Protective Effects of Different Doses of Ginsenoside-Rb1 Experimental Cataract Model That in Chick Embryos

References

• Wale MZ, Derbew M, Tilahun M, Terefe M. Cataract and associated factors among adults visiting ophthalmic clinic at Debre Markos comprehensive specialized hospital, northwest Ethiopia, 2020. SAGE Open Med. 2021;9:2050312121989636. doi:10.1177/2050312121989636.
   Web of Science ®Google Scholar
• Moreau KL, King JA. Protein misfolding and aggregation in cataract disease and prospects for prevention. Trends Mol Med. 2012;18(5):273–282. doi:10.1016/j.molmed.2012.03.005.
   PubMed Web of Science ®Google Scholar
• Truscott RJ, Friedrich MG. The etiology of human age-related cataract. Proteins don’t last forever. Biochim Biophys Acta. 2016;1860(1 Pt B):192–198. doi:10.1016/j.bbagen.2015.08.016.
   PubMed Web of Science ®Google Scholar
• World Health Organization. World report on vision. 8 October 2019. Available from: https://www.who.int/publications/i/item/9789241516570.
   Google Scholar
• Wang W, Yan W, Müller A, He M. A global view on output and outcomes of cataract surgery with national indices of socioeconomic development. Invest Ophthalmol Vis Sci. 2017;58(9):3669–3676. doi:10.1167/iovs.17-21489.
   PubMed Web of Science ®Google Scholar
• Beebe DC, Holekamp NM, Shui YB. Oxidative damage and the prevention of age-related cataracts. Ophthalmic Res. 2010;44(3):155–165. doi:10.1159/000316481.
   PubMed Web of Science ®Google Scholar
• El-Missiry MA. Antioxidant enzyme: boD–Books on Demand. 2012.
   Google Scholar
• Vurmaz A, Duman R, Sabaner MC, Ertekin T, Bilir A. Antioxidant effects of piperine in in-vivo chick embryo cataract model induced by steroids. Cutan Ocul Toxicol. 2019;38(2):182–189. doi:10.1080/15569527.2019.1570521.
   PubMed Web of Science ®Google Scholar
• Vurmaz A, Ertekin A, Sabaner MC, Atay E, Bozkurt E, Bilir A. Effects of vitamin E in a glucocorticoid induced cataract model in chicken embryos. Biotech Histochem. 2021;96(6):431–438. doi:10.1080/10520295.2020.1818284.
   PubMed Web of Science ®Google Scholar
• Xue JF, Liu ZJ, Hu JF, Chen H, Zhang JT, Chen NH. Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. Brain Res. 2006;1106(1):91–98. doi:10.1016/j.brainres.2006.05.106.
   PubMed Web of Science ®Google Scholar
• Sathyanath R, Hanumantha Rao BR, Kim HG, Cho JH, Son CG. Saponin and non-saponin fractions of red ginseng ameliorate cisplatin-induced pica in rats. Pharm Biol. 2013;51(8):1052–1060. doi:10.3109/13880209.2013.775660.
   PubMed Web of Science ®Google Scholar
• Kim JY, Park JY, Kang HJ, Kim OY, Lee JH. Beneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a randomized, double-blind, placebo-controlled trial. Nutr J. 2012;11:47. doi:10.1186/1475-2891-11-47.
   PubMed Web of Science ®Google Scholar
• Kim YK, Guo Q, Packer L. Free radical scavenging activity of red ginseng aqueous extracts. Toxicology. 2002;172(2):149–156. doi:10.1016/s0300-483x(01)00585-6.
   PubMed Web of Science ®Google Scholar
• Huynh TP, Mann SN, Mandal NA. Botanical compounds: effects on major eye diseases. Evid Based Complement Alternat Med. 2013;2013:549174. doi:10.1155/2013/549174.
   PubMed Web of Science ®Google Scholar
• Lee SM, Sun JM, Jeong JH, Kim MK, Wee WR, Park JH, Lee JH. Analysis of the effective fraction of sun ginseng extract in selenite induced cataract rat model. J Korean Ophthalmol Soc. 2010;51(5):733–739. doi:10.3341/jkos.2010.51.5.733.
