323
Views
5
CrossRef citations to date
0
Altmetric
Alternative Medicine

Linking endotypes to omics profiles in difficult-to-control asthma using the diagnostic Chinese medicine syndrome differentiation algorithm

, PhD, , MS, , MD, , MD, , PhD, , PhD, , PhD, , MD, , PhD, , MD, , MD & , MD, PhD show all
Pages 532-542 | Received 11 Sep 2018, Accepted 28 Feb 2019, Published online: 27 Mar 2019

References

  • Britton J. Parasites, allergy, and asthma. Am J Respir Crit Care Med 2003;168:266–267. doi:10.1164/rccm.2305011.
  • Israel E, Reddel HK. Severe and difficult-to-treat asthma in Adults. N Engl J Med 2017;377:965–976. doi:10.1056/NEJMra1608969.
  • Adamko DJ, Sykes BD, Rowe BH. The metabolomics of asthma: novel diagnostic potential. Chest 2012;141:1295–1302. doi:10.1378/chest.11-2028.
  • Durham AL, Wiegman C, Adcock IM. Epigenetics of asthma. Biochim Biophys Acta 2011;1810:1103–1109. doi:10.1016/j.bbagen.2011.03.006.
  • Yucesoy B, Kaufman KM, Lummus ZL, Weirauch MT, Zhang G, Cartier A, Boulet L-P, et al. Genome-wide association study identifies novel loci associated with diisocyanate-induced occupational asthma. Toxicol Sci 2015;146:192–201. doi:10.1093/toxsci/kfv084.
  • Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 2011;43:887–892.
  • García-Sánchez A, Isidoro-García M, García-Solaesa V, Sanz C, Hernández-Hernández L, Padrón-Morales J, Lorente-Toledano F, et al. Genome-wide association studies (GWAS) and their importance in asthma. Allergol Immunopathol (Madr) 2015;43:601–608. doi:10.1016/j.aller.2014.07.004.
  • Lee JW, Jaffar Z, Pinkerton KE, Porter V, Postma B, Ferrini M, Holian A, et al. Alterations in DNA methylation and airway hyperreactivity in response to in utero exposure to environmental tobacco smoke. Inhal Toxicol 2015;27:724. doi:10.3109/08958378.2015.1104402.
  • Suzuki MM, Bird A. DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 2008;9:465–476. doi:10.1038/nrg2341.
  • Lorincz MC, Dickerson DR, Schmitt M, Groudine M. Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells. Nat Struct Mol Biol 2004;11:1068–1075. doi:10.1038/nsmb840.
  • Kabesch M, Adcock IM. Epigenetics in asthma and COPD. Biochimie 2012;94:2231–2241. doi:10.1016/j.biochi.2012.07.017.
  • Comhair SA, McDunn J, Bennett C, Fettig J, Erzurum SC, Kalhan SC. Metabolomic endotype of asthma. J Immunol 2015;195:643–650. doi:10.4049/jimmunol.1500736.
  • Saude EJ, Skappak CD, Regush S, Cook K, Benzvi A, Becker A, et al. Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy. J Allergy Clin Immunol 2011;127:757–764. doi:10.1016/j.jaci.2010.12.1077.
  • Chang C, Guo ZG, He B, Yao WZ. Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis. Acta Pharmacol Sin 2015;36:1356–1366. doi:10.1038/aps.2015.102.
  • McGeachie MJ, Dahlin A, Qiu W, Croteau-Chonka DC, Savage J, Wu AC, Wan ES, et al. The metabolomics of asthma control: a promising link between genetics and disease. Immun Inflamm Dis 2015;3:224–238. doi:10.1002/iid3.61.
  • Yang IV, Schwartz DA. Epigenetic mechanisms and the development of asthma. J Allergy Clin Immunol 2012;130:1243–1255. doi:10.1016/j.jaci.2012.07.052.
  • Fu X, Mervin LH, Li X, Yu H, Li J, Zobir SZM, et al. Toward Understanding the Cold, Hot, and neutral nature of Chinese medicines using in silico mode-of-action analysis. J Chem Inf Model 2017;57:468–483. doi:10.1021/acs.jcim.6b00725.
