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Retina and Choroid

Discernibility of the Interdigitation Zone (IZ), a Potential Optical Coherence Tomography (OCT) Biomarker for Visual Dysfunction in Aging

ORCID Icon, , , , , , , , & ORCID Icon show all
Pages 1050-1056 | Received 05 Mar 2023, Accepted 19 Jul 2023, Published online: 04 Aug 2023

References

  • Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Vision Loss Expert Group of the Global Burden of Disease Study, et al. Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis. Lancet Glob Health. 2017;5(12):e1221–e1234. doi: 10.1016/S2214-109X(17)30393-5.
  • Jaffe GJ, Westby K, Csaky KG, Monés J, Pearlman JA, Patel SS, Joondeph BC, Randolph J, Masonson H, Rezaei KA. C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2/3 trial. Ophthalmol. 2021;128(4):576–586. doi: 10.1016/j.ophtha.2020.08.027.
  • Liao DS, Grossi FV, El Mehdi D, Gerber MR, Brown DM, Heier JS, Wykoff CC, Singerman LJ, Abraham P, Grassmann F, et al. Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial. Ophthalmol. 2020;127(2):186–195. doi: 10.1016/j.ophtha.2019.07.011.
  • Appeliis I. FDA approves SYFOVRE™ (pegcetacoplan injection) as the first and only treatment for geographic atrophy (GA), a leading cause of blindness; 2023. Available from: https://investors.apellis.com/news-releases/news-release-details/fda-approves-syfovretm-pegcetacoplan-injection-first-and-only. Accessed Feb 24, 2023.
  • Wang JJ, Rochtchina E, Lee AJ, Chia E-M, Smith W, Cumming RG, Mitchell P. Ten-year incidence and progression of age-related maculopathy: the blue mountains eye study. Ophthalmol. 2007;114(1):92–98. doi: 10.1016/j.ophtha.2006.07.017.
  • Schmetterer L, Scholl H, Garhöfer G, Janeschitz-Kriegl L, Corvi F, Sadda SR, Medeiros FA. Endpoints for clinical trials in ophthalmology. Prog Retin Eye Res. 2023;101160. doi: 10.1016/j.preteyeres.2022.101160.
  • Schmidt-Erfurth U, Klimscha S, Waldstein S, Bogunović H. A view of the current and future role of optical coherence tomography in the management of age-related macular degeneration. Eye. 2017;31(1):26–44. doi: 10.1038/eye.2016.227.
  • Jaffe GJ, Chakravarthy U, Freund KB, Guymer RH, Holz FG, Liakopoulos S, Monés JM, Rosenfeld PJ, Sadda SR, Sarraf D, et al. Imaging features associated with progression to geographic atrophy in age-related macular degeneration: classification of atrophy Meeting Report 5. Ophthalmol Retina. 2021;5(9):855–867. doi: 10.1016/j.oret.2020.12.009.
  • Food and Drug Administration. 2020. Patient-focused drug development: collecting comprehensive and representative input. Guidance for industry. Food and drug administration staff, and other stakeholders. FDA-2018-D-1893. <https://www.fda.gov/regulatory-information/search-fda-guidance-documents/patient-focused-drug-development-collecting-comprehensive-and-representative-input>. Accessed February12, 2023.
  • Owsley C, McGwin G, Clark ME, Jackson GR, Callahan MA, Kline LB, Witherspoon CD, Curcio CA. Delayed rod-mediated dark adaptation is a functional biomarker for incident early age-related macular degeneration. Ophthalmol. 2016;123(2):344–351. doi: 10.1016/j.ophtha.2015.09.041.
  • Zhang Y, Sadda SR, Sarraf D, Swain TA, Clark ME, Sloan KR, Warriner WE, Owsley C, Curcio CA. Spatial dissociation of subretinal drusenoid deposits and impaired scotopic and mesopic sensitivity in AMD. Invest Ophthalmol Vis Sci. 2022;63(2):32–32. doi: 10.1167/iovs.63.2.32.
