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Retina and Choroid

Identification of Potential Therapeutic Targets for Myopic Choroidal Neovascularization via Discovery-Driven Data Mining

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Pages 1160-1169 | Received 24 Apr 2023, Accepted 21 Aug 2023, Published online: 29 Aug 2023

References

  • Holden BA, Fricke TR, Wilson DA, Jong M, Naidoo KS, Sankaridurg P, Wong TY, Naduvilath TJ, Resnikoff S. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology. 2016;123(5):1036–1042. doi: 10.1016/j.ophtha.2016.01.006.
  • Zhang Y. Wildsoet CFJPimb, science t. Rpe and choroid mechanisms underlying ocular growth and myopia. Prog Mol Biol Transl. 2015;134:221–240.
  • Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010;29(2):144–168. doi: 10.1016/j.preteyeres.2009.12.002.
  • Summers JA. The choroid as a sclera growth regulator. Exp Eye Res. 2013;114:120–127. doi: 10.1016/j.exer.2013.03.008.
  • Chiang ST, Phillips JR, Backhouse S. Effect of retinal image defocus on the thickness of the human choroid. Ophthalmic Physiol Opt. 2015;35(4):405–413. doi: 10.1111/opo.12218.
  • Neelam K, Cheung CM, Ohno-Matsui K, Lai TY, Wong TY. Choroidal neovascularization in pathological myopia. Prog Retin Eye Res. 2012;31(5):495–525. doi: 10.1016/j.preteyeres.2012.04.001.
  • Jia Y, Bailey ST, Wilson DJ, Tan O, Klein ML, Flaxel CJ, Potsaid B, Liu JJ, Lu CD, Kraus MF, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration. Ophthalmology. 2014;121(7):1435–1444. doi: 10.1016/j.ophtha.2014.01.034.
  • Harb E, Hyman L, Gwiazda J, Marsh-Tootle W, Zhang Q, Hou W, Norton TT, Weise K, Dirkes K, Zangwill LM. Choroidal thickness profiles in myopic eyes of young adults in the correction of myopia evaluation trial cohort. Am J Ophthalmol. 2015;160(1):62–71 e62. doi: 10.1016/j.ajo.2015.04.018.
  • Cagiltay E, Akay F, Demir O, Aydin E, Akmaz B, Pamuk B. The increment of choroidal thickness in euthyroid graves’ ophthalmopathy: Is it an early sign of venous congestion? J Ophthalmol. 2018;2018:5891531–5891536. doi: 10.1155/2018/5891531.
  • Wakabayashi T, Ikuno Y, Oshima Y, Hamasaki T, Nishida K. Aqueous concentrations of vascular endothelial growth factor in eyes with high myopia with and without choroidal neovascularization. J Ophthalmol. 2013;2013:257381–257385. doi: 10.1155/2013/257381.
  • Lai TYY, Cheung CMG, Mieler WF. Ophthalmic application of anti-vegf therapy. Asia Pac J Ophthalmol. 2017;6(6):479–480. doi: 10.22608/APO.2017500.
  • Shalaby A, Lewis K, Bush K, Meredith P, Di Simplicio S, Lockwood A. Licence to save: a uk survey of anti-vegf use for the eye in 2015. Eye. 2016;30(11):1404–1406. doi: 10.1038/eye.2016.154.
  • Cheung CMG, Arnold JJ, Holz FG, Park KH, Lai TYY, Larsen M, Mitchell P, Ohno-Matsui K, Chen S-J, Wolf S, et al. Myopic choroidal neovascularization: review, guidance, and consensus statement on management. Ophthalmology. 2017;124(11):1690–1711. doi: 10.1016/j.ophtha.2017.04.028.
  • Liu L, Zhu D, Ding W, Zhang T, Ma X, Zou J. Mirna-21-hif-1α-vegf axis is associated with myopic choroidal neovascularization in guinea pigs. Ophthalmic Res. 2022;65(5):493–505. doi: 10.1159/000522511.
