Asthma phenotypes and associated comorbidities in a large cohort of adolescents in Israel

References

• Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469–478. Epub 2004/04/15. doi:10.1111/j.1398-9995.2004.00526.x.
   PubMed Web of Science ®Google Scholar
• Asher I, Pearce N. Global burden of asthma among children. Int J Tuberc Lung Dis 2014;18:1269–1278. Epub 2014/10/10. doi:10.5588/ijtld.14.0170.
   PubMed Web of Science ®Google Scholar
• Bateman ED, Jithoo A. Asthma and allergy - a global perspective. Allergy 2007;62:213–215. Epub 2007/02/15. doi:10.1111/j.1398-9995.2007.01324.x.
   PubMed Web of Science ®Google Scholar
• Palomares O, Akdis M, Martin-Fontecha M, Akdis CA. Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunol Rev 2017;278:219–236. Epub 2017/06/29. doi:10.1111/imr.12555.
   PubMed Web of Science ®Google Scholar
• Miyasaka T, Dobashi-Okuyama K, Takahashi T, Takayanagi M, Ohno I. The interplay between neuroendocrine activity and psychological stress-induced exacerbation of allergic asthma. Allergol Int 2017;67:32–42. Epub 2017/05/26. doi:10.1016/j.alit.2017.04.013. PubMed PMID: 28539203.
   PubMed Web of Science ®Google Scholar
• Chung KF. Defining phenotypes in asthma: a step towards personalized medicine. Drugs 2014;74:719–728. Epub 2014/05/07. doi:10.1007/s40265-014-0213-9.
   PubMed Web of Science ®Google Scholar
• Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014;43:343–373. Epub 2013/12/18. doi:10.1183/09031936.00202013.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Castro M, Bacharier LB, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2011;127:382–389 e1–13. Epub 2011/01/05. PubMed PMID: 21195471; PubMed Central PMCID: PMCPMC3060668. doi:10.1016/j.jaci.2010.11.015.
   PubMed Web of Science ®Google Scholar
• Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008;178:218–224. Epub 2008/05/16. PubMed PMID: 18480428; PubMed Central PMCID: PMCPMC3992366. doi:10.1164/rccm.200711-1754OC.
   PubMed Web of Science ®Google Scholar
• Sonnappa S, Bastardo CM, Wade A, Saglani S, McKenzie SA, Bush A, Aurora P, et al. Symptom-pattern phenotype and pulmonary function in preschool wheezers. J Allergy Clin Immunol 2010;126:519–526 e1–7. Epub 2010/06/29. doi:10.1016/j.jaci.2010.04.018.
   PubMed Web of Science ®Google Scholar
• Savenije OE, Granell R, Caudri D, Koppelman GH, Smit HA, Wijga A, de Jongste JC. Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA. J Allergy Clin Immunol 2011;127:1505–1512. e14. Epub 2011/03/18. doi:10.1016/j.jaci.2011.02.002.
   PubMed Web of Science ®Google Scholar
• Pite H, Gaspar A, Morais-Almeida M. Preschool-age wheezing phenotypes and asthma persistence in adolescents. Allergy Asthma Proc 2016;37:231–241. Epub 2016/04/15. doi:10.2500/aap.2016.37.3955.
   PubMed Web of Science ®Google Scholar
• Carr TF, Bleecker E. Asthma heterogeneity and severity. World Allergy Organ J 2016;9:41Epub 2016/12/17. doi:10.1186/s40413-016-0131-2. PubMed PMID: 27980705; PubMed Central PMCID: PMCPMC5129643.
   PubMed Web of Science ®Google Scholar
• Lee E, Lee SH, Kwon JW, Kim YH, Yoon J, Cho HJ, Yang SI, Jung YH, Kim HY, Seo JH, et al. Persistent asthma phenotype related with late-onset, high atopy, and low socioeconomic status in school-aged Korean children. BMC Pulm Med 2017;17:45. Epub 2017/02/25. PubMed PMID: 28231776; PubMed Central PMCID: PMCPMC5324247. doi:10.1186/s12890-017-0387-5.
