Effects of Ripasudil, a Rho-Kinase Inhibitor, on Scar Formation in a Mouse Model of Filtration Surgery

References

• Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311(18):1901–1911.
   PubMed Web of Science ®Google Scholar
• Cholkar K, Trinh HM, Pal D, Mitra AK. Discovery of novel inhibitors for the treatment of glaucoma. Expert Opin Drug Discov. 2015;10(3):293–313.
   PubMed Web of Science ®Google Scholar
• Sharpe RA, Kammerdiener LL, Williams DB, Das SK, Nutaitis MJ. Efficacy of. selective laser trabeculoplasty following incisional glaucoma surgery. Int J Ophthalmol. 2018;11(1):71–76.
   PubMed Web of Science ®Google Scholar
• Salim S. Current variations of glaucoma filtration surgery. Curr Opin Ophthalmol. 2012;23(2):89–95.
   PubMed Web of Science ®Google Scholar
• Lukowski ZL, Min J, Beattie AR, Meyers CA, Levine MA, Stoller G, Schultz GS, Samuelson DA, Sherwood MB. Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model. J Glaucoma. 2013;22(2):145–151.
   PubMed Web of Science ®Google Scholar
• Skuta GL, Parrish RK, 2nd. Wound healing in glaucoma filtering surgery. Surv Ophthalmol. 1987;32(3):149–170.
   PubMed Web of Science ®Google Scholar
• Xi X, McMillan DH, Lehmann GM, Sime PJ, Libby RT, Huxlin KR, Feldon SE, Phipps RP. Ocular fibroblast diversity: implications for inflammation and ocular wound healing. Invest Ophthalmol Vis Sci. 2011;52(7):4859–4865.
   PubMed Web of Science ®Google Scholar
• Fan Gaskin JC, Nguyen DQ, Soon Ang G, O'Connor J, Crowston JG. Wound healing modulation in glaucoma filtration surgery-conventional practices and new perspectives: the role of antifibrotic agents (part I). J Curr Glaucoma Pract. 2014;8(2):37–45.
   PubMedGoogle Scholar
• Liu Y, Ko JA, Yanai R, Kimura K, Chikama T, Sagara T, Nishida T. Induction by latanoprost of collagen gel contraction mediated by human tenon fibroblats: role of intracellular signalling molecules. Invest Ophthalmol Vis Sci. 2008;49(4):1429–1436.
   PubMed Web of Science ®Google Scholar
• Meyer-ter-Vehn T, Sieprath S, Katzenberger B, Gebhardt S, Grehn F, Schlunck G. Contractility as a prerequisite for TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci. 2006;47(11):4895–4904.
   PubMed Web of Science ®Google Scholar
• Sime PJ, O'Reilly KM. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clin Immunol. 2001;99(3):308–319.
   PubMed Web of Science ®Google Scholar
• Cordeiro MF, Chang L, Lim KS, Daniels JT, Pleass RD, Siriwardena D, Khaw PT. Modulating conjunctival wound healing. Eye. 2000;14(3):536–547.
   PubMed Web of Science ®Google Scholar
• Hinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat M-L, Gabbiani G. The myofibroblast one function, multiple origins. Am J Pathol. 2007;170(6):1807–1816.
   PubMed Web of Science ®Google Scholar
• Hinz B. Formation and function of the myofibroblast during tissue repair. J Invest Dermatol. 2007;127(3):526–537.
   PubMed Web of Science ®Google Scholar
• Tanihara H, Inoue T, Yamamoto T, Kuwayama Y, Abe H, Suganami H, Araie M, K-115 Clinical Study Group. Additive intraocular pressure-lowering effects of the Rho kinase inhibitor ripasudil (K-115) combined with timolol or latanoprost: a report of 2 randomized clinical trials. JAMA Ophthalmol. 2015;133(7):755–761.
   PubMed Web of Science ®Google Scholar
• Koga T, Koga T, Awai M, Tsutsui J, Yue BY, Tanihara H. Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motibility in cultured human trabecular meshwork cells. Exp Eye Res. 2006;82(3):362–370.
   PubMed Web of Science ®Google Scholar
• Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature. 2002;420(6916):629–635.
   PubMed Web of Science ®Google Scholar
• Liao JK, Seto M, Noma K. Rho kinase (ROCK) inhbitors. J Cardiovasc Pharmacol. 2007;50(1):17–24.
   PubMed Web of Science ®Google Scholar
• Wang J, Liu X, Zhong Y. Rho/Rho-associated kinase pathway in glaucoma. Int J Oncol. 2013;43(5):1357–1367.
