Biosynthesis of iron nanoparticles using brown algae Spatoglossum asperum and its antioxidant and anticancer activities through in vitro and in silico studies

References

• Abdelhafez, O. H., T. F. S. Ali, J. R. Fahim, S. Y. Desoukey, S. Ahmed, F. A. Behery, M. S. Kamel, T. A. Gulder, and U. R. Abdelmohsen. 2020. Anti-inflammatory potential of green synthesized silver nanoparticles of the soft coral Nephthea sp. supported by metabolomics analysis and docking studies. International Journal of Nanomedicine 15:5345–60. doi: 10.2147/IJN.S239513.
   PubMed Web of Science ®Google Scholar
• Ahmed, S. A., Rahman, A. A., Elsayed, K. N., Abd El-Mageed, H. R., Mohamed, H. S. and S. A. Ahmed, 2020. Cytotoxic activity, molecular docking, pharmacokinetic properties and quantum mechanics calculations of the brown macroalga Cystoseira trinodis compounds. Journal of Biomolecular Structure and Dynamics :1–19. doi: 10.1080/07391102.2020.1774418.
   Web of Science ®Google Scholar
• Alphandéry, E. 2020. Bio-synthesized iron oxide nanoparticles for cancer treatment. International Journal of Pharmaceutics 586:119472. doi: 10.1016/j.ijpharm.2020.119472.
   PubMed Web of Science ®Google Scholar
• Anjali, K. P., B. M. Sangeetha, G. Devi, R. Raghunathan, and S. Dutta. 2019. Bioprospecting of seaweeds (Ulva lactuca and Stoechospermum marginatum): The compound characterization and functional applications in medicine-a comparative study. Journal of Photochemistry and Photobiology. B, Biology 200:111622. doi: 10.1016/j.jphotobiol.2019.111622.
   PubMed Web of Science ®Google Scholar
• Anjali, K. P., B. M. Sangeetha, R. Raghunathan, G. Devi, and S. Dutta. 2021. Seaweed mediated fabrication of zinc oxide nanoparticles and their antibacterial, antifungal and anticancer applications. ChemistrySelect 6 (4):647–56. doi: 10.1002/slct.202003517.
   Web of Science ®Google Scholar
• Ansari, M. A., and Asiri, S. M. M. 2021. Green synthesis, antimicrobial, antibiofilm and antitumor activities of superparamagnetic γ-Fe2O3 NPs and their molecular docking study with cell wall mannoproteins and peptidoglycan. International Journal of Biological Macromolecules 171:44–58. doi: 10.1016/j.ijbiomac.2020.12.162.
   PubMed Web of Science ®Google Scholar
• Ara, J., V. Sultana, R. Qasim, S. Ehteshamul‐Haque, and V. U. Ahmad. 2005. Biological activity of Spatoglossum asperum: A brown alga. Phytotherapy Research : PTR 19 (7):618–23. doi: 10.1002/ptr.1699.
   PubMed Web of Science ®Google Scholar
• Arias, L. S., Pessan, J. P., Vieira, A. P. M., Lima, T. Delbem, A. C. B., and Monteiro, D. R. 2018. Iron oxide nanoparticles for biomedical applications: A perspective on synthesis, drugs, antimicrobial activity, and toxicity. Antibiotics 7 (2):46. doi: 10.3390/antibiotics7020046.
   Web of Science ®Google Scholar
• Bai, J., X. Gongsun, L. Xue, and M. M. Zangeneh. 2021. Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer. Journal of Experimental Nanoscience 16 (1):397–409. doi: 10.1080/17458080.2021.1998460.
   Web of Science ®Google Scholar
• Bhutkar, M. A., D. S. Randive, S. D. Bhinge, G. H. Wadkar, S. S. Todkar, and K. P. Shejawal. 2022. Development of gold, silver, and iron nanoparticles using isolated berberine: Its characterization and antimicrobial and cytotoxic activities against COLO320DM and Hela cells. Gold Bulletin 55 (1):93–103. doi: 10.1007/s13404-022-00309-9.
   Web of Science ®Google Scholar
• Bibi, I., N. Nazar, S. Ata, M. Sultan, A. Ali, A. Abbas, K. Jilani, S. Kamal, F. M. Sarim, M. I. Khan, et al. 2019. Green synthesis of iron oxide nanoparticles using pomegranate seeds extract and photocatalytic activity evaluation for the degradation of textile dye. Journal of Materials Research and Technology 8 (6):6115–24. doi: 10.1016/j.jmrt.2019.10.006.
