The role of HDAC2 in cigarette smoke–induced airway inflammation in a murine model of asthma and the effect of intervention with roxithromycin

References

• Hekking PP, Bel EH. Developing and emerging clinical asthma phenotypes. J Allergy Clin Immunol Pract 2014;2:671–680.
   PubMed Web of Science ®Google Scholar
• Thomson NC, Shepherd M, Spears M, Chaudhuri R. Corticosteroid insensitivity in smokers with asthma: clinical evidence, mechanisms, and management. Treat Respir Med 2006;5:467–481.
   PubMedGoogle Scholar
• Yao H, Rahman I. Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD. Am J Physiol Lung Cell Mol Physiol 2012;303:L557–566.
   PubMed Web of Science ®Google Scholar
• Kuo MH, Allis CD. Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 1998;20:615–626.
   PubMed Web of Science ®Google Scholar
• Adcock IM, Ito K, Barnes PJ. Histone deacetylation: an important mechanism in inflammatory lung diseases. COPD 2005;2:445–455.
   PubMedGoogle Scholar
• Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, et al. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 2000;287:1040–1046.
   PubMed Web of Science ®Google Scholar
• Parameswaran K, Cox G, Radford K, Janssen LJ, Sehmi R, O'Byrne PM. Cysteinyl leukotrienes promote human airway smooth muscle migration. Am J Respir Crit Care Med 2002;166:738–742.
   PubMed Web of Science ®Google Scholar
• Krymskaya VP, Ammit AJ, Hoffman RK, Eszterhas AJ, Panettieri RA, Jr. Activation of class IA PI3K stimulates DNA synthesis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2001;280: L1009–1018.
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 2013;131:636–645.
   PubMed Web of Science ®Google Scholar
• Kobayashi Y, Bossley C, Gupta A, Akashi K, Tsartsali L, Mercado N, et al. Passive smoking impairs histone deacetylase-2 in children with severe asthma. Chest 2014;145:305–312.
   PubMed Web of Science ®Google Scholar
• To Y, Ito K, Kizawa Y, Failla M, Ito M, Kusama T, et al. Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;182:897–904.
   PubMed Web of Science ®Google Scholar
• Choe HS, Lee SJ, Han CH, Shim BS, Cho YH. Clinical efficacy of roxithromycin in men with chronic prostatitis/chronic pelvic pain syndrome in comparison with ciprofloxacin and aceclofenac: a prospective, randomized, multicenter pilot trial. J Infect Chemother 2014;20:20–25.
   PubMed Web of Science ®Google Scholar
• Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med 2008;177:148–155.
   PubMed Web of Science ®Google Scholar
• Slater M, Rivett DW, Williams L, Martin M, Harrison T, Sayers I, et al. The impact of azithromycin therapy on the airway microbiota in asthma. Thorax 2014;69:673–674.
   PubMed Web of Science ®Google Scholar
• Xu S, Tian BP, Zhang LH, Hua W, Xia LX, Chen ZH, et al. Prevention of allergic airway hyperresponsiveness and remodeling in mice by Astragaliradix antiasthmatic decoction. BMC Complement Altern Med 2013;13:369.
   PubMed Web of Science ®Google Scholar
• Ou XM, Wen FQ, Uhal BD, Feng YL, Huang XY, Wang T, et al. Simvastatin attenuates experimental small airway remodelling in rats. Respirology 2009;14:734–745.
   PubMed Web of Science ®Google Scholar
• Ci X, Chu X, Xu X, Li H, Deng X. Short-term roxithromycin treatment attenuates airway inflammation via MAPK/NF-kappaB activation in a mouse model of allergic asthma. Inflamm Res 2012;61:749–758.
   PubMed Web of Science ®Google Scholar
• Dong J, Wong CK, Cai Z, Jiao D, Chu M, Lam CW. Amelioration of allergic airway inflammation in mice by regulatory IL-35 through dampening inflammatory dendritic cells. Allergy 2015;70:921–932.
   PubMed Web of Science ®Google Scholar
• Singh SP, Barrett EG, Kalra R, Razani-Boroujerdi S, Langley RJ, Kurup V, et al. Prenatal cigarette smoke decreases lung cAMP and increases airway hyperresponsiveness. Am J Respir Crit Care Med 2003;168:342–347.
   PubMed Web of Science ®Google Scholar
• Tournoy KG, Kips JC, Schou C, Pauwels RA. Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness. Clin Exp Allergy 2000;30:79–85.
   PubMed Web of Science ®Google Scholar
• Chapman DG, Irvin CG. Mechanisms of airway hyper-responsiveness in asthma: the past, present and yet to come. Clin Exp Allergy 2015;45:706–719.
   PubMed Web of Science ®Google Scholar
• Gray SG, Ekstrom TJ. The human histone deacetylase family. Exp Cell Res 2001;262:75–83.
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Histone deacetylase-2 and airway disease. Ther Adv Respir Dis 2009;3:235–243.
