Irreversiblity of Remodeled Features on High-Resolution Computerized Tomography Scans of Asthmatic Patients on Conventional Therapy: A 6-Year Longitudinal Study

References

• Djukanovic R, Roche W R, Wilson J W, Beasley C R, Twentyman O P, Howarth R H, Holgate S T. Mucosal inflammation in asthma. Am Rev Respir Dis 1990; 142: 434–457
   PubMed Web of Science ®Google Scholar
• Bergeron C, Boulet L P. Structural changes in airway diseases. Characteristics, mechanisms, consequences, and pharmacologic modulation. Chest 2006; 129: 1068–1087
   PubMed Web of Science ®Google Scholar
• Nakano Y, Muller N L, King G G, Niimi A, Kalloger S E, Mishima M, Pare P D. Quantitative assessment of airway remodeling using high resolution CT. Chest 2002; 122: 271–275
   PubMed Web of Science ®Google Scholar
• Lynch D A, Newell J D, Tschomper B A, Cink T M, Newman L S, Bethel R. Uncomplicated asthma in adults: comparison of CT appearance of the lungs in asthmatic and healthy subjects. Radiology 1993; 188: 829–833
   PubMed Web of Science ®Google Scholar
• King G G, Muller N L, Pare P D. Evaluation of airways in obstructive pulmonary diseaae using high resolution computed tomography. Am J Respir Crit Care Med 1999; 159: 992–1004
   PubMed Web of Science ®Google Scholar
• Paganin F, Trussard E S, Chanez P, Giron J, Godard P, Senac J P, Michel F B, Bousquet J. Chest radiography and high resolution computed tomography of the lungs in asthma. Am Rev Respir Dis 1992; 146: 1084–1087
   PubMed Web of Science ®Google Scholar
• Capraz F, Kunter E, Cermik H, Ilvan A, Pocan S. The effect of inhaled budesonid and formoterol on bronchial remodeling and HRCT features in young asthmatics. Lung 2007; 185: 89–96
   PubMed Web of Science ®Google Scholar
• American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987; 136: 225–244
   PubMed Web of Science ®Google Scholar
• Global strategy for asthma management and prevention. National Institutes of Health. National Heart, Lung, and Blood Institute, Bethesda, MD 1995, NHLBI/WHO Workshop Report. Publication 95–3659
   Google Scholar
• Lynch D A, Newell J, Hale V, Dyer D, Corkery K, Fox N L, Gerend P, Fick R. Correlation of CT findings with clinical evaluations in 261 patients with symptomatic bronchiectasis. Am J Roentgenol 1999; 173: 53–58
   PubMed Web of Science ®Google Scholar
• Hazelton H R, Newell J D, Jr, Cook J L, Huitt G A, Lynch D A. CT findings in 14 patients with Mycobacterium chelonae pulmonary infection. Am J Roentgenol 2000; 175: 413–416
   PubMed Web of Science ®Google Scholar
• Grenier P, Maurice F, Musset D, Menu Y, Nahum H. Bronchiectasis: Assessment of thin section CT. Radiology 1986; 161: 95–99
   PubMed Web of Science ®Google Scholar
• Park C S, Muller N L, Worthy S A, Kim S J, Awadah N, Fitzgerald M. Airway obstruction in asthmatic and healthy individuals: Insiratory and expiratory thin- section CT findings. Radiology 1999; 203: 361–367
   Google Scholar
• Grenier P, Mourey-Gerosa I, Benali K, Brauner M W, Leung A N, Lenoir S, Cordeau M P, Mazoyer B. Abnormalities of the airways and lung parencyhma in asthmatics: CT observations in 50 patints and inter and intraobserver variability. Eur Radiol 1996; 6: 199–206
   PubMed Web of Science ®Google Scholar
• Forster W L, Pratt P C, Roggli V L, Godwin J D, Halvoersen R A, Putman C E. Centrilobular emphysema: CT-pathologic correlation. Radiology 1986; 159: 27–32
   PubMedGoogle Scholar