   Google Scholar
• Caban-Toktas, S., A. Sahin, S. Lule, G. Esendagli, I. Vural, K. Karlı Oguz, F. Soylemezoglu, M. Mut, T. Dalkara, M. Khan, et al. 2020. Combination of paclitaxel and R-flurbiprofen loaded PLGA nanoparticles suppresses glioblastoma growth on systemic administration. International Journal of Pharmaceutics 578:119076. doi: 10.1016/j.ijpharm.2020.119076.
   PubMed Web of Science ®Google Scholar
• Chandran, M., D. Yuvaraj, L. Christudhas, and K. V. Ramesh. 2016. Bio synthesis of iron nanoparticles using the brown seaweed, Dictyota dicotoma. Biotechnol. Indian J 12 (12):112. Doi: https://www.tsijournals.com/articles/biosynthesis-of-iron-nanoparticles-using-the-brown-seaweed-dictyota-dicotoma.html.
   Google Scholar
• Ebrahimzadeh, M. A., A. Naghizadeh, O. Amiri, M. Shirzadi-Ahodashti, and S. Mortazavi-Derazkola. 2020. Green and facile synthesis of Ag nanoparticles using Crataegus pentagyna fruit extract (CP-AgNPs) for organic pollution dyes degradation and antibacterial application. Bioorganic Chemistry 94:103425. doi: 10.1016/j.bioorg.2019.103425.
   PubMed Web of Science ®Google Scholar
• El-Kassas, H. Y., M. A. Aly-Eldeen, and S. M. Gharib. 2016. Green synthesis of iron oxide (Fe3O4) nanoparticles using two selected brown seaweeds: Characterization and application for lead bioremediation. Acta Oceanologica Sinica 35 (8):89–98. doi: 10.1007/s13131-016-0880-3.
   Web of Science ®Google Scholar
• El-Sheekh, M. M., H. Y. El-Kassas, N. G. Shams El-Din, D. I. Eissa, and B. A. El-Sherbiny. 2021. Green synthesis, characterization applications of iron oxide nanoparticles for antialgal and wastewater bioremediation using three brown algae. International Journal of Phytoremediation :1–15. doi: 10.1080/15226514.2021.1915957.
   Web of Science ®Google Scholar
• Fatima, F., S. Siddiqui, and W. A. Khan. 2021. Nanoparticles as novel emerging therapeutic antibacterial agents in the antibiotics resistant era. Biological Trace Element Research 199 (7):2552–64. doi: 10.1007/s12011-020-02394-3.
   PubMed Web of Science ®Google Scholar
• Fouda, A., S. E. D. Hassan, A. M. Abdo, and M. S. El-Gamal. 2020. Antimicrobial, antioxidant and larvicidal activities of spherical silver nanoparticles synthesized by endophytic Streptomyces spp. Biological Trace Element Research 195 (2):707–24. doi: 10.1007/s12011-019-01883-4.
   PubMed Web of Science ®Google Scholar
• Goldsmith, H. S. 2019. Potential improvement of survival statistics for glioblastoma multiforme (WHO IV). Surgical Neurology International 10:123–4. doi: 10.25259/SNI-185-2019.
   PubMedGoogle Scholar
• Ishwarya, R., B. Vaseeharan, S. Subbaiah, A. K. Nazar, M. Govindarajan, N. S. Alharbi, S. Kadaikunnan, J. M. Khaled, and M. N. Al-Anbr. 2018. Sargassum wightii-synthesized ZnO nanoparticles–from antibacterial and insecticidal activity to immunostimulatory effects on the green tiger shrimp Penaeus semisulcatus. Journal of Photochemistry and Photobiology. B, Biology 183:318–30. doi: 10.1016/j.jphotobiol.2018.04.049.
   PubMed Web of Science ®Google Scholar
• Jayalakshmi, L., J. Gomathy, J. Jayanthi, and M. Ragunathan. 2021. In vitro anti-oxidant and anti-cancer efficacy of silver nanoparticles synthesized from the seaweed Syringodium isoetifolium (D.)(1939) collected from the Pulicat Lake of Tamil Nadu. Uttar Pradesh Journal of Zoology 42 (12):54–67. Doi: https://www.mbimph.com/index.php/UPJOZ/article/view/2203.