  • Lin X, Li X, Lin X. A review on applications of computational methods in drug screening and design. Molecules. 2020;25(6):1375. doi: 10.3390/molecules25061375.
  • Fang J, Zhang P, Zhou Y, Chiang C-W, Tan J, Hou Y, Stauffer S, Li L, Pieper AA, Cummings J, et al. Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease. Nat Aging. 2021;1(12):1175–1188. doi: 10.1038/s43587-021-00138-z.
  • Perry A, Loftus B, Moroose R, Lynch T, Hollywood D, Watson R, Woodson K, Lawler M. In silico mining identifies igfbp3 as a novel target of methylation in prostate cancer. Br J Cancer. 2007;96(10):1587–1594. doi: 10.1038/sj.bjc.6603767.
  • Chiang AP, Butte AJ. Systematic evaluation of drug–disease relationships to identify leads for novel drug uses. Clin Pharmacol Ther. 2009;86(5):507–510. doi: 10.1038/clpt.2009.103.
  • Southall NT, Natarajan M, Lau LPL, Jonker AH, Deprez B, Guilliams T, Hunter L, Rademaker C, Hivert V, Ardigò D. The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases–recommendations of the irdirc data mining and repurposing task force. Orphanet J Rare Dis. 2019;14(1):225. doi: 10.1186/s13023-019-1193-3.
  • Baran J, Gerner M, Haeussler M, Nenadic G, Bergman CM. Pubmed2ensembl: a resource for mining the biological literature on genes. PLoS One. 2011;6(9):e24716. doi: 10.1371/journal.pone.0024716.
  • Wang J-H, Zhao L-F, Wang H-F, Wen Y-T, Jiang K-K, Mao X-M, Zhou Z-Y, Yao K-T, Geng Q-S, Guo D, et al. Genclip 3: mining human genes’ functions and regulatory networks from pubmed based on co-occurrences and natural language processing. Bioinformatics. 2019;2019(6):1973–1975. doi: 10.1093/bioinformatics/btz807.
  • Buniello A, MacArthur JAL, Cerezo M, Harris LW, Hayhurst J, Malangone C, McMahon A, Morales J, Mountjoy E, Sollis E, et al. The nhgri-ebi gwas catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res. 2019;47(D1):D1005–D1012. doi: 10.1093/nar/gky1120.
  • Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, Iglesias AI, Meester-Smoor MA, Tompson SW, Fan Q, et al. Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nat Genet. 2018;50(6):834–848. doi: 10.1038/s41588-018-0127-7.
  • Raudvere U, Kolberg L, Kuzmin I, Arak T, Adler P, Peterson H, Vilo J. G: profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Res. 2019;47(W1):W191–W198. doi: 10.1093/nar/gkz369.
  • Gillespie M, Jassal B, Stephan R, Milacic M, Rothfels K, Senff-Ribeiro A, Griss J, Sevilla C, Matthews L, Gong C, et al. The reactome pathway knowledgebase 2022. Nucleic Acids Res. 2022;50(D1):D687–D692. doi: 10.1093/nar/gkab1028.
  • Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al. String v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–D613. doi: 10.1093/nar/gky1131.
  • Kohl M, Wiese S, Warscheid B. Cytoscape: software for visualization and analysis of biological networks. Methods Mol Biol. 2011;696:291–303.
  • Chin C-H, Chen S-H, Wu H-H, Ho C-W, Ko M-T, Lin C-Y. Cytohubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl 4):S11. doi: 10.1186/1752-0509-8-S4-S11.
  • Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC, Imamichi T, Chang W. David: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 2022;50(W1):W216–W221. doi: 10.1093/nar/gkac194.
  • Krallinger M, Leitner F, Valencia A. Analysis of biological processes and diseases using text mining approaches. Bioinformat Methods Clin Res. 2010;593:341–382.
  • Reimand J, Kull M, Peterson H, Hansen J, Vilo J. G: profiler—a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res. 2007;35(Web Server issue):W193–W200. doi: 10.1093/nar/gkm226.