   PubMed Web of Science ®Google Scholar
• Reinke SN, Gallart-Ayala H, Gomez C, Checa A, Fauland A, Naz S, Kamleh MA, Djukanović R, Hinks. Metabolomics analysis identifies different metabotypes of asthma severity. Eur Respir J 2017;49:1601740. Epub 2017/03/31. PubMed PMID: 28356371; PubMed Central PMCID: PMCPMC5399350. doi:10.1183/13993003.01740-2016.
   PubMed Web of Science ®Google Scholar
• Zoratti EM, Krouse RZ, Babineau DC, Pongracic JA, O'Connor GT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, et al. Asthma phenotypes in inner-city children. J Allergy Clin Immunol 2016;138:1016–1029. Epub 2016/10/11. PubMed PMID: 27720016; PubMed Central PMCID: PMCPMC5104222. doi:10.1016/j.jaci.2016.06.061.
   PubMed Web of Science ®Google Scholar
• Boulet LP, FitzGerald JM, Reddel HK. The revised 2014 GINA strategy report: opportunities for change. Curr Opin Pulm Med 2015;21:1–7. Epub 2014/11/19. doi:10.1097/mcp.0000000000000125.
   PubMed Web of Science ®Google Scholar
• Garden FL, Simpson JM, Mellis CM, Marks GB. Change in the manifestations of asthma and asthma-related traits in childhood: a latent transition analysis. Eur Respir J 2016;47:499–509. Epub 2015/10/24. doi:10.1183/13993003.00284-2015.
   PubMed Web of Science ®Google Scholar
• Corren J. Asthma phenotypes and endotypes: an evolving paradigm for classification. Discov Med 2013;15:243–249. Epub 2013/05/03.
   PubMed Web of Science ®Google Scholar
• Pembrey L, Barreto ML, Douwes J, Cooper P, Henderson J, Mpairwe H, Ardura-Garcia C, Chico M, Brooks C, Cruz AA, et al. Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration. ERJ Open Res 2018;4. Epub 2018/08/29. PubMed PMID: 30151371; PubMed Central PMCID: PMCPMC6104297. doi:10.1183/23120541.00013-2018.
   PubMedGoogle Scholar
• Spycher BD, Silverman M, Kuehni CE. Phenotypes of childhood asthma: are they real? Clin Exp Allergy 2010;40:1130–1141. Epub 2010/06/16. doi:10.1111/j.1365-2222.2010.03541.x.
   PubMed Web of Science ®Google Scholar
• Just J, Bourgoin-Heck M, Amat F. Clinical phenotypes in asthma during childhood. Clin Exp Allergy 2017;47:848–855. Epub 2017/04/20. doi:10.1111/cea.12939.
   PubMed Web of Science ®Google Scholar
• Eguiluz-Gracia I, Tay TR, Hew M, Escribese MM, Barber D, O'Hehir RE, Torres MJ. Recent developments and highlights in biomarkers in allergic diseases and asthma. Allergy 2018;73:2290–2305. Epub 2018/10/06. doi:10.1111/all.13628.
   PubMed Web of Science ®Google Scholar
• Weatherburn CJ, Guthrie B, Mercer SW, Morales DR. Comorbidities in adults with asthma: population-based cross-sectional analysis of 1.4 million adults in Scotland. Clin Exp Allergy 2017;47:1246–1252. Epub 2017/07/01. doi:10.1111/cea.12971.
   PubMed Web of Science ®Google Scholar
• Gershon AS, Wang C, Guan J, To T. Burden of comorbidity in individuals with asthma. Thorax 2010;65:612–618. Epub 2010/07/16. doi:10.1136/thx.2009.131078.
   PubMed Web of Science ®Google Scholar
• Zhang T, Carleton BC, Prosser RJ, Smith AM. The added burden of comorbidity in patients with asthma. J Asthma 2009;46:1021–1026. Epub 2009/12/10. doi:10.3109/02770900903350473.
   PubMed Web of Science ®Google Scholar
• Ferkh KE, Nwaru BI, Griffiths C, Patel A, Sheikh A. Healthcare costs of asthma comorbidities: a systematic review protocol. BMJ Open 2017;7:e015102. Epub 2017/06/02. PubMed PMID: 28566366; PubMed Central PMCID: PMCPMC5730013. doi:10.1136/bmjopen-2016-015102.
