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Cornea

Dermatophagoides Pteronyssinus 1 (DerP1) May Trigger NLRP3-Mediated Corneal Epithelial Cell Pyroptosis by Elevating Interleukin-33 Expression Levels

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Pages 1100-1111 | Received 01 Mar 2023, Accepted 17 Aug 2023, Published online: 25 Aug 2023

References

  • Rigoli L, Briuglia S, Caimmi S, Ferraú V, Gallizzi R, Leonardi S, La Rosa M, Salpietro C. Gene-environment interaction in childhood asthma. Int J Immunopathol Pharmacol. 2011;24(4 Suppl):41–47. doi:10.1177/03946320110240S409.
  • Maziak W, Behrens T, Brasky TM, Duhme H, Rzehak P, Weiland SK, Keil U. Are asthma and allergies in children and adolescents increasing? Results from ISAAC phase I and phase III surveys in Münster, Germany. Allergy. 2003;58(7):572–579. doi:10.1034/j.1398-9995.2003.00161.x.
  • La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S, Tomarchio S, Avitabile T, Reibaldi A. Allergic conjunctivitis: a comprehensive review of the literature. Ital J Pediatr. 2013;39(1):18. doi:10.1186/1824-7288-39-18.
  • Abelson MB, Shetty S, Korchak M, Butrus SI, Smith LM. Advances in pharmacotherapy for allergic conjunctivitis. Expert Opin Pharmacother. 2015;16(8):1219–1231. doi:10.1517/14656566.2015.1040760.
  • Hornof M, Toropainen E, Urtti A. Cell culture models of the ocular barriers. Eur J Pharm Biopharm. 2005;60(2):207–225. doi:10.1016/j.ejpb.2005.01.009.
  • Leong YY, Tong L. Barrier function in the ocular surface: from conventional paradigms to new opportunities. Ocul Surf. 2015;13(2):103–109. doi:10.1016/j.jtos.2014.10.003.
  • Yoon S, Han S, Jeon KJ, Kwon S. Effects of collected road dusts on cell viability, inflammatory response, and oxidative stress in cultured human corneal epithelial cells. Toxicol Lett. 2018;284:152–160. doi:10.1016/j.toxlet.2017.12.012.
  • Xiang P, Liu RY, Sun HJ, Han YH, He RW, Cui XY, Ma LQ. Molecular mechanisms of dust-induced toxicity in human corneal epithelial cells: water and organic extract of office and house dust. Environ Int. 2016;92–93:348–356. doi:10.1016/j.envint.2016.04.013.
  • Zhang L, Lu R, Zhao G, Pflugfelder SC, Li DQ. TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium. Int J Biochem Cell Biol. 2011;43(9):1383–1391. doi:10.1016/j.biocel.2011.06.003.
  • Préfontaine D, Lajoie-Kadoch S, Foley S, Audusseau S, Olivenstein R, Halayko AJ, Lemière C, Martin JG, Hamid Q. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J Immunol. 2009;183(8):5094–5103. doi:10.4049/jimmunol.0802387.
  • Salimi M, Barlow JL, Saunders SP, Xue L, Gutowska-Owsiak D, Wang X, Huang LC, Johnson D, Scanlon ST, McKenzie AN. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med. 2013;210(13):2939–2950. doi:10.1084/jem.20130351.
  • Imai Y, Yasuda K, Sakaguchi Y, Haneda T, Mizutani H, Yoshimoto T, Nakanishi K, Yamanishi K. Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice. Proc Natl Acad Sci U S A. 2013;110(34):13921–13926. doi:10.1073/pnas.1307321110.
  • Sakashita M, Yoshimoto T, Hirota T, Harada M, Okubo K, Osawa Y, Fujieda S, Nakamura Y, Yasuda K, Nakanishi K, and, others. Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis. Clin Exp Allergy. 2008;38(12):1875–1881. doi:10.1111/j.1365-2222.2008.03114.x.
  • Lin W, Zhou Q, Liu C, Ying M, Xu S. Increased plasma IL-17, IL-31, and IL-33 levels in chronic spontaneous urticaria. Sci Rep. 2017;7(1):17797. doi:10.1038/s41598-017-18187-z.
  • Matsuba-Kitamura S, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Taki Y, Muto T, Ikeda T, Mimura O, Nakanishi K. Contribution of IL-33 to induction and augmentation of experimental allergic conjunctivitis. Int Immunol. 2010;22(6):479–489. doi:10.1093/intimm/dxq035.
  • Pichery M, Mirey E, Mercier P, Lefrancais E, Dujardin A, Ortega N, Girard JP. Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain. J Immunol. 2012;188(7):3488–3495. doi:10.4049/jimmunol.1101977.
  • Savinko T, Matikainen S, Saarialho-Kere U, Lehto M, Wang G, Lehtimäki S, Karisola P, Reunala T, Wolff H, Lauerma A. IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Invest Dermatol. 2012;132(5):1392–1400. doi:10.1038/jid.2011.446.
  • Aoki S, Hayakawa M, Ozaki H, Takezako N, Obata H, Ibaraki N, Tsuru T, Tominaga S, Yanagisawa K. ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells. Mol Cell Biochem. 2010;335(1-2):75–81. doi:10.1007/s11010-009-0244-9.
  • Milovanovic M, Volarevic V, Radosavljevic G, Jovanovic I, Pejnovic N, Arsenijevic N, Lukic ML. IL-33/ST2 axis in inflammation and immunopathology. Immunol Res. 2012;52(1–2):89–99. doi:10.1007/s12026-012-8283-9.