   Google Scholar
• Zhang G, Zhang M, Yu J, Kang L, Guan H. Ginsenoside Rg1 prevents H2O2-induced lens opacity. Curr Eye Res. 2021;46(8):1159–1165. doi:10.1080/02713683.2020.1869266.
   PubMed Web of Science ®Google Scholar
• Kim J, Han SY, Min H. Ginseng for an eye: effects of ginseng on ocular diseases. J Ginseng Res. 2020;44(1):1–7. doi:10.1016/j.jgr.2018.11.006.
   PubMed Web of Science ®Google Scholar
• Gao Y, Chu S, Zhang Z, Chen N. Hepataprotective effects of ginsenoside Rg1 - a review. J Ethnopharmacol. 2017;206:178–183. doi:10.1016/j.jep.2017.04.012.
   PubMed Web of Science ®Google Scholar
• Chen CF, Chiou WF, Zhang JT. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol Sin. 2008;29(9):1103–1108. doi:10.1111/j.1745-7254.2008.00868.x.
   PubMed Web of Science ®Google Scholar
• Wang X-F, Liu X-J, Zhou Q-M, Du J, Zhang T-L, Lu Y-Y, Su S-B. Ginsenoside rb1 reduces isoproterenol-induced cardiomyocytes apoptosis in vitro and in vivo. Evid Based Complement Alternat Med. 2013;2013:454389. doi:10.1155/2013/454389.
   PubMed Web of Science ®Google Scholar
• Liu D, Zhang H, Gu W, Liu Y, Zhang M. Neuroprotective effects of ginsenoside Rb1 on high glucose-induced neurotoxicity in primary cultured rat hippocampal neurons. PLoS One. 2013;8(11):e79399. doi:10.1371/journal.pone.0079399.
   PubMed Web of Science ®Google Scholar
• Endale M, Im EJ, Lee JY, Kim SD, Yayeh T, Song YB, Kwak YS, Kim C, Kim SH, Roh SS, et al. Korean red ginseng saponin fraction rich in ginsenoside-Rb1, Rc and Rb2 attenuates the severity of mouse collagen-induced arthritis. Mediators Inflamm. 2014;2014:748964. doi:10.1155/2014/748964.
   PubMed Web of Science ®Google Scholar
• Duman R, Ertekin T, Duman R, Vurmaz A, Köken T, Bilir A. Comparison of the efficacy of different hydrocortisone-induced cataract models in developing chick embryos. J Pharm Res Int. 2018;21(3):1–7. doi:10.9734/JPRI/2018/39888.
   Web of Science ®Google Scholar
• Ishikawa S, Hashizume K, Nishigori H, Tezuka Y, Sanbe A, Kurosaka D. Effect of astaxanthin on cataract formation induced by glucocorticoids in the chick embryo. Curr Eye Res. 2015;40(5):535–540. doi:10.3109/02713683.2014.935445.
   PubMed Web of Science ®Google Scholar
• Richardson RB, Ainsbury EA, Prescott CR, Lovicu FJ. Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation. Int J Radiat Biol. 2020;96(11):1339–1361. doi:10.1080/09553002.2020.1812759.
   PubMed Web of Science ®Google Scholar
• Lee JW, Iwatsuru M, Nishigori H. Glucocorticoid-induced cataract of developing chick embryo as a screening model for anticataract agents. J Ocul Pharmacol Ther. 1995;11(4):533–541. doi:10.1089/jop.1995.11.533.
   PubMed Web of Science ®Google Scholar
• Liu X, Chen J, Sun N, Li N, Zhang Z, Zheng T, Li Z. Ginsenoside Rb1 ameliorates autophagy via the AMPK/mTOR pathway in renal tubular epithelial cells in vitro and in vivo. Int J Biol Macromol. 2020;163:996–1009. doi:10.1016/j.ijbiomac.2020.07.060.
   PubMed Web of Science ®Google Scholar
• Wang LC, Lee TF. Effect of ginseng saponins on cold tolerance in young and elderly rats. Planta Med. 2000;66(2):144–147. doi:10.1055/s-2000-11122.
   PubMed Web of Science ®Google Scholar
• Yao F-D, Yang J-Q, Huang Y-C, Luo M-P, Yang W-J, Zhang B, Liu X-J. Antinociceptive effects of Ginsenoside Rb1 in a rat model of cancer-induced bone pain. Exp Ther Med. 2019;17(5):3859–3866. doi:10.3892/etm.2019.7404.
