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Review

A Perspective on the Use of Fluorescent Imaging to Reveal Mechanisms of Breakup

, &
Pages 1355-1361 | Received 27 Jan 2022, Accepted 30 Jun 2022, Published online: 21 Jul 2022

References

  • Lemp MA, Baudouin C, Baum J, Dogru M, Foulks GN, Kinoshita S, Laibson P, McCulley J, Murube J, Pfugfelder SC, et al. The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye workshop (2007). Ocul Surf. 2007;5:75–92.
  • Choudhury A, Dey M, Dixit HN, Feng JJ. Tear-film breakup: the role of membrane-associated mucin polymers. Phys Rev E. 2021;103(013108):1–13.
  • Norn MS. Desiccation of the precorneal film. I. Corneal wetting-time. Acta Ophthalmol (Copenh)). 1969;47(4):865–880. doi:10.1111/j.1755-3768.1969.tb03711.x.
  • Mengher LS, Bron AJ, Tonge SR, Gilbert DJ. A non-invasive instrument for clinical assessment of the pre-corneal tear film stability. Curr Eye Res. 1985;4(1):1–7. doi:10.3109/02713688508999960.
  • Tsubota K, Yokoi N, Shimazaki J, Watanabe H, Dogru M, Yamada M, Kinoshita S, Kim H-M, Tchah H-W, Hyon JY, et al. New perspectives on dry eye definition and diagnosis: a consensus report by the Asia Dry Eye Society Ocul Surf. Ocul Surf. 2017;15(1):65–76.
  • Bitton E, Lovasik JV. Longitudinal analysis of precorneal tear film rupture patterns. Adv Exp Med Biol. 1998;438:381–389.
  • Guillon JP. Tear film structure and contact lenses. In: Holly FJ (ed), The preocular tear film in health, disease and contact lens wear. Lubbock, TX: Dry Eye Institute; 1986: p. 914–939.
  • Yokoi N, Georgiev GA. Tear film-oriented diagnosis and tear film-oriented therapy for dry eye based on tear film dynamics. Invest Ophthalmol Vis Sci. 2018;59(14):DES13–DES22. doi:10.1167/iovs.17-23700.
  • Yokoi N, Georgiev GA. Tear-film-orientated diagnosis for dry eye. Jpn J Ophthalmol. 2019;63(2):127–136. doi:10.1007/s10384-018-00645-4.
  • King-Smith PE, Begley CG, Braun RJ. Mechanisms, imaging and structure of tear film breakup. Ocul Surf. 2018;16(1):4–30. doi:10.1016/j.jtos.2017.09.007.
  • Geerling G, Tauber J, Baudouin C, Goto E, Matsumoto Y, O'Brien T, Rolando M, Tsubota K, Nichols KK. The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2011;52(4):2050–2064. doi:10.1167/iovs.10-6997g.
  • Jones L, Downie LE, Korb D, Benitez-Del-Castillo JM, Dana R, Deng SX, Dong PN, Geerling G, Hida RY, Liu Y, et al. TFOS DEWS II management and therapy report. Ocul Surf. 2017;15(3):575–628. doi:10.1016/j.jtos.2017.05.006.
  • Wolffsohn JS, Arita R, Chalmers R, Djalilian A, Dogru M, Dumbleton K, Gupta PK, Karpecki P, Lazreg S, Pult H, et al. TFOS DEWS II diagnostic methodology report. Ocul Surf. 2017;15(3):539–574. doi:10.1016/j.jtos.2017.05.001.
  • Bron AJ. Methodologies to diagnose and monitor dry eye disease: report of the diagnostic methodology subcommittee of the international dry eye workshop (2007). Ocul Surf. 2007;5:108–152.
  • Hamano H, Kaufman HE. The physiology of the cornea and contact lens applications. New York: Churchill Livingstone; 1987:p. ix. 100, [104] of plates.
  • Luke RA, Braun RJ, Driscoll TA, Begley CG, Awisi-Gyau D. Parameter estimation for evaporation-driven tear film thinning. Bull Math Biol. 2020;82(6):71:1–41. doi:10.1007/s11538-020-00745-8.
  • Bron AJ, Argueso P, Irkec M, Bright FV. Clinical staining of the ocular surface: mechanisms and interpretations. Prog Retin Eye Res. 2015;44:36–61. doi:10.1016/j.preteyeres.2014.10.001.
  • Himebaugh NL, Nam J, Bradley A, Liu H, Thibos LN, Begley CG. Scale and spatial distribution of aberrations associated with tear breakup. Optom Vis Sci. 2012;89(11):1590–1600. doi:10.1097/OPX.0b013e31826cfae5.
  • King-Smith PE, Nichols JJ, Nichols KK, Fink BA, Braun RJ. Contributions of evaporation and other mechanisms to tear film thinning and breakup: a review. Optom Vis Sci. 2008;85(8):623–630. doi:10.1097/OPX.0b013e318181ae60.
  • Nichols JJ, Mitchell GL, King-Smith PE. Thinning rate of the precorneal and prelens tear films. Invest Ophthalmol Vis Sci. 2005;46(7):2353–2361. doi:10.1167/iovs.05-0094.
  • Nichols JJ, King-Smith PE, Hinel EA, Thangavelu M, Nichols KK. The use of fluorescent quenching in studying the contribution of evaporation to tear thinning. Invest Ophthalmol Vis Sci. 2012;53(9):5426–5432. doi:10.1167/iovs.12-10033.
