubMed Web of Science ®Google Scholar
• Harkavyi A, Abuirmeileh A, Lever R, Kingsbury A, Biggs C, Whitton P. Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson’s disease. J Neuroinflamm. 2008;5:19. doi:10.1186/1742-2094-5-19.
   PubMed Web of Science ®Google Scholar
• Perry T, Haughey N, Mattson M, Egan J, Greig N. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther. 2002;302(3):881–88. doi:10.1124/jpet.102.037481.
   PubMed Web of Science ®Google Scholar
• Kastin A, Akerstrom V. Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Relat Metab Disord. 2003;27:313–18. doi:10.1038/sj.ijo.0802206.
   PubMed Web of Science ®Google Scholar
• Kastin A, Akerstrom V, Pan W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J Mol Neurosci. 2002;18:7–14. doi:10.1385/JMN:18:1-2:07.
   PubMed Web of Science ®Google Scholar
• Holz G. Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor–mediated signal transduction in the pancreatic β-cell. Diabetes. 2004;53(1):5–13. doi:10.2337/diabetes.53.1.5.
   PubMed Web of Science ®Google Scholar
• Oeseburg H, deBoer R, Buikema H, vanderHarst P, vanGilst W, Silljé H. Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A. Arterioscl Throm Vas. 2010;30(7):1407–14. doi:10.1161/ATVBAHA.110.206425.
   Web of Science ®Google Scholar
• Fujita H, Morii T, Fujishima H, Sato T, Shimizu T, Hosoba M, Tsukiyama K, Narita T, Takahashi T, Drucker D, et al. The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential. Kidney Int. 2014;85(3):579–89. doi:10.1038/ki.2013.427.
   PubMed Web of Science ®Google Scholar
• Cerny O, Anderson K, Stephens L, Hawkins P, Sebo P. cAMP signaling of adenylate cyclase toxin blocks the oxidative burst of neutrophils through Epac-mediated inhibition of phospholipase C activity. J Immunol. 2017;198(3):1285–96. doi:10.4049/jimmunol.1601309.
   PubMed Web of Science ®Google Scholar
• Kong L, Zhou X, Li F, Yodoi J, McGinnis J, Cao W. Neuroprotective effect of overexpression of thioredoxin on photoreceptor degeneration in Tubby mice. Neurobiol Dis. 2010;38(3):446–55. doi:10.1016/j.nbd.2010.03.005.
   PubMed Web of Science ®Google Scholar
• Xu C, Yuan X, Pan Z, Shen G, Kim J. Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol Cancer Ther. 2006;5(8):1918–26. doi:10.1158/1535-7163.MCT-05-0497.
   PubMed Web of Science ®Google Scholar
• Copple I, Goldring C, Kitteringham N, Park B. The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity. Toxicol. 2008;246(1):24–33. doi:10.1016/j.tox.2007.10.029.
   PubMed Web of Science ®Google Scholar
• Lupachyk P, Watcho R, Stavniichuk H, Shevalye I, Obrosova G. Endoplasmic reticulum stress plays a key role in the pathogenesis of diabetic peripheral neuropathy. Diabetes. 2013;62:944–52. doi:10.2337/db12-0716.
   PubMed Web of Science ®Google Scholar