   PubMed Web of Science ®Google Scholar
• de Groot EP, Duiverman EJ, Brand PL. Comorbidities of asthma during childhood: possibly important, yet poorly studied. Eur Respir J 2010;36:671–678. Epub 2010/10/12. doi:10.1183/09031936.00185709.
   PubMed Web of Science ®Google Scholar
• Boulet LP, Boulay ME. Asthma-related comorbidities. Expert Rev Respir Med 2011;5:377–393. Epub 2011/06/28. doi:10.1586/ers.11.34.
   PubMed Web of Science ®Google Scholar
• Cazzola M, Calzetta L, Bettoncelli G, Novelli L, Cricelli C, Rogliani P. Asthma and comorbid medical illness. Eur Respir J 2011;38:42–49. Epub 2010/12/24. doi:10.1183/09031936.00140310.
   PubMed Web of Science ®Google Scholar
• Ullmann N, Mirra V, Di Marco A, Pavone M, Porcaro F, Negro V, Onofri A, Cutrera R. Asthma: differential diagnosis and comorbidities. Front Pediatr 2018;6:276. Epub 2018/10/20. PubMed PMID: 30338252; PubMed Central PMCID: PMCPMC6178921. doi:10.3389/fped.2018.00276.
   PubMed Web of Science ®Google Scholar
• Tay TR, Hew M. Comorbid “treatable traits” in difficult asthma: current evidence and clinical evaluation. Allergy 2018;73:1369–1382. Epub 2017/11/28. doi:10.1111/all.13370.
   PubMed Web of Science ®Google Scholar
• Bardin PG, Rangaswamy J, Yo SW. Managing comorbid conditions in severe asthma. Med J Aust 2018;209:S11–SS7. Epub 2018/11/21.
   PubMed Web of Science ®Google Scholar
• Oțelea MR, Rașcu A, The Asthma Obese Phenotype. In: Huang K-HG, ed. Asthma diagnosis and management. London, UK: IntechOpen; 2018:165–184.
   Google Scholar
• Graif Y, Shohat T, Machluf Y, Farkash R, Chaiter Y. Association between asthma and migraine - a cross-sectional study of over 110,000 Adolescents. Clin Respir J 2018;12:2491–2496. Epub 2018/07/14. doi:10.1111/crj.12939.
   PubMed Web of Science ®Google Scholar
• Labor M, Labor S, Juric I, Fijacko V, Grle SP, Plavec D. Mood disorders in adult asthma phenotypes. J Asthma 2018;55:57–65. Epub 2017/05/11. doi:10.1080/02770903.2017.1306546.
   PubMed Web of Science ®Google Scholar
• Adamia N, Jorjoliani L, Khachapuridze D, Katamadze N, Chkuaseli N. Allergic diseases and asthma in adolescents. Georgian Med News 2015;243:58–62. Epub 2015/06/20.
   Google Scholar
• Ross MK, Romero T, Sim MS, Szilagyi PG. Obese- and allergic-related asthma phenotypes among children across the United States. J Asthma 2018;1–10. Epub 2018/04/20. doi: 10.1080/02770903.2018.1466317.
   PubMed Web of Science ®Google Scholar
• Fischer GB, Sarria EE, Mattiello R, Mocelin HT, Castro-Rodriguez JA. Post infectious bronchiolitis obliterans in children. Paediatr Respir Rev 2010;11:233–239. Epub 2010/11/27. doi:10.1016/j.prrv.2010.07.005.
   PubMed Web of Science ®Google Scholar
• Skobeloff EM, Spivey WH, St CSS, Schoffstall JM. The influence of age and sex on asthma admissions. JAMA 1992;268:3437–3440. Epub 1992/12/23.
   PubMed Web of Science ®Google Scholar
• Meurer JR, George V, Subichin S, Yauck J, Layde P. Asthma severity among children hospitalized in 1990 and 1995. Arch Pediatr Adolesc Med 2000;154:143–149. Epub 2000/02/09.
