2,362
Views
2
CrossRef citations to date
0
Altmetric
Cornea and Ocular Surface

Analysis of Biomechanical Response After Corneal Crosslinking with Different Fluence Levels in Porcine Corneas

, , , , , , ORCID Icon, & show all
Pages 719-723 | Received 01 Mar 2022, Accepted 14 Apr 2023, Published online: 05 May 2023

References

  • Seiler T, Spoerl E, Huhle M, Kamouna A. Conservative therapy of keratoconus by enhancement of collagen cross-links. Invest Ophthalmol Vis Sci. 1996;37:1017.
  • Santhiago MR, Randleman JB. The biology of corneal cross-linking derived from ultraviolet light and riboflavin. Exp Eye Res. 2021;202:108355. doi:10.1016/j.exer.2020.108355.
  • Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg. 2003;29(9):1780–1785. doi:10.1016/s0886-3350(03)00407-3.
  • Wollensak G, Spörl E, Reber F, Pillunat L, Funk R. Corneal endothelial cytotoxicity of riboflavin/UVA treatment in vitro. Ophthalmic Res. 2003;35(6):324–328. doi:10.1159/000074071.
  • Wollensak G, Spoerl E, Wilsch M, Seiler T. Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J Cataract Refract Surg. 2003;29(9):1786–1790. doi:10.1016/s0886-3350(03)00343-2.
  • Seiler TG, Batista A, Frueh BE, Koenig K. Riboflavin concentrations at the endothelium during corneal cross-linking in humans. Invest Ophthalmol Vis Sci. 2019;60(6):2140–2145. doi:10.1167/iovs.19-26686.
  • Lang PZ, Hafezi NL, Khandelwal SS, Torres-Netto EA, Hafezi F, Randleman JB. Comparative functional outcomes after corneal crosslinking using standard, accelerated, and accelerated with higher total fluence protocols. Cornea. 2019;38(4):433–441. doi:10.1097/ICO.0000000000001878.
  • Shetty R, Pahuja N, Roshan T, Deshmukh R, Francis M, Ghosh A, Sinha Roy A. Customized corneal cross-linking using different UVA beam profiles. J Refract Surg. 2017;33(10):676–682. doi:10.3928/1081597X-20170621-07.
  • Seiler TG, Fischinger I, Koller T, Zapp D, Frueh BE, Seiler T. Customized corneal cross-linking: one-year results. Am J Ophthalmol. 2016;166:14–21. doi:10.1016/j.ajo.2016.02.029.
  • Mazzotta C, Sgheri A, Bagaglia SA, Rechichi M, Di Maggio A. Customized corneal crosslinking for treatment of progressive keratoconus: clinical and OCT outcomes using a transepithelial approach with supplemental oxygen. J Cataract Refract Surg. 2020;46(12):1582–1587. doi:10.1097/j.jcrs.0000000000000347.
  • Hafezi F, Kling S, Gilardoni F, Hafezi N, Hillen M, Abrishamchi R, Gomes JAP, Mazzotta C, Randleman JB, Torres-Netto EA. Individualized corneal cross-linking with riboflavin and UV-A in ultrathin corneas: the Sub400 protocol. Am J Ophthalmol. 2021;224:133–142. doi:10.1016/j.ajo.2020.12.011.
  • Abrishamchi R, Abdshahzadeh H, Hillen M, Hafezi N, Torres-Netto EA, Aslanides IM, Chen S, Randleman JB, Hafezi F. High-fluence accelerated epithelium-off corneal cross-linking protocol provides dresden protocol-like corneal strengthening. Transl Vis Sci Technol. 2021;10(5):10. doi:10.1167/tvst.10.5.10.
  • Boschetti F, Conti D, Soriano EM, Mazzotta C, Pandolfi A. Experimental in-vitro investigation on epi-off-crosslinking on porcine corneas. PLOS One. 2021;16(4):e0249949. doi:10.1371/journal.pone.0249949.
  • Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res. 1998;66(1):97–103. doi:10.1006/exer.1997.0410.
  • Hammer A, Richoz O, Arba Mosquera S, Tabibian D, Hoogewoud F, Hafezi F. Corneal biomechanical properties at different corneal cross-linking (CXL) irradiances. Invest Ophthalmol Vis Sci. 2014;55(5):2881–2884. doi:10.1167/iovs.13-13748.
  • Fischinger I, Seiler TG, Wendelstein J, Tetz K, Fuchs B, Bolz M. Biomechanical response after corneal crosslinking with riboflavin dissolved in dextran solution versus hydroxy propyl methyl cellulose. J Refract Surg. 2021;37(9):631–635. doi:10.3928/1081597X-20210610-04.