  • Zhang X, Li H, Li L, Li GX, Liu SG, Li M, et al. Exploration of traditional Chinese medicine clinical phenotype in chronic persistent bronchial asthma. World Sci Technol Mod Tradit Chin Med Materia Medica (Chin) 2017;19:1517–1521.
  • Hong ML, Song Y, Li XM. Effects and mechanisms of actions of Chinese herbal medicines for asthma. Chin J Integr Med 2011;17:483–491. doi:10.1007/s11655-011-0780-5.
  • Zhao C, Li GZ, Wang C, Niu J. Advances in patient classification for traditional Chinese medicine: a machine learning perspective. Evid Based Complement Alternat Med 2015;2015:376716. doi:10.1155/2015/376716.
  • Qiu J. When the East meets the West: the future of traditional Chinese medicine in the 21st century. Natl Sci Rev 2015;2:377–380. doi:10.1093/nsr/nwv049.
  • Fauzi FM, Koutsoukas A, Lowe R, Joshi K, Fan TP, Bender A. Chemogenomics approaches to rationalising compound action of traditional Chinese and ayurvedic medicines. J Cheminform 2014;6:131–132.
  • Li XL, Xu ZX, Wang YQ, Guo R, Hao YM, Lei Z, et al. Clinical evaluation on patients with bronchial asthma in remission based on four diagnostic information. Mod Tradit Chin Med Materia Medica 2014;6:1294–1299.
  • Ni W, Yu SX, Wang HC, Zhang HY, Li PC, Wu YG. Study on the relationship between insufficiency of the kidney-yang and airway inflammation in asthmatics in the remmision stage–analysis of 175 cases of asthmatics. Chin J Basic Med Tradit Chin Med (Chin) 2001;7:60–61.
  • Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014; 43:343–373. doi:10.1183/09031936.00202013.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402–408. doi:10.1006/meth.2001.1262.
  • Hebbring SJ. The challenges, advantages and future of phenome-wide association studies. Immunology 2014;141:157–165. doi:10.1111/imm.12195.
  • Gu PQ, Chen HJ. Modern bioinformatics meets traditional Chinese medicine. Brief Bioinform 2014;15:984–1003. doi:10.1093/bib/bbt063.
  • Li GF, He ZH, Shao FF, Ou AH, Lin XZ. Patient classification of hypertension in traditional Chinese medicine using multi-label learning techniques. BMC Med Genomics 2015;8:S4.
  • Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, et al. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Hum Genet 2014; 133:95–109. doi:10.1007/s00439-013-1355-7.
  • Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, et al. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet 2011;89:529–542. doi:10.1016/j.ajhg.2011.09.008.
  • Denny JC, Ritchie MD, Basford MA, Pulley JM, Bastarache L, Brown-Gentry K, Wang D, et al. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics 2010;26:1205–1210. doi:10.1093/bioinformatics/btq126.
  • Li XL, Xu ZX, Wang YQ, Guo R, Hao YM. Correlation study on the tongue and complexion parameters characteristic of different syndromes in patients with asthma and pulmonary function. China J Tradit Chin Med Pharm (Chin) 2014; 3232–3235.
  • Zha Q, Lin S, Zhang C, Chang C, Xue H, Lu C, Jiang M, et al. Xiaoqinglong granules as add-on therapy for asthma: latent class analysis of symptom predictors of response. Evid Based Complement Alternat Med 2013;2013:1. doi:10.1155/2013/759476.
  • Ikeda Y, Iizuka A, Amagaya S, Ishige A, Komatsu Y, Fujihira E. Anti-type I allergic mechanisms of mao-bushi-saishin-to in mice. Jpn J Pharmacol 2000;82:29–33.
  • Li XM, Brown L. Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy. J Allergy Clin Immunol 2009;123:297–306. doi:10.1016/j.jaci.2008.12.026.
