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Cornea

Development and Assessment of a Simulator for in Vivo Confocal Microscopy in Fungal and Acanthamoeba Keratitis

, , , , , , , & show all
Pages 1484-1489 | Received 22 Nov 2019, Accepted 09 May 2020, Published online: 29 Jun 2020

References

  • Flanagan B, Nestel D, Joseph M. Making patient safety the focus: crisis resource management in the undergraduate curriculum. Med Educ. 2004;38:56–66. doi:10.1046/j.1365-2923.2004.01701.x.
  • Cook D, Hatala R, Brydges R, Zendejas B, Szostek J, Wang A, Erwin P, Hamstra S. Technology-enhanced simulation for health professions education: a systematic review and meta-analysis. JAMA - J Am Med Assoc. 2011;306(9):978–88. doi:10.1001/jama.2011.1234.
  • Serna-Ojeda JC, Graue-Hernandez EO, Guzman-Salas PJ, Rodriguez-Loaiza JL. Simulation training in ophthalmology. Gac Med Mex. 2017;153:111–15.
  • Erie JC. Corneal wound healing after photorefractive keratectomy: a 3-year confocal microscopy study. Trans Am Ophthalmol Soc. 2003;101:293–333.
  • Kumar RL, Cruzat A, Hamrah P. Current state of in vivo confocal microscopy in management of microbial keratitis. Semin Ophthalmol. 2010;25(5–6):166–70. doi:10.3109/08820538.2010.518516.
  • Alomar TS, Al-Aqaba M, Gray T, Lowe J, Dua HS. Histological and confocal microscopy changes in chronic corneal edema: implications for endothelial transplantation. Investig Ophthalmol Vis Sci. 2011;52(11):8193–207. doi:10.1167/iovs.11-8047.
  • D V P, Zhang J, McGhee CN. In vivo confocal microscopy of the inflamed anterior segment: a review of clinical and research applications. Clin Exp Ophthalmol. 2019. doi:10.1111/ceo.13512.
  • Austin A, Lietman T, Rose-Nussbaumer J. Update on the management of infectious keratitis. Ophthalmology. 2017;124(11):1678–89. doi:10.1016/j.ophtha.2017.05.012.
  • Wang YE, Tepelus TC, Vickers LA, Baghdasaryan E, Gui W, Huang P, Irvine JA, Sadda S, Hsu HY, Lee OL. Role of in vivo confocal microscopy in the diagnosis of infectious keratitis. Int Ophthalmol. 2019:4. doi:10.1007/s10792-019-01134-4.
  • Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J. The persistent dilemma of microbial keratitis: global burden, diagnosis, and antimicrobial resistance. Surv Ophthalmol. 2019;64(3):255–71. doi:10.1016/j.survophthal.2018.12.003.
  • Vaddavalli PK, Garg P, Sharma S, Sangwan VS, Rao GN, Thomas R. Role of confocal microscopy in the diagnosis of fungal and acanthamoeba keratitis. Ophthalmology. 2011;118(1):29–35. doi:10.1016/j.ophtha.2010.05.018.
  • Tu EY, Joslin CE, Sugar J, Booton GC, Shoff ME, Fuerst PA. The relative value of confocal microscopy and superficial corneal scrapings in the diagnosis of Acanthamoeba keratitis. Cornea. 2008;27(7):764–72. doi:10.1097/ICO.0b013e31816f27bf.
  • Kanavi MR, Javadi M, Yazdani S, Mirdehghanm S. Sensitivity and specificity of confocal scan in the diagnosis of infectious keratitis. Cornea. 2007;26(7):782–86. doi:10.1097/ICO.0b013e318064582d.
  • Chidambaram JD, Prajna NV, Larke NL, Palepu S, Lanjewar S, Shah M, Elakkiya S, Lalitha P, Carnt N, Vesaluoma MH, et al. Prospective study of the diagnostic accuracy of the in vivo laser scanning confocal microscope for severe microbial keratitis. Ophthalmology. 2016;123(11):2285–93. doi:10.1016/j.ophtha.2016.07.009.
  • Elaine Wang Y, Tepelus T, Gui W,A, Irvine JL, Lee OY, Hsu H. Reduction of acanthamoeba cyst density associated with treatment detected by in vivo confocal microscopy in acanthamoeba keratitis. 2019. doi:10.1097/ICO.0000000000001857.