   PubMedGoogle Scholar
• Chen Y, Dales R, Stewart P, Johansen H, Scott G, Taylor G. Hospital readmissions for asthma in children and young adults in Canada. Pediatr Pulmonol 2003;36:22–26. Epub 2003/05/29. doi:10.1002/ppul.10307.
   PubMed Web of Science ®Google Scholar
• Raghavan D, Jain R. Increasing awareness of sex differences in airway diseases. Respirology 2016;21:449–459. Epub 2015/12/19. doi:10.1111/resp.12702.
   PubMed Web of Science ®Google Scholar
• Fuseini H, Newcomb DC. Mechanisms driving gender differences in asthma. Curr Allergy Asthma Rep 2017;17:19. Epub 2017/03/24. doi:10.1007/s11882-017-0686-1.
   PubMed Web of Science ®Google Scholar
• Tse SM, Rifas-Shiman SL, Coull BA, Litonjua AA, Oken E, Gold DR. Sex-specific risk factors for childhood wheeze and longitudinal phenotypes of wheeze. J Allergy Clin Immunol 2016;138:1561–1568.e6. Epub 2016/06/02. PubMed PMID: 27246527; PubMed Central PMCID: PMCPMC5083247. doi:10.1016/j.jaci.2016.04.005.
   PubMed Web of Science ®Google Scholar
• Machluf Y, Farkash R, Fink D, Chaiter Y. Asthma severity and heterogeneity: insights from prevalence trends and associated demographic variables and anthropometric indices among Israeli adolescents. J Asthma 2018;55:826–836. Epub 2017/09/06. doi:10.1080/02770903.2017.1373809.
   PubMed Web of Science ®Google Scholar
• Machluf Y, Navon N, Yona A, Pirogovsky A, Palma E, Tal O, et al. From a quality assurance and control system for medical processes, through epidemiological trends of medical conditions, to a nationwide health project. In: Eldin AB, ed. Modern approaches to quality control. Rijeka, Croatia: InTech; 2011:259–282.
   Google Scholar
• Chaiter Y, Machluf Y, Pirogovsky A, Palma E, Yona A, Shohat T, Yitzak A, Ash N, Cohen A, Chaiter Y. Quality control and quality assurance of medical committee performance in the Israel Defense Forces. Int J Health Care Qual Assur 2010;23:507–515. Epub 2010/09/18.
   PubMedGoogle Scholar
• Chaiter Y, Palma E, Machluf Y, Yona A, Cohen A, Pirogovsky A, Shohat T, Yitzak A, Tal O, Ash N. Quality-assuring intervention for technical medical staff at medical committees. Int J Health Care Qual Assur 2011;24:19–30. Epub 2011/04/05.
   PubMedGoogle Scholar
• Machluf Y, Pirogovsky A, Palma E, Yona A, Navon A, Shohat T, Yitzak A, Tal O, ash N, Nachman M, et al. Coordinated computerized systems aimed at management, control, and quality assurance of medical processes and informatics. Int J Health Care Qual Assur 2012;25:663–681. Epub 2013/01/02. doi:10.1108/09526861211270622.
   PubMedGoogle Scholar
• Machluf Y, Fink D, Farkash R, Rotkopf R, Pirogovsky A, Tal O, Shohat T, Weisz G, Ringler E, Dagan D, et al. Adolescent BMI at Northern Israel: from trends, to associated variables and comorbidities, and to medical signatures. Medicine (Baltimore) 2016;95:e3022. Epub 2016/03/26. doi:10.1097/md.0000000000003022.
   PubMed Web of Science ®Google Scholar
• Bousquet J. Global initiative for asthma (GINA) and its objectives. Clin Exp Allergy 2000;30: 2–5. Epub 2000/06/13.
   PubMed Web of Science ®Google Scholar
• Amelink M, de Nijs SB, de Groot JC, van Tilburg PMB, van Spiegel PI, Krouwels FH, Lutter R, Zwinderman AH, Weersink EJ, ten Brinke A, et al. Three phenotypes of adult-onset asthma. Allergy 2013;68:674–680. Epub 2013/04/18. doi:10.1111/all.12136.