   PubMedGoogle Scholar
• Nagasaki T, Matsumoto H. Influences of smoking and aging on allergic airway inflammation in asthma. Allergol Int 2013;62:171–179.
   PubMed Web of Science ®Google Scholar
• Thomson NC, Chaudhuri R, Heaney LG, Bucknall C, Niven RM, Brightling CE, et al. Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma. J Allergy Clin Immunol 2013;131:1008–1016.
   PubMed Web of Science ®Google Scholar
• Juusela M, Pallasaho P, Rönmark E, Sarna S, Sovijärvi A, Lundbäck B. Dose-dependent association of smoking and bronchial hyperresponsiveness. Eur Respir J 2013;42:1503–1512.
   PubMed Web of Science ®Google Scholar
• Pease JE, Sabroe I. The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med 2002;1:19–25.
   PubMedGoogle Scholar
• Larsen CG, Anderson AO, Oppenheim JJ, Matsushima K. Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor. Immunology 1989;68:31–36.
   PubMed Web of Science ®Google Scholar
• St-Laurent J, Bergeron C, Page N, Couture C, Laviolette M, Boulet LP. Influence of smoking on airway inflammation and remodelling in asthma. Clin Exp Allergy 2008;38:1582–1589.
   PubMed Web of Science ®Google Scholar
• Chaudhuri R, Livingston E, McMahon AD, Thomson L, Borland W, Thomson NC. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med 2003;168:1308–1311.
   PubMed Web of Science ®Google Scholar
• Shute JK, Vrugt B, Lindley IJ, Holgate ST, Bron A, Aalbers R, et al. Free and complexed interleukin-8 in blood and bronchial mucosa in asthma. Am J Respir Crit Care Med 1997;155:1877–1883.
   PubMed Web of Science ®Google Scholar
• Krishnaswamy G, Hall K, Youngberg G, Hossler F, Johnson D, Block WA, et al. Regulation of eosinophil-active cytokine production from human cord blood-derived mast cells. J Interferon Cytokine Res 2002;22:379–388.
   PubMed Web of Science ®Google Scholar
• Sabatini F, Silvestri M, Sale R, Scarso L, Defilippi AC, Risso FM, et al. Fibroblast-eosinophil interaction: modulation of adhesion molecules expression and chemokine release by human fetal lung fibroblasts in response to IL-4 and TNF-alpha. Immunol Lett 2002;84:173–178.
   PubMed Web of Science ®Google Scholar
• De Boer WI. Cytokines and therapy in COPD: a promising combination? Chest 2002;121:209S–218S.
   PubMed Web of Science ®Google Scholar
• Barnes PJ, Ito K, Adcock IM. Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet 2004;363:731–733.
   PubMed Web of Science ®Google Scholar
• Ito K, Lim S, Caramori G, Chung KF, Barnes PJ, Adcock IM. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 2001;15:1110–1112.
   PubMedGoogle Scholar
• Li L, Sun J, Xu C, Zhang H, Wu J, Liu B, et al. Icariin ameliorates cigarette smoke induced inflammatory responses via suppression of NF-kappaB and modulation of GR in vivo and in vitro. PLoS One 2014;9: e102345.
   PubMed Web of Science ®Google Scholar
• Condliffe AM, Cadwallader KA, Walker TR, Rintoul RC, Cowburn AS, Chilvers ER. Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells. Respir Res 2000;1:24–29.
   PubMedGoogle Scholar
• Marwick JA, Caramori G, Stevenson CS, Casolari P, Jazrawi E, Barnes PJ, et al. Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med 2009;179:542–548.
   PubMed Web of Science ®Google Scholar
• Voskas D, Ling LS, Woodgett JR. Signals controlling un-differentiated states in embryonic stem and cancer cells: role of the phosphatidylinositol 3' kinase pathway. J Cell Physiol 2014;229:1312–1322.
   PubMed Web of Science ®Google Scholar
• Gao A, Liu B, Shi X, Jia X, Ye M, Jiao S, et al. Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts. Toxicol Lett 2007;170:30–41.
   PubMed Web of Science ®Google Scholar
• Livingood CS, Head ES, Johnson EA, Nilasena S. Erythromycin in local treatment of cutaneous bacterial infections. J Am Med Assoc 1953;153:1266–1270.
   PubMed Web of Science ®Google Scholar
• Zarogoulidis P, Papanas N, Kioumis I, Chatzaki E, Maltezos E, Zarogoulidis K. Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. Eur J Clin Pharmacol 2012;68:479–503.
   PubMed Web of Science ®Google Scholar
• Dai Y, Li F, Wu L, Wang R, Li P, Yan S, et al. Roxithromycin treatment inhibits TGF-beta1-induced activation of ERK and AKT and down-regulation of caveolin-1 in rat airway smooth muscle cells. Respir Res 2014;15:96.
   PubMed Web of Science ®Google Scholar