Temporal Transcriptome Analysis Suggests Modulation of Key Pathways and Hub Genes in a Mice Model of Multi-Drug Resistant (MDR) Pseudomonas aeruginosa Endophthalmitis

References

• Pathengay A, Moreker MR, Puthussery R, Ambatipudi S, Jalali S, Majji AB, Mathai A, Husssain N, Dave V, Sharma S, et al. Clinical and microbiologic review of culture-proven endophthalmitis caused by multidrug-resistant bacteria in patients seen at a tertiary eye care center in southern India. Retina. 2011;31(9):1806–1811.
   PubMed Web of Science ®Google Scholar
• Eifrig CW, Scott IU, Flynn HW, Jr., Miller D. Endophthalmitis caused by Pseudomonas aeruginosa. Ophthalmology. 2003;110(9):1714–1717. doi:10.1016/S0161-6420(03)00572-4.
   PubMed Web of Science ®Google Scholar
• Sridhar J, Kuriyan AE, Flynn HW, Jr, Miller D. Endophthalmitis caused by pseudomonas aeruginosa: clinical features, antibiotic susceptibilities, and treatment outcomes. Retina. 2015;35(6):1101–1106. doi:10.1097/IAE.0000000000000469.
   PubMed Web of Science ®Google Scholar
• Falavarjani KG, Alemzadeh SA, Habibi A, Hadavandkhani A, Askari S, Pourhabibi A. Pseudomonas aeruginosa endophthalmitis: clinical outcomes and antibiotic susceptibilities. Ocul Immunol Inflamm. 2017;25(3):377–381. doi:10.3109/09273948.2015.1132740.
   PubMed Web of Science ®Google Scholar
• Bawankar P, Bhattacharjee H, Barman M, Soibam R, Deka H, Chandra Kuri G, Medhi J. Outbreak of multidrug-resistant Pseudomonas Aeruginosa endophthalmitis due to contaminated trypan blue solution. J Ophthalmic Vis Res. 2019;14(3):257–266. doi:10.18502/jovr.v14i3.4781.
   PubMed Web of Science ®Google Scholar
• Parchand SM, Agrawal D, Chatterjee S, Gangwe A, Mishra M, Agrawal D. Post-cataract surgery cluster endophthalmitis due to multidrug-resistant Pseudomonas aeruginosa: A retrospective cohort study of six clusters. Indian J Ophthalmol. 2020;68(7):1424–1431. doi:10.4103/ijo.IJO_1612_19.
   PubMed Web of Science ®Google Scholar
• Peyman GA, Raichand M, Bennett TO. Management of endophthalmitis with pars plana vitrectomy. Br J Ophthalmol. 1980;64(7):472–475. doi:10.1136/bjo.64.7.472.
   PubMed Web of Science ®Google Scholar
• Kernt M, Kampik A. Endophthalmitis: pathogenesis, clinical presentation, management, and perspectives. Clin Ophthalmol. 2010;4(4):121–135. doi:10.2147/opth.s6461.
   PubMedGoogle Scholar
• Miller FC, Coburn PS, Huzzatul MM, LaGrow AL, Livingston E, Callegan MC. Targets of immunomodulation in bacterial endophthalmitis. Prog Retin Eye Res. 2019;73:100763. doi:10.1016/j.preteyeres.2019.05.004.
   PubMed Web of Science ®Google Scholar
• Naik P, Singh S, Vishwakarma S, Kaur I, Dave VP, Kumar A, Joseph J. Multidrug-resistant pseudomonas aeruginosa evokes differential inflammatory responses in human microglial and retinal pigment epithelial cells. Microorganisms. 2020;8(5):735. doi:10.3390/microorganisms8050735.
   PubMed Web of Science ®Google Scholar
• Naik P, Singh S, Rudraprasad D, Dave VP, Kumar A, Joseph J. Multidrug-resistant Pseudomonas aeruginosa triggers differential inflammatory response in patients with endophthalmitis. Trans Vis Sci Tech. 2021;10(9):26. doi:10.1167/tvst.10.9.26.
   PubMed Web of Science ®Google Scholar
• Rajamani D, Singh PK, Rottmann BG, Singh N, Bhasin MK, Kumar A. Temporal retinal transcriptome and systems biology analysis identifies key pathways and hub genes in Staphylococcus aureus endophthalmitis. Sci Rep. 2016;6:21502. doi:10.1038/srep21502.
   PubMed Web of Science ®Google Scholar
• Naik P, Pandey S, Naik MN, Mishra DK, Boyenpally SR, Joseph J. Transcriptomic and histological analysis of exacerbated immune response in multidrug-resistant pseudomonas aeruginosa in a murine model of endophthalmitis. Front Immunol. 2022;12:789023.
   PubMed Web of Science ®Google Scholar
• Ramadan RT, Ramirez R, Novosad BD, Callegan MC. Acute inflammation and loss of retinal architecture and function during experimental Bacillus endophthalmitis. Curr Eye Res. 2006;31(11):955–965. doi:10.1080/02713680600976925.
   PubMed Web of Science ®Google Scholar
• Mishra R, Lahon A, Banerjea AC. Dengue virus degrades USP33-ATF3 axis via extracellular vesicles to activate human microglial cells. J Immunol. 2020;205(7):1787–1798. doi:10.4049/jimmunol.2000411.
   PubMed Web of Science ®Google Scholar
• Ashida H, Kim M, Sasakawa C. Exploitation of the host ubiquitin system by human bacterial pathogens. Nat Rev Microbiol. 2014;12(6):399–413. doi:10.1038/nrmicro3259.
   PubMed Web of Science ®Google Scholar
• Jiang X, Chen ZJ. The role of ubiquitylation in immune defence and pathogen evasion. Nat Rev Immunol. 2011;12(1):35–48. doi:10.1038/nri3111.
   PubMed Web of Science ®Google Scholar
• Giese MJ, Shum DC, Rayner SA, Mondino BJ, Berliner JA. Adhesion molecule expression in a rat model of Staphylococcus aureus endophthalmitis. Invest Ophthalmol Vis Sci. 2000; 41(1):145–153.
   PubMed Web of Science ®Google Scholar
• Deshmukh D, Chakrabarti M, Jayasudha R, Hasnat Ali M, Tyagi M, Sharma S, Joseph J. Elevated cytokine levels in vitreous as biomarkers of disease severity in infectious endophthalmitis. PLOS One. 2018;13(10):e0205292. doi:10.1371/journal.pone.0205292.
   PubMed Web of Science ®Google Scholar
• Giese MJ, Sumner HL, Berliner JA, Mondino BJ. Cytokine expression in a rat model of Staphylococcus aureus endophthalmitis. Invest Ophthalmol Vis Sci. 1998;39(13):2785–2790.
   PubMed Web of Science ®Google Scholar
• Chen M, Xu H. Parainflammation, chronic inflammation, and age-related macular degeneration. J Leukoc Biol. 2015;98(5):713–725. doi:10.1189/jlb.3RI0615-239R.
   PubMed Web of Science ®Google Scholar
• Kumar A, Kumar A. Role of Staphylococcus aureus virulence factors in inducing inflammation and vascular permeability in a mouse model of bacterial endophthalmitis. PloS One. 2015;10(6):e0128423. doi:10.1371/journal.pone.0128423.
   PubMed Web of Science ®Google Scholar
• Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT. Complement system part ©–- molecular mechanisms of activation and regulation. Front Immnol. 2015; 2(6):262.
   Google Scholar