   PubMed Web of Science ®Google Scholar
• Moore WC, Fitzpatrick AM, Li X, Hastie AT, Li H, Meyers DA, Bleecker ER. Clinical heterogeneity in the severe asthma research program. Ann Am Thorac Soc 2013;10:S118–S124. Epub 2013/12./01. PubMed PMID: 24313761; PubMed Central PMCID: PMCPMC3960988. doi:10.1513/AnnalsATS.201309-307AW.
   PubMedGoogle Scholar
• Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, Chen TJ, Bai YM. Asthma and attention-deficit/hyperactivity disorder: a nationwide population-based prospective cohort study. J Child Psychol Psychiatry 2013;54:1208–1214. Epub 2013/06/05. doi:10.1111/jcpp.12087.
   PubMed Web of Science ®Google Scholar
• Borschuk AP, Rodweller C, Salorio CF. The influence of comorbid asthma on the severity of symptoms in children with attention-deficit hyperactivity disorder. J Asthma 2018;55:66–72. Epub 2017/05/02. doi:10.1080/02770903.2017.1306549.
   PubMed Web of Science ®Google Scholar
• Carlson SM, Kim J, Khan DA, King K, Lucarelli RT, McColl R, Peshock R, Brown ES. Hippocampal volume in patients with asthma: Results from the Dallas Heart Study. J Asthma 2017;54:9–16. Epub 2016/05/18. PubMed PMID: 27187077; PubMed Central PMCID: PMCPMC5602555. doi:10.1080/02770903.2016.1186174.
   PubMed Web of Science ®Google Scholar
• Al-Amin M, Zinchenko A, Geyer T. Hippocampal subfield volume changes in subtypes of attention deficit hyperactivity disorder. Brain Res 2018;1685:1–8. Epub 2018/02/11. doi:10.1016/j.brainres.2018.02.007.
   PubMed Web of Science ®Google Scholar
• Chatzikonstantinou A. Epilepsy and the hippocampus. Front Neurol Neurosci 2014;34:121–142. Epub 2014/04/30. doi:10.1159/000356435.
   PubMedGoogle Scholar
• Klein B, Mrowetz H, Thalhamer J, Scheiblhofer S, Weiss R, Aigner L. Allergy enhances neurogenesis and modulates microglial activation in the hippocampus. Front Cell Neurosci 2016;10:169. Epub 2016/07/23. PubMed PMID: 27445696; PubMed Central PMCID: PMCPMC4923262. doi:10.3389/fncel.2016.00169.
   PubMed Web of Science ®Google Scholar
• Lee LY, Gu Q. Role of TRPV1 in inflammation-induced airway hypersensitivity. Curr Opin Pharmacol 2009;9:243–249. PubMed PMID: PMC2704095. doi:10.1016/j.coph.2009.02.002.
   PubMed Web of Science ®Google Scholar
• Rosenberg SL, Miller GE, Brehm JM, Celedon JC. Stress and asthma: novel insights on genetic, epigenetic, and immunologic mechanisms. J Allergy Clin Immunol 2014;134:1009–1015. Epub 2014/08/19. PubMed PMID: 25129683; PubMed Central PMCID: PMCPMC4252392. doi:10.1016/j.jaci.2014.07.005.
   PubMed Web of Science ®Google Scholar
• van der Schans J, Pleiter JC, de Vries TW, Schuiling-Veninga CC, Bos JH, Hoekstra PJ, Hak E. Association between medication prescription for atopic diseases and attention-deficit/hyperactivity disorder. Ann Allergy Asthma Immunol 2016;117:186–191. Epub 2016/06/19. doi:10.1016/j.anai.2016.05.025.
   PubMed Web of Science ®Google Scholar
• Reddy AP, Gupta MR. Management of asthma: the current US and European guidelines. Adv Exp Med Biol 2014;795:81–103. Epub 2013/10/29. doi:10.1007/978-1-4614-8603-9_6.
   PubMed Web of Science ®Google Scholar
• Oksel C, Haider S, Fontanella S, Frainay C, Custovic A. Classification of pediatric asthma: from phenotype discovery to clinical practice. Front Pediatr 2018;6:258. Epub 2018/10/10. PubMed PMID: 30298124; PubMed Central PMCID: PMCPMC6160736. doi:10.3389/fped.2018.00258.
   PubMed Web of Science ®Google Scholar