  • You J, Lin J, Zhou YF, Peng XD, He H, Li C, Zhu GQ, Zhao XQ, Zhao GQ. Role of the IL-33/ST2/p38 signaling pathway in the immune response of corneal epithelial cells to Aspergillus fumigatus infection. Int J Ophthalmol. 2019;12(4):549–556.
  • Wang J, Zheng Y, Chen G, Lv Y, Lian F, Jiang D, Ke W, Liu L, Fan C, Gong S. The changes in pyroptosis-related inflammatory factors in the peripheral blood of patients with Henoch-Schonlein purpura. Ann Palliat Med. 2021;10(6):6687–6693. doi:10.21037/apm-21-1227.
  • Yang Z, Liang C, Wang T, Zou Q, Zhou M, Cheng Y, Peng H, Ji Z, Deng Y, Liao J. NLRP3 inflammasome activation promotes the development of allergic rhinitis via epithelium pyroptosis. Biochem Biophys Res Commun. 2020;522(1):61–67. doi:10.1016/j.bbrc.2019.11.031.
  • Theofani E, Semitekolou M, Morianos I, Samitas K, Xanthou G. Targeting NLRP3 inflammasome activation in severe asthma. J Clin Med. 2019;8(10):1615.
  • Downs KP, Nguyen H, Dorfleutner A, Stehlik C. An overview of the non-canonical inflammasome. Mol Aspects Med. 2020;76:100924. doi:10.1016/j.mam.2020.100924.
  • Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H. Corrigendum: the receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015;16(12):1292–1292. doi:10.1038/ni1215-1292a.
  • Chen H, Gan X, Li Y, Gu J, Liu Y, Deng Y, Wang X, Hong Y, Hu Y, Su L. NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye. Ocul Surf. 2020;18(4):783–794. doi:10.1016/j.jtos.2020.07.001.
  • Wang S, Yuan YH, Chen NH, Wang HB. The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson’s disease. Int Immunopharmacol. 2019;67:458–464. doi:10.1016/j.intimp.2018.12.019.
  • Swanson KV, Deng M, Ting PY. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19(8):477–489. doi:10.1038/s41577-019-0165-0.
  • Broz P, Pelegrin P, Feng S. The gasdermins, a protein family executing cell death and inflammation. Nat Rev Immunol. 2020;20(3):143–157.
  • Liu X, Xia S, Zhang Z, Wu H, Lieberman J. Channelling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov. 2021;20(5):384–405. doi:10.1038/s41573-021-00154-z.
  • Tang R, Lyu X, Liu Y, Wang R, Wang L, Li H, Sun J, Zhi Y, Gu J, Guan K, et al. Diagnostic accuracy and safety of Dermatophagoides pteronyssinus extracts used for skin prick test. Chin Med J (Engl). 2022;135(21):2563–2569. doi:10.1097/CM9.0000000000002262.
  • Cayrol C, Girard JP. Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family. Immunol Rev. 2018;281(1):154–168. doi:10.1111/imr.12619.
  • Kotsiou OS, Gourgoulianis KI, Zarogiannis SG. IL-33/ST2 axis in organ fibrosis. Front Immunol. 2018;9:2432. doi:10.3389/fimmu.2018.02432.
  • Jiang H-R, Milovanović M, Allan D, Niedbala W, Besnard A-G, Fukada SY, Alves-Filho JC, Togbe D, Goodyear CS, Linington C, et al. IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages. Eur J Immunol. 2012;42(7):1804–1814. doi:10.1002/eji.201141947.
  • Li S, Wu Y, Yang D, Wu C, Ma C, Liu X, Moynagh PN, Wang B, Hu G, Yang S. Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis. J Exp Med. 2019;216(11):2562–2581. doi:10.1084/jem.20190377.
  • Ke J, Cai G. Effect of IL-33 on pyroptosis of macrophages in mice with sepsis via NF-κB/p38 MAPK signaling pathway. Acta Cirurgica Brasileira. 2021;36(5):e360501.
  • Madouri F, Guillou N, Fauconnier L, Marchiol T, Rouxel N, Chenuet P, Ledru A, Apetoh L, Ghiringhelli F, Chamaillard M, and, others. Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation. J Mol Cell Biol. 2015;7(4):351–365. doi:10.1093/jmcb/mjv012.
  • Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 2014;59(3):898–910. doi:10.1002/hep.26592.
  • Sharma BR, Kanneganti TD. NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol. 2021;22(5):550–559. doi:10.1038/s41590-021-00886-5.
  • Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K. Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes. J Allergy Clin Immunol. 2011;127(3):806–814.e4. doi:10.1016/j.jaci.2010.12.006.
  • Ln A, Ll A, Chao XB, Blc D, Ch A, Ms A, Jn C, Ye RC, Xsaef G, Yuan L. Airborne particulate matter (PM2.5) triggers cornea inflammation and pyroptosis via NLRP3 activation. Ecotoxicol Environ Saf. 2021;207:111306.
  • He W-t, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang Z-H, Zhong C-Q, Han J. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res. 2015;25(12):1285–1298. doi:10.1038/cr.2015.139.
  • Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660–665. doi:10.1038/nature15514.
  • Ayesha Z, Bofeng A, John K, Kombe T, Jin J. Pharmacological Inhibitors of the NLRP3 Inflammasome. Front Immunol. 2019;10:2538–2538. doi:10.3389/fimmu.2019.02538.

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