  • Seiler TG, Fischinger I, Senfft T, Schmidinger G, Seiler T. Intrastromal application of riboflavin for corneal crosslinking. Invest Ophthalmol Vis Sci. 2014;55(7):4261–4265. doi:10.1167/iovs.14-14021.
  • Lammer J, Laggner M, Pircher N, Fischinger I, Hofmann C, Schmidinger G. Endothelial safety and efficacy of ex-vivo collagen cross linking (CXL) of human corneal transplants. Am J Ophthalmol. 2020;214:127–133. doi:10.1016/j.ajo.2020.02.024.
  • Seiler TG, Komninou MA, Nambiar MH, Schuerch K, Frueh BE, Buchler P. Oxygen kinetics during corneal cross-linking with and without supplementary oxygen. Am J Ophthalmol. 2021;223:368–376. doi:10.1016/j.ajo.2020.11.001.
  • Richoz O, Hammer A, Tabibian D, Gatzioufas Z, Hafezi F. The biomechanical effect of corneal collagen cross-linking (CXL) with riboflavin and UV-A is oxygen dependent. Transl Vis Sci Technol. 2013;2(7):6. doi:10.1167/tvst.2.7.6.
  • Brittingham S, Tappeiner C, Frueh BE. Corneal cross-linking in keratoconus using the standard and rapid treatment protocol: differences in demarcation line and 12-month outcomes. Invest Ophthalmol Vis Sci. 2014;55(12):8371–8376. doi:10.1167/iovs.14-15444.
  • Sachdev GS, Ramamurthy S, B S, Dandapani R. Comparative analysis of safety and efficacy of topography-guided customized cross-linking and standard cross-linking in the treatment of progressive keratoconus. Cornea. 2021;40(2):188–193. doi:10.1097/ICO.0000000000002492.
  • Cassagne M, Pierne K, Galiacy SD, Asfaux-Marfaing MP, Fournie P, Malecaze F. Customized topography-guided corneal collagen cross-linking for keratoconus. J Refract Surg. 2017;33(5):290–297. doi:10.3928/1081597X-20170201-02.
  • Kamaev P, Friedman MD, Sherr E, Muller D. Photochemical kinetics of corneal cross-linking with riboflavin. Invest Ophthalmol Vis Sci. 2012;53(4):2360–2367. doi:10.1167/iovs.11-9385.
  • Koller T, Mrochen M, Seiler T. Complication and failure rates after corneal crosslinking. J Cataract Refract Surg. 2009;35(8):1358–1362. doi:10.1016/j.jcrs.2009.03.035.
  • Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135(5):620–627. doi:10.1016/s0002-9394(02)02220-1.
  • Wen D, Li Q, Song B, Tu R, Wang Q, O'Brart DPS, McAlinden C, Huang J. Comparison of standard versus accelerated corneal collagen cross-linking for keratoconus: a meta-analysis. Invest Ophthalmol Vis Sci. 2018;59(10):3920–3931. doi:10.1167/iovs.18-24656.
  • Males JJ, Viswanathan D. Comparative study of long-term outcomes of accelerated and conventional collagen crosslinking for progressive keratoconus. Eye. 2018;32(1):32–38. doi:10.1038/eye.2017.296.
  • Thorsrud A, Hagem AM, Sandvik GF, Drolsum L. Superior outcome of corneal collagen cross-linking using riboflavin with methylcellulose than riboflavin with dextran as the main supplement. Acta Ophthalmol. 2019;97(4):415–421. doi:10.1111/aos.13928.
  • Lenk J, Herber R, Oswald C, Spoerl E, Pillunat LE, Raiskup F. Risk factors for progression of keratoconus and failure rate after corneal cross-linking. J Refract Surg. 2021;37(12):816–823. doi:10.3928/1081597X-20210830-01.
  • Rapuano PB, Mathews PM, Florakis GJ, Trokel SL, Suh LH. Corneal collagen crosslinking in patients treated with dextran versus isotonic hydroxypropyl methylcellulose (HPMC) riboflavin solution: a retrospective analysis. Eye Vis. 2018;5:23. doi:10.1186/s40662-018-0116-z.
  • Shajari M, Kolb CM, Agha B, Steinwender G, Muller M, Herrmann E, Schmack I, Mayer WJ, Kohnen T. Comparison of standard and accelerated corneal cross-linking for the treatment of keratoconus: a meta-analysis. Acta Ophthalmol. 2019;97(1):e22–e35. doi:10.1111/aos.13814.
  • Noor IH, Seiler TG, Noor K, Seiler T. Continued long-term flattening after corneal cross-linking for keratoconus. J Refract Surg. 2018;34(8):567–570. doi:10.3928/1081597X-20180607-01.