468
Views
24
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Alveolar Macrophage Subpopulations in Bronchoalveolar Lavage and Induced Sputum of Asthmatic and Control Subjects

, M.SC., , M.SC., , M.D., F.R.C.P.C. & , PH.D.
Pages 1-8 | Published online: 02 Jul 2009

References

  • Nicod L P. Pulmonary defense mechanisms. Respiration 1999; 66: 2–11
  • Kraal G, Broug E, van Iwaarden J F, Persoons J HA, Thepen T. The role of alveolar macrophages in pulmonary immune function. Lung Macrophages and Dendritic Cells in Health and Disease, M. F. Lipscomb, S. W. Russell. Marcel Dekker Inc., New York 1997; 203–20
  • Kobzik L, Huang S, Paulauskis J D, Godleski J J. Particle opsonization and lung macrophage cytokine response. In vitro and in vivo analysis. J Immunol 1993; 151: 2753–2759
  • Wilkes D S, Yarbrough W C, Jr, Weissler J C. Human alveolar macrophages inhibit immunoglobulin production in response to direct B cell mitogen. Am J Respir Cell Mol Biol 1993; 9: 141–147
  • Holt P G. Down-regulation of immune responses in the lower respiratory tract: the role of alveolar macrophages. Clin Exp Immunol 1986; 63: 261–270
  • Schauble T L, Boom W H, Finegan C K, Rich E A. Characterization of suppressor function of human alveolar macrophages for T lymphocyte responses to phytohemagglutinin: cellular selectivity, reversibility, and early events in T cell activation. Am J Respir Cell Mol Biol 1993; 8: 89–97
  • Bissonnette E Y. Alveolar macrophages in the pathogenesis of asthma. Res Devel Allergy Clin Immunol 2000; 1: 129–141
  • Peters-Golden M. The alveolar macrophage: the forgotten cell in asthma. Am J Respir Cell Mol Biol 2004; 31: 3–7
  • Fuller R W. The role of the alveolar macrophage in asthma. Respir Med 1989; 83: 177–178
  • Agea E, Forenza N, Piattoni S, Russano A, Monaco A, Flenghi L, Bistoni O, Gillies D A, Azuma M, Bertotto A, Spinozzi F. Expression of B7 co-stimulatory molecules and CD1a antigen by alveolar macrophages in allergic bronchial asthma. Clin Exp Allergy 1998; 28: 1359–1367
  • Catena E, Mazzarella G, Peluso G F, Micheli P, Cammarata A, Marsico S A. Phenotypic features and secretory pattern of alveolar macrophages in atopic asthmatic patients. Monaldi Arch Chest Dis 1993; 48: 6–15
  • Poulter L W, Burke C M. Macrophages and allergic lung disease. Immunobiology 1996; 195: 574–587
  • Poulter L W, Janossy G, Power C, Sreenan S, Burke C. Immunological/physiological relationships in asthma: potential regulation by lung macrophages. Immunol Today 1994; 15: 258–261
  • Jansen H M. The role of alveolar macrophages and dentritic cells in allergic airway sensitization. Allergy 1996; 51: 279–292
  • Careau E, Bissonnette E Y. Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness. Am J Respir Cell Mol Biol 2004; 31: 22–27
  • Lensmar C, Elmberger G, Sandgren P, Skold C M, Eklund A. Leukocyte counts and macrophage phenotypes in induced sputum and bronchoalveolar lavage fluid from normal subjects. Eur Respir J 1998; 12: 595–600
  • Spiteri M A, Clarke S W, Poulter L W. Isolation of phenotypically and functionally distinct macrophage subpopulations from human bronchoalveolar lavage. Eur Respir J 1992; 5: 717–726
  • Lensmar C, Prieto J, Dahlen B, Eklund A, Grunewald J, Roquet A. Airway inflammation and altered alveolar macrophage phenotype pattern after repeated low-dose allergen exposure of atopic asthmatic subjects. Clin Exp Allergy 1999; 29: 1632–1640
  • Alexis N, Soukup J, Ghio A, Becker S. Sputum phagocytes from healthy individuals are functional and activated: a flow cytometric comparison with cells in bronchoalveolar lavage and peripheral blood. Clin Immunol 2000; 97: 21–32
  • Daeron M. Fc receptor biology. Annu Rev Immunol 1997; 15: 203–234
  • Balbo P, Silvestri M, Rossi G A, Crimi E, Burastero S E. Differential role of CD80 and CD86 on alveolar macrophages in the presentation of antigen to T lymphocytes in asthma. Clin Exp Allergy 2001; 31: 625–636
  • Burastero S E, Magnani Z, Confetti C, Abbrazzese L, Oddera S, Balbo P, Rossi G A, Crimi E. Increased expression of the CD80 accessory molecule by alveolar macrophages in asthmatic subjects and its functional involvement in allergen presentation to autologous TH2 lymphocytes. J Allergy Clin Immunol 1999; 103: 1136–1142
  • Larché M, Till S J, Haselden B M, North J, Barkans J, Corrigan C J, Ray A B, Robinson D S. Costimulation through CD86 is involved in airway antigen-presenting cell and T cell responses to allergen in atopic asthmatics. J Immunol 1998; 161: 6375–6382
  • Harris N, Peach R, Naemura J, Linsley P S, Le Gros G, Ronchese F. CD80 costimulation is essential for the induction of airway eosinophilia. J Exp Med 1997; 185: 177–182
  • Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003; 3: 23–35
  • Holcomb I N, Kabakoff R C, Chan B, Baker T W, Gurney A, Henzel W, Nelson C, Lowman H B, Wright B D, Skelton N J, Frantz G D, Tumas D B, Peale F U, Jr., Shelton D L, Hebert C C. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 2000; 19: 4046–4055
