150
Views
1
CrossRef citations to date
0
Altmetric
Diagnostics

Utility and efficiency of methacholine challenge testing in evaluating pediatric asthma: unraveling the diagnostic conundrum

, MDORCID Icon &
Pages 69-74 | Received 23 May 2019, Accepted 31 Aug 2019, Published online: 17 Sep 2019

References

  • Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, MacIntyre NR, McKay RT, Wanger JS, Anderson SD, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161:309–329. doi:10.1164/ajrccm.161.1.ats11-99.
  • Perpina M, Pellicer C, de Diego A, Compte L, Macian V. Diagnostic value of the bronchial provocation test with methacholine in asthma. A Bayesian analysis approach. Chest 1993;104:149–154. doi:10.1378/chest.104.1.149.
  • Cockcroft DW. Direct challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 2010;138:18S–24S. doi:10.1378/chest.10-0088.
  • Parsons JP, Hallstrand TS, Mastronarde JG, Kaminsky DA, Rundell KW, Hull JH, Storms WW, Weiler JM, Cheek FM, Wilson KC, et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med 2013;187:1016–1027. doi:10.1164/rccm.201303-0437ST.
  • De Baets F, Bodart E, Dramaix-Wilmet M, Van Daele S, de Bilderling G, Masset S, Vermeire P, Michel O. Exercise-induced respiratory symptoms are poor predictors of bronchoconstriction. Pediatr Pulmonol 2005;39:301–305. doi:10.1002/ppul.20185.
  • Bavarian B, Mehrkhani F, Ziaee V, Yousefi A, Nourian R. Sensitivity and specificity of self-reported symptoms for exercise induced bronchospasm diagnosis in children. Iran J Pediatr 2009;19:47–51.
  • Kliegman R, Stanton B, St. Geme JW, Schor NF, Behrman RE, Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier; 2016:37–39
  • Le Souef PN. Validity of methods used to test airway responsiveness in children. Lancet 1992;339:1282–1284.
  • Joseph-Bowen J, de Klerk NH, Firth MJ, Kendall GE, Holt PG, Sly PD. Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children. Am J Respir Crit Care Med 2004;169:850–854. doi:10.1164/rccm.200304-556OC.
  • Lee E, Kim Y-H, Han S, Yang S-I, Jung Y-H, Seo J-H, Kim H-B, Lee SY, Kwon J-W, Hong S-J, et al. Different cutoff values of methacholine bronchial provocation test depending on age in children with asthma. World J Pediatr 2017;13:439–445. doi:10.1007/s12519-017-0026-5.
  • Mazi A, Lands LC. Effect of lowering methacholine challenge test cutoff in children. Ann Allergy Asthma Immunol 2014;113:393–397. doi:10.1016/j.anai.2014.06.024.
  • Pare PD, McParland BE, Seow CY. Structural basis for exaggerated airway narrowing. Can J Physiol Pharmacol 2007;85:653–658. doi:10.1139/Y07-051.
  • Bosse Y, Riesenfeld EP, Pare PD, Irvin CG. It's not all smooth muscle: non-smooth-muscle elements in control of resistance to airflow. Annu Rev Physiol 2010;72:437–462. doi:10.1146/annurev-physiol-021909-135851.
  • Holley AB, Cohee B, Walter RJ, Shah AA, King CS, Roop S. Eucapnic voluntary hyperventilation is superior to methacholine challenge testing for detecting airway hyperreactivity in nonathletes. J Asthma 2012;49:614–619. doi:10.3109/02770903.2012.697955.
  • Anderson SD, Charlton B, Weiler JM, Nichols S, Spector SL, Pearlman DS, A305 Study Group. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res 2009;10:4. doi:10.1186/1465-9921-10-4.
  • Bhatia R, Schwendeman E. Efficient use of simple exercise-induced bronchoconstriction challenge testing in pediatric exercise-induced dyspnea. Respir Care 2019;64:71–76. doi:10.4187/respcare.06283.
  • Coates AL, Wanger J, Cockcroft DW, Culver BH, Carlsen K-H, Diamant Z, Gauvreau G, Hall GL, Hallstrand TS, Horvath I, et al. ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. Eur Respir J 2017;49:1601526. doi:10.1183/13993003.01526-2016.
  • Coates AL, Dell SD, Cockcroft DW, Gauvreau GM. The PD20 but not the PC20 in a methacholine challenge test is device independent. Ann Allergy Asthma Immunol 2017;118:508–509. doi:10.1016/j.anai.2017.01.010.
  • Gilbert R, Auchincloss JH. Jr., Post-test probability of asthma following methacholine challenge. Chest 1990;97:562–565. doi:10.1378/chest.97.3.562.
  • Palmeiro EM, Hopp RJ, Biven RE, Bewtra AK, Nair NN, Townley RG. Probability of asthma based on methacholine challenge. Chest 1992;101:630–633. doi:10.1378/chest.101.3.630.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.