   Google Scholar
• Jiang, H., J. Li, A. Chen, Y. Li, M. Xia, P. Guo, S. Yao, and S. Chen. 2018. Fucosterol exhibits selective antitumor anticancer activity against HeLa human cervical cell line by inducing mitochondrial mediated apoptosis, cell cycle migration inhibition and downregulation of m-TOR/PI3K/Akt signalling pathway. Oncology Letters 15 (3):3458–63. doi: 10.3892/ol.2018.7769.
   PubMed Web of Science ®Google Scholar
• Jothirethinam, A., S. Prathiba, N. Shanthi, and K. Arunkumar. 2015. Green synthesized silver nanoparticles prepared from the antimicrobial crude extracts of two brown seaweeds against plant pathogens. American Journal of Nanotechnology 6 (2):31–9. doi: 10.3844/ajnsp.2015.31.39.
   Google Scholar
• Kamble, R. V., S. D. Bhinge, S. K. Mohite, D. S. Randive, and M. A. Bhutkar. 2021. In vitro targeting and selective killing of mcf-7 and colo320dm cells by 5-fluorouracil anchored to carboxylated SWCNTs and MWCNTs. Journal of Materials Science. Materials in Medicine 32 (6):71. doi: 10.1007/s10856-021-06540-8.
   PubMed Web of Science ®Google Scholar
• Karpagavinayagam, P., and C. Vedhi. 2019. Green synthesis of iron oxide nanoparticles using Avicennia marina flower extract. Vacuum 160:286–92. doi: 10.1016/j.vacuum.2018.11.043.
   Web of Science ®Google Scholar
• Kaur, P., N. Singh, P. Pal, and A. Kaur. 2018. Variation in composition, protein and pasting characteristics of different pigmented and non pigmented rice (Oryza sativa L.) grown in Indian Himalayan region. Journal of Food Science and Technology 55 (9):3809–20. doi: 10.1007/s13197-018-3361-1.
   PubMed Web of Science ®Google Scholar
• Keabadile, O. P., A. O. Aremu, S. E. Elugoke, and O. E. Fayemi. 2020. Green and traditional synthesis of copper oxide nanoparticles—Comparative study. Nanomaterials 10 (12):2502. doi: 10.3390/nano10122502.
   Web of Science ®Google Scholar
• Kumar, R. B., and M. X. Suresh. 2012. A computational perspective of molecular interactions through virtual screening, pharmacokinetic and dynamic prediction on ribosome toxin A chain and inhibitors of Ricinus communis. Pharmacognosy Research 4 (1):2–10. doi: 10.4103/0974-8490.91027.
   PubMedGoogle Scholar
• Li, J., C. Cai, C. Yang, J. Li, T. Sun, and G. Yu. 2019. Recent advances in pharmaceutical potential of brown algal polysaccharides and their derivatives. Current Pharmaceutical Design 25 (11):1290–311. doi: 10.2174/1381612825666190618143952.
   PubMed Web of Science ®Google Scholar
• Lohrasbi, S., M. A. J. Kouhbanani, N. Beheshtkhoo, Y. Ghasemi, A. M. Amani, and S. Taghizadeh. 2019. Green synthesis of iron nanoparticles using Plantago major leaf extract and their application as a catalyst for the decolorization of azo dye. BioNanoScience 9 (2):317–22. doi: 10.1007/s12668-019-0596-x.
   Web of Science ®Google Scholar
• Madani, F., S. S. Esnaashari, M. C. Bergonzi, T. J. Webster, H. M. Younes, M. Khosravani, and M. Adabi. 2020. Paclitaxel/methotrexate co-loaded PLGA nanoparticles in glioblastoma treatment: Formulation development and in vitro antitumor activity evaluation. Life Sciences 256:117943. doi: 10.1016/j.lfs.2020.117943.
   PubMed Web of Science ®Google Scholar
• Mahdavi, M., F. Namvar, M. B. Ahmad, and R. Mohamad. 2013. Green biosynthesis and characterization of magnetic iron oxide (Fe3O4) nanoparticles using seaweed (Sargassum muticum) aqueous extract. Molecules 18 (5):5954–64. doi: 10.3390/molecules18055954.