  • Owsley C, Swain TA, McGwin G, Clark ME, Kar D, Crosson JN, Curcio CA. How vision is impaired from aging to early and intermediate age-related macular degeneration: insights from ALSTAR2 baseline. Transl Vis Sci Technol. 2022;11(7):17–17. doi: 10.1167/tvst.11.7.17.
  • Owsley C, Swain TA, McGwin G, Jr Clark ME, Kar D, Curcio CA. Biologically guided optimization of test target location for rod-mediated dark adaptation in age-related macular degeneration: ALSTAR2 baseline. Ophthalmol Sci. 2023;3(2):100274. doi: 10.1016/j.xops.2023.100274.
  • Lee AY, Lee CS, Blazes MS, Owen JP, Bagdasarova Y, Wu Y, Spaide T, Yanagihara RT, Kihara Y, Clark ME, et al. Exploring a structural basis for delayed rod-mediated dark adaptation in age-related macular degeneration via deep learning. Transl Vis Sci Technol. 2020;9(2):62–62. doi: 10.1167/tvst.9.2.62.
  • Spaide RF, Curcio CA. Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model. Retina. 2011;31(8):1609–1619. doi: 10.1097/IAE.0b013e3182247535.
  • Staurenghi G, Sadda S, Chakravarthy U, Spaide RF; International Nomenclature for Optical Coherence Tomography (IN•OCT) Panel. Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN•OCT consensus. Ophthalmol. 2014;121(8):1572–1578. doi: 10.1016/j.ophtha.2014.02.023.
  • Steinberg R, Wood I, Hogan M. Pigment epithelial ensheathment and phagocytosis of extrafoveal cones in human retina. Philos Trans R Soc Lond B Biol Sci. 1977;277(958):459–474. doi: 10.1098/rstb.1977.0028.
  • Nawrot M, West K, Huang J, Possin DE, Bretscher A, Crabb JW, Saari JC. Cellular retinaldehyde-binding protein interacts with ERM-binding phosphoprotein 50 in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2004;45(2):393–401. doi: 10.1167/iovs.03-0989.
  • Zhang X, Hughes BA. KCNQ and KCNE potassium channel subunit expression in bovine retinal pigment epithelium. Exp Eye Res. 2013;116:424–432. doi: 10.1016/j.exer.2013.10.013.
  • Swarup A, Samuels IS, Bell BA, Han JY, Du J, Massenzio E, Abel ED, Boesze-Battaglia K, Peachey NS, Philp NJ. Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells. Am J Physiol Cell Physiol. 2019;316(1):C121–C133. doi: 10.1152/ajpcell.00410.2018.
  • Rudolf M, Curcio CA, Schlötzer-Schrehardt U, Sefat AMM, Tura A, Aherrahrou Z, Brinkmann M, Grisanti S, Miura Y, Ranjbar M. Apolipoprotein AI mimetic peptide L-4F removes Bruch’s membrane lipids in aged nonhuman primates. Invest Ophthalmol Vis Sci. 2019;60(2):461–472. doi: 10.1167/iovs.18-25786.
  • Penberthy KK, Lysiak JJ, Ravichandran KS. Rethinking phagocytes: clues from the retina and testes. Trends Cell Biol. 2018;28(4):317–327. doi: 10.1016/j.tcb.2018.01.004.
  • Lamb TD, Pugh EN. Dark adaptation and the retinoid cycle of vision. Prog Retin Eye Res. 2004;23(3):307–380. doi: 10.1016/j.preteyeres.2004.03.001.
  • Rii T, Itoh Y, Inoue M, Hirakata A. Foveal cone outer segment tips line and disruption artifacts in spectral-domain optical coherence tomographic images of normal eyes. Am J Ophthalmol. 2012;153(3):524–529. e1. doi: 10.1016/j.ajo.2011.08.021.
  • Gu R, Deng G, Jiang Y, Jiang C, Xu G. Area of the cone interdigitation zone in healthy Chinese adults and its correlation with macular volume. BMC Ophthalmol. 2018;18(1):188. doi: 10.1186/s12886-018-0862-7.
  • Park SJ, Woo SJ, Park KH, Hwang J-M, Chung H. Morphologic photoreceptor abnormality in occult macular dystrophy on spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2010;51(7):3673–3679. doi: 10.1167/iovs.09-4169.
