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ORIGINAL ARTICLE

Nε-(Carboxymethyl)Lysine, a Major Advanced Glycation End Product in Exhaled Breath Condensate as a Biomarker of Small Airway Involvement in Asthma

, MD, , MD, PhD, , MD, , MD, PhD, , MD & , MD, PhD
Pages 861-866 | Published online: 02 Jul 2009

References

  • Jeffery P K. Remodeling in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164: S28–S38
  • Taha R A, Minshall E M, Miotto D, Shimbara A, Luster A, Hogg J C, Hamid Q A. Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals. J Allergy Clin Immunol 1999; 103: 476–483
  • Christodoulopoulos P, Leung D Y, Elliott M W, Hogg J C, Muro S, Toda M, Laberge S, Hamid Q A. Increased number of glucocorticoid receptor-beta-expressing cells in the airways in fatal asthma. J Allergy Clin Immunol 2000; 106: 479–484
  • Kraft M, Djukanovic R, Wilson S, Holgate S T, Martin R J. Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 1996; 154: 1505–1510
  • Brownlee M. Advanced glycosylation in diabetes and aging. Annu Rev Med 1995; 46: 223–224
  • Baynes J W. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40: 405–412
  • Morbini P, Villa C, Campo I, Zorzetto M, Inghilleri S, Luisetti M. The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease?. Mod Pathol 2006; 19: 1437–1445
  • Sheideler L, Manke H G, Schwulera U, Inacker O, Hämmerler H. Detection of nonvolatile macromolecules in breath. Am Rev Respir Dis 1993; 148: 778–784
  • Corradi M, Montuschi P, Donnelly L E, Pesci A, Kharitonov S A, Barnes P J. Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases. Am J Respir Crit Care Med 2001; 163: 854–858
  • Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis 1987; 136: 225–244
  • Montuschi P, Corradi M, Ciabattoni G, Nightingale J, Kharitonov S A, Barnes P J. Increased 8-isoprostanes, a marker of oxidative stress, in exhaled condensate of asthma. Am J Respir Crit Care Med 1999; 160: 216–220
  • Takeuchi M, Makita Z, Yanagisawa K, Kameda Y, Koike T. Detection of noncarboxymethyllysine and carboxymethyllysine advanced glycation end products (AGE) in serum of diabetic patients. Mol Med 1999; 5: 393–405
  • Chaudhuri R, Livingston E, McMahon A D, Lafferty J, Fraser I, Spears M, McSharry C P, Thomson N C. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am J Respir Crit Care Med 2006; 174: 127–133
  • Verbanck S, Schuermans D, Paiva M, Meysman M, Vincken W. Small airway function improvement after smoking cessation in smokers without airway obstruction. Am J Respir Crit Care Med 2006; 174: 853–857
  • O'Donnell D E, Flüge T, Gerken F, Hamilton A, Webb K, Aguilaniu B, Make B, Magnussen H. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 2004; 23: 832–840
  • Wenzel S E, Szefler S J, Leung D Y, Sloan S I, Rex M D, Martin R J. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 1997; 156: 737–743
  • Carroll N, Cooke C, James A. The distribution of eosinophils and lymphocytes in the large and small airways of asthmatics. Eur Respir J 1997; 10: 292–300
  • Hamid Q, Song Y, Kotsimbos T C, Minshall E, Bai T R, Hegele R G, Hogg J C. Inflammation of small airways in asthma. J Allergy Clin Immunol 1997; 100: 44–51
  • Hall G L, Hantos Z, Petak F, Wildhaber J H, Tiller K, Burton P R, Sly P D. Airway and respiratory tissue mechanics in normal infants. Am J Respir Crit Care Med 2000; 162: 1397–1402
  • Houghton C M, Woodcock A A, Singh D. A comparison of lung function methods for assessing dose-response effects of salbutamol. Br J Clin Pharmacol 2004; 58: 134–141
  • Mitsunobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida K, Takata S, Yokoi T, Mishima M, Tanizaki Y. Complexity of terminal airspace geometry assessed by computed tomography in asthma. Am J Respir Crit Care Med 2003; 167: 411–417
  • Battaglia S, Hertog H D, Timmers M C, Lazeroms S PG, Vignola A M, Rabe K F, Bellia V, Hiemstra P S, Sterk P J. Small airways function and molecular markers in exhaled air in mild asthma. Thorax 2005; 60: 639–644
  • Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M. Role of small airways in asthma: Investigation using high-resolution computed tomography. J Allergy Clin Immunol 2006; 118: 1019–1025
  • Schmidt A M, Yan S D, Yan S F, Stern D M. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 2001; 108: 949–955
  • Cipollone F, Iezzi A, Fazia M, Zucchelli M, Pini B, Cuccurullo C, De Cesare D, De Blasis G, Muraro R, Bei R, Chiarelli F, Schmidt A M, Cuccurullo F, Mezzetti A. The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control. Circulation 2003; 108: 1070–1077
  • Hoffmann M A, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath M F, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt A M. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 1999; 97: 889–901
  • Lander H L, Tauras J M, Ogiste J S, Hori O, Moss R A, Schmidt A M. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidative stress. J Biol Chem 1997; 272: 17810–17814
  • Yan S F, Ramasamy R, Naka Y, Schmidt A M. Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ Res 2003; 93: 1159–1169
  • Schmidt A M, Vianna M, Gerlach M, Brett J, Ryan J, Kao J, Esposito C, Hegarty H, Hurley W, Clauss M, Wang F, Pan Y-C E, Tsang T C, Stern D. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem 1992; 267: 14987–14997
  • Cheng C, Tsuneyama K, Kominami R, Shinohara H, Sakurai S, Yonekura H, Watanabe T, Takano Y, Yamamoto H, Yamamoto Y. Expression profiling of endogenous secretory receptor for advanced glycation end products in human organs. Mod Pathol 2005; 18: 1385–1396

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