  • Raes G, Brys L, Dahal B K, Brandt J, Grouten J, Brombacher F, Vanham G, Noel W, Bogaert T, Boonetaes I, Kindt A, Van der Bergh R, Leenen P J, De Baetselier P, Ghassaben G H. Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J Leukoc Biol 2005; 77: 321–327
  • Pin I., Gibson P G., Kolendowicz R. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992; 47: 25–29
  • Pizzichini E, Pizzichini M MM, Efthimiadis A, Evan S, Morris M M, Squillace D, Gleich G J, Dolovich J, Hargreave F E. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 1996; 154: 308–317, (2 Pt 1)
  • St-Laurent J, Boulay M E, Prince P, Bissonnette E Y, Boulet L P. Comparison of cell fixation methods of induced sputum specimens: an immunocytochemical analysis. J Immunol Methods 2006; 308: 36–42
  • Gauvreau G M, Lee J M, Watson R M, Irani A MA, Schwartz L B, O'Byrne P M. Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics. Am J Respir Crit Care Med 2000; 161: 1473–1478
  • Prince P, Bertrand M, Boulay M E, Bernier M C, Boulet L P. Optimization of the conditions for preservation of induced sputum: influence of freezing on cellular analysis. Chest 2005; 128: 980–985
  • Spiteri M A, Poulter L W. Characterization of immune inducer and suppressor macrophages from the normal human lung. Clin Exp Immunol 1991; 83: 157–162
  • Lemiere C, Taha R, Olivenstein R, Hamid Q. Comparison of cellular composition of induced sputum analyzed with Wright staining and immunocytochemistry. J Allergy Clin Immunol 2001; 108: 521–523
  • Woltmann G, Ward R J, Symon F A, Rew D A, Pavord I D, Wardlaw A J. Objective quantitative analysis of eosinophils and bronchial epithelial cells in induced sputum by laser scanning cytometry. Thorax 1999; 54: 124–130
  • Taha R, Laberge S, Hamid Q, Olivenstein R. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients. Chest 2001; 120: 595–601
  • Zeibecoglou K, Ying S, Meng Q, Poulter L W. Macrophage subpopulations and macrophage-derived cytokines in sputum of atopic and nonatopic asthmatic subjects and atopic and normal control subjects. J Allergy Clin Immunol 2000; 106: 697–704
  • Poulter L W, Campbell D A, Munro C, Janossy G. Discrimination of human macrophages and dendritic cells by means of monoclonal antibodies. Scand J Immunol 1986; 24: 351–357
  • Campbell D A, Poulter L W, du Bois R M. Phenotypic analysis of alveolar macrophages in normal subjects and in patients with interstitial lung disease. Thorax 1986; 41: 429–434
  • Tormey V J, Bernard S, Ivory K, Burke C M, Poulter L W. Fluticasone propionate-induced regulation of the balance within macrophage subpopulations. Clin Exp Immunol 2000; 119: 4–10
  • Pantelidis P, MCGrath S, Southcott A M, Black C M, du Bois R M. Tumor necrosis factor-α production in fibrosing alveolitis macrophage subset specific. Respir Res 2001; 2: 365–372
  • Ulevitch R J, Tobias P S. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995; 13: 437–457
  • Viksman M Y, Liu M C, Bickel C A, Schleimer R P, Bochner B S. Phenotypic analysis of alveolar macrophages and monocytes in allergic airways inflammation. Am J Respir Crit Care Med 1997; 155: 858–863
  • Viksman M Y, Bochner B S, Peebles R S, Schleimer R P, Liu M C. Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge. Clin Immunol 2002; 104: 77–85
  • Alexis N, Soukup J, Nierkens S, Becker S. Association between airways hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma. Am J Physio Lung Cell Mol Physiol 2001; 280: L369–L375
  • Virchow J C, Jr, Julius P, Matthys H, Kroegel C, Luttmann W. CD14 expression and soluble CD14 after segmental allergen provocation in atopic asthma. Eur Respir J 1998; 11: 317–323
  • Arnaout M A. Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response. Immunol Rev 1990; 114: 145–180
  • Alexis N E, Becker S, Bromberg P A, Devlin R, Peden D B. Circulating CD11b expression correlates with the neutrophil response and airway mCD14 expression is enhanced following ozone exposure in humans. Clin Immunol 2004; 111: 126–131
  • Lechmann M, Krooshoop D J, Dudziak D, Kremmer E, Kuhnt C, Figdor C G, Schuler G, Steinkasserer A. The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells. J Exp Med 2001; 194: 1813–1821
  • te Velde A A, de Waal M R, Huijbens R J, de Vries J E, Figdor C G. IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10. J Immunol 1992; 149: 4048–4052
  • Manzotti C N, Liu M K, Burke F, Dussably L, Zheng Y, Sansom D M. Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86. Eur J Immunol 2006; 36: 1413–1422
  • Mark D A, Donovan C E, De Sanctis G T, Krinzman S J, Kobzik L, Linsley P S, Sayegh M H, Lederer J, Perkins D L, Finn P W. Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation. Int Immunol 1998; 10: 1647–1655
  • Broide D H, Lotz M, Cuomo A J, Coburn D A, Federman E C, Wasserman S I. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 1992; 89: 958–967

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.