Are Genes Associated with Energy Metabolism Important in Asthma and BMI?

References

• Huang S L, Shiao G, Chou P. Association between body mass index and allergy in teenage girls in Taiwan. Clin Exp Allergy 1999; 29: 323–329
   PubMed Web of Science ®Google Scholar
• Chen Y, Dales R, Krewski D, Breithaupt K. Increased effects of smoking and obesity on asthma among female Canadians: the National Population Health Survey, 1994–1995. Am J Epidemiol 1999; 150: 255–262
   PubMed Web of Science ®Google Scholar
• Luder E, Melnik T A, DiMaio M. Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. J Pediatr 1998; 132: 699–703
   PubMed Web of Science ®Google Scholar
• Guler N, Kirerleri E, Ones U, Tamay Z, Salmayenli N, Darendeliler F. Leptin: does it have any role in childhood asthma?. J Allergy Clin Immunol 2004; 114: 254–259
   PubMed Web of Science ®Google Scholar
• Loffreda S, Yang S Q, Lin H Z, Karp C L, Brengman M L, Wang D J, Klein A S, Bulkley G B, Bao C, Noble P W, Lane M DD, Iehl A M. Leptin regulates proinflammatory immune responses. Faseb J 1998; 12: 57–65
   PubMed Web of Science ®Google Scholar
• Lord G M, Matarese G, Howard J K, Baker R J, Bloom S R, Lechler R I. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394: 897–901
   PubMed Web of Science ®Google Scholar
• Gainsford T, Roberts A W, Kimura S, Metcalf D, Dranoff G, Mulligan R C, Begley C G, Robb L, Alexander W S. Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production. Blood 1998; 91: 2745–2752
   PubMed Web of Science ®Google Scholar
• O'Donnell C P, Schaub C D, Haines A S, Berkowitz D E, Tankersley C G, Schwartz A R, Smith P L. Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med 1999; 159: 1477–1484, (5 Pt 1)
   PubMed Web of Science ®Google Scholar
• Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000; 68: 437–446
   PubMed Web of Science ®Google Scholar
• Mancuso P, Gottschalk A, Phare S M, Peters-Golden M, Lukacs N W, Huffnagle G B. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol 2002; 168: 4018–4024
   PubMed Web of Science ®Google Scholar
• Busso N, So A, Chobaz-Peclat V, Morard C, Martinez-Soria E, Talabot-Ayer D, Gabay C. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 2002; 168: 875–882
   PubMed Web of Science ®Google Scholar
• Shore S A, Schwartzman I N, Mellema M S, Flynt L, Imrich A, Johnston R A. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 2005; 115: 103–109
   PubMed Web of Science ®Google Scholar
• Gurkan F, Atamer Y, Ece A, Kocyigit Y, Tuzun H, Mete N. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. Ann Allergy Asthma Immunol 2004; 93: 277–280
   PubMed Web of Science ®Google Scholar
• Farooqi I S, Matarese G, Lord G M, Keogh J M, Lawrence E, Agwu C, Sanna V, Jebb S A, Pena F, Fontana S, Lechler R I, DePaoli A M, O'Rahilly S. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002; 110: 1093–1103
   PubMed Web of Science ®Google Scholar
• Stenius-Aarniala B, Poussa T, Kvarnstrom J, Gronlund E L, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ 2000; 320(7238)827–832
   PubMed Web of Science ®Google Scholar
• Dixit V D, Schaffer E M, Pyle R S, Colins G D, Sakthivel S K, Palaniappan R, Lillard J W, Jr., Taub D D. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest 2004; 114: 57–66
   PubMed Web of Science ®Google Scholar
• Xia Q, Pang W, Pan H, Zheng Y, Kang J S, Zhu S G. Effects of ghrelin on the proliferation and secretion of splenic T lymphocytes in mice. Regul Pept 2004; 122: 173–178
   PubMedGoogle Scholar
• Matsuda K, Nishi Y, Okamatsu Y, Kojima M, Matsuishi T. Ghrelin and leptin: a link between obesity and allergy?. J Allergy Clin Immunol 2006; 117: 705–706
   PubMed Web of Science ®Google Scholar