  • Daas L, Viestenz A, Schnabel PA, Fries FN, Hager T, Szentmáry N, Seitz B. Confocal microscopy as an early relapse marker for acanthamoeba keratitis. Clin Anat. 2018;31(1):60–63. doi:10.1002/ca.22925.
  • Lagali N, Bourghardt B, Germundsson J, Eden U, Danyali R, Rinaldo M, Fagerholm P. Laser-scanning in vivo confocal microscopy of the cornea: imaging and analysis methods for preclinical and clinical applications. In: Lagali N, editor. Confocal laser microscopy - principles and applications in medicine, biology, and the food sciences. 2013. p. 51–80. doi:10.5772/55216.
  • Petroll WM, Robertson DM. In vivo confocal microscopy of the cornea: new developments in image acquisition, reconstruction, and analysis using the HRT-rostock corneal module. Ocul Surf. 2015;13(3):187–203. doi:10.1016/j.jtos.2015.05.002.
  • Kheirkhah A, Satitpitakul V, Syed ZA, Müller R, Goyal S, Tu EY, Dana R. Factors influencing the diagnostic accuracy of laser-scanning in vivo confocal microscopy for acanthamoeba keratitis. Cornea. 2018;37(7):818–23. doi:10.1097/ICO.0000000000001507.
  • Alqahtani DA, Rotgans JI, Mamede S, Alalwan I, Magzoub MEM, Altayeb FM, Mohamedani MA, Schmidt HG. Does time pressure have a negative effect on diagnostic accuracy?. Acad Med. 2016;91(5):710–16. doi:10.1097/ACM.0000000000001098.
  • Hau SC, Dart JKG, Vesaluoma M, Parmar DN, Claerhout I, Bibi K, Larkin DFP. Diagnostic accuracy of microbial keratitis with in vivo scanning laser confocal microscopy. Br J Ophthalmol. 2010;94(8):982–87. doi:10.1136/bjo.2009.175083.
  • Kheirkhah A, Syed ZA, Satitpitakul V, Goyal S, Müller R, Tu EY, Dana R. Sensitivity and specificity of laser-scanning in vivo confocal microscopy for filamentous fungal keratitis: role of observer experience. Am J Ophthalmol. 2017;179:81–89. doi:10.1016/j.ajo.2017.04.011.
  • Roth M, Daas L, Renner-Wilde A, Cvetkova-Fischer N, Saeger M, Herwig-Carl M, Matthaei M, Fekete A, Kakkassery V, Walther G, et al. The German keratomycosis registry. Initial results of a multicenter survey. Das Deutsche Pilz-Keratitis-Register. Der Ophthalmol. 2019. doi:10.1007/s00347-019-0871-9.
  • Daas L, Szentmáry N, Eppig T, Langenbucher A, Hasenfus A, Roth M, Saeger M, Nölle B, Lippmann B, Böhringer D, et al. The German Acanthamoeba keratitis register: initial results of a multicenter study. Ophthalmologe. 2015 Apr;3:1–11.
  • Böhnke M. A new system for storing donor corneas. Klin Monbl Augenheilkd. 1991;198(2):135–37. doi:10.1055/s-2008-1045945.
  • Tavakoli M, Malik RA. Corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies. J Vis Exp. 2011;47:1–7. doi:10.3791/2194.
  • Pinnock A, Shivshetty N, Roy S, Rimmer S, Douglas I, MacNeil S, Garg P. Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis. Graefe’s Arch Clin Exp Ophthalmol. 2017;255(2):333–42. doi:10.1007/s00417-016-3546-0.
  • Guthoff RF, Zhivov A, Stachs O. In vivo confocal microscopy, an inner vision of the cornea - A major review. Clin Exp Ophthalmol. 2009;37(1):100–17. doi:10.1111/j.1442-9071.2009.02016.x.
  • Cook DA, Hamstra SJ, Brydges R, Zendejas B, Szostek JH, Wang AT, Erwin PJ, Hatala R. Comparative effectiveness of instructional design features in simulation-based education: systematic review and meta-analysis. Med Teach. 2013;35(1):e867–98. doi:10.3109/0142159X.2012.714886.
  • Samia H, Khan S, Lawrence J, Delaney CP. Simulation and its role in training. Clin Colon Rectal Surg. 2013;26(1):47–55. doi:10.1055/s-0033-1333661.

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