  • Webber WR, Jones DP. Continuous fluorophotometric method of measuring tear turnover rate in humans and analysis of factors affecting accuracy. Med Biol Eng Comput. 1986;24(4):386–392. doi:10.1007/BF02442693.
  • Lakowicz JR. Principles of Fluorescence Spectroscopy. New York, NY: Springer; 2006:p. 55–56.
  • King-Smith PE, Ramamoorthy P, Braun RJ, Nichols JJ. Tear film images and breakup analyzed using fluorescent quenching. Invest Ophthalmol Vis Sci. 2013;54(9):6003–6011. doi:10.1167/iovs.13-12628.
  • Tomlinson A, Doane MG, McFadyen A. Inputs and outputs of the lacrimal system: review of production and evaporative loss. Ocul Surf. 2009;7(4):186–129. doi:10.1016/S1542-0124(12)70186-6.
  • Peng CC, Cerretani C, Li Y, Bowers S, Shahsavarani S, Lin MC, Radke CJ. Flow evaporimeter to assess evaporative resistance of human tear-film lipid layer. Ind Eng Chem Res. 2014;53(47):18130–18139. doi:10.1021/ie5030497.
  • Dursch TJ, Li W, Taraz B, Lin MC, Radke CJ. Tear-film evaporation rate from simultaneous ocular-surface temperature and tear-breakup area. Optom Vis Sci. 2018;95(1):5–12. doi:10.1097/OPX.0000000000001156.
  • Kimball SH, King-Smith PE, Nichols JJ. Evidence for the major contribution of evaporation to tear film thinning between blinks. Invest Ophthalmol Vis Sci. 2010;51(12):6294–6297. doi:10.1167/iovs.09-4772.
  • King-Smith PE, Fink BA, Nichols JJ, Nichols KK, Braun RJ, McFadden GB. The contribution of lipid layer movement to tear film thinning and breakup. Invest Ophthalmol Vis Sci. 2009;50(6):2747–2756. doi:10.1167/iovs.08-2459.
  • Paugh JR, Tse J, Nguyen T, Sasai A, Chen E, De Jesus MT, Kwan J, Nguyen AL, Farid M, Garg S, et al. Efficacy of tear breakup time test in dry eye. Cornea. 2020;39(1):92–98. doi:10.1097/ICO.0000000000002148.
  • Abusharha AA, Pearce EI, Fagehi R. Effect of ambient temperature on the human tear film. Eye Contact Lens. 2016;42(5):308–312. doi:10.1097/ICL.0000000000000210.
  • Leiske D, Leiske DL, Leiske C, Leiske CI, Leiske D, Leiske DR, Toney M, Toney MF, Senchyna M, Ketelson H, et al. Temperature-induced transitions in the structure and interfacial rheology of human meibum. Biophys J. 2012;102(2):369–376. doi:10.1016/j.bpj.2011.12.017.
  • Borchman D, Foulks GN, Yappert MC, Bell J, Wells E, Neravetla S, Greenstone V. Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction. Invest Ophthalmol Vis Sci. 2011;52(6):3805–3817. doi:10.1167/iovs.10-6514.
  • Butovich IA. On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids. Invest Ophthalmol Vis Sci. 2008;49(9):3779–3789. doi:10.1167/iovs.08-1889.
  • Lu H, Wojtowicz J, Butovich I. Differential scanning calorimetric evaluation of human meibomian gland secretions and model lipid mixtures: transition temperatures and cooperativity of melting. Chem Phys Lip. 2013;170-171:55–64. doi:10.1016/j.chemphyslip.2013.03.005.
  • King-Smith PE, Reuter KS, Braun RJ, Nichols JJ, Nichols KK. Tear film breakup and structure studied by simultaneous video recording of fluorescence and tear film lipid layer, TFLL, images. Invest Ophthalmol Vis Sci. 2013;54(7):4900–4909. doi:10.1167/iovs.13-11878.
  • McDonald JE, Brubaker S. Meniscus-induced thinning of tear films. Am J Ophthalmol. 1971;72(1):139–146. doi:10.1016/0002-9394(71)91604-7.
  • Holly FJ. Formation and rupture of the tear film. Exp Eye Res. 1973;15(5):515–525. doi:10.1016/0014-4835(73)90064-X.
  • Yánez-Soto B, Leonard BC, Raghunathan VK, Abbott NL, Murphy CJ. Effect of stratification on surface properties of corneal epithelial cells. Invest Ophthalmol Vis Sci. 2015;56(13):8340–8348. doi:10.1167/iovs.15-17468.
  • Peng CC, Cerretani C, Braun RJ, Radke CJ. Evaporation-driven instability of the precorneal tear film. Adv Colloid Interface Sci. 2014;206:250–264. doi:10.1016/j.cis.2013.06.001.
  • de Gennes P-G, Brochard-Wyart F, Quere D. Capillarity and Wetting Phenomena. New York, NY: Springer; 2004.
  • Luke RA, Braun RJ, Begley CG. Mechanistic determination of tear film thinning via fitting simplified models to tear breakup. MAIO. 2022;3(1):71–100. doi:10.35119/maio.v3i1.114.
  • Zhong L, Braun RJ, Begley CG, King-Smith PE. Dynamics of fluorescent imaging for rapid tear thinning. Bull Math Biol. 2019;81(1):39–80. doi:10.1007/s11538-018-0517-0.
  • Luke RA, Braun RJ, Driscoll TA, Awisi-Gyau D, Begley CG. Parameter estimation for mixed mechanism tear film thinning. Bull Math Biol. 2021; 83(5):56–39. doi:10.1007/s11538-021-00871-x.