   PubMed Web of Science ®Google Scholar
• Manam, D. V. K., and D. M. Subbaiah. 2020. Biosynthesis and characterization of silver nanoparticles from marine macroscopic brown seaweed Colpomenia sinuosa and its anti-fungal efficacy against dermatophytic and non dermatophytic fungi. Int J Pharm Sci 11 (2):59–68. Doi: https://www.scihorizon.com/cdn/pdf/1603783901_6a39f26268d3bd8d23ad.pdf.
   Google Scholar
• Mansuya, P., P. Aruna, S. Sridhar, J. S. Kumar, and S. Babu. 2010. Antibacterial activity and qualitative phytochemical analysis of selected seaweeds from Gulf of Mannar region. Journal of Experimental Sciences 1 (8):23–6.
   Google Scholar
• Mishra, P., S. Ray, S. Sinha, B. Das, M. I. Khan, S. K. Behera, S. I. Yun, S. K. Tripathy, and A. Mishra. 2016. Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition. Biochemical Engineering Journal 105:264–72. doi: 10.1016/j.bej.2015.09.021.
   Web of Science ®Google Scholar
• Movahhedin, N., H. Nazemiyeh, J. Barar, S. Esnaashari, and A. H. Movahhedin. 2018. Chemical constituent and biological activities of Spatoglossum asperum J. Agardh from Oman Sea. Letters in Drug Design & Discovery 15 (3):263–9. doi: 10.2174/1570180814666170407103936.
   Web of Science ®Google Scholar
• Namvar, F., H. S. Rahman, R. Mohamad, J. Baharara, M. Mahdavi, E. Amini, M. S. Chartrand, and S. K. Yeap. 2014. Cytotoxic effect of magnetic iron oxide nanoparticles synthesized via seaweed aqueous extract. International Journal of Nanomedicine 9:2479–88. doi: 10.2147/IJN.S59661.
   PubMed Web of Science ®Google Scholar
• Norouzi, M., V. Yathindranath, J. A. Thliveris, B. M. Kopec, T. Siahaan, and D. W. Miller. 2020. Doxorubicin-loaded iron oxide nanoparticles for glioblastoma therapy: A combinational approach for enhanced delivery of nanoparticles. Scientific Reports 10 (1):1–18. doi: 10.1038/s41598-020-68017-y.
   PubMed Web of Science ®Google Scholar
• Ohgaki, H., and P. Kleihues. 2005. Epidemiology and etiology of gliomas. Acta Neuropathologica 109 (1):93–108. doi: 10.1007/s00401-005-0991-y.
   PubMed Web of Science ®Google Scholar
• Palanisamy, S., M. Vinosha, T. Marudhupandi, P. Rajasekar, and N. M. Prabhu. 2017. In vitro antioxidant and antibacterial activity of sulfated polysaccharides isolated from Spatoglossum asperum. Carbohydrate Polymers 170:296–304. doi: 10.1016/j.carbpol.2017.04.085.
   PubMed Web of Science ®Google Scholar
• Pandit, P., and T. N. Gayatri. 2020. Introduction to green nanomaterials. In Green nanomaterials, ed. S. Ahmed and W. Ali, 1–21. Singapore: Springer. doi: 10.1007/978-981-15-3560-4_1.
   Google Scholar
• Phull, A. R., A. Ali, K. R. Dhong, M. Zia, P. G. Mahajan, and H. J. Park. 2021. Synthesis, characterization, anticancer activity assessment and apoptosis signaling of fucoidan mediated copper oxide nanoparticles. Arabian Journal of Chemistry 14 (8):103250. doi: 10.1016/j.arabjc.2021.103250.
   Web of Science ®Google Scholar
• Piñeros, M., L. Mery, I. Soerjomataram, F. Bray, and E. Steliarova-Foucher. 2021. Scaling up the surveillance of childhood cancer: A global roadmap. Journal of the National Cancer Institute 113 (1):9–15. doi: 10.1093/jnci/djaa069.
   PubMedGoogle Scholar
• Ravichandran, A., P. Subramanian, V. Manoharan, T. Muthu, R. Periyannan, M. Thangapandi, K. Ponnuchamy, B. Pandi, and P. N. Marimuthu. 2018. Phyto-mediated synthesis of silver nanoparticles using fucoidan isolated from Spatoglossum asperum and assessment of antibacterial activities. Journal of Photochemistry and Photobiology. B, Biology 185:117–25. doi: 10.1016/j.jphotobiol.2018.05.031.
