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Retina/Choroid

Downregulation of miR-146a-5p Inhibits Choroidal Neovascularization via the NF-κB Signaling Pathway by Targeting OTUD7B

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Pages 1514-1525 | Received 08 Dec 2019, Accepted 11 May 2020, Published online: 08 Jun 2020

References

  • Bourne RRA, Flaxman SR, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, et al. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis. Lancet Global Health. 2017;5(9):e888–e897. doi:10.1016/S2214-109X(17)30293-0.
  • Cheung LK, Eaton A. Age-related macular degeneration. Pharmacotherapy. 2013;33(8):838–55. doi:10.1002/phar.1264.
  • Tolentino M. Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease. Surv Ophthalmol. 2011;56(2):95–113. doi:10.1016/j.survophthal.2010.08.006.
  • Apte RS, Richter J, Herndon J, Ferguson TA. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med. 2006;3(8):e310. doi:10.1371/journal.pmed.0030310.
  • Zhang Q, Lenardo MJ, Baltimore D. 30 years of NF-kappaB: a blossoming of relevance to human pathobiology. Cell. 2017;168(1–2):37–57. doi:10.1016/j.cell.2016.12.012.
  • Kiriakidis S, Andreakos E, Monaco C, Foxwell B, Feldmann M, Paleolog E. VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2. J Cell Sci. 2003;116(Pt 4):665–74. doi:10.1242/jcs.00286.
  • Zhang B, Wang D, Ji T-F, Shi L, Yu J-L. Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model. Oncotarget. 2017;8:10.
  • Jo N, Ogata N, Aoki M, Otsuji T, Morishita R, Kaneda Y, Matsumura M. Effective transfection of a cis element “decoy” of the nuclear factor-kappaB binding site into the experimental choroidal neovascularization. Curr Eye Res. 2002;24(6):465–73. doi:10.1076/ceyr.24.6.465.8600.
  • Yodkeeree S, Pompimon W, Limtrakul P. Crebanine, an aporphine alkaloid, sensitizes TNF-alpha-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-kappaB-regulated gene products. Tumour Biol. 2014;35(9):8615–24. doi:10.1007/s13277-014-1998-6.
  • Karin M. Nuclear factor-κB in cancer development and progression. Nature. 2006;441(7092):431–36. doi:10.1038/nature04870.
  • Chen K, Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet. 2007;8(2):93–103. doi:10.1038/nrg1990.
  • Bartel DP. Metazoan MicroRNAs. Cell. 2018;173(1):20–51. doi:10.1016/j.cell.2018.03.006.
  • Bartel DP. MicroRNAs: genomics, Biogenesis, Mechanism, and Function. Cell. 2004;116(2):281–97. doi:10.1016/S0092-8674(04)00045-5.
  • Zhang P, Wang H, Luo X, Liu H, Lu B, Li T, Yang S, Gu Q, Li B, Wang F, et al. MicroRNA-155 inhibits polarization of macrophages to M2-type and suppresses choroidal neovascularization. Inflammation. 2018;41(1):143–53. doi:10.1007/s10753-017-0672-8.
  • Cai J, Yin G, Lin B, Wang X, Liu X, Chen X, Yan D, Shan G, Qu J, Wu S. Roles of NFkappaB-miR-29s-MMP-2 circuitry in experimental choroidal neovascularization. J Neuroinflammation. 2014;11(1):88. doi:10.1186/1742-2094-11-88.
  • Boldin MP, Taganov KD, Rao DS, Yang L, Zhao JL, Kalwani M, Garcia-Flores Y, Luong M, Devrekanli A, Xu J, et al. miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med. 2011;208(6):1189–201. doi:10.1084/jem.20101823.
  • Simanovich E, Brod V, Rahat MM, Rahat MA. Function of miR-146a-5p in tumor cells as a regulatory switch between cell death and angiogenesis: macrophage therapy revisited. Front Immunol. 2017;8:1931. doi:10.3389/fimmu.2017.01931.
  • Menard C, Rezende FA, Miloudi K, Wilson A, Tetreault N, Hardy P, SanGiovanni JP, De Guire V, Sapieha P. MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD. Oncotarget. 2016;7(15):19171–84. doi:10.18632/oncotarget.8280.
  • Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ. Isolation and characterization of two novel A20-like proteins. Biochem J. 2001;357(Pt 3):617–23. doi:10.1042/bj3570617.
  • Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, et al. OTUD7B controls non-canonical NF-kappaB activation through deubiquitination of TRAF3. Nature. 2013;494(7437):371–74. doi:10.1038/nature11831.
  • Enesa K, Zakkar M, Chaudhury H, Luong le A, Rawlinson L, Mason JC, Haskard DO, Dean JL, Evans PC. NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. J Biol Chem. 2008;283(11):7036–45. doi:10.1074/jbc.M708690200.