  • Sisk RA, Berrocal AM, Lam BL. Loss of foveal cone photoreceptor outer segments in occult macular dystrophy. Ophthalmic Surg Lasers Imaging. 2010;41(3):1–3. doi: 10.3928/15428877-20100215-49.
  • Milam AH, Li Z-Y, Fariss RN. Histopathology of the human retina in retinitis pigmentosa. Prog Retin Eye Res. 1998;17(2):175–205.
  • Mitamura Y, Mitamura-Aizawa S, Katome T, Naito T, Hagiwara A, Kumagai K, Yamamoto S. Photoreceptor impairment and restoration on optical coherence tomographic image. J Ophthalmol. 2013;2013:518170. doi: 10.1155/2013/518170.
  • Puche N, Querques G, Benhamou N, Tick S, Mimoun G, Martinelli D, Soubrane G, Souied E. High-resolution spectral domain optical coherence tomography features in adult onset foveomacular vitelliform dystrophy. Br J Ophthalmol. 2010;94(9):1190–1196. doi: 10.1136/bjo.2009.175075.
  • Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, et al. High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy. Ophthalmol. 2010;117(9):1800–1809.e2. doi: 10.1016/j.ophtha.2010.01.042.
  • Kominami A, Ueno S, Kominami T, Nakanishi A, Piao C-H, Ra E, Yasuda S, Asami T, Terasaki H. Restoration of cone interdigitation zone associated with improvement of focal macular ERG after fovea-off rhegmatogenous retinal reattachment. Invest Ophthalmol Vis Sci. 2016;57(4):1604–1611. doi: 10.1167/iovs.15-19030.
  • Itoh Y, Inoue M, Rii T, Hirota K, Hirakata A. Correlation between foveal cone outer segment tips line and visual recovery after epiretinal membrane surgery. Invest Ophthalmol Vis Sci. 2013;54(12):7302–7308. doi: 10.1167/iovs.13-12702.
  • Itoh Y, Inoue M, Rii T, Hiraoka T, Hirakata A. Significant correlation between visual acuity and recovery of foveal cone microstructures after macular hole surgery. Am J Ophthalmol. 2012;153(1):111–119. e1. doi: 10.1016/j.ajo.2011.05.039.
  • Curcio CA, McGwin G, Sadda SR, Hu Z, Clark ME, Sloan KR, Swain T, Crosson JN, Owsley C. Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods. BMC Ophthalmol. 2020;20(1):196. doi: 10.1186/s12886-020-01467-0.
  • Davis MD, Gangnon RE, Lee LY, Hubbard LD, Klein B, Klein R, Ferris FL, Bressler SB, Milton RC, Age-Related Eye Disease Study Group. The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS report No. 17. Arch Ophthalmol. 2005;123(11):1484–1498. doi: 10.1001/archopht.123.11.1484.
  • Kleefeldt N, Bermond K, Tarau I-S, Hillenkamp J, Berlin A, Sloan KR, Ach T. Quantitative fundus autofluorescence: advanced analysis tools. Transl Vis Sci Technol. 2020;9(8):2–2. doi: 10.1167/tvst.9.8.2.
  • Berlin A, Clark ME, Swain TA, Fischer NA, McGwin G, Sloan KR, Owsley C, Curcio CA. Impact of the aging lens and posterior capsular opacification on quantitative autofluorescence imaging in age-related macular degeneration. Transl Vis Sci Technol. 2022;11(10):23. doi: 10.1167/tvst.11.10.23.
  • Park D-W, Lujan BJ. Normal interdigitation zone loss by motion-tracked OCT. Ophthalmol Retina. 2017;1(5):394. doi: 10.1016/j.oret.2017.05.005.
  • Rossant F, Grieve K, Paques M. Highlighting directional reflectance properties of retinal substructures from D-OCT images. IEEE Trans Biomed Eng. 2019;66(11):3105–3118. doi: 10.1109/TBME.2019.2900425.
  • Curcio C, Millican CL, Allen K, Kalina R. Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci. 1993;34(12):3278–3296.