• Badman M K, Flier J S. The gut and energy balance: visceral allies in the obesity wars. Science 2005; 307(5717)1909–1914
   PubMedGoogle Scholar
• Ukkola O, Ravussin E, Jacobson P, Snyder E E, Chagnon M, Sjostrom L, Bouchard C. Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. J Clin Endocrinol Metab 2001; 86: 3996–3999
   Google Scholar
• Miller S A, Dykes D D, Polesky H F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988; 16: 1215
   PubMed Web of Science ®Google Scholar
• Barrett J C, Fry B, Maller J, Daly M J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005; 21: 263–265
   PubMed Web of Science ®Google Scholar
• Sood A, Ford E S, Camargo C A, Jr. Association between leptin and asthma in adults. Thorax 2006; 61: 300–305
   PubMed Web of Science ®Google Scholar
• Unal M, Eskandari G, Muslu N, Pata Y S, Akbas Y. Serum leptin levels in patients with allergic rhinitis. Otolaryngol Head Neck Surg 2006; 134: 331–333
   PubMed Web of Science ®Google Scholar
• Kim K W, Shin Y H, Lee K E, Kim E S, Sohn M H, Kim K E. Relationship between adipokines and manifestations of childhood asthma. Pediatr Allergy Immunol 2008
   Google Scholar
• Portoles O, Sorli J V, Frances F, Coltell O, Gonzalez J I, Saiz C, Corella D. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. Eur J Epidemiol 2006; 21: 605–612
   PubMed Web of Science ®Google Scholar
• Considine R V, Sinha M K, Heiman M L, Kriauciunas A, Stephens T W, Nyce M R, Ohannesian J P, Marco C C, McKee M J, Bauer T L, Caro J F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292–295
   PubMed Web of Science ®Google Scholar
• Echwald S M, Sorensen T D, Sorensen T I, Tybjaerg-Hansen A, Andersen T, Chung W K, Leibel R L, Pedersen O. Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity. Biochem Biophys Res Commun 1997; 233: 248–252
   PubMed Web of Science ®Google Scholar
• Gotoda T, Manning B S, Goldstone A P, Imrie H, Evans A L, Strosberg A D, McKeigue P M, Scott J, Aitman T J. Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Genet 1997; 6: 869–876
   PubMed Web of Science ®Google Scholar
• Silver K, Watson J, Chung W K, Yao F, Parikh V V, Andersen R, Cheskin L J, Elahi D, Muller D, Leibel R L, Shuldiner A R. The Gln223Arg and Lys656Asn polymorphisms in the human leptin receptor do not associate with traits related to obesity. Diabetes 1997; 46: 1898–1900
   PubMedGoogle Scholar
• Matsuoka N, Ogawa Y, Hosoda K, Matsuda J, Masuzaki H, Miyawaki T, Azuma N, Natsui K, Nishimura H, Yoshimasa Y, Nishi S, Thompson D B, Nakao K. Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia 1997; 40: 1204–1210
   PubMed Web of Science ®Google Scholar
• Yiannakouris N, Yannakoulia M, Melistas L, Chan J L, Klimis-Zacas D, Mantzoros C S. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab 2001; 86: 4434–4439
   PubMed Web of Science ®Google Scholar
• Chagnon Y C, Chung W K, Perusse L, Chagnon M, Leibel R L, Bouchard C. Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Quebec Family Study. Int J Obes Relat Metab Disord 1999; 23: 278–286
   PubMedGoogle Scholar
• Chagnon Y C, Wilmore J H, Borecki I B, Gagnon J, Perusse L, Chagnon M, Collier G R, Leon A S, Skinner J S, Rao D C, Bouchard C. Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J Clin Endocrinol Metab. 2000; 85: 29–34
   PubMed Web of Science ®Google Scholar
• Loos R J, Rankinen T, Chagnon Y, Tremblay A, Perusse L, Bouchard C. Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Quebec Family Study. Int J Obes (Lond) 2006; 30: 183–190
   PubMedGoogle Scholar
• Miraglia d el, Giudice E, Santoro N, Cirillo G, Raimondo P, Grandone A, D'Aniello A, Di Nardo M, Perrone L. Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity. Int J Obes Relat Metab Disord 2004; 28: 447–450
   PubMedGoogle Scholar