EVALUATION OF THE CARCINOGENIC RISK OF BIOCHEMICALLY INERT INSOLUBLE PARTICLES BY THE EPA USING RAT INHALATION DATA

REFERENCES

• Albert , R. E. , Lewtas , J. , Nesnow , S. , Thorslund , T. W. , and Anderson , E. 1983 . Comparative potency method for cancer risk assessment: Application to diesel particle emissions . Risk Anal. 3 : 101 – 117 .
   Google Scholar
• Bond , J. A. , Harkema , J. R. , Henderson , R. F. , Mauderly , J. L. , McClellan , R. O. , and Wolff , R. K. 1989. Molecular dosimetry of inhaled diesel exhaust. In Assessment of inhalation hazards , eds. U. Mohr , D. V. Bates , D. L. Dungworth , P. N. Lee , R. O. McClellan , and F. J. C. Roe , pp. 315–324. ILSI Monographs. Berlin : Springer-Verlag.
   Google Scholar
• Brightwell , J. , Fouillet , X. , Cassano-Zoppi , A.-L. , Bernstein , D. , Crawley , F. , Duchosal , F. , Gatz , R. , Perczel , S. , and Pfeifer , H. 1989 . Tumours of the respiratory tract in rats and hamsters following chronic inhalation of engine exhaust emissions . J. Appl. Toxicol. 9 : 23 – 31 .
   PubMed Web of Science ®Google Scholar
• Churg , A. 1994 . Analysis of mineral particles in human autopsy lungs comparisons with predictive models . In Toxic and carcinogenic effects of solid particles in the respiratory tract , eds. U. Mohr , D. L. Dungworth , J. L. Mauderly , and G. Oberdörster , pp. 307 – 319 . Washington , DC : ILSI .
   Google Scholar
• Driscoll , K. E. , Mauer , J. K. , Hassenbein , D. , Carter , J. , Janssen , Y. M. W. , Mossman , B. T. , Osier , M. , and Oberdörster , G. 1994 , Contribution of macrophage-derived cytokines and cytokine networks to mineral dust-induced lung inflammation . In Toxic and carcinogenic effects of solid particles in the respiratory tract , eds. U. Mohr , D. L. Dungworth , J. L. Mauderly , and G. Oberdörster , pp. 177 – 189 . Washington , DC : ILSI .
   Google Scholar
• Driscoll , K. E. , Carter , J. , Oberdörster , G. , and Pepelko , W. 1995 . Inflammation, cytokine expression and mutagenesis in rat lung after carbon black inhalation . Toxicologist 15 : 46 ( abstr. ).
   Google Scholar
• Enterline , P. E. 1972 . A review of mortality data for American coal miners . In Coal worker's pneumoconiosis , eds. I. Selikoff , M. Key , and D. Lee , Ann. NY Acad. Sci. 200 : 260 – 272 .
   Google Scholar
• Finch , G. L. , Nikula , K. I. , Barr , E. B. , Bechtold , W. E. , Chen , B. T. , Griffith , W. C. , Hobbs , C. H. , Hoover , M. D. , and Mauderly , J. L. 1995 . Lung tumor synergism between 239PuO2 and cigarette smoke inhaled by F344 rats . Toxicologist 15 : 47 .
   Google Scholar
• Garshick , E. , Schenker , M. B. , Munoz , A. , Segal , M. , Smith , T. J. , Woskie , S. R. , Hammond , S. K. , and Speizer , F. E. 1987 . A case-control study of lung cancer and diesel exhaust exposure in railroad workers . Am. Rev. Respir. Dis. 135 : 1242 – 1248 .
   PubMed Web of Science ®Google Scholar
• Garshick , E. , Schenker , M. B. , Munoz , A. , Segal , M. , Smith , T. J. , Woskie , S. R. , Hammond , S. K. , and Speizer , F. E. 1988 . A retrospective cohort study of lung cancer and diesel exhaust exposure in railroad workers . Am. Rev. Respir. Dis. 137 : 820 – 825 .