  • Jackson GR, Edwards JG. A short-duration dark adaptation protocol for assessment of age-related maculopathy. J Ocul Biol Dis Infor. 2008;1(1):7–11. doi: 10.1007/s12177-008-9002-6.
  • Leibrock C, Reuter T, Lamb T. Molecular basis of dark adaptation in rod photoreceptors. Eye. 1998;12(3):511–520. doi: 10.1038/eye.1998.139.
  • Srinivasan VJ, Monson BK, Wojtkowski M, Bilonick RA, Gorczynska I, Chen R, Duker JS, Schuman JS, Fujimoto JG. Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2008;49(4):1571–1579. doi: 10.1167/iovs.07-0838.
  • Ross DH, Clark ME, Godara P, Huisingh C, McGwin G, Owsley C, Litts KM, Spaide RF, Sloan KR, Curcio CA. RefMoB, a reflectivity feature model-based automated method for measuring four outer retinal hyperreflective bands in optical coherence tomography. Invest Ophthalmol Vis Sci. 2015;56(8):4166–4176. doi: 10.1167/iovs.14-15256.
  • Yao X, Son T, Kim T-H, Le D. Interpretation of anatomic correlates of outer retinal bands in optical coherence tomography. Exp Biol Med. 2021;246(20):2140–2150. doi: 10.1177/15353702211022674.
  • Sohaib Fasih-Ahmad ZW, Mishra Z, Vatanatham C, Clark M, Curcio C, Owsley C, Sadda SVas, Jewel Hu Z. AI in the retina using OCTA: relationship between delayed RMDA and the ellipsoid and interdigitation zones in age-related macular degeneration (AMD): ALSTAR2 baseline. Invest Ophthalmol Vis Sci. 2023;64(8):293.
  • Lujan BJ, Roorda A, Knighton RW, Carroll J. Revealing Henle’s fiber layer using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52(3):1486–1492. doi: 10.1167/iovs.10-5946.
  • Lujan BJ, Roorda A, Croskrey JA, Dubis AM, Cooper RF, Bayabo J-K, Duncan JL, Antony BJ, Carroll J. Directional optical coherence tomography provides accurate outer nuclear layer and Henle fiber layer measurements. Retina. 2015;35(8):1511–1520. doi: 10.1097/IAE.0000000000000527.
  • Munch IC, Altuntas C, Li XQ, Jackson GR, Klefter ON, Larsen M. Dark adaptation in relation to choroidal thickness in healthy young subjects: a cross-sectional, observational study. BMC Ophthalmol. 2016;16(1):105. doi: 10.1186/s12886-016-0273-6.
  • Lamb TD, Pugh EN. Phototransduction, dark adaptation, and rhodopsin regeneration the proctor lecture. Invest Ophthalmol Vis Sci. 2006;47(12):5137–5152. doi: 10.1167/iovs.06-0849.
  • Ishikawa M, Sawada Y, Yoshitomi T. Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells. Exp Eye Res. 2015;133:3–18. doi: 10.1016/j.exer.2015.02.017.
  • Anderson DH, Fisher SK. The relationship of primate foveal cones to the pigment epithelium. J Ultrastruct Res. 1979;67(1):23–32. doi: 10.1016/s0022-5320(79)80014-3.
  • Daniele LL, Adams RH, Durante DE, Pugh EN, Jr, Philp NJ. Novel distribution of junctional adhesion molecule‐C in the neural retina and retinal pigment epithelium. J Comp Neurol. 2007;505(2):166–176. doi: 10.1002/cne.21489.
  • Han JY, Kinoshita J, Bisetto S, Bell BA, Nowak RA, Peachey NS, Philp NJ. Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: insight gained from cell-specific Bsg deletion. FASEB J. 2020;34(4):5401–5419. doi: 10.1096/fj.201902961R.
  • Pollreisz A, Messinger JD, Sloan KR, Mittermueller TJ, Weinhandl AS, Benson EK, Kidd GJ, Schmidt-Erfurth U, Curcio CA. Visualizing melanosomes, lipofuscin, and melanolipofuscin in human retinal pigment epithelium using serial block face scanning electron microscopy. Exp Eye Res. 2018;166:131–139. doi: 10.1016/j.exer.2017.10.018.