   PubMed Web of Science ®Google Scholar
• Salem, D. M., M. M. Ismail, and M. A. Aly-Eldeen. 2019. Biogenic synthesis and antimicrobial potency of iron oxide (Fe3O4) nanoparticles using algae harvested from the Mediterranean Sea, Egypt. The Egyptian Journal of Aquatic Research 45 (3):197–204. doi: 10.1016/j.ejar.2019.07.002.
   Web of Science ®Google Scholar
• Sandhiya, V., B. Gomathy, M. R. Sivasankaran, P. Thirunavukkarasu, A. Mugip Rahaman, and S. Asha. 2021a. Green synthesis of silver nanoparticles from Guava (Psidium guajava Linn.) leaf for antibacterial, antioxidant and cytotoxic activity on HT-29 cells (Colon cancer). Annals of the Romanian Society for Cell Biology 25 (6):20148–63. https://www.annalsofrscb.ro/index.php/journal/article/view/10001.
   Google Scholar
• Sandhiya, V., P. Thirunavukkarasu, B. Gomathy, M. Sridhar, S. Rajeshkumar, M. Ravi, and S. Asha. 2021b. Agnp-Hp synthesized using red marine algae Halymenia pseudofloresii and its pharmacological activities. Annals of the Romanian Society for Cell Biology 25 (6):19433–50. Doi: https://annalsofrscb.ro/index.php/journal/article/view/9758.
   Google Scholar
• Sharma, A., A. K. Goyal, and G. Rath. 2018. Recent advances in metal nanoparticles in cancer therapy. Journal of Drug Targeting 26 (8):617–32. doi: 10.1080/1061186X.2017.1400553.
   PubMed Web of Science ®Google Scholar
• Shejawal, K. P., D. S. Randive, S. D. Bhinge, M. A. Bhutkar, S. S. Todkar, A. S. Mulla, and N. R. Jadhav. 2021a. Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: Their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell. Journal of Materials Science: Materials in Medicine 32 (2):1–12. doi: 10.1007/s10856-021-06489-8.
   PubMed Web of Science ®Google Scholar
• Shejawal, K. P., D. S. Randive, S. D. Bhinge, M. A. Bhutkar, G. H. Wadkar, S. S. Todkar, and S. K. Mohite. 2021b. Functionalized carbon nanotube for colon-targeted delivery of isolated lycopene in colorectal cancer: In vitro cytotoxicity and in vivo roentgenographic study. Journal of Materials Research 36 (24):4894–907. doi: 10.1557/s43578-021-00431-y.
   Web of Science ®Google Scholar
• Sherwin, E. R. 1978. Oxidation and antioxidants in fat and oil processing. Journal of the American Oil Chemists’ Society 55 (11):809–14. doi: 10.1007/BF02682653.
   Web of Science ®Google Scholar
• Soe-Htun, U., S. P. Pa Kyaw, M. Kyawt Wai, J. San, S. Moh Khaing, and C. T. Pyae Phyo Aye. 2021. A review on the seaweed resources of Myanmar. Journal of Aquaculture and Marine Biology 10 (4):152–66. doi: 10.15406/jamb.2021.10.00317.
   Google Scholar
• Suganthy, N., S. A. Nisha, S. K. Pandian, and K. P. Devi. 2013. Evaluation of Gelidiella acerosa, the red algae inhabiting South Indian coastal area for antioxidant and metal chelating potential. Biomedicine & Preventive Nutrition 3 (4):399–406. doi: 10.1016/j.bionut.2013.03.007.
   Google Scholar
• Suganya, S., B. Dhanalakshmi, S. D. Kumar, and P. Santhanam. 2020. Cytotoxic effect of silver nanoparticles synthesized from Sargassum wightii on cervical cancer cell line. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 90 (4):811–8. doi: 10.1007/s40011-019-01152-3.
   Google Scholar
• Tanna, B., B. Choudhary, A. Mishra, O. P. Chauhan, M. K. Patel, S. Shokralla, T. K. Z. El-Abedin, H. O. Elansary, and E. A. Mahmoud. 2021. Antioxidant, scavenging, reducing, and anti-proliferative activities of selected tropical brown seaweeds confirm the nutraceutical potential of Spatoglossum asperum. Foods 10 (10):2482. doi: 10.3390/foods10102482.