   PubMed Web of Science ®Google Scholar
• Fırat F, Bilir A, Atay E, Demirbaş H. Evaluation of anti-epileptic Lacosamide treatment on neural tube development: chick embryo experimental model. Med Sci Discov. 2022;9(8):475–480. doi:10.36472/msd.v9i8.793.
   Google Scholar
• Truscott RJ. Age-related nuclear cataract-oxidation is the key. Exp Eye Res. 2005 May;80(5):709–725. doi:10.1016/j.exer.2004.12.007.
   PubMed Web of Science ®Google Scholar
• Zigler JS, Datiles MB. Pathogenesis of Cataracts. In Tasman W, Jaeger E (Ed). Duane’s Clinical Ophthalmology (Vol 1, pp. 1–13. Ch. 72B), 2010.
   Google Scholar
• Helms S. Cancer prevention and therapeutics: panax ginseng. Altern Med Rev. 2004;9(3):259–274.
   PubMedGoogle Scholar
• Lee D, Lee DS, Jung K, Hwang GS, Lee HL, Yamabe N, Lee HJ, Eom DW, Kim KH, Kang KS. Protective effect of ginsenoside Rb1 against tacrolimus-induced apoptosis in renal proximal tubular LLC-PK1 cells. J Ginseng Res. 2018;42(1):75–80. doi:10.1016/j.jgr.2016.12.013.
   PubMed Web of Science ®Google Scholar
• Na JY, Kim S, Song K, Lim KH, Shin GW, Kim JH, Kim B, Kwon YB, Kwon J. Anti-apoptotic activity of ginsenoside Rb1 in hydrogen peroxide-treated chondrocytes: stabilization of mitochondria and the inhibition of caspase-3. J Ginseng Res. 2012;36(3):242–247. doi:10.5142/jgr.2012.36.3.242.
   PubMed Web of Science ®Google Scholar
• Jung M. Inhibitory effect of sun ginseng extract on cataractogenesis in rat [dissertation], 2009.
   Google Scholar
• Saw CL, Yang AY, Cheng DC, Boyanapalli SS, Su ZY, Khor TO, Gao S, Wang J, Jiang ZH, Kong AN. Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations. Chem Res Toxicol. 2012;25(8):1574–1580. doi:10.1021/tx2005025.
   PubMed Web of Science ®Google Scholar
• Dong C, Liu P, Wang H, Dong M, Li G, Li Y. Ginsenoside Rb1 attenuates diabetic retinopathy in streptozotocin-induced diabetic rats1. Acta Cir Bras. 2019;34(2):e201900201. doi:10.1590/s0102-8650201900201.
   PubMed Web of Science ®Google Scholar
• Song Z, Si N, Xiao W. A novel mutation in the CRYAA gene associated with congenital cataract and microphthalmia in a Chinese family. BMC Med Genet. 2018;19(1):190. doi:10.1186/s12881-018-0695-5.
   PubMed Web of Science ®Google Scholar
• Chepelinsky AB, Piatigorsky J, Pisano MM, Dubin RA, Wistow G, Limjoco TI, Klement JF, Jaworski CJ. Lens protein gene expression: alpha-crystallins and MIP. Lens Eye Toxic Res. 1991;8(2-3):319–344.
   PubMedGoogle Scholar
• Andley UP. Effects of alpha-crystallin on lens cell function and cataract pathology. Curr Mol Med. 2009;9(7):887–892. doi:10.2174/156652409789105598.
   PubMed Web of Science ®Google Scholar
• Shiels A, Bennett TM, Hejtmancik JF. Cat-map: putting cataract on the map. Mol Vis. 2010;16:2007–2015.
   PubMed Web of Science ®Google Scholar
• Bhagyalaxmi SG, Padma T, Reddy GB, Reddy KR. Association of G > A transition in exon-1 of alpha crystallin gene in age-related cataracts. Oman J Ophthalmol. 2010;3(1):7–12. doi:10.4103/0974-620X.60014.
   PubMedGoogle Scholar
• Zhou P, Luo Y, Liu X, Fan L, Lu Y. Down-regulation and CpG island hypermethylation of CRYAA in age-related nuclear cataract. FASEB J. 2012;26(12):4897–4902. doi:10.1096/fj.12-213702.
