Topical Dexamethasone Counters Intravitreal Ivermectin-Induced Ocular Toxicity in a Rabbit Model

References

• Edwards G. Ivermectin: does P-glycoprotein play a role in neurotoxicity? Filaria J. 2003;2(Suppl 1):S8. doi:10.1186/1475-2883-2-S1-S8.
   PubMedGoogle Scholar
• Woodward KN. Toxicity in animals: target species. Curr Pharm Biotechnol. 2012;13(6):952–968.
   PubMed Web of Science ®Google Scholar
• Klement P. An oral ivermectin regimen that eradicates pinworms (Syphacia spp.) in laboratory rats and mice. Laboratory Animal Science. 1996;46(3) :286–290.
   PubMedGoogle Scholar
• Roder JD, Stair EL. An overview of ivermectin toxicosis. Vet Hum Toxicol . 1998;40(6) :369–370.
   PubMedGoogle Scholar
• Kiki-Mvouaka S, Ménez C, Borin C, Lyazrhi F, Foucaud-Vignault M, Dupuy J, Collet X, Alvinerie M, Lespine A. Role of P-glycoprotein in the disposition of macrocyclic lactones: a comparison between ivermectin, eprinomectin, and moxidectin in mice. Drug Metab Dispos. 2010;38(4):573–580. doi:10.1124/dmd.109.030700.
   PubMed Web of Science ®Google Scholar
• Houston DM, Parent J, Matushek KJ. Ivermectin toxicosis in a dog. J Am Vet Med Assoc. 1987;191(1):78–80.
   PubMed Web of Science ®Google Scholar
• Merola V, Khan S, Gwaltney-Brant S. Ivermectin toxicosis in dogs: a retrospective study. J Am Anim Hosp Assoc. 2009;45(3):106–111. doi:10.5326/0450106.
   PubMed Web of Science ®Google Scholar
• Meekins JM, Guess SC, Rankin AJ. Retinopathy associated with ivermectin toxicosis in five cats. J Am Vet Med Assoc. 2015;246(11):1238–1241. doi:10.2460/javma.246.11.1238.
   PubMed Web of Science ®Google Scholar
• Pollio D, Michau TM, Weaver E, Kuebelbeck KL. Electroretinographic changes after intravenous lipid emulsion therapy in a dog and a foal with ivermectin toxicosis. Vet Ophthalmol. 2018;21(1):82–87. doi:10.1111/vop.12410.
   PubMed Web of Science ®Google Scholar
• Newland HS, White AT, Greene BM, Murphy RP, Taylor HR. Ocular manifestations of onchocerciasis in a rain forest area of west Africa. Br J Ophthalmol. 1991;75(3):163–169. doi:10.1136/bjo.75.3.163.
   PubMed Web of Science ®Google Scholar
• Otranto D, Dantas-Torres F, Cebeci Z, Yeniad B, Buyukbabani N, Boral OB, Gustinelli A, Mounir T, Mutafchiev Y, Bain O. Human ocular filariasis: further evidence on the zoonotic role of Onchocerca lupi. Parasit Vectors. 2012;5(1):84. doi:10.1186/1756-3305-5-84.
   PubMedGoogle Scholar
• Chesnais CB, Pion SD, Boullé C, Gardon J, Gardon-Wendel N, Fokom-Domgue J, Kamgno J, Boussinesq M. Individual risk of post-ivermectin serious adverse events in subjects infected with Loa loa. EClinicalMedicine. 2020;28:100582. doi:10.1016/j.eclinm.2020.100582.
   PubMedGoogle Scholar
• Summers MA, Moore JL, McAuley JW. Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy. Ann Pharmacother. 2004;38(10):1631–1634. doi:10.1345/aph.1E068.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Lu M, Sun X, Li C, Kuang X, Ruan X. Expression and activity of p-glycoprotein elevated by dexamethasone in cultured retinal pigment epithelium involve glucocorticoid receptor and pregnane X receptor. Invest Ophthalmol Vis Sci. 2012;853(7):3508–3515. doi:10.1167/iovs.11-9337.