   PubMed Web of Science ®Google Scholar
• Hammond , E. C. , Selikoff , I. J. , and Seidman , H. 1979 . Asbestos exposure, cigarette smoking and death rates . Ann. NY Acad. Sci. 330 : 473 – 490 .
   Google Scholar
• Harris , J. E. 1983 . Diesel emissions and lung cancer . Risk Anal. 3 : 83 – 100 .
   Google Scholar
• Health Effects Institute . 1995 . Diesel exhaust A critical analysis of emissions, exposure, and health effects . Cambridge , MA : Health Effects Institute .
   Google Scholar
• Heinrich , U. , Fuhst , R. , Dasenbrock , C. , Muhle , H. , Koch , W. , and Mohr , U. 1993a . Long-term inhalation exposure of rats and mice to diesel exhaust (DE), carbon black (CB), and titanium dioxide . In Toxic and carcinogenic effects of solid panicles in the respiratory tract, 4th Int. Symp. , Hannover , p. 25 ( abstr. ).
   Google Scholar
• Heinrich , U. , Creutzenberg , O. , Hoymann , H.-G. , Peters , L. , and Dasenbrock , C. 1993b . Subchronic inhalation exposure of rats to carbon black and/or irritant gases . In Toxic and carcinogenic effects of solid particles in the respiratory tract, 4th Int. Symp. , Hannover , p. 24 ( abstr. ).
   Google Scholar
• Heinrich , U. , Fuhst , R. , Rittinghausen , S. , Creutzenberg , O. , Bellmann , B. , Koch , W. , and Levsen , K. 1995 . Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black,titanium dioxide . Inhal. Toxicol. 7 : 553 – 556 .
   Google Scholar
• IARC . 1989 . Dieselgasoline engine exhaustssome nitroarenes . IARC Monogr. Eval. Carcinogen. Risks Hum. 46 : 41 – 185 .
   PubMedGoogle Scholar
• Ishinishi , N. , Kuwabara , N. , Nagase , S. , Suzuki , T. , Ishiwata , S. , and Kohno , T. , 1986 . Long-term inhalation studies on effects of exhaust from heavy and light duty diesel engines on F344 rats . In Carcinogenic and mutagenic effects of diesel engine exhaust , eds. N. Ishinishi , A. Koizumi , R. O. McClellan , and W. Stöber , pp. 349 – 360 . Amsterdam : Elsevier .
   Google Scholar
• Karagianes , M. T. , Palmer , R. F. , and Busch , R. H. 1981 . Effects of inhaled diesel emissions and coal dust in rats . Am. Ind. Hyg. Assoc. J. 42 : 382 – 391 .
   PubMed Web of Science ®Google Scholar
• Lee , K. P. , Trochimowicz , H. J. , and Reinhardt , C. F. 1985 . Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years . Toxicol. Appl. Pharmacol. 70 : 179 – 192 .
   Google Scholar
• Lewis , T. R. , Green , F. H. Y. , Moorman , W. J. , Burg , J. R. , and Lynch , D. W. 1989 . A chronic inhalation toxicity study of diesel engine emissions and coal dust, alone and combined . J. Am. Coll. Toxicol. 8 : 345 – 375 .
   Google Scholar
• Martin , J. C. , Daniel , H. , and LeBouffant , L. 1977. Short- and long-term experimental study of the toxicity of coal-mine dust and of some of its constituents. In Inhaled particles IV , ed. W. H. Walton , pp. 361–370. Oxford : Pergamon Press.
   Google Scholar
• Mauderly , J. L. 1994a . Contribution of inhalation bioassays to the assessment of human health risks from solid airborne particles . In Toxic and carcinogenic effects of solid particles in the respiratory tract , eds. U. Mohr , D. L. Dungworth , J. L. Mauderly , and G. Oberdörster , pp, 355 – 365 . Washington , DC : ILSI .
