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ORIGINAL ARTICLE

β2-Adrenoceptor Polymorphisms Predict Response to β2-Agonists in Children with Acute Asthma

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Pages 383-388 | Published online: 02 Jul 2009

References

  • Koga T, Kamimura T, Oshita Y, Narita Y, Mukaino T, Nishimura M, Mizoguchi Y, Aizawa H. Determinants of bronchodilator responsiveness in patients with controlled asthma. J Asthma 2006; 43(1)71–74
  • Tsai H J, Shaikh N, Kho J Y, Battle N, Naqvi M, Navarro D, Matallana H, Lilly C M, Eng C S, Kumar G, Thyne S, Watson H G, Meade K, Lenoir M, Choudhry S, Burchard E G. beta(2)-Adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmatics. Hum Genet 2006; 119(5)547–557
  • Ramsay C E, Hayden C M, Tiller K J, Burton P R, Goldblatt J, Lesouef P N. Polymorphisms in the beta2-adrenoreceptor gene are associated with decreased airway responsiveness. Clin Exp Allergy 1999; 29(9)1195–1203
  • Turki J, Pak J, Green S A, Martin R J, Liggett S B. Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. J Clin Invest 1995; 95(4)1635–1641
  • Hall I P, Wheatley A, Wilding P, Liggett S B. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 1995; 345(8959)1213–1214
  • Weir T D, Mallek N, Sandford A J, Bai T R, Awadh N, Fitzgerald J M, Cockcroft D, James A, Liggett S B, Pare P D. beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. Am J Respir Crit Care Med 1998; 158(3)787–791
  • Contopoulos-Ioannidis D G, Manoli E N, Ioannidis J P. Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J Allergy Clin Immunol 2005; 115(5)963–972
  • Joos L, Sandford A J. Genotype predictors of response to asthma medications. Curr Opin Pulm Med 2002; 8(1)9–15
  • Johnson M. The beta-adrenoceptor. Am J Respir Crit Care Med 1998; 158(5 Pt 3)S146–S153
  • Reihsaus E, Innis M, MacIntyre N, Liggett S B. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993; 8(3)334–339
  • Hall I P, Blakey J D, Al Balushi K A, Wheatley A, Sayers I, Pembrey M E, Ring S M, McArdle W L, Strachan D P. Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study. Lancet 2006; 368(9537)771–779
  • Green S A, Turki J, Bejarano P, Hall I P, Liggett S B. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 1995; 13(1)25–33
  • Chong L K, Chowdry J, Ghahramani P, Peachell P T. Influence of genetic polymorphisms in the beta2-adrenoceptor on desensitization in human lung mast cells. Pharmacogenetics 2000; 10(2)153–162
  • Joos L, Pare P D, Sandford A J. beta(2)-Adrenergic receptor polymorphisms and asthma. Curr Opin Pulm Med 2001; 7(2)69–74
  • Martin A C, Laing I A, Khoo S K, Zhang G, Rueter K, Teoh L, Taheri S, Hayden C M, Geelhoed G C, Goldblatt J, LeSouef P N. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. Am J Respir Crit Care Med 2006; 173(6)617–622
  • Qureshi F, Pestian J, Davis P, Zaritsky A. Effect of nebulized ipratropium on the hospitalization rates of children with asthma. N Engl J Med 1998; 339(15)1030–1035
  • National Asthma Council of Australia. 2002
  • Miller S A, Dykes D D, Polesky H F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16(3)1215
  • Holloway J W, Dunbar P R, Riley G A, Sawyer G M, Fitzharris P F, Pearce N, Le Gros G S, Beasley R. Association of beta2-adrenergic receptor polymorphisms with severe asthma. Clin Exp Allergy 2000; 30(8)1097–1103
  • Stephens M, Smith N J, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68(4)978–989
  • SPSS Inc. SPSS for Windows. Release 11. Chicago, Illinois 2001
  • Browne G J, Penna A S, Phung X, Soo M. Randomised trial of intravenous salbutamol in early management of acute severe asthma in children. Lancet 1997; 349(9048)301–305
  • Yung M, South M. Randomised controlled trial of aminophylline for severe acute asthma. Arch Dis Child 1998; 79(5)405–410
  • Ciarallo L, Sauer A H, Shannon M W. Intravenous magnesium therapy for moderate to severe pediatric asthma: results of a randomized, placebo-controlled trial. J Pediatr 1996; 129(6)809–814
  • Roberts G, Newsom D, Gomez K, Raffles A, Saglani S, Begent J, Lachman P, Sloper K, Buchdahl R, Habel A. Intravenous salbutamol bolus compared with an aminophylline infusion in children with severe asthma: a randomised controlled trial. Thorax 2003; 58(4)306–310
  • Martinez F D, Graves P E, Baldini M, Solomon S, Erickson R. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100(12)3184–3188
  • Israel E, Chinchilli V M, Ford J G, Boushey H A, Cherniack R, Craig T J, Deykin A, Fagan J K, Fahy J V, Fish J, Kraft M, Kunselman S J, Lazarus S C, Lemanske R F, Jr., Liggett S B, Martin R J, Mitra N, Peters S P, Silverman E, Sorkness C A, Szefler S J, Wechsler M E, Weiss S T, Drazen J M. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet 2004; 364(9444)1505–1512
  • Wechsler M E, Lehman E, Lazarus S C, Lemanske R F, Jr., Boushey H A, Deykin A, Fahy J V, Sorkness C A, Chinchilli V M, Craig T J, DiMango E, Kraft M, Leone F, Martin R J, Peters S P, Szefler S J, Liu W, Israel E. beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med 2006; 173(5)519–526
  • Litonjua A A. The significance of beta2-adrenergic receptor polymorphisms in asthma. Curr Opin Pulm Med 2006; 12(1)12–17
  • Salpeter S R, Buckley N S, Ormiston T M, Salpeter E E. Meta-Analysis: Effect of Long-Acting {beta}-Agonists on Severe Asthma Exacerbations and Asthma-Related Deaths. Ann Intern Med 2006
  • Telleria J J, Blanco-Quiros A, Muntion S, Antonio Garrote J, Arranz E, Armentia A, Diez I, Castro J. Tachyphylaxis to beta2-agonists in Spanish asthmatic patients could be modulated by beta2-adrenoceptor gene polymorphisms. Respir Med 2006; 100(6)1072–1078
  • Wechsler M E, Israel E. How pharmacogenomics will play a role in the management of asthma. Am J Respir Crit Care Med 2005; 172(1)12–18

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