Diagnosis of Dry Eye Disease Using Principal Component Analysis: A Study in Animal Models of the Disease

References

• Goren MB, Goren SB. Diagnostic tests in patients with symptoms of keratoconjunctivitis sicca. Am J Ophthalmol. 1988;106(5):570–74. doi:10.1016/0002-9394(88)90587-9.
   PubMed Web of Science ®Google Scholar
• Lucca JA, Nunez JN, Farris RL. A comparison of diagnostic tests for keratoconjunctivitis sicca: lactoplate, schirmer, and tear osmolarity. Clao J. 1990;16:109–12.
   PubMedGoogle Scholar
• Farris RL, Stuchell RN, Mandel ID. Basal and reflex human tear analysis. I. Physical measurements: osmolarity, basal volumes, and reflex flow rate. Ophthalmology. 1981;88(8):852–57. doi:10.1016/S0161-6420(81)34939-2.
   PubMed Web of Science ®Google Scholar
• van Bijsterveld OP. Diagnostic tests in the sicca syndrome. Arch Ophthalmol. 1969;82(1):10–14. doi:10.1001/archopht.1969.00990020012003.
   PubMedGoogle Scholar
• Vitali C, Moutsopoulos HM, Bombardieri S. The european community study group on diagnostic criteria for sjogren’s syndrome. Sensitivity and specificity of tests for ocular and oral involvement in sjogren’s syndrome. Ann Rheum Dis. 1994;53(10):637–47. doi:10.1136/ard.53.10.637.
   PubMed Web of Science ®Google Scholar
• Farris RL. Tear osmolarity–a new gold standard? Adv Exp Med Biol. 1994;350:495–503.
   PubMedGoogle Scholar
• Tomlinson A, Khanal S, Ramaesh K, Diaper C, McFadyen A. Tear film osmolarity: determination of a referent for dry eye diagnosis. Invest Ophthalmol Vis Sci. 2006;47(10):4309–15. doi:10.1167/iovs.05-1504.
   PubMed Web of Science ®Google Scholar
• Methodologies to diagnose and monitor dry eye disease: report of the diagnostic methodology subcommittee of the international dry eye workshop (2007). Ocul Surf. 2007;5(2):108–52. doi:10.1016/S1542-0124(12)70083-6.
   PubMed Web of Science ®Google Scholar
• Jolliffe IT, Cadima J. Principal component analysis: A review and recent developments. Philos Trans A Math Phys Eng Sci. 2016;374:20150202.
   PubMed Web of Science ®Google Scholar
• Ringner M. What is principal component analysis? Nat Biotechnol. 2008;26(3):303–04. doi:10.1038/nbt0308-303.
   PubMed Web of Science ®Google Scholar
• Abdi H, Williams LJ. Principal components analysis. Wiley Interdiscip Rev Comput Stat. 2010;2:433–50. doi:10.1002/wics.101.
   Google Scholar
• Cohenford MA, Rigas B. Cytologically normal cells from neoplastic cervical samples display extensive structural abnormalities on ir spectroscopy: implications for tumor biology. Proc Natl Acad Sci U S A. 1998;95(26):15327–32. doi:10.1073/pnas.95.26.15327.
   PubMed Web of Science ®Google Scholar
• Cohenford MA, Lim S, Brown C, Chaudhry MA, Sigdel S, Beckelhimer E, Rigas B. Ft-ir microspectroscopy of mouse colon tissues: insight into the chemistry of carcinogenesis and diagnostic potential. Am J Pathol. 2012;181(6):1961–68. doi:10.1016/j.ajpath.2012.08.039.
   PubMed Web of Science ®Google Scholar
• Giuliani A. The application of principal component analysis to drug discovery and biomedical data. Drug Discov Today. 2017;22(7):1069–76. doi:10.1016/j.drudis.2017.01.005.
   PubMed Web of Science ®Google Scholar
• Honkanen R, Huang W, Huang L, Kaplowitz K, Weissbart S, Rigas B. A new rabbit model of chronic dry eye disease induced by complete surgical dacryoadenectomy. Curr Eye Res. 2019;44(8):863–72. doi:10.1080/02713683.2019.1594933.