  • Song L, Lin C, Gong H, Wang C, Liu L, Wu J, Tao S, Hu B, Cheng SY, Li M, et al. miR-486 sustains NF-kappaB activity by disrupting multiple NF-kappaB-negative feedback loops. Cell Res. 2013;23(2):274–89. doi:10.1038/cr.2012.174.
  • Sagara N, Kawaji T, Takano A, Inomata Y, Inatani M, Fukushima M, Tanihara H. Effect of pitavastatin on experimental choroidal neovascularization in rats. Exp Eye Res. 2007;84(6):1074–80. doi:10.1016/j.exer.2007.02.005.
  • Agarwal V, Bell GW, Nam JW, Bartel DP. Predicting effective microRNA target sites in mammalian mRNAs. Elife. 2015;4:e05005.
  • Lee SHS, Kim HJ, Shin OK, Choi JS, Kim J, Cho YH, Ha J, Park TK, Lee JY, Park K, et al. Intravitreal Injection of AAV expressing soluble VEGF receptor-1 variant induces anti-VEGF activity and suppresses choroidal neovascularization. Invest Ophthalmol Vis Sci. 2018;59(13):5398–407. doi:10.1167/iovs.18-24926.
  • Caicedo A, Espinosa-Heidmann DG, Pina Y, Hernandez EP, Cousins SW. Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. Exp Eye Res. 2005;81(1):38–47. doi:10.1016/j.exer.2005.01.013.
  • Xie P, Zhang W, Yuan S, Chen Z, Yang Q, Yuan D, Wang F, Liu Q. Suppression of experimental choroidal neovascularization by curcumin in mice. PLoS One. 2012;7(12):e53329. doi:10.1371/journal.pone.0053329.
  • Lai K, Xu L, Jin C, Wu K, Tian Z, Huang C, Zhong X, Ye H. Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) inhibits experimental choroidal neovascularization in vivo and VEGF-induced cell migration and tube formation in vitro. Invest Ophthalmol Vis Sci. 2011;52(8):5702–12. doi:10.1167/iovs.10-6370.
  • Krause TA, Alex AF, Engel DR, Kurts C, Eter N. VEGF-production by CCR2-dependent macrophages contributes to laser-induced choroidal neovascularization. PLoS One. 2014;9(4):e94313. doi:10.1371/journal.pone.0094313.
  • Sakurai E, Taguchi H, Anand A, Ambati BK, Gragoudas ES, Miller JW, Adamis AP, Ambati J. Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44(6):2743–49. doi:10.1167/iovs.02-1246.
  • Choudhuri S, Chowdhury IH, Das S, Dutta D, Saha A, Sarkar R, Mandal LK, Mukherjee S, Bhattacharya B. Role of NF-kappaB activation and VEGF gene polymorphisms in VEGF up regulation in non-proliferative and proliferative diabetic retinopathy. Mol Cell Biochem. 2015;405(1–2):265–79. doi:10.1007/s11010-015-2417-z.
  • Harada M, Morimoto K, Kondo T, Hiramatsu R, Okina Y, Muko R, Matsuda I, Kataoka T. Quinacrine inhibits ICAM-1 transcription by blocking DNA binding of the NF-kappaB subunit p65 and sensitizes human lung adenocarcinoma A549 cells to TNF-alpha and the Fas Ligand. Int J Mol Sci. 2017;18:12. doi:10.1167/iovs.19-27493.
  • Sung IS, Park SY, Jeong KY, Kim HM. Investigation of the preventive effect of calcium on inflammation-mediated choroidal neovascularization. Life Sci. 2019;233:116727. doi:10.1016/j.lfs.2019.116727.
  • Shi JH, Sun SC. Tumor necrosis factor receptor-associated factor regulation of nuclear factor kappaB and mitogen-activated protein kinase pathways. Front Immunol. 2018;9:1849. doi:10.3389/fimmu.2018.01849.
  • McNally RS, Davis BK, Clements CM, Accavitti-Loper MA, Mak TW, Ting JP. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J Biol Chem. 2011;286(6):4098–106. doi:10.1074/jbc.M110.147371.
  • Li Y, Zhao L, Shi B, Ma S, Xu Z, Ge Y, Liu Y, Zheng D, Shi J. Functions of miR-146a and miR-222 in tumor-associated macrophages in breast cancer. Sci Rep. 2015;5(1):18648. doi:10.1038/srep18648.
  • Huang C, Liu XJ, QunZhou XJ, Ma TT, Meng XM, Li J. MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264.7 macrophages. Int Immunopharmacol. 2016;32:46–54. doi:10.1016/j.intimp.2016.01.009.
  • Zhou YX, Zhao W, Mao LW, Wang YL, Xia LQ, Cao M, Shen J, Chen J. Long non-coding RNA NIFK-AS1 inhibits M2 polarization of macrophages in endometrial cancer through targeting miR-146a. Int J Biochem Cell Biol. 2018;104:25–33. doi:10.1016/j.biocel.2018.08.017.
  • Yang Y, Liu F, Tang M, Yuan M, Hu A, Zhan Z, Li Z, Li J, Ding X, Lu L. Macrophage polarization in experimental and clinical choroidal neovascularization. Sci Rep. 2016;6(1):30933. doi:10.1038/srep30933.
  • Xu N, Bo Q, Shao R, Liang J, Zhai Y, Yang S, Wang F, Sun X. Chitinase-3-Like-1 promotes M2 macrophage differentiation and induces choroidal neovascularization in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2019;60:4596–605.

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