   Google Scholar
• Mauderly , L. L. 1994b . Noncancer pulmonary effects of chronic inhalation exposure of animals to solid particles . In Toxic and carcinogenic effects of solid particles in the respiratory tract , eds. U. Mohr , D. L. Dungworth , J. L. Mauderly , and G. Oberdörster , pp. 43 – 55 . Washington , DC : ILSI .
   Google Scholar
• Mauderly , J. L. , Jones , R. K. , Griffith , W. C. , Henderson , R. F. , and McClellan , R. O. 1987 . Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation . Fundam. Appl. Toxicol. 9 : 208 – 221 .
   PubMedGoogle Scholar
• McClellan , R. O. , Cuddihy , R. G. , Griffith , W. C. , and Mauderly , J. L. 1989 . Integrating diverse data sets to assess risks of airborne pollutants . In Assessment of inhalation hazards , eds. U. Mohr , D. V. Bates , D. L. Dungworth , P. N. Lee , R. O. McClellan , and F. J. C. Roe , pp. 3 – 22 . Berlin : Springer Verlag .
   Google Scholar
• National Toxicology Program . 1993 . Technical Report on the ToxicologyCarcinogenesis Studies of Talc (CAS no. 14807-96-6) in F344/N RatsB6C3F, Mice (Inhalation Studies). NTP TR 421, NIH Publication no. 93-3152 . Research Triangle Park , NC : National Toxicology Program .
   Google Scholar
• Nikula , K. J. , Snipes , M. B. , Barr , E. B. , Griffith , W. C. , Henderson , R. F. , and Mauderly , J. L. 1995 . Comparative toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon black in F344 rats . fundam. Appl. Toxicol. 25 : 80 – 94 .
   PubMedGoogle Scholar
• Oberdörster , G. , and Yu , C. P. 1990 . The carcinogenic potential of inhaled diesel exhaust A particle effect? J. Aerosol Sci. 21 ( 51 ): 397 – 401 .
   Google Scholar
• Pepelko , W. E. , and Peirano , W. B. 1983 . Health effects of exposure to diesel engine emissions A summary of animal studies conducted by the U.S. Environmental Protection Agency's Health Effects Research Laboratories at Cincinnati, Ohio . J. Am. Coll. Toxicol. 2 : 253 – 306 .
   Google Scholar
• Sagai , M. , Saito , H. , Ichinose , T. , Kodana , M. , and Mori , Y. 1993 . Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in the mouse . Free Radical Biol. Med. 14 : 37 – 47 .
   PubMed Web of Science ®Google Scholar
• Tong , H. Y. , and Karasek , F. W. 1984 . Quantitation of polycyclic aromatic hydrocarbons in diesel exhaust particulate matter by high-performance liquid chromatography fractionation and high-resolution gas chromatography . Anal. Chem. 56 : 2129 – 2134 .
   PubMed Web of Science ®Google Scholar
• U.S. Environmental Protection Agency . 1991 . Alpha2u-Globulin Association with Chemically Induced Renal ToxicityNeoplasia in the Male Rat , pp. 1 – 118 . EPA/625/3-91/019f . Washington , DC : U.S. EPA .
   Google Scholar
• U.S. Environmental Protection Agency . 1994 , Health Assessment Document for Diesel Emissions. External Review Draft . EPA 600/8-90/057B Washington , DC : U.S. EPA.
   Google Scholar
• Warheit , D. B. , and Hartsky , M. A. 1994 . Influence of gender, species, and strain differences in pulmonary toxicological assessments of inhaled particles and/or fibers . In Toxic and carcinogenic effects of solid particles in the respiratory tract , eds. U. Mohr , D. L. Dungworth , J. L. Mauderly , and G. Oberdörster , pp. 353 – 265 . Washington , DC : ILSI .
   Google Scholar
• Yu , C. P. , Yoou , K. J. , and Chen , Y. K. 1991 . Retention modeling of diesel exhaust particles in rats and humans . J. Aerosol Med. 4 : 79 .
   Google Scholar