   PubMed Web of Science ®Google Scholar
• Honkanen RA, Huang L, Xie G, Rigas B. Phosphosulindac is efficacious in an improved concanavalin a-based rabbit model of chronic dry eye disease. Transl Res. 2018;198:58–72. doi:10.1016/j.trsl.2018.04.002.
   PubMed Web of Science ®Google Scholar
• Honkanen R, Huang W, Huang L, Kaplowitz K, Weissbart S, Rigas B. A new rabbit model of chronic dry eye disease induced by complete surgical dacryoadenectomy. Curr Eye Res. 2019;in press:1–10.
   Web of Science ®Google Scholar
• Bhattacharya D, Ning Y, Zhao F, Stevenson W, Chen R, Zhang J, Wang M. Tear production after bilateral main lacrimal gland resection in rabbits. Invest Ophthalmol Vis Sci. 2015;56(13):7774–83. doi:10.1167/iovs.15-17550.
   PubMed Web of Science ®Google Scholar
• Destruel PL, Zeng N, Maury M, Mignet N, Boudy V. In vitro and in vivo evaluation of in situ gelling systems for sustained topical ophthalmic delivery: state of the art and beyond. Drug Discov Today. 2016;22(4):638–651.
   PubMed Web of Science ®Google Scholar
• Zheng W, Ma M, Du E, Zhang Z, Jiang K, Gu Q, Ke B. Therapeutic efficacy of fibroblast growth factor 10 in a rabbit model of dry eye. Mol Med Rep. 2015;12(5):7344–50. doi:10.3892/mmr.2015.4368.
   PubMed Web of Science ®Google Scholar
• Nagelhout TJ, Gamache DA, Roberts L, Brady MT, Yanni JM. Preservation of tear film integrity and inhibition of corneal injury by dexamethasone in a rabbit model of lacrimal gland inflammation-induced dry eye. J Ocul Pharmacol Ther. 2005;21(2):139–48. doi:10.1089/jop.2005.21.139.
   PubMed Web of Science ®Google Scholar
• Honkanen RA, Huang L, Rigas B. A rabbit model of aqueous-deficient dry eye disease induced by concanavalin a injection into the lacrimal glands: application to drug efficacy studies. J Vis Exp. 2020;155.
   Google Scholar
• Honkanen RA, Huang L, Huang W, Rigas B. Establishment of a severe dry eye model using complete dacryoadenectomy in rabbits. J Vis Exp. 2019; Submitted.
   Web of Science ®Google Scholar
• Bron AJ, Evans VE, Smith JA. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea. 2003;22(7):640–50. doi:10.1097/00003226-200310000-00008.
   PubMed Web of Science ®Google Scholar
• Savini G, Prabhawasat P, Kojima T, Grueterich M, Espana E, Goto E. The challenge of dry eye diagnosis. Clin Ophthalmol. 2008;2(1):31–55. doi:10.2147/OPTH.S1496.
   PubMedGoogle Scholar
• Lemp MA. Report of the national eye institute/industry workshop on clinical trials in dry eyes. Clao J. 1995;21:221–32.
   PubMedGoogle Scholar
• Cerny BA, Kaiser HF. A study of a measure of sampling adequacy for factor-analytic correlation matrices. Multivariate Behav Res. 1977;12(1):43–47. doi:10.1207/s15327906mbr1201_3.
   PubMed Web of Science ®Google Scholar
• Doughty MJ. Rose bengal staining as an assessment of ocular surface damage and recovery in dry eye disease-a review. Cont Lens Anterior Eye. 2013;36(6):272–80. doi:10.1016/j.clae.2013.07.008.
   PubMed Web of Science ®Google Scholar
• Khan-Lim D, Berry M. Still confused about rose bengal? Curr Eye Res. 2004;29(4–5):311–17. doi:10.1080/02713680490516864.
   PubMed Web of Science ®Google Scholar
• Tsubota K, Kaido M, Yagi Y, Fujihara T, Shimmura S. Diseases associated with ocular surface abnormalities: the importance of reflex tearing. Br J Ophthalmol. 1999;83(1):89–91. doi:10.1136/bjo.83.1.89.
   PubMed Web of Science ®Google Scholar
• Lemp MA. Recent developments in dry eye management. Ophthalmology. 1987;94(10):1299–304. doi:10.1016/S0161-6420(87)80015-5.
   PubMed Web of Science ®Google Scholar