• Stern E J, Frank M S. Small airway diseases of the lungs: Findings at expiratory CT. Am J Roentgenol 1994; 162: 791–798
   PubMedGoogle Scholar
• Hodson J, Chir B, Trickey S E. Bronchial wall thickening in asthma. Clin Radiol 1960; 11: 182–191
   Google Scholar
• Harmanci (Kurt) E, Kebapci M, Metintas M, Ozkan R. High-resolution computed tomography findings are correlated with diseases severity in asthma. Respiration 2002; 69: 420–426
   PubMedGoogle Scholar
• Olivieri D, Chetta A, Del Donno M, Bertorelli G, Casalini A, Pesci A, Testi R, Foresi A. Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: a placebo-controlled study. Am J Respir Crit Care Med 1997; 155: 1864–1871
   PubMed Web of Science ®Google Scholar
• Hamid Q, Song Y, Kotsimbos T C, Minshall E, Bai T R, Hegele R G, Hogg J C. Inflammation of small airways in asthma. J Allergy Clin Immunol 1997; 100: 44–51
   PubMed Web of Science ®Google Scholar
• Tulic M K, Hamid Q. New insights into the pathophysiology of the small airways in asthma. Clin Chest Med 2006; 27: 41–52
   PubMed Web of Science ®Google Scholar
• Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M. Role of small airways in asthma: investigation using high-resolution computed tomography. J Allergy Clin Immunol 2006; 118: 1019–1025
   PubMed Web of Science ®Google Scholar
• Homer R J, Elias J A. Consequences of long-term inflammation. Airway remodeling. Clin Chest Med 2000; 21: 331–343
   PubMedGoogle Scholar
• Boulet L P, Turcotte H, Laviolette M, Naud F, Bernier M C, Martel S, Chakir J. Airway hyperresponsiveness and subepithelial collagen deposition in recently diagnosed vs long standing mild asthma. Am J Respir Crit Care Med 2000; 162: 1308–1313
   PubMed Web of Science ®Google Scholar
• Chakir J, Shannon J, Molet S, Fukahusa M, Elias J, Laviolette M, Boulet L P, Hamid Q. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol 2003; 111: 1293–1298
   PubMed Web of Science ®Google Scholar
• Lee Y M, Park J S, Hwang J H, Park S W, Uh S T, Kim Y H, Park C S. High-resolution CT findings in patients with near fatal asthma. Comparison of patients with mild-to-moderate asthma and normal control subjects and changes in airway abnormalities following steroid treatment. Chest 2004; 126: 1840–1848
   PubMed Web of Science ®Google Scholar
• Canonica G W. Treating asthma as an inflammatory disease. Chest 2006; 130(suppl 1)21–28
   Google Scholar
• Hashimoto M, Tanaka H, Abe S. Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD. Chest 2005; 127: 965–972
   PubMed Web of Science ®Google Scholar
• Gono K, Fujimoto K, Kawakami S, Kubo K. Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma. Eur Respir J 2003; 22: 965–971
   PubMed Web of Science ®Google Scholar
• Bergeron C, Hauber H P, Gotfried M, Newman K, Dhanda R, Servi R J, Ludwig M S, Hamid Q. Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide. J Allergy Clin Immunol 2005; 116: 983–989
   PubMed Web of Science ®Google Scholar
• Ohbayashi H. One-year evaluation of the preventative effect of hydrofluoroalkane-beclomethasone dipropionate on eosinophilic inflammation of asthmatic peripheral airways. Respiration 2007; 74: 146–153
   PubMedGoogle Scholar
• Tunon d e, Lara J M, Laurent F, Giraud V, Perez T, Aguilaniu B, Meziane H, Merle-Basset A, Chanez P. Air trapping in mild and moderate asthma: effect of inhaled corticosteroids. J Allergy Clin Immunol 2007; 119: 583–590
   PubMedGoogle Scholar