   PubMed Web of Science ®Google Scholar
• Charan J, Kantharia ND. How to calculate sample size in animal studies? J Pharmacol Pharmacother. 2013;4(4):303–306. doi:10.4103/0976-500X.119726.
   PubMedGoogle Scholar
• Walker M, Hamley JID, Milton P, Monnot F, Pedrique B, Basáñez M-G. Designing antifilarial drug trials using clinical trial simulators. Nat Commun. 2020;11(1):2685. doi:10.1038/s41467-020-16442-y.
   PubMed Web of Science ®Google Scholar
• Chandler RE. Serious Neurological Adverse Events after Ivermectin-Do They Occur beyond the Indication of Onchocerciasis? Am J Trop Med Hyg. 2018;98(2):382–388. doi:10.4269/ajtmh.17-0042.
   PubMed Web of Science ®Google Scholar
• GabAllh M, El-Mashad A, Amin A, Darweish M. Pathological studies on effects of ivermectin on male and female rabbits. Benha Veterinary Medical Journal. 2017;32(1):104–112. doi:10.21608/bvmj.2017.31162.
   Google Scholar
• Siegner SW, Giovanoni RL, Erickson KA, Netland PA. Distribution of verapamil and norverapamil in the eye and systemic circulation after topical administration of verapamil in rabbits. J Ocul Pharmacol Ther. 1998;14(2):159–168. doi:10.1089/jop.1998.14.159.
   PubMed Web of Science ®Google Scholar
• Liu L, Liu X. Roles of Drug Transporters in Blood-Retinal Barrier. In: Liu X, Pan G, editors. Drug transporters in drug disposition, effects and toxicity. Advances in experimental medicine and biology. vol 1141. Singapore: Springer; 2019.
   Google Scholar
• Choi Y, Eom Y, Yoon EG, Song JS, Kim IH, Kim HM. Efficacy of topical ivermectin 1% in the treatment of demodex blepharitis. Cornea. 2022;41(4):427–434. doi:10.1097/ICO.0000000000002802.
   PubMed Web of Science ®Google Scholar
• Frederikse PH, Kasinathan C. Lens GABA receptors are a target of GABA-related agonists that mitigate experimental myopia. Med Hypotheses. 2015;84(6):589–592. doi:10.1016/j.mehy.2015.03.008.
   PubMed Web of Science ®Google Scholar
• Merriman-Smith BR, Young MA, Jacobs MD, Kistler J, Donaldson PJ. Molecular identification of P-glycoprotein: a role in lens circulation? Invest Ophthalmol Vis Sci. 2002;43(9):3008–3015.
   PubMed Web of Science ®Google Scholar
• Régina A, Romero IA, Greenwood J, Adamson P, Bourre JM, Couraud PO, Roux F. Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT. J Neurochem. 1999;73(5):1954–1963.
   PubMed Web of Science ®Google Scholar
• Narang VS, Fraga C, Kumar N, Shen J, Throm S, Stewart CF, Waters CM. Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Am J Physiol Cell Physiol. 2008;295(2):C440–50. doi:10.1152/ajpcell.00491.2007.
   PubMed Web of Science ®Google Scholar
• Areskog M, von Samson-Himmelstjerna G, Alvinerie M, Sutra JF, Höglund J. Dexamethasone treatment interferes with the pharmacokinetics of ivermectin in young cattle. Vet Parasitol. 2012;190(3-4):482–488. doi:10.1016/j.vetpar.2012.07.011.
   PubMed Web of Science ®Google Scholar
• Dey S, Kurade NP, Khurana KL, Dan A. Clinicobiochemical changes in ivermectin toxicity in Doberman pinscher pups. J Parasit Dis. 2017;41(2):580–583. doi:10.1007/s12639-016-0806-1.
   PubMedGoogle Scholar