  • Lu C, Hu X, Wang G, Leach L, Yang S, Kearsey M, Luo Z. Why do essential proteins tend to be clustered in the yeast interactome network? Mol Biosyst. 2010;6(5):871–877. doi: 10.1039/b921069e.
  • Ohno-Matsui K, Suzaki M, Teshima R, Okami N. Real-world data on ranibizumab for myopic choroidal neovascularization due to pathologic myopia: results from a post-marketing surveillance in japan. Eye. 2018;32(12):1871–1878. doi: 10.1038/s41433-018-0192-2.
  • Inhoffen W, Ziemssen F. Morphological features of myopic choroidal neovascularization: differences to neovascular age-related macular degeneration. Ophthalmologe. 2012;109(8):749–757. doi: 10.1007/s00347-011-2498-3.
  • Miao H, Tao Y, Li X-x. Inflammatory cytokines in aqueous humor of patients with choroidal neovascularization. Mol Vis. 2012; 18:574–580.
  • Roychoudhury J, Herndon JM, Yin J, Apte RS, Ferguson TA. Targeting immune privilege to prevent pathogenic neovascularization. Invest Ophthalmol Vis Sci. 2010;51(7):3560–3566. doi: 10.1167/iovs.09-3890.
  • Ball SG, Shuttleworth CA, Kielty CM. Mesenchymal stem cells and neovascularization: role of platelet‐derived growth factor receptors. J Cell Mol Med. 2007;11(5):1012–1030. doi: 10.1111/j.1582-4934.2007.00120.x.
  • Chen M, Glenn JV, Dasari S, McVicar C, Ward M, Colhoun L, Quinn M, Bierhaus A, Xu H, Stitt AW. Rage regulates immune cell infiltration and angiogenesis in choroidal neovascularization. PLoS One. 2014;9(2):e89548. doi: 10.1371/journal.pone.0089548.
  • Tomida D, Nishiguchi KM, Kataoka K, Yasuma TR, Iwata E, Uetani R, Kachi S, Terasaki H. Suppression of choroidal neovascularization and quantitative and qualitative inhibition of vegf and ccl2 by heparin. Invest Ophthalmol Vis Sci. 2011;52(6):3193–3199. doi: 10.1167/iovs.10-6737.
  • Lin H-J, Wei C-C, Chang C-Y, Chen T-H, Hsu Y-A, Hsieh Y-C, Chen H-J, Wan L. Role of chronic inflammation in myopia progression: clinical evidence and experimental validation. EBioMedicine. 2016;10:269–281. doi: 10.1016/j.ebiom.2016.07.021.
  • Ritchey ER, Zelinka CP, Tang J, Liu J, Fischer AJ. The combination of igf1 and fgf2 and the induction of excessive ocular growth and extreme myopia. Exp Eye Res. 2012;99:1–16. doi: 10.1016/j.exer.2012.03.019.
  • Tobe T, Ortega S, Luna JD, Ozaki H, Okamoto N, Derevjanik NL, Vinores SA, Basilico C, Campochiaro PA. Targeted disruption of the fgf2 gene does not prevent choroidal neovascularization in a murine model. Am J Pathol. 1998;153(5):1641–1646. doi: 10.1016/S0002-9440(10)65753-7.
  • Murakami M, Simons M. Fibroblast growth factor regulation of neovascularization. Curr Opin Hematol. 2008;15(3):215–220. doi: 10.1097/MOH.0b013e3282f97d98.
  • Hu W, Criswell MH, Fong S-L, Temm CJ, Rajashekhar G, Cornell TL, Clauss MA. Differences in the temporal expression of regulatory growth factors during choroidal neovascular development. Exp Eye Res. 2009;88(1):79–91. doi: 10.1016/j.exer.2008.10.014.
  • Han W, Yap MK, Wang J, Yip SP. Family-based association analysis of hepatocyte growth factor (hgf) gene polymorphisms in high myopia. Invest Ophthalmol Vis Sci. 2006;47(6):2291–2299. doi: 10.1167/iovs.05-1344.
