1,333
Views
4
CrossRef citations to date
0
Altmetric
Retina/Optic Nerve

Compromised Blood Flow in the Optic Nerve Head after Systemic Administration of Aldosterone in Rats: A Possible Rat Model of Retinal Ganglion Cell Loss

, , , , &
Pages 777-785 | Received 29 Oct 2021, Accepted 10 Jan 2022, Published online: 21 Mar 2022

References

  • Zhao M, Célérier I, Bousquet E, Jeanny JC, Jonet L, Savoldelli M, Offret O, Curan A, Farman N, Jaisser F, et al. Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy. J Clin Invest. 2012;122(7):2672–2679.
  • Zhao M, Valamanesh F, Celerier I, Savoldelli M, Jonet L, Jeanny JC, Jaisser F, Farman N, Behar-Cohen F. The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in Müller glial cells. FASEB J. 2010;24(9):3405–3415.
  • Allingham MJ, Tserentsoodol N, Saloupis P, Mettu PS, Cousins SW. Aldosterone exposure causes increased retinal edema and severe retinopathy following laser-induced retinal vein occlusion in mice. Invest Ophthalmol Vis Sci. 2018;59(8):3355–3365.
  • Wilkinson-Berka JL, Tan G, Jaworski K, Harbig J, Miller AG. Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology. Circ Res. 2009;104(1):124–133.
  • Hatakeyama H, Miyamori I, Fujita T, Takeda Y, Takeda R, Yamamoto H. Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells. J Biol Chem. 1994;269(39):24316–24320.
  • Kobayashi M, Hirooka K, Ono A, Nakano Y, Nishiyama A, Tsujikawa A. The relationship between the renin-angiotensin-aldosterone system and NMDA receptor-mediated signal and the prevention of retinal ganglion cell death. Invest Ophthalmol Vis Sci. 2017;58(3):1397–1403.
  • Takasago Y, Hirooka K, Nakano Y, Kobayashi M, Ono A. Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival. J Renin Angiotensin Aldosterone Syst. 2018;19(3):1470320318795001.
  • Nitta E, Hirooka K, Tenkumo K, Fujita T, Nishiyama A, Nakamura T, Itano T, Shiraga F. Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma. Cell Death Dis. 2013;4(7):e711.
  • Ohshima Y, Higashide T, Sakaguchi K, Sasaki M, Udagawa S, Ohkubo S, Yoneda T, Sugiyama K. The association of primary aldosteronism with glaucoma-related fundus abnormalities. PLoS One. 2020;15(11):e0242090.
  • Yamada Y, Higashide T, Udagawa S, Takeshima S, Sakaguchi K, Nitta K, Sugiyama K. The relationship between interocular asymmetry of visual field defects and optic nerve head blood flow in patients with glaucoma. J Glaucoma. 2019;28(3):231–237.
  • Wada Y, Higashide T, Nagata A, Sugiyama K. Longitudinal changes in optic nerve head blood flow in normal rats evaluated by laser speckle flowgraphy. Invest Ophthalmol Vis Sci. 2016;57(13):5568–5575.
  • Shiga Y, Asano T, Kunikata H, Nitta F, Sato H, Nakazawa T, Shimura M. Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy. Invest Ophthalmol Vis Sci. 2014;55(6):3899–3904.
  • Tamplin MR, Broadhurst KA, Vitale AH, Hashimoto R, Kardon RH, Grumbach IM. Longitudinal testing of retinal blood flow in a mouse model of hypertension by laser speckle flowgraphy. Transl Vis Sci Technol. 2021;10(2):16.
  • Thunhorst RL, Xue B, Beltz TG, Johnson AK. Age-related changes in thirst, salt appetite, and arterial blood pressure in response to aldosterone-dexamethasone combination in rats. Am J Physiol Regul Integr Comp Physiol. 2015;308(10):807–815.
  • Wehling M, Ulsenheimer A, Schneider M, Neylon C, Christ M. Rapid effects of aldosterone on free intracellular calcium in vascular smooth muscle and endothelial cells: subcellular localization of calcium elevations by single cell imaging. Biochem Biophys Res Commun. 1994;204(2):475–481.