   PubMed Web of Science ®Google Scholar
• Shimizu Y, Dobashi K, Iizuka K, Horie T, Suzuki K, Tukagoshi H, Nakazawa T, Nakazato Y, Mori M. Contribution of small GTPase Rho and its target protein rock in a murine model of lung fibrosis. Am J Respir Crit Care Med. 2001;163(1):210–217.
   PubMed Web of Science ®Google Scholar
• Nagatoya K, Moriyama T, Kawada N, Takeji M, Oseto S, Murozono T, Ando A, Imai E, Hori M. Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction. Kidney Int. 2002;61(5):1684–1695.
   PubMed Web of Science ®Google Scholar
• Hartmann S, Ridley AJ, Lutz S. The function of Rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease. Front Pharmacol. 2015;6:276.
   PubMed Web of Science ®Google Scholar
• Ko JA, Sotani Y, Ibrahim DG, Kiuchi Y. Role of macrophage migration inhibitory factor (MIF) in the effects of oxidative stress on human retinal pigment epithelial cells. Cell Biochem Funct. 2017;35(7):426–432.
   PubMed Web of Science ®Google Scholar
• Adachi K, Asada Y, Hirakata T, Onoue M, Iwamoto S, Kasuga T, Matsuda A. Alteration of gene expression in mice after. glaucoma filtration surgery. Sci Rep. 2020;10(1):15036.
   PubMed Web of Science ®Google Scholar
• Prum BE, Jr, Rosenberg LF, Gedde SJ, Mansberger SL, Stein JD, Moroi SE, Herndon LW, Jr, Lim MC, Williams RD. Primary open-angle glaucoma preferred practice pattern guidelines. Ophthalmology. 2016;123(1):P41–P111.
   PubMed Web of Science ®Google Scholar
• Daneshvar R, Amini N. Rho-associated kinase inhibitors: potential future treatments for glaucoma. J Ophthalmic Vis Res. 2014;9(3):395–398.
   PubMedGoogle Scholar
• Lark KK, Pasha AS, Yan X, Edward DP. The effect of latanoprost and brimonidine on rabbit subconjunctival fibroblasts. J Glaucoma. 1999;8:72–76.
   PubMed Web of Science ®Google Scholar
• Young TL, Higginbotham EJ, Zou XL, Farber MD. Effects of topical glaucoma drugs on fistulized rabbit conjunctiva. Ophthalmology. 1990;97(11):1423–1427.
   PubMed Web of Science ®Google Scholar
• Honjo M, Tanihara H, Inatani M, Kido N, Sawamura T, Yue BY, Narumiya S, Honda Y. Effetcs of Rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci. 2001;42:137–144.
   PubMed Web of Science ®Google Scholar
• Inoue T, Tanihara H. Rho-associated kinase inhibitors: a novel glaucoma therapy. Prog Retin Eye Res. 2013;37:1–12.
   PubMed Web of Science ®Google Scholar
• Kitaoka Y, Kitaoka Y, Kumai T, Lam TT, Kuribayashi K, Isenoumi K, Munemasa Y, Motoki M, Kobayashi S, Ueno S. Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina. Brain Res. 2004;1018(1):111–118.
   PubMed Web of Science ®Google Scholar
• Hirata A, Inatani M, Inomata Y, Yonemura N, Kawaji T, Honjo M, Tanihara H. Y-27632. a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia. Graefes Arch Clin Exp Ophthalmol. 2008;246(1):51–59.
   PubMed Web of Science ®Google Scholar
• Futakuchi A, Inoue T, Fujimoto T, Inoue-Mochita M, Kawai M, Tanihara H. The effects of ripasudil (K-115), a Rho kinase inhibitor, on activation of human conjunctival fibroblasts. Exp Eye Res. 2016;149:107–115.
   PubMed Web of Science ®Google Scholar
• Kojima S, Sugiyama T, Shinji T, Ueki JD, Oku M, Ikeda HT. Effects of ripasudil, a Rho-associated protein kinase inhibitor, on conjunctival scarring in a canine filtration surgery model. Curr Top Pharma. 2015;19:67–73.
   Google Scholar
• Mizuno Y, Okada N, Onoe H, Tokumo K, Okumichi H, Hirooka K, Kiuchi Y. Effect of the rho-kinase inhibitor ripasudil in needling with mitomycin C for the failure of filtering bleb after trabeculectomy: a cross-sectional study. BMC Ophthalmol. 2022;22(1):433.
   PubMed Web of Science ®Google Scholar
• Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993;122(1):103–111.
   PubMed Web of Science ®Google Scholar
• Yamanaka O, Kitano-Izutani A, Tomoyose K, Reinach PS. Pathobiology of wound healing after gluacoma filtration surgery. BMC Ophthalmol. 2015;15(S1):157.
   PubMed Web of Science ®Google Scholar