  • Afarid M, Torabi-Nami M, Nemati A, Khosravi A, Malekzadeh M. Brain-derived neurotrophic factor in patients with advanced age-related macular degeneration. Int J Ophthalmol. 2015;8(5):991–995.
  • Katoh M, Nakagama H. Fgf receptors: cancer biology and therapeutics. Med Res Rev. 2014;34(2):280–300. doi: 10.1002/med.21288.
  • Ebrahem Q, Chaurasia SS, Vasanji A, Qi JH, Klenotic PA, Cutler A, Asosingh K, Erzurum S, Anand-Apte B. Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo. Am J Pathol. 2010;176(1):496–503. doi: 10.2353/ajpath.2010.080642.
  • Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, et al. Single-nucleotide polymorphisms in the promoter region of matrix metalloproteinase-1,-2, and-3 in Japanese with high myopia. Invest Ophthalmol Vis Sci. 2010;51(9):4432–4436. doi: 10.1167/iovs.09-4871.
  • Wong CW, Yanagi Y, Tsai ASH, Shihabuddeen WA, Cheung N, Lee SY, Jonas JB, Cheung CMG. Correlation of axial length and myopic macular degeneration to levels of molecular factors in the aqueous. Sci Rep. 2019;9(1):15708. doi: 10.1038/s41598-019-52156-y.
  • Jabłońska-Trypuć A, Matejczyk M, Rosochacki S. Matrix metalloproteinases (mmps), the main extracellular matrix (ecm) enzymes in collagen degradation, as a target for anticancer drugs. J Enzyme Inhib Med Chem. 2016;31(sup1):177–183. doi: 10.3109/14756366.2016.1161620.
  • Shchuko AG, Zaitseva NV, Yurieva TN, Chernykh ER, Mikhalevich IM, Shevela EY, Grigorieva AV. Intraocular cytokines and their correlations with clinical parameters in patients with myopic choroidal neovascularization. Ophthalmologica. 2017;237(2):96–104. doi: 10.1159/000455271.
  • Mammadzada P, Gudmundsson J, Kvanta A, André H. Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis. Acta Ophthalmol. 2016;94(8):805–814. doi: 10.1111/aos.13119.
  • Patel C, Narayanan SP, Zhang W, Xu Z, Sukumari-Ramesh S, Dhandapani KM, Caldwell RW, Caldwell RB. Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy. Am J Pathol. 2014;184(11):3040–3051. doi: 10.1016/j.ajpath.2014.07.012.
  • Zhou J, Fu B-q. The research on gene-disease association based on text-mining of pubmed. BMC Bioinform. 2018;19:1–8.
  • Rebholz-Schuhmann D, Oellrich A, Hoehndorf R. Text-mining solutions for biomedical research: enabling integrative biology. Nat Rev Genet. 2012;13(12):829–839. doi: 10.1038/nrg3337.
  • Freshour SL, Kiwala S, Cotto KC, Coffman AC, McMichael JF, Song JJ, Griffith M, Griffith OL, Wagner AH. Integration of the drug–gene interaction database (dgidb 4.0) with open crowdsource efforts. Nucleic Acids Res. 2021;49(D1):D1144–D1151. doi: 10.1093/nar/gkaa1084.
  • Thomas J, McNaught J, Ananiadou S. Applications of text mining within systematic reviews. Res Synth Methods. 2011;2(1):1–14. doi: 10.1002/jrsm.27.
  • Leveziel N, Marillet S, Dufour Q, Lichtwitz O, Bentaleb Y, Pelen F, Ingrand P, Bourne R. Prevalence of macular complications related to myopia–results of a multicenter evaluation of myopic patients in eye clinics in france. Acta Ophthalmol. 2020;98(2):e245–e251. doi: 10.1111/aos.14246.
  • Podkolodnaya O, Yarkova E, Demenkov P, Konovalova O, Ivanisenko V, Kolchanov N. Application of the andcell computer system to reconstruction and analysis of associative networks describing potential relationships between myopia and glaucoma. Russ J Genet Appl Res. 2011;1(1):21–28. doi: 10.1134/S2079059711010059.

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