  • Pollreisz A, Neschi M, Sloan KR, Pircher M, Mittermueller T, Dacey DM, Schmidt-Erfurth U, Curcio CA. Atlas of human retinal pigment epithelium organelles significant for clinical imaging. Invest Ophthalmol Vis Sci. 2020;61(8):13–13. doi: 10.1167/iovs.61.8.13.
  • Pollreisz A, Sedova A, Lindell M, Arsenault Z, Packer O, Kar D, Kim YJ, Sloan KR, Schmidt-Erfurth U, Marsh M. Three-dimensional reconstruction of human retinal pigment epithelium (RPE) permits a novel view of the RPE–photoreceptor outer segment (OS) interface. Invest Ophthalmol Vis Sci. 2022;63(7):871–871.
  • Zekavat SM, Sekimitsu S, Ye Y, Raghu V, Zhao H, Elze T, Segrè AV, Wiggs JL, Natarajan P, Del Priore L, et al. Photoreceptor layer thinning is an early biomarker for age-related macular degeneration: epidemiologic and genetic evidence from UK Biobank OCT data. Ophthalmol. 2022;129(6):694–707. doi: 10.1016/j.ophtha.2022.02.001.
  • Lu CD, Lee B, Schottenhamml J, Maier A, Pugh EN, Fujimoto JG. Photoreceptor layer thickness changes during dark adaptation observed with ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2017;58(11):4632–4643. doi: 10.1167/iovs.17-22171.
  • Owsley C, Clark ME, Huisingh CE, Curcio CA, McGwin G. Visual function in older eyes in normal macular health: association with incident early age-related macular degeneration 3 years later. Invest Ophthalmol Vis Sci. 2016;57(4):1782–1789. doi: 10.1167/iovs.15-18962.
  • Owsley C, Clark ME, McGwin G. Natural history of rod-mediated dark adaptation over 2 years in intermediate age-related macular degeneration. Transl Vis Sci Technol. 2017;6(3):15–15. doi: 10.1167/tvst.6.3.15.
  • Charng J, Attia MS, Arunachalam S, Lam W-S, Creaney J, Muruganandan S, Read C, Millward M, Spiro J, Chakera A, et al. Increased interdigitation zone visibility on optical coherence tomography following systemic fibroblast growth factor receptor 1‐3 tyrosine kinase inhibitor anticancer therapy. Clin Exp Ophthalmol. 2021;49(6):579–590. doi: 10.1111/ceo.13940.
  • Jackson GR, Owsley C, McGwin G. Aging and dark adaptation. Vision Res. 1999;39(23):3975–3982. doi: 10.1016/s0042-6989(99)00092-9.
  • Tappeiner C, Barthelmes D, Abegg MH, Wolf S, Fleischhauer JC. Impact of optic media opacities and image compression on quantitative analysis of optical coherence tomography. Invest Ophthalmol Vis Sci. 2008;49(4):1609–1614. doi: 10.1167/iovs.07-1264.
  • Sura AA, Chen L, Messinger JD, Swain TA, McGwin G, Freund KB, Curcio CA. Measuring the contributions of basal laminar deposit and Bruch’s membrane in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2020;61(13):19–19. doi: 10.1167/iovs.61.13.19.
  • Chen L, Messinger JD, Kar D, Duncan JL, Curcio CA. Biometrics, impact, and significance of basal linear deposit and subretinal Drusenoid deposit in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2021;62(1):33–33. doi: 10.1167/iovs.62.1.33.
  • Chen S, Abu-Qamar O, Kar D, Messinger JD, Hwang Y, Moult EM, Lin J, Baumal CR, Witkin A, Liang MC, et al. Ultrahigh resolution optical coherence tomography markers of normal aging and early age-related macular degeneration. Ophthalmol Sci. 2023;3(3):100277. doi: 10.1016/j.xops.2023.100277.
  • Zhang T, Kho AM, Yiu G, Srinivasan VJ. Visible light optical coherence tomography (OCT) quantifies subcellular contributions to outer retinal band 4. Transl Vis Sci Technol. 2021;10(3):30–30. doi: 10.1167/tvst.10.3.30.

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