   PubMed Web of Science ®Google Scholar
• Liao J, Su X, Chen P, Wang X, Xu L, Li X, Thean L, Tan C, Tan AG, Tay WT, et al. Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract. Hum Mol Genet. 2014;23(22):6119–6128. doi:10.1093/hmg/ddu315.
   PubMed Web of Science ®Google Scholar
• Graw J, Löster J. Developmental genetics in ophthalmology. Ophthalmic Genet. 2003;24(1):1–33. doi:10.1076/opge.24.1.1.13888.
   PubMedGoogle Scholar
• Bloemendal H, de Jong W, Jaenicke R, Lubsen NH, Slingsby C, Tardieu A. Ageing and vision: structure, stability and function of lens crystallins. Prog Biophys Mol Biol. 2004;86(3):407–485. doi:10.1016/j.pbiomolbio.2003.11.012.
   PubMed Web of Science ®Google Scholar
• Yonova-Doing E, Zhao W, Igo RP, Wang C, Sundaresan P, Lee KE, Jun GR, Alves AC, Chai X, Chan ASY, et al. Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract. Commun Biol. 2020;3(1):755. doi:10.1038/s42003-020-01421-2.
   PubMed Web of Science ®Google Scholar
• Christopher KL, Pedler MG, Shieh B, Ammar DA, Petrash JM, Mueller NH. Alpha-crystallin-mediated protection of lens cells against heat and oxidative stress-induced cell death. Biochim Biophys Acta. 2014;1843(2):309–315. doi:10.1016/j.bbamcr.2013.11.010.
   PubMed Web of Science ®Google Scholar
• Horwitz J. Alpha-crystallin. Exp Eye Res. 2003;76(2):145–153. doi:10.1016/s0014-4835(02)00278-6.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhou S, Hu X, Chai J. Ginsenosides induce extensive changes in gene expression and inhibit oxidative stress-induced apoptosis in human lens epithelial cells. BMC Complement Med Ther. 2020;20(1):44. doi:10.1186/s12906-020-2826-8.
   PubMedGoogle Scholar
• Park C, Cha H-J, Song K-S, Kim H-S, Bang EJin, Lee H, Jin C-Y, Kim G-Y, Choi YH. Nrf2-mediated activation of HO-1 is required in the blocking effect of compound K, a ginseng saponin metabolite, against oxidative stress damage in ARPE-19 human retinal pigment epithelial cells. J Ginseng Res. 2023;47(2):311–318. doi:10.1016/j.jgr.2022.09.007.
   PubMed Web of Science ®Google Scholar
• Chen L, Geng N, Chen T, Xiao Q, Zhang H, Huo H, et al. Ginsenoside Rb1 improves post-cardiac arrest myocardial stunning and cerebral outcomes by regulating the Keap1/Nrf2 pathway. Int J Mol Sci. 2023;24(5):5059. doi:10.3390/ijms24055059.
   Web of Science ®Google Scholar
• Yang JE, Jia N, Wang D, He Y, Dong L, Yang AG. Ginsenoside Rb1 regulates neuronal injury and Keap1-Nrf2/ARE signaling pathway in cerebral infarction rats. J Biol Regul Homeost Agents. 2020;34(3):1091–1095. doi:10.23812/20-143-l-7.
   PubMed Web of Science ®Google Scholar
• Liu X-F, Hao J-L, Xie T, Malik TH, Lu C-B, Liu C, Shu C, Lu C-W, Zhou D-D. Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress. Aging Cell. 2017;16(5):934–942. doi:10.1111/acel.12645.
   PubMed Web of Science ®Google Scholar
• Lu J-M, Weakley, S, Yang Z, Hu M, Yao Q, Chen C. Ginsenoside Rb1 directly scavenges hydroxyl radical and hypochlorous acid. Curr Pharm Des. 2012;18(38):6339–6347. doi:10.2174/138161212803832254.
   PubMed Web of Science ®Google Scholar
• Park J, MacGavin S, Niederbrach L, Mchaourab HS. Interplay between Nrf2 and αB-crystallin in the lens and heart of zebrafish under proteostatic stress. bioRxiv 2023.04.04.535454. doi:10.1101/2023.04.04.535454.
   Google Scholar