  • Nagai T, Arai Y, Emori M, Nunome S-y, Yabe T, Takeda T, Yamada H, et al. Anti-allergic activity of a Kampo (Japanese herbal) medicine "Sho-seiryu-to (Xiao-Qing-Long-Tang)" on airway inflammation in a mouse model. Int Immunopharmacol 2004;4:1353–1365. doi:10.1016/j.intimp.2004.05.021.
  • Nagai T, Nakao M, Shimizu Y, Kodera Y, Oh-Ishi M, Maeda T, et al. Proteomic analysis of anti-inflammatory effects of a kampo (Japanese herbal) medicine "Shoseiryuto (Xiao-Qing-Long-Tang)" on airway inflammation in a mouse model. Evid Based Complement Alternat Med 2011;2011:604196. doi:10.1093/ecam/nep151.
  • Kao ST, Lin CS, Hsieh CC, Hsieh WT, Lin JG. Effects of xiao-qing-long-tang (XQLT) on bronchoconstriction and airway eosinophil infiltration in ovalbumin-sensitized guinea pigs: in vivo and in vitro studies. Allergy 2001;56:1164–1171.
  • Kao ST, Chang CH, Chen YS, Chiang SY, Lin JG. Effects of Ding-Chuan-Tang on bronchoconstriction and airway leucocyte infiltration in sensitized guinea pigs. Immunopharmacol Immunotoxicol 2004;26:113–124. doi:10.1081/IPH-120029949.
  • Chan CK, Kuo ML, Shen JJ, See LC, Chang HH, Huang JL. Ding Chuan Tang, a Chinese herb decoction, could improve airway hyper-responsiveness in stabilized asthmatic children: a randomized, double-blind clinical trial. Pediatr Allergy Immunol 2006;17:316–322. doi:10.1111/j.1399-3038.2006.00406.x.
  • Lauer FT, Mitchell LA, Bedrick E, McDonald JD, Lee W-Y, Li W-W, Olvera H, et al. Temporal-spatial analysis of U.S.-Mexico border environmental fine and coarse PM air sample extract activity in human bronchial epithelial cells. Toxicol Appl Pharmacol 2009;238:1–10. doi:10.1016/j.taap.2009.04.021.
  • Franciosi L, Postma DS, van den Berge M, Govorukhina N, Horvatovich PL, Fusetti F, Poolman B, et al. Susceptibility to COPD: differential proteomic profiling after acute smoking. PLoS One 2014;9:e102037. doi:10.1371/journal.pone.0102037.
  • Burchiel SW, Thompson TA, Lauer FT, Oprea TI. Activation of dioxin response element (DRE)-associated genes by benzo(a)pyrene 3,6-quinone and benzo(a)pyrene 1,6-quinone in MCF-10A human mammary epithelial cells. Toxicol Appl Pharmacol 2007;221:203–214. doi:10.1016/j.taap.2007.02.020.
  • Ouyang B, Bernstein DI, Lummus ZL, Ying J, Boulet L-P, Cartier A, Gautrin D, et al. Interferon-gamma promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma. Toxicol Sci 2013;133:218–224. doi:10.1093/toxsci/kft079.
  • Fan S, Huang K, Ai R, Wang M, Wang W. Predicting CpG methylation levels by integrating Infinium HumanMethylation450 BeadChip array data. Genomics 2016;107:132–137. doi:10.1016/j.ygeno.2016.02.005.
  • Yang X, Han H, De Carvalho DD, Lay FD, Jones PA, Liang G. Gene body methylation can alter gene expression and is a therapeutic target in cancer. Cancer Cell 2014;26:577–590. doi:10.1016/j.ccr.2014.07.028.
  • Jung J, Kim S-H, Lee H-S, Choi GS, Jung Y-S, Ryu DH, Park H-S, et al. Serum metabolomics reveals pathways and biomarkers associated with asthma pathogenesis. Clin Exp Allergy 2013;43:425–433. doi:10.1111/cea.12089.
  • Huang YT, Liang L, Moffatt MF, Cookson WO, Lin X. iGWAS: Integrative genome-wide association studies of genetic and genomic data for disease susceptibility using mediation analysis. Genet Epidemiol 2015;39:347–356. doi:10.1002/gepi.21905.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.