  • Wehling M, Neylon CB, Fullerton M, Bobik A, Funder JW. Nongenomic effects of aldosterone on intracellular Ca2+ in vascular smooth muscle cells. Circ Res. 1995;76(6):973–979.
  • Schneider M, Ulsenheimer A, Christ M, Wehling M. Nongenomic effects of aldosterone on intracellular calcium in porcine endothelial cells. Am J Physiol. 1997;272(4 Pt 1):E616–620.
  • Arima S, Kohagura K, Xu HL, Sugawara A, Abe T, Satoh F, Takeuchi K, Ito S. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J Am Soc Nephrol. 2003;14(9):2255–2263.
  • Wong S, Brennan FE, Young MJ, Fuller PJ, Cole TJ. A direct effect of aldosterone on endothelin-1 gene expression in vivo. Endocrinology. 2007;148(4):1511–1517.
  • Yu DY, Su EN, Cringle SJ, Morgan WH, McAllister IL, Yu PK. Local modulation of retinal vein tone. Invest Ophthalmol Vis Sci. 2016;57(2):412–419.
  • Kushibiki M, Yamada M, Oikawa K, Tomita H, Osanai T, Okumura K. Aldosterone causes vasoconstriction in coronary arterioles of rats via angiotensin II type-1 receptor: influence of hypertension. Eur J Pharmacol. 2007;572(2–3):182–188.
  • Heylen E, Huang A, Sun D, Kaley G. Nitric oxide-mediated dilation of arterioles to intraluminal administration of aldosterone. J Cardiovasc Pharmacol. 2009;54(6):535–542.
  • Toda N, Nakanishi S, Tanabe S. Aldosterone affects blood flow and vascular tone regulated by endothelium-derived NO: therapeutic implications. Br J Pharmacol. 2013;168(3):519–533.
  • Lyngsø KS, Assersen K, Dalgaard EG, Skott O, Jensen BL, Hansen PB. Does aldosterone play a significant role for regulation of vascular tone? J Cardiovasc Pharmacol. 2016;68(1):1–10.
  • Fujita M, Minamino T, Asanuma H, Sanada S, Hirata A, Wakeno M, Myoishi M, Okuda H, Ogai A, Okada K, et al. Aldosterone nongenomically worsens ischemia via protein kinase C-dependent pathways in hypoperfused canine hearts. Hypertension. 2005;46(1):113–117.
  • Romagni P, Rossi F, Guerrini L, Quirini C, Santiemma V. Aldosterone induces contraction of the resistance arteries in man. Atherosclerosis. 2003;166(2):345–349.
  • Schmidt BM, Oehmer S, Delles C, Bratke R, Schneider MP, Klingbeil A, Fleischmann EH, Schmieder RE. Rapid nongenomic effects of aldosterone on human forearm vasculature. Hypertension. 2003;42(2):156–160.
  • de Kloet ER, Van Acker SA, Sibug RM, Oitzl MS, Meijer OC, Rahmouni K, de Jong W. Brain mineralocorticoid receptors and centrally regulated functions. Kidney Int. 2000;57(4):1329–1336.
  • Lai M, Horsburgh K, Bae SE, Carter RN, Stenvers DJ, Fowler JH, Yau JL, Gomez-Sanchez CE, Holmes MC, Kenyon CJ, et al. Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia. Eur J Neurosci. 2007;25(6):1832–1842.
  • Rana I, Suphapimol V, Jerome JR, Talia DM, Deliyanti D, Wilkinson-Berka JL. Angiotensin II and aldosterone activate retinal microglia. Exp Eye Res. 2020;191:107902.
  • Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 2007;8(1):57–69.
  • Brocca ME, Pietranera L, de Kloet ER, De Nicola AF. Mineralocorticoid receptors, neuroinflammation and hypertensive encephalopathy. Cell Mol Neurobiol. 2019;39(4):483–492.
  • Marissal-Arvy N, Lombès M, Petterson J, Moisan MP, Mormède P. Gain of function mutation in the mineralocorticoid receptor of the brown Norway rat. J Biol Chem. 2004;279(38):39232–39239.
  • Cavallari LH, Fashingbauer LA, Camp JR, King ST, Geenen DL. Hypertension-induced renal fibrosis and spironolactone response vary by rat strain and mineralocorticoid receptor gene expression. J Renin Angiotensin Aldosterone Syst. 2008;9(3):146–153.
  • Mitchell P, Leung H, Wang JJ, Rochtchina E, Lee AJ, Wong TY, Klein R. Retinal vessel diameter and open-angle glaucoma: the Blue Mountains Eye Study. Ophthalmology. 2005;112(2):245–250.