   PubMed Web of Science ®Google Scholar
• Thakkar, J. P., T. A. Dolecek, C. Horbinski, Q. T. Ostrom, D. D. Lightner, J. S. Barnholtz-Sloan, and J. L. Villano. 2014. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiology, Biomarkers & Prevention 23 (10):1985–96. doi: 10.1158/1055-9965.EPI-14-0275.
   PubMed Web of Science ®Google Scholar
• Tharrun Daniel Paul, L., R. Kumar Sah, and T. Palaniyandi. 2020. Molecular docking studies of pancreatic cancer expressed proteins with Psidium guajava (guava) derived bioactive compounds. International Journal of Research in Pharmaceutical Sciences 11 (SPL4):3176–83. doi: 10.26452/ijrps.v11iSPL4.4664.
   Google Scholar
• Tian, W., C. Chen, X. Lei, J. Zhao, and J. Liang. 2018. CASTp 3.0: Computed atlas of surface topography of proteins. Nucleic Acids Research 46 (W1):W363–W367. doi: 10.1093/nar/gky473.
   PubMed Web of Science ®Google Scholar
• Tucker, J. M., and D. M. Townsend. 2005. Alpha-tocopherol: Roles in prevention and therapy of human disease. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 59 (7):380–7. doi: 10.1016/j.biopha.2005.06.005.
   PubMed Web of Science ®Google Scholar
• Uma, R., V. Sivasubramanian, and S. N. Devaraj. 2011. Evaluation of in vitro antioxidant activities and antiproliferative activity of green microalgae, Desmococcus olivaceous and Chlorococcum humicola. Journal of Algal Biomass Utilization 2 (3):82–93. Doi: http://storage.unitedwebnetwork.com/files/517/e789f8cb9f807ed5480487e48442fb79.pdf.
   Google Scholar
• Van Den Hengel, S. K., R. K. Balvers, I. J. C. Dautzenberg, D. J. M. Van Den Wollenberg, J. J. Kloezeman, M. L. Lamfers, P. A. E. Sillivis-Smit, and R. C. Hoeben. 2013. Heterogeneous reovirus susceptibility in human glioblastoma stem-like cell cultures. Cancer Gene Therapy 20 (9):507–13. doi: 10.1038/cgt.2013.47.
   PubMed Web of Science ®Google Scholar
• Viswanathan, S., T. Palaniyandi, P. Kannaki, R. Shanmugam, G. Baskar, A. M. Rahaman, L. T. D. Paul, B. K. Rajendran, and A. Sivaji. 2022a. Biogenic synthesis of gold nanoparticles using red seaweed Champia parvula and its anti-oxidant and anticarcinogenic activity on lung cancer. Particulate Science and Technology :1–9. doi: 10.1080/02726351.2022.2074926.
   Web of Science ®Google Scholar
• Viswanathan, S., T. Palaniyandi, R. Shanmugam, T. M, B. K. Rajendran, and A. Sivaji. 2022b. Biomedical potential of silver nanoparticles capped with active ingredients of Hypnea valentiae, red algae species. Particulate Science and Technology 40 (6):686–96. doi: 10.1080/02726351.2021.1992059.
   Web of Science ®Google Scholar
• Yew, Y. P., K. Shameli, M. Miyake, N. Kuwano, N. Khairudin, S. E. B. Mohamad, and K. X. Lee. 2016. Green synthesis of magnetite (Fe3O4) nanoparticles using seaweed (Kappaphycus alvarezii) extract. Nanoscale Research Letters 11 (1):1–7. doi: 10.1186/s11671-016-1498-2.
   PubMed Web of Science ®Google Scholar
• Yusefi, M., K. Shameli, R. R. Ali, S. W. Pang, and S. Y. Teow. 2020. Evaluating anticancer activity of plant-mediated synthesized iron oxide nanoparticles using Punica granatum fruit peel extract. Journal of Molecular Structure 1204:127539. doi: 10.1016/j.molstruc.2019.127539.
   Web of Science ®Google Scholar
• Zhang, D., G. Ramachandran, R. A. Mothana, N. A. Siddiqui, R. Ullah, O. M. Almarfadi, G. Rajivgandhi, and N. Manoharan. 2020. Biosynthesized silver nanoparticles using Caulerpa taxifolia against A549 lung cancer cell line through cytotoxicity effect/morphological damage. Saudi Journal of Biological Sciences 27 (12):3421–7. doi: 10.1016/j.sjbs.2020.09.017.